ライフサイエンスコーパス: oxidized LDL

1 d that the peptides isolated from the Cu(2+)-oxidized LDL all contained kynurenine residues in place

2 peptides with absorbance at 365 nm in Cu(2+)-oxidized LDL not treated with DNPH.

3 The product profile we observed in Cu(2+)-oxidized LDL was remarkably different from the profiles

4 as human plasma, MDA-modified LDL and Cu(2+)-oxidized LDL.

5 llular cholesterol accumulation in humans 3) oxidized LDL, LDL, and cholesterol, but not high-density

6 Apolipoprotein E, lipoprotein(a), oxidized LDL (low density lipoprotein)'s and large LDL p

7 (IL23A), adrenergic beta-2 receptor (ADRB2), oxidized LDL (lectin-like) receptor 1 (OLR1), and IL-8 r

8 oprostanes (p = 0.065), they failed to alter oxidized LDL or autoantibodies to oxidized LDL.

9 Although oxidized LDL (OxLDL) is thought to contribute to lesion

10 lerotic lesion size ( approximately 40%) and oxidized LDL and macrophage content of the plaques.

11 lpha, tumor necrosis factor [TNF]-alpha, and oxidized LDL [ox-LDL]) by use of Northern blot and ribon

12 In univariate analyses, lower BMI and oxidized LDL, and higher waist-hip ratio, hsCRP and zonu

13 In univariate analyses, lower BMI and oxidized LDL, and higher waist-hip ratio, hsCRP, and zon

14 w-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, wherea

15 opolysaccharide, native LDL cholesterol, and oxidized LDL-cholesterol stimulation.

16 addition to hyperglycemia, extravasated and oxidized LDL is an important insult to the diabetic reti

17 e proliferator-activated receptor gamma, and oxidized LDL receptors were elevated in the livers of do

18 aATP correlated negatively with glycemia and oxidized LDL.

19 cells were also found to internalize LDL and oxidized LDL (oxLDL) readily.

20 t deprivation, free cholesterol loading, and oxidized LDL.

21 observed in APOE4 macrophages after LPS and oxidized LDL activation.

22 phagocytic capacity in response to LPS, and oxidized LDL-induced expression of ApoE and Abca1.

23 density lipoprotein [LDL]), macrophages, and oxidized LDL was performed in retinal sections from four

24 AD decreased malondialdehyde and oxidized LDL at 7 d (35% and 11%, respectively; P < 0.01

25 fect on increasing the binding of native and oxidized LDL to biglycan than versican.

26 tran, and, most importantly, both native and oxidized LDL, resulting in intracellular lipid accumulat

27 wth factors, heavy metals, nitric oxide, and oxidized LDL.

28 FAH), which mediates inactivation of PAF and oxidized LDL.

29 he lipid hydroperoxide-modified proteins and oxidized LDL was confirmed.

30 licated pregnancies with elevated STBEVs and oxidized LDL levels (such as preeclampsia).

31 chment of triglyceride-rich lipoproteins and oxidized LDLs, HDL cholesterol fall, adipokine imbalance

32 of large triglyceride-rich lipoproteins and oxidized LDLs, lower HDL cholesterol and adiponectin con

33 asma total-cholesterol (total-c), LDL-c, and oxidized-LDL to levels similar to lean; lessened protein

34 increased levels of oxidized lipids (such as oxidized LDL and pro-inflammatory HDL), upregulation of

35 Atherogenic lipoproteins such as oxidized LDL are implicated in the pathogenesis of ather

36 by favoring the formation of pro-atherogenic oxidized LDL.

37 Because oxidized LDL (ox-LDL) is implicated in many proatherogen

38 Because oxidized LDL (oxLDL) is thought to promote atherogenesis

39 Cross talk between oxidized LDL (ox-LDL) and angiotensin II (Ang II) may be

40 lso found on the cell surface where it binds oxidized LDL, an important factor in atherogenesis.

41 o- to threefold higher plasma levels of both oxidized LDL (oxLDL) and cLDL compared with control mice

42 e enhanced tissue factor pathway activity by oxidized LDL, but not the increased mRNA or protein indu

43 vascular plaque buildup is mainly caused by oxidized LDL (ox-LDL) rather than native-LDL.

44 Promoter activity was enhanced by oxidized LDL, and LPS was inhibited by DETA-NO.

45 e factor messenger RNA (mRNA) was induced by oxidized LDL or native LDL; however, native LDL did not

46 within an atherogenic lesion are induced by oxidized LDL.

47 of calcium flux suppressed SR-A induction by oxidized LDL.

48 ver, upregulation of TLR-4 in macrophages by oxidized LDL suggests that TLR-4 may provide a potential

49 Activation of monocyte/macrophages (M/Ms) by oxidized LDL further increased ALP activity in coculture

50 re induced by lipopolysaccharide (LPS) or by oxidized LDL but not native LDL.

51 phore greatly enhanced SR-A up-regulation by oxidized LDL or other treatments that promote intracellu

52 Many cell functions are altered in vitro by oxidized LDL, but few have been examined in vivo.

53 oxidative stress indexes (protein carbonyls, oxidized LDLs, and 8-iso-prostaglandin-F(2alpha)) were m

54 ased SR-A gene transcription induced by cell-oxidized LDL up-regulated SR-A mRNA and increased by 30-

55 In THP-1 cells, oxidized LDL induced monocyte-to-macrophage differentiat

56 Cholesterol (oxidized LDL) uptake and accumulation were markedly incr

57 d NAD(P)H oxidase expression and circulating oxidized LDL, suggesting a potential for increased oxida

58 ma was due to a 260% increase of circulating oxidized LDL (oxLDL) binding to its receptor, LOX-1, and

59 min E levels (P<0.0001), reduced circulating oxidized LDL (P=0.03), and reduced LDL oxidative suscept

60 d human subjects, they show that circulating oxidized LDL and circulating monocyte-derived tissue fac

61 In conclusion, oxidized LDL-mediated PGIS nitration and associated thro

62 In contrast, oxidized LDL (OxLDL), which is mainly formed in the aort

63 o malondialdehyde-LDL also recognized copper oxidized LDL, acrolein-LDL, or LDL modified by arachidon

64 Copper-oxidized LDL (Cu-OxLDL) was able to compete with 125I-Mo

65 Copper-oxidized LDL also increased SR-A receptor expression.

66 Levels of IgG antibodies against copper-oxidized LDL were lower in sIgM.Ldlr(-/-) mice fed a hig

67 low-density lipoprotein (MDA-LDL) and copper-oxidized LDL (Cu-OxLDL) were measured in 765 subjects in

68 dies to malondialdehyde (MDA)-LDL and copper-oxidized LDL (Cu-OxLDL), and apolipoprotein B-100-immune

69 centrations of native LDL (n-LDL) and copper-oxidized LDL.

70 r ERK activation than that induced by copper-oxidized LDL +/- glycation (P < 0.05).

71 d and internalized more than 60% less copper-oxidized LDL and LDL modified by monocyte-generated reac

72 EC) uptake of experimentally prepared copper-oxidized LDL (oxLDL).

73 HAECs were incubated with copper-oxidized LDL, and the supernatant was subsequently purif

74 Compared with copper-oxidized LDL, L5 was only mildly oxidized, although its

75 DL had little effect, incubation with either oxidized LDL or LPS/TNF-alpha significantly increased su

76 HL does, however, enhance oxidized LDL uptake by peritoneal macrophages.

77 In contrast, extensively oxidized LDL and acetyl-LDL, which are more electronegat

78 elative effect on the binding of extensively oxidized LDL to proteoglycans compared with native LDL.

79 isms of OxLDL were obtained with extensively oxidized LDL unlikely to occur in early stages of athero

80 heat-denatured enzymes, oxidized fibrinogen, oxidized LDL, and native or oxidized amyloid beta-peptid

81 at acidic pH, displays binding activity for oxidized LDL (ox-LDL).

82 t least some of the macrophage receptors for oxidized LDL can recognize both the lipid and the protei

83 Data support a proatherogenic role for oxidized LDL in atherosclerosis and several studies show

84 present in oxidized LDL, lipid extracts from oxidized LDL were fractionated by normal phase HPLC.

85 ively fragmented phospholipids isolated from oxidized LDL, a synthetic oxidized alkylphospholipid (az

86 fractions containing lysophospholipids from oxidized LDL or phospholipase A2-treated native LDL stim

87 However, neither conditioned medium from oxidized-LDL-activated M/Ms or transwell coculture had t

88 Glucose-oxidized LDL resulted in phosphorylation of extracellula

89 The mitogenic effect of glucose-oxidized LDL was mediated by CD36 and by extracellular s

90 Hence, oxidized LDL administered in vivo can injure the endothe

91 In ARPE19 cells and HMVECs, oxidized LDL and 7kCh induced VEGF 8- to 10-fold above c

92 Consonant with this hypothesis, HOCl oxidized LDL cholesterol in the presence of Cl- and at a

93 sults of recent studies that demonstrate how oxidized LDL affects cellular function, and highlights k

94 Extensively copper- and hypochlorite-oxidized LDL bound poorly to versican and biglycan.

95 sed HLA II and CD11c expression and impaired oxidized LDL uptake.

96 lysoPC was consistent with its abundance in oxidized LDL.

97 )-PAF analogs were 100-fold more abundant in oxidized LDL than PAF.

98 re the likely source of PAF-like activity in oxidized LDL.

99 them to previously undetectable agonists in oxidized LDL.

100 cero-3-phosphocholines (C(4)-PAF analogs) in oxidized LDL that comigrated with PAF-like activity.

101 usive precursors for PAF-like bioactivity in oxidized LDL.

102 an atherogenic lysophospholipid contained in oxidized LDL, rapidly induces P-selectin expression in b

103 e present review is that oxysterols found in oxidized LDL (oxLDL) play a role in atherogenesis.

104 We identified mediators in oxidized LDL that induced an inflammatory reaction in vi

105 r the formation of modified phospholipids in oxidized LDL remain poorly understood.

106 lude oxidatively fragmented phospholipids in oxidized LDL.

107 ocholesterol, the major oxysterol present in oxidized LDL and atherosclerotic lesions, in Abcg1(+/+),

108 antimigratory activity of lysoPC present in oxidized LDL, lipid extracts from oxidized LDL were frac

109 hese proteins can play a significant role in oxidized LDL uptake by activated macrophages in vitro an

110 of low-density lipoprotein (LDL), including oxidized LDL and acetylated LDL, but not native LDL.

111 esponse to oxidized phospholipids, including oxidized LDL.

112 o a number of immobilized proteins including oxidized LDL, IgG, amyloid beta peptide 1-42, C4b-bindin

113 ls specific for lesional antigens, including oxidized LDLs and heat shock protein 60 (HSP60), may pro

114 bility to macromolecules in vivo, we infused oxidized LDL, native LDL, or their solvent intravenously

115 with native LDL or solvent control infusion, oxidized LDL infusion increased (1) the number of injure

116 n monocyte-derived macrophages that ingested oxidized LDL, while enhancing high-density lipoprotein-s

117 last growth factor-2 significantly inhibited oxidized LDL and lysoPC-induced DNA synthesis in SMC; ir

118 -specific inhibition of superoxide inhibited oxidized LDL-induced NF-kappaB (nuclear factor-kappaB) a

119 Interestingly, oxidized LDL induced more ABCA1 in wild type macrophages

120 Intraretinal oxidized LDL was absent in nondiabetic subjects but pres

121 a superoxide scavenger, reduced intraretinal oxidized LDL and glycated LDL levels, PGIS nitration, an

122 C and uptake at 37 degrees C of 125I-labeled oxidized LDL by activated THP-1 cells was inhibited by 3

123 P, but not by low-density lipoprotein (LDL), oxidized LDL, VLDL, apoC-I, apoC-III, or heparin.

124 ncluding fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant

125 (DKO) were treated with control LDL, GV-LDL, oxidized LDL (ox-LDL) or LDL aggregated by vortexing (vx

126 They took-up less oxidized LDL, whereas CD11c expression, interaction with

127 higher levels of intracellular lipid levels (oxidized LDL, ox-LDL) and elevated transcript levels for

128 roxide production in response to its ligand, oxidized LDL (low-density lipoprotein).

129 itive inhibition with the SR-binding ligands oxidized LDL and malondialdehyde-acetaldehyde-modified L

130 Like oxidized LDL, LGE2-LDL, but not native LDL, undergoes re

131 ardiomyocytes in relation to the lectin-like oxidized LDL receptor (LOX-1).

132 The lectin-like oxidized LDL receptor 1 (LOX-1) is a key player in the d

133 The lectin-like oxidized LDL receptor LOX-1 mediates endothelial cell (E

134 ltured endothelial cells through lectin-like oxidized LDL receptor-1 (LOX-1) signaling, and glycosyla

135 vate platelets via its receptor, lectin-like oxidized LDL receptor-1 (LOX-1), and alphabeta amyloid p

136 iation of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronar

137 t-activating factor receptor and lectin-like oxidized LDL receptor-1 to attenuate Akt activation and

138 including TLR9, pentraxin-3, and lectin-like oxidized LDL receptor-1, was regulated, in part, via a M

139 human DCs via DC-ASGPR, but not lectin-like oxidized-LDL receptor, Dectin-1, or DC-specific ICAM-3-g

140 her total antioxidant status (TAS) and lower oxidized LDL as expected.

141 Therefore, we measured oxidized LDL (oxLDL), advanced glycation end products-mo

142 clustering-responsive receptor that mediates oxidized LDL uptake by macrophages.

143 ociated phospholipase A2 (Lp-PLA2), Mercodia oxidized LDL (OxLDL) with antibody 4E6, oxidized phospho

144 Mildly oxidized LDL also activated MAP and Jun kinases and incr

145 Mildly oxidized LDL and methyl-LDL, which have an electrophoret

146 We conclude that: (a) mildly oxidized LDL can induce an increased apoJ/PON ratio, and

147 results suggest that HO-1 induced by mildly oxidized LDL may protect against the induction of inflam

148 isoform of HO, was highly induced by mildly oxidized LDL, and augmented induction was observed with

149 dicate that a highly electronegative, mildly oxidized LDL subfraction present in human hypercholester

150 important, they demonstrate that even mildly oxidized LDL formed in atherosclerotic lesions may activ

151 These findings support a role for mildly oxidized LDL in the redox regulation of macrophage diffe

152 Injection of mildly oxidized LDL (but not native LDL) into BL/6 mice (but no

153 roxidation, reverses the oxidation of mildly oxidized LDL (MM-LDL), and inhibits the ability of MM-LD

154 l nature, the mitogenic components of mildly oxidized LDL (moxLDL) remain unclear.

155 We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two pr

156 We now demonstrate that mildly oxidized LDL generated by incubation with oxygen radical

157 Oxidized phospholipids in the mildly oxidized LDL appear to be responsible for HO-1 induction

158 atment of HepG2 cells in culture with mildly oxidized LDL (but not native LDL) resulted in reduced mR

159 here it was induced by treatment with mildly oxidized LDL (moxLDL) and IFN-gamma.

160 al lipopolysaccharide (LPS) and by minimally oxidized LDL (mmLDL), as a model for subclinical endotox

161 inding was effectively competed by minimally oxidized LDL but not by native LDL.

162 (IL)-1beta and IL-6 as well as by minimally oxidized LDL.

163 e ability of the cells to generate minimally oxidized LDL.

164 dentical to those present in human minimally oxidized LDL and in murine atherosclerotic lesions.

165 We have developed a model of minimally oxidized LDL (mmLDL) in which native LDL is modified by

166 h of treatment with as little as 5 microg/ml oxidized LDL.

167 ncubated with native LDL (50 micrograms/mL), oxidized LDL (30 micrograms/mL), or lipopolysaccharide (

168 PC), a major component of minimally modified/oxidized-LDL (MM-LDL) mimics the biological activities a

169 ssociated phospholipase A2, myeloperoxidase, oxidized LDL, lipoprotein (a), isoprostanes, and small,

170 C. pneumoniae in the presence or absence of oxidized LDL, then measured foam cell formation.

171 Scavenger receptor-mediated accumulation of oxidized LDL (OxLDL)-derived cholesteryl ester is consid

172 arteries from the pro-inflammatory action of oxidized LDL.

173 beta(2)GP1 as well as to delipidated apoB of oxidized LDL but not to native apoB.

174 ry wall might increase the atherogenicity of oxidized LDL, since it enables its binding to vascular b

175 lipoprotein regulation given its binding of oxidized LDL in vitro and its colocalization to a region

176 e data suggest that the increased binding of oxidized LDL to LPL-ECM may be due to the exposure of no

177 correlates with increased negative charge of oxidized LDL and with a moderate increase in thioflavin

178 ic acid metabolites, which are components of oxidized LDL found in large amounts in atherosclerotic p

179 dylcholine (lyso-PC), abundant components of oxidized LDL, mediate the effects of atherogenic lipids.

180 (pravastatin) therapy reduced the content of oxidized LDL, inflammatory cells (macrophage, T cells) i

181 Accordingly, we studied the effects of oxidized LDL (oxLDL) or tumor necrosis factor-alpha (TNF

182 Thus, C. pneumoniae augments the effects of oxidized LDL on cell death independent of a sustained in

183 on, protect against the cytotoxic effects of oxidized LDL, and inhibit platelet activation.

184 dative stress (autoantibodies to epitopes of oxidized LDL, F2-isoprostanes, 8-hydroxy-2'-deoxyguanosi

185 rs to various oxidation-specific epitopes of oxidized LDL, including OxPLs containing phosphorylcholi

186 We separated total lipid extracts of oxidized LDL using high-performance liquid chromatograph

187 hological sequence leading from formation of oxidized LDL in the artery wall to cellular dysfunction

188 One proposed mechanism involves fusion of oxidized LDL in the arterial wall; another involves oxid

189 arterial proteoglycans, facilitate fusion of oxidized LDL in vivo.

190 orescence (NIRF) approach for the imaging of oxidized LDL in atherosclerosis.

191 -60, and a change in T-dependent isotypes of oxidized LDL-specific antibodies.

192 rcholesterolemia leads to elevated levels of oxidized LDL (oxLDL) in plasma and that this induces exp

193 ults demonstrate that the baseline levels of oxidized LDL (oxLDL), MDA-modified LDL (MDA-LDL), and ad

194 expression could link the elevated levels of oxidized LDL and fibrin deposition known to precede CAV.

195 s, diabetes increased intraretinal levels of oxidized LDL and glycated LDL, induced PGIS nitration, e

196 Levels of oxidized LDL and Lp(a) lipoprotein were measured in a to

197 Levels of oxidized LDL are reported as the oxidized phospholipid c

198 Circulating levels of oxidized LDL are strongly associated with angiographical

199 the constituents and molecular mechanisms of oxidized LDL-mediated HO-1 induction, human renal epithe

200 In monocytes cultured in the presence of oxidized LDL, strong induction and colocalization of TF

201 fected with C. pneumoniae in the presence of oxidized LDL.

202 A range of oxidized LDL species is thus generated, ultimately resul

203 his was evidenced by the cross-reactivity of oxidized LDL with antibodies against hemoglobin that was

204 inflammation is triggered by recognition of oxidized LDL (oxLDL) by Kupffer cells (KCs).

205 due to its ability to block the retention of oxidized LDL in vivo.

206 Hypoxic lipid accumulation and storage of oxidized LDL, cholesteryl esters and triglycerides were

207 Accordingly, treatment of oxidized LDL with phospholipase A(1) greatly reduced pho

208 ation that occurs depends upon the uptake of oxidized LDL (Ox-LDL), a process in which the scavenger

209 oxidized phospholipids, blocks the uptake of oxidized LDL (OxLDL) by macrophages.

210 lso discovered that CD36-dependent uptake of oxidized LDL (oxLDL) in vitro and foam cell formation in

211 TZDs markedly stimulate the uptake of oxidized LDL (oxLDL) into adipocytes, and this requires

212 of CD36 expression and macrophage uptake of oxidized LDL (oxLDL).

213 PPARalpha(-/-) mice had increased uptake of oxidized LDL and decreased cholesterol efflux.

214 ation and dysfunction by mediating uptake of oxidized LDL and inducing pro-atherogenic signaling.

215 b) mice have increased binding and uptake of oxidized LDL, in part due to a post-transcriptional incr

216 and atherogenesis by mediating the uptake of oxidized LDL.

217 Generation of oxidized LDLs and reduced nitric oxide (NO) availability

218 xamined the tissue-specific effects of AT on oxidized LDL (ox-LDL)-mediated endothelial dysfunction i

219 tudy evaluated the impact of atorvastatin on oxidized LDL (OxLDL) in patients with acute coronary syn

220 xidation-specific epitopes (OSE), present on oxidized LDL (OxLDL), apoptotic cells, cell debris and m

221 we determined the effect of rosiglitazone on oxidized LDL (oxLDL)-induced apoptosis.

222 sis when challenged with free cholesterol or oxidized LDL loading.

223 induced by loading with free cholesterol or oxidized LDL.

224 n in the RPE, induced by vitamin A dimers or oxidized LDL, inhibits these defense mechanisms by activ

225 ae, human heat-shock protein 60 (hHSP60), or oxidized LDL (ox-LDL).

226 There was no difference in hsCRP or oxidized LDL concentrations after egg doses.

227 xposed to LPS (10 microg/mL), native LDL, or oxidized LDL (30 microg/mL) for 6 hours.

228 POE4 macrophages when stimulated with LPS or oxidized LDL.

229 rated by platelet-activating factor (PAF) or oxidized LDL that acts as a PAF mimetic.

230 to platelet-derived growth factor (PDGF) or oxidized LDL (oxLDL) (p < 0.0001).

231 se and 24-h postdose serum hsCRP, and plasma oxidized LDL were measured.

232 Previously oxidized LDL aggregated rapidly and spontaneously at pH

233 et of fluid flow, atherogenic flow profiles, oxidized LDL, and proatherosclerotic cytokines all stimu

234 erogenic lipoprotein that, unlike profoundly oxidized LDL (OxLDL), is not recognized by scavenger rec

235 expression by small-interfering RNA promoted oxidized-LDL-mediated monocyte adhesion to ECs, EC migra

236 eptide, high-sensitivity C-reactive protein, oxidized LDL antibody, soluble receptor tumor necrosis f

237 or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions

238 We also observed reduced oxidized LDL uptake and increased cholesterol efflux by

239 20 mumol/liter of rosiglitazone reduced oxidized LDL-induced apoptosis by 40% and neutralizing a

240 muli, including shear stress, cyclic strain, oxidized LDL, hyperglycemia, and cell growth, modulate e

241 Plasma markers of oxidant stress (oxidized LDL and autoantibodies) were also measured.

242 ghly analogous to acetylated LDL rather than oxidized LDL.

243 However, direct evidence that oxidized LDL causes atherosclerosis is lacking.

244 and in vitro migration assays, we found that oxidized LDL (oxLDL), but not native LDL, inhibited migr

245 It is hypothesized that oxidized LDL exposes similar molecular patterns recogniz

246 We hypothesized that oxidized LDL mediated the activation of the tissue facto

247 Although there is the possibility that oxidized LDL activates the NLRP3 inflammasome in vivo, o

248 These findings reveal that oxidized LDL/CD36 signaling in macrophages links dysregu

249 ing, and functional energetics revealed that oxidized LDL upregulated effectors of long-chain fatty a

250 Here we show that oxidized LDL and amyloid-beta trigger inflammatory signa

251 We previously showed that oxidized LDL (oxLDL) formed in the setting of hyperlipid

252 e evidence has been accumulated showing that oxidized LDL promotes pro-atherogenic events.

253 These results suggest that oxidized LDL and its lysoPC moiety stimulate SMC to ente

254 gether with biglycan or versican allowed the oxidized LDL to bind the proteoglycans in an LPL dose-de

255 atory transcription factor NFkappaB, and the oxidized LDL receptor LOX-1.

256 ion of molecular mechanisms that involve the oxidized LDL receptor (LOX-1), endothelial localized nit

257 rosclerotic lesions, where MafB mediates the oxidized LDL-activated LXR/RXR-induced expression of apo

258 rkers of LDL oxidation such as antibodies to oxidized LDL (Ab-OxLDL) and LDL-containing immune comple

259 ical role in the production of antibodies to oxidized LDL and consequently in the formation of LDL-co

260 Monoclonal antibodies to oxidized LDL, cloned from the apo E-deficient mice, also

261 (PK) of a human recombinant IgG1 antibody to oxidized LDL (anti-oxLDL) in cynomolgus monkey.

262 B cells and significantly higher antibody to oxidized LDL and cardiolipin.

263 rate diminished plasma IgG autoantibodies to oxidized LDL epitopes in 12/15-lipoxygenase knockout mic

264 d to alter oxidized LDL or autoantibodies to oxidized LDL.

265 lower titers of plasma IgG autoantibodies to oxidized LDL.

266 6 modulates platelet function via binding to oxidized LDL (oxLDL), cell-derived microparticles, and t

267 CD36 binding to oxidized LDL triggers signaling cascades that are requir

268 We now report that CRP binds to oxidized LDL (OxLDL) and oxidized PtC (OxPtC), but does

269 ester accumulation in macrophages exposed to oxidized LDL and that mice with deletions of either rece

270 alternatively stimulated and then exposed to oxidized LDL.

271 tent of LDL; however, the addition of LPL to oxidized LDL together with biglycan or versican allowed

272 The immune response to oxidized LDL (OxLDL) may play an important role in ather

273 ipate in macrophage signaling in response to oxidized LDL.

274 did not affect endothelial cell responses to oxidized LDL, but lesion formation was partially reduced

275 Here, we show that the single-transmembrane oxidized LDL (oxLDL) receptor (LOX-1) resides in proximi

276 stress or pathways involved in transmitting oxidized LDL-mediated signals in circulating platelets a

277 outcomes including plasma triacylglycerols, oxidized LDL, and LDL cholesterol.

278 rs including 15-lipoxygenase and lectin-type oxidized LDL receptor-1 both in vitro and in vivo.

279 However, unlike oxidized LDL, C. pneumoniae infection does not activate

280 r receptor PPARgamma dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilita

281 ), by AT(1) receptor activation, upregulates oxidized LDL (ox-LDL) endothelial receptor LOX-1 gene ex

282 Using oxidized LDL as a representative protein ligand for H2O2

283 udy assesses whether oxidative stress, using oxidized LDL (ox-LDL) as a proxy, is associated with met

284 in cultured DRG neurons from adult rat using oxidized LDLs (oxLDLs).

285 same products are also detected in in vitro oxidized LDL.

286 cells express cyclooxygenase-2, but the way oxidized LDL stimulates cyclooxygenase-2 transcription i

287 ify the specific oxidative modifications, we oxidized LDL in the presence of Cu(2+), treated with DNP

288 To test whether oxidized LDL could injure endothelial cells and alter en

289 gress in delineating the mechanisms by which oxidized LDL effects changes in gene expression will be

290 lipoprotein (LDL) is non-atherogenic, while oxidized LDL (ox-LDL) is critical to atherosclerosis.

291 cept by immunizing experimental animals with oxidized LDL particles unexpectedly resulted in activati

292 Incubation of endothelial cells with oxidized LDL (OxLDL) or lysolecithin resulted in decreas

293 68) fractions were inversely correlated with oxidized LDL, IL-10, IL-6, and C-reactive protein.

294 estigated whether maternal immunization with oxidized LDL (OxLDL) before pregnancy protects the fetus

295 assessed in bovine aortic ECs incubated with oxidized LDL (ox-LDL).

296 context of their potential interactions with oxidized LDL and atherogenesis.

297 ) macrophages, especially after loading with oxidized LDL.

298 Moreover, stimulation with oxidized LDL induced dramatically greater gene expressio

299 appaB binding to DNA by prior treatment with oxidized LDL.

300 ntibodies, which bind the PC of OxPLs within oxidized LDL (OxLDL), also reduces atherogenesis.