ライフサイエンスコーパス: oxime

1 n synthase kinase 3beta (6-bromoindirubin-3'-oxime).

2 ysed Beckmann rearrangement of the zerumbone oxime.

3 ed lethality in 6/11 animals without amidine-oxime.

4 e generated from the ferrocenecarboxaldehyde oxime.

5 the design of a new class of reactive O-aryl oximes.

6 a hydroxylamine to provide the corresponding oximes.

7 -nitroso derivative to the corresponding E/Z-oximes.

8 nnulations of alkynes with readily available oximes.

9 allyl oximes enables rapid access to O-vinyl oximes.

10 ocoupling of radicals from readily available oximes.

11 followed by conversion to ketohydrazones or oximes.

12 h respect to both the iodoalkynes and chloro-oximes.

13 ss odoriferous properties of both isomers of oximes.

14 ve generation of iminyl radicals from simple oximes.

15 l-mediated and metal-catalyzed) reactions of oximes.

16 ifluoro-4-hydroxybenzylidene-imidazolinone-2-oxime-1-benzoimidazole), which binds Red Broccoli with h

17 The addition of the neutral oxime 2,3-butanedione monoxime increases the rate of rea

18 condensation of hydrazonophenylacetaldehyde oxime (2), obtained from 2-isonitrosoacetophenone (1), w

19 fic isolation of a diastereo and enantiopure oxime, 2-phenylpropanaldehyde oxime, from prior multidim

20 h RS41A and the standard peripherally active oxime, 2-pyridinealdoxime methiodide.

21 lohexan-1-ones 1a-1c, 4-silacyclohexan-1-one oximes 2a-2c, 1,4-azasilepan-7-ones 3a-3c, 1,4-azasilepa

22 xybenzylidene)hydrazono-2-phenylacetaldehyde oxime (5) and (4-methylbenzylidene)hydrazono-2-phenylace

23 ylbenzylidene)hydrazono-2-phenylacetaldehyde oxime (6), respectively.

24 he indirubin derivative 6-bromo-indirubin-3'-oxime (6BIO) as a promising antimetastatic agent.

25 f JAK/STAT3 signaling in 6-bromoindirubin-3'-oxime (6BIO)-mediated growth inhibition of human melanom

26 iptional inhibitor named 6-bromoindirubin-3'-oxime (6BIO).

27 yl-2-(propan-2-ylidenehydrazono)acetaldehyde oxime (7).

28 5 min after OP exposure, i.p,) with amidine oximes 7a-c and 12a, 12c, 12e, 12f, and 15b (145 mumol/k

29 ith (99m)Tc-labeled hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) or PET with (15)O-water.

30 )-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime (A-967079) abolishes JT010-elicited pain.

31 yl)ethynyl]-2-cyclohexen-1-one-O-(methyl-11C)oxime, a negative allosteric modulator of the metabotrop

32 isomers of 2-hydrazono-2-phenylacetaldehyde oxime, a reagent in the synthetic route, reveal existenc

33 hiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime] activators of human CAR.

34 Alcohols, oximes, aldehydes, and ketones are known to react under

35 oduct via a previously uncharacterized retro oxime-aldol reaction.

36 an NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime), an unselective but hitherto the most potent K(Ca

37 4,5,6,7-tetrahydroindole from cyclohexanone oxime and acetylene.

38 lood-brain barrier, the pH dependence of the oxime and amine ionizing groups of the compounds and the

39 bstrates for PFTase and as reactants in both oxime and hydrazone formation.

40 ntramolecular hydrogen bond formation in the oxime and hydroxy derivatives was confirmed by IR and (1

41 he formation of complex heterocycles through oxime and oxime ether radical cation intermediates produ

42 y alcohol are converted to pentafluorobenzyl oxime and pentafluorobenzoyl ester derivatives, which ar

43 beta-elimination and formation of pyridine-4-oxime and phenyl vinyl ketone and ends with the formatio

44 f reactions starting from a bis(cyanoalkenyl)oxime and proceeding via nitrone cycloadditions have bee

45 2,3-dioxoporphyrin can be converted, via the oxime and using the acid- or oxidant-induced reaction pa

46 of highly substituted pyrroles directly from oximes and alkynes was developed via independent optimiz

47 as well as different O-nucleophiles, such as oximes and benzyl alcohols.

48 prepared by Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C-H acti

49 vel electron donor-acceptor complexes of the oximes and Et3N was proposed as a key step of this proce

50 The formation of oximes and hydrazones is employed in numerous scientific

51 The formation of oximes and hydrazones is widely used in chemistry and bi

52 ; other anticancer compounds identified were Oximes and L-alpha-Terpinol.

53 hlorophosphite-mediated Beckmann ligation of oximes and p-toluenesulfonyl azide gives access to N-sul

54 of isomeric bicyclo[2.2.1]heptane-7- and -8-oximes and their corresponding C-nitroso derivatives, wh

55 S-11 (6-bromo-5-methyl-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydroxyimino)indolin-2-on

56 PTP inhibitors TRO-19622 (cholest-4-en-3-one oxime) and TAT-Bcl-X(L)-BH4.

57 elective PIFA mediated dehydrogenation of an oxime, and a subsequent Lossen rearrangement which occur

58 base in DMSO-d6 to afford the corresponding oxime, and no reverse isomerization from the oxime to th

59 with technetium 99m-hexamethylpropyleneamine oxime, and then reinfused intravenously.

60 tively modified with biotin, dyes, aliphatic oximes, and hydroxylamines.

61 pplicable to the use of alcohols, carbonyls, oximes, and thio-carboxylic acids as nucleophiles on bot

62 alpha,beta-Unsaturated O-pivaloyl oximes are coupled to alkenes by Rh(III) catalysis to af

63 such as alcohols, amides, carboxylates, and oximes are discussed.

64 Reactivation capacities of novel oximes are rank ordered by their relative reactivation r

65 method to prepare phenols with benzaldehyde oxime as a hydroxide surrogate.

66 urrent tandem catalysis by reacting with the oxime as a triplet sensitizer in the first catalytic cyc

67 ere we created seven uncharged acetamido bis-oximes as candidate antidotes.

68 present work, we achieved this goal by using oxime-based chemical conjugation to synthesize dimers of

69 We report the compatibility of various oxime-based compounds with the use of the Ugi multicompo

70 tion discusses miscellaneous applications of oxime-based glycoconjugates, such as enantioselective ca

71 The described oxime-based library protocol provides detailed procedure

72 forms; (ii) tethering with aldehydes to form oxime-based linkages with sufficient purity; and (iii) d

73 ture and have been employed for syntheses of oxime-based metal complexes and cage-compounds, oxime fu

74 ery and reuse, we have developed a fluorous, oxime-based palladacycle 1 and demonstrated that it is a

75 res of SNO-OCTs can be employed to modify an oxime-bearing styrene copolymer and introduce an array o

76 oach to various alpha-phosphorus-substituted oximes (beta-oximinoalkyl-substituted phosphonates, phos

77 te a GSK3beta inhibitor (6-bromoindirubin-3'-oxime BIO) for amelioration of bone destruction in a mur

78 the GSK3beta inhibitor 6-bromo-indirubin-3'-oxime (BIO) and the PPARgamma inhibitor GW9662 (GW) enha

79 by GSK-3beta antagonist 6-bromoindirubin-30-oxime (BIO) for Wnt signaling activation during embryoni

80 ffects of GSK3 inhibitor 6-bromoindirubin-3'-oxime (BIO) predicted unstable TERT repression dependent

81 Bromoindirubin-3'-oxime (BIO), previously reported to promote podocyte sur

82 Wnt signaling activator (6-bromoindirubin-3'-oxime [BIO]) or inhibitor (JW74), in the presence or abs

83 a set of well-defined conjugates bearing an oxime bond between the chain and the substrate.

84 dy drug conjugates (NDCs) were produced, via oxime bond formation between ketones on the side chain o

85 D) peptide to modify the O-hydroxylamines by oxime bond formation.

86 The resulting oxime bond was found to rapidly hydrolyze at pH2 releasi

87 (+)(pyridinium) cleavage and ether C(beta)-O(oxime) bond formation in aqueous media has been presente

88 The advantages of the oxime-bonded, site-specific NDCs were even more apparent

89 After a brief introduction to oxime bonds and their relative stabilities compared to r

90 agen model peptides that are cross-linked by oxime bonds between 4-aminooxyproline (Aop) and 4-oxoace

91 e Jahn-Teller axis due to the u(3)-oxo and u-oxime bridges.

92 olecular, beta-estradiol 6-(O-carboxy-methyl)oxime-BSA, was covalently immobilized onto the optical f

93 The resulting alpha-phosphorus-substituted oximes can be considered as useful P-, N-, and O-ligands

94 The reactivity of this class of oximes can be harnessed via the triplet energy transfer

95 ng has occurred, common therapeutics such as oximes cannot reactivate the cholinesterase enzyme and r

96 Above room temperature, both types of oxime carbamate acted as selective new precursors for am

97 Oxime carbamates derived from the volatile diethylamine

98 A set of oxime carbamates having N-alkyl and N,N-dialkyl substitu

99 radicals were generated by UV irradiation of oxime carbonate precursors.

100 In most cases, arenes with oximes, carboxylic acids, and amines as directing groups

101 A simple reaction scheme utilizing oxime chemistry was identified as a means to efficiently

102 reactions based on Huisgen cycloaddition and oxime chemistry, where the oxime linkage is redox active

103 ction behavior of N-benzoylethylpyridinium-4-oxime chloride in aqueous media under mild reaction cond

104 hiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime (CITCO) as a selective human CAR (hCAR) agonist, a

105 hiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime (CITCO) is a dual agonist for human constitutive a

106 hiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO).

107 hiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO).

108 iazole-5-carbaldehyde-O-(3,4-dichlorobenz yl)oxime (CITCO)], pregnane X receptor (PXR) [rifampicin],

109 ous tags (PFBHA and PFBHA- d(2)) through the oxime click reaction.

110 (C7-R)-nitroso compound to the corresponding oximes compared with that of the (C8-S)-nitroso derivati

111 The best oxime-conjugated knottin dimer achieved an unprecedented

112 substrates by pinacolborane (pinBH) affords oxime-containing chiral tertiary boronic esters with yie

113 yed a key role in both the ease by which the oxime could be reduced and the subsequent reactivity of

114 The application of an oxime cross-linked hydrogel system is demonstrated.

115 e to promote cascade, tandem condensation to oximes, cyclization to nitrones, and 1,3-dipolar cycload

116 volves the reversible generation of unstable oxime cyclotrimers, which are readily intercepted by bor

117 ridin-3-yl-methyl)hydroxylamine, yielding an oxime derivative that is stable through the subsequent D

118 go a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields.

119 n and subsequent separation and detection of oxime derivatives of 2-alkylcyclobutanones by high perfo

120 The released oxime-derivatives of the carbonylated-OxPLs are subseque

121 Reaction of the oxime derived from 2-(oxo-cyclopentyl)acetic acid ethyl

122 reductive elimination was conducted using an oxime-derived Pd(IV) complex, which revealed the interme

123 ry photocycloaddition reaction involving the oxime did not provide the intended polyheterocyclic fene

124 We now report that the oxime-directed CAHB of alkyl-substituted methylidene and

125 Oxime-directed catalytic asymmetric hydroboration is div

126 oxime (fresh, musty, green) and cyclocitral oxime (earthy with patchouli, moss and leather notes).

127 zed isomerization of easily prepared O-allyl oximes enables rapid access to O-vinyl oximes.

128 step, excitation of 2 causes cleavage of the oxime ester (Phi = 0.56) followed by base generation aft

129 In this process, an oxime ester function reacts with an aromatic C-H bond un

130 ft of the palladacycle-ligated methyl ketone oxime ester to enable the C-C bond formation by reductiv

131 other C-H functionalization reactions using oxime esters and potentially other carbonyl derivatives

132 st into the N-O bond of O-pentafluorobenzoyl oxime esters generates imino-Pd(II) intermediates, which

133 Methyl ketone oxime esters have been found to be excellent coupling pa

134 nts for the efficacy of O-pentafluorobenzoyl oxime esters in aza-Heck reactions of this type.

135 that end, latent PBGs were designed that are oxime esters of aliphatic acids, which undergo Norrish t

136 h undergo Norrish type II reactions to yield oxime esters of aromatic acids that are efficient PBGs.

137 ational design of thioaryl naphthylmethanone oxime ether analogs containing functional properties of

138 ently with various directing groups, such as oxime ether and benzothiazole.

139 FeCl(3).6H(2)O/NaBH(4) reduction of a chiral oxime ether and chemoselective amidation of the resultin

140 on of complex heterocycles through oxime and oxime ether radical cation intermediates produced via PE

141 clear predictions as to how the formation of oxime ether radical cations can be tuned by substituents

142 2'-arylbenzaldehyde and 2'-arylacetophenone oxime ether radical cations.

143 alent, inserting into the 1,2-dielectrophilc oxime ether to ultimately give rise to the desired N-het

144 talyzed annulation of alpha,beta-unsaturated oxime ether with alkyne has been reported.

145 ck of the aryl ring onto the nitrogen of the oxime ether.

146 s with the formation of O-alkylated pyridine oxime ether.

147 Axially chiral cyclohexylidene oxime ethers exhibit unique chirality because of the res

148 ord single geometric isomers of aryl alkynyl oxime ethers has also been developed.

149 epared by the reduction of pure (Z)-ethanone oxime ethers in up to 99% ee using 15% of catalyst.

150 pha-oximino ketenes derived from alpha-diazo oxime ethers provides 2H-azirines bearing quaternary cen

151 eening molecular targets of water-soluble 3'-oxime ethers revealed 6ha as preferential inhibitor of i

152 thesis of single geometric isomers of diaryl oxime ethers through Suzuki coupling of N-alkoxyimidoyl

153 synthesis of spirocyclic NH-azetidines from oxime ethers using either an alkyl Grignard reagent or t

154 A series of 2'-arylbenzaldehyde oxime ethers were synthesized and shown to generate the

155 zed cascade annulation/allylation of alkynyl oxime ethers with allyl halides has been established.

156 atalyzed ortho-C-H arylation of acetophenone oxime ethers with aryl pinacol boronic esters, leading t

157 mechanistic analysis to 2'-arylbenzaldehyde oxime ethers with substituents also present on the centr

158 try to give single E- or Z-isomers of diaryl oxime ethers.

159 asing the 3'-aminooxy oligonucleotides by an oxime exchange reaction.

160 xaldehyde (Fc-1) and ferrocenecarboxaldehyde oxime (Fc-2).

161 t ambient temperature include methoxy-phenyl oxime, followed by n-hexanol and 3Z-hexenal, which gives

162 Oxime group reorientation of one of the bis-oximes, forcing it to point into the active center for r

163 rs of the intermediates as well as different oximes (formaldehyde and acetone oxime) were considered.

164 -imine intermediates, allows rapid hydrazone/oxime formation even with relatively low concentrations

165 act as superior catalysts for hydrazone and oxime formation, speeding the reaction considerably over

166 ABAO and aldehydes is kinetically similar to oxime formations performed under stoichiometric aniline

167 position of the phenyl group adjacent to the oxime, forming a quinoline moiety.

168 es containing cyclopalladated alkylamine and oxime frameworks, which represent the first examples of

169 the sensory impressions were (+)-isomenthone oxime (fresh, musty, green) and cyclocitral oxime (earth

170 nd enantiopure oxime, 2-phenylpropanaldehyde oxime, from prior multidimensional separation, is descri

171 f 2-bromo-2-cyclohexen-1-ol, formation of an oxime function, conversion to an oximoyl chloride, intra

172 Steric hindrance near the oxime functional group played a key role in both the eas

173 ealed a number of features, most notably the oxime functionality to be important to this selectivity.

174 is of bilanes and hexapyrroles containing an oxime functionality, prepared by two and three consecuti

175 me-based metal complexes and cage-compounds, oxime functionalizations, and the preparation of new cla

176 (h) AChE mutants that, when coupled with an oxime, give rise to catalytic reactivation and aging res

177 nge of substrates, the C-H bonds beta to the oxime group are selectively oxidized.

178 Derivatives with an oxime group at the 6-position exhibited the greatest bac

179 Oxime group reorientation of one of the bis-oximes, forc

180 in conferring nucleophilic reactivity of the oxime group.

181 Both oxime groups in these bis-oximes were attached to the sa

182 e protonation of the heterocyclic amines and oxime groups of the bis-oximes resulted in equilibration

183 A new pentadentate oxime has been designed to drive the preferential coordi

184 While formation of hydrazone and oxime has been traditionally regarded as being limited b

185 esis of novel axially chiral cyclohexylidene oximes has been developed by catalytic desymmetrization

186 -ylacetate and N-tosyl-4-chloro-3-piperidone oxime have been used to construct the tetracyclic skelet

187 g uptake of (99m)Tc-hexamethylpropyleneamine oxime (HMPAO) is reported to be partially dependent on t

188 leukocytes ((99m)Tc-hexamethylpropyleneamine oxime [HMPAO]-labeled white blood cells [WBC]).

189 everal CNS-directed, uncharged aliphatic bis-oximes holding promise for use as protonation-dependent,

190 ith 2-PAM, the most promising cyclic amidine-oxime (i.e., 12e) showed comparable or greater reactivat

191 Even at 25% of the initial dose of amidine-oxime (i.e., a dose of 36 mumol/kg, i.p.), 7b and 12e pr

192 ta-catenin activity with 6-bromoindirubin-3'-oxime improved cardiac contractility and ameliorated int

193 synthesized by Beckmann rearrangement of its oxime in the presence of ZnCl2.

194 byproduct formation and high selectivity for oximes in good yield and purity.

195 by reacting dicarboxylic acid chlorides with oximes in the presence of excess triethylamine.

196 mpound, as well as IQ-1 and three additional oxime indenoquinoxalines, were found to be high-affinity

197 glutathione adducts derived from the quinone oxime intermediates of dronedarone and NDBD.

198 diastereomeric (E,Z) and enantiomeric (R,S) oxime into a third reactor column where isomerization oc

199 We showed that (E)-O-benzoylethylpyridine-4-oxime is formed in aqueous solution by a base-induced ta

200 Optimization and scope of the O-allyl oxime isomerization and subsequent pyrrole formation are

201 d optical spectrum from that of the starting oxime (lambdamax = 667 nm).

202 The replacement of the carbonyl group with oxime leads to a reduction of the difference in the phot

203 ddition, we interrogated an 840-member novel oxime library for reactivation of Y337A/F338A hAChE-OP c

204 tically modified with compound 1 followed by oxime ligation and click reaction to simultaneously inco

205 zontal lineN functions, synthetic aspects of oxime ligation and methodologies for introducing the ami

206 uential click approach with a combination of oxime ligation and strain promoted alkyne-azide cycloadd

207 lusters and glycodendrimers obtained through oxime ligation are described in terms of synthetic desig

208 effect comparable to fluorine and introduce oxime ligation as a tool for the functionalization of sy

209 The oxime ligation demonstrates tunable reaction kinetics wi

210 up was introduced by C-H amidation, enabling oxime ligation for the installation of an even greater r

211 s was demonstrated by an intercellular photo-oxime ligation that could be remotely cleaved and disass

212 ermed OPRAH) by total chemical synthesis and oxime ligation, with an acceleration of the final ligati

213 n be modified with diverse molecular tags by oxime ligation.

214 ural polyethylenglycol (PEG) linker by using oxime ligation.

215 ns of cells for subsequent cell assembly via oxime ligation.

216 etones and aldehydes with high efficiency by oxime ligation.

217 A photodeprotection-oxime-ligation sequence permits user-defined quantities

218 ant zwitterionic polysaccharide PS A1 via an oxime link.

219 cycloaddition and oxime chemistry, where the oxime linkage is redox active and switchable.

220 n auristatin through a stable, non-cleavable oxime linkage to afford a chemically homogeneous ADC.

221 25285/NCTC 9343 via a physiologically stable oxime linkage to furnish the first semisynthetic bacteri

222 h was then site-selectively modified through oxime linkage with benzylalkoxyamine or 5 kDa-poly(ethyl

223 to an auristatin derivative through a stable oxime linkage.

224 ycans to recombinantly produced proteins via oxime linkages.

225 Directed by an oxime-masked alcohol, annulation chemoselectively occurs

226 halen-1-yl)methanone O-2-(diethylamino)ethyl oxime (MND) exhibited the best safety profile.

227 The presence of an oxime moiety in the aromatic photosubstrate allowed the

228 is limitation, we report an efficient MTM 2'-oxime (MTM(ox)) conjugation strategy for rapid MTM diver

229 P conjugates to delineate the most efficient oxime-mutant enzyme pairs for catalytic bio-scavenging.

230 r catalyst, which would initially reduce the oxime N-O bond to generate a nucleophilic copper(II) ena

231 The oxime N-O bond undergoes oxidative addition to Pd(0)(PCy

232 (SKA-31), 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), and 1-ethylbenzimidazolin-2-one (EBIO), a

233 was developed by the covalent linkage of an oxime nucleophile and a peripheral site ligand.

234 ymmetrical oxabenzonorbornadienes (OBD) with oxime nucleophiles was investigated.

235 re made to resolve enantiomers of the chosen oximes on chiral GC columns.

236 lidine arises from conjugate addition of the oxime onto the diene to afford a transient nitrone that

237 in one location through the formation of an oxime or a hydrazone linkage.

238 Oxime or hydrazone formation was then employed to immobi

239 products (imines) to thermodynamic products (oximes or acylhydrazones) based on the reactivities of t

240 sights into the chemistry of nitrile oxides, oximes, oxazete, and nitroso compounds as well as S(N)Vi

241 Initial gold-promoted addition of the oxime oxygen to the activated alkyne afforded the O-viny

242 alpha,beta-Unsaturated oxime pivalates are proposed to undergo reversible C(sp(

243 s to the monocarbam linker, siderophore, and oxime portion of the molecules were examined.

244 The 10 best reactivating oximes, predominantly hydroxyimino acetamide derivatives

245 activated transport path opens upon retinal oxime production, instead of or in addition to the natur

246 ii) direct in vitro biological evaluation of oxime products without purification.

247 on and cyclization of 2'-alkynylacetophenone oxime radical cations using photoinduced electron transf

248 ign that implements an unprecedentedly rapid oxime reaction (>150 M(-1) s(-1)) with high specificity

249 Amidine-oxime reactivation rates for OP-inactivated acetylcholin

250 t therapy to combat OP poisoning involves an oxime reactivator (2-PAM, obidoxime, TMB4, or HI-6) comb

251 phosphonylated hAChE with an imidazole-based oxime reactivator, RS-170B.

252 he synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contai

253 A new class of amidine-oxime reactivators of organophosphate (OP)-inhibited cho

254 Current antidotes, including oxime reactivators that attack the OP-AChE conjugate to

255 g azide-alkyne, tetrazine-trans-cyclooctene, oxime, reductive amination, native chemical ligation, Su

256 and alkoxyamines, to generate hydrazones and oximes, respectively.

257 [1,3] sigmatropic rearrangements of O-vinyl oximes, respectively.

258 erocyclic amines and oxime groups of the bis-oximes resulted in equilibration among up to 16 distinct

259 eplacement of the N,N-dioxide moiety with an oxime, ring-opening of the central diketopiperazine, and

260 Starting with the initial lead oxime RS41A identified in our earlier study and extendin

261 High conversion (100%) with >90% oxime selectivity is achieved at room temperature under

262 potential of metal-involving conversions of oxime species for application in various fields of chemi

263 lizes the unique triplet state reactivity of oximes, specifically 2-isoxazoline-3-carboxylates.

264 PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnos

265 earrangement product with beta-ester O-allyl oxime substrates.

266 ound-induced mechanochemical scission of the oxime sulfonate mechanophore also generates a ketone fun

267 Here we demonstrate that oxime sulfonates-known photoacid generators-are also aci

268 Technetium- Tc 99 m Hexamethylpropyleneamine Oxime (Tc-99 m HMPAO) during ictal and interictal state

269 this is the first report of a nonquaternary oxime that has, comparable to 2-PAM, in vitro potency fo

270 photolysis of acetophenone O-allylcarbamoyl oxime, the corresponding oxazolidin-2-onylmethyl radical

271 f an alphaC-lithiated O-silyl ethyl pyruvate oxime to benzoquinone, which is followed by an oxa-Micha

272 oxime, and no reverse isomerization from the oxime to the C-nitroso compound was observed.

273 Phthaloyl chlorides reacted with acetone oxime to yield 3-(1-methylethenyl)-1H-2,3-benzoxazine-1,

274 catalysis of the intermolecular addition of oximes to activated alkynes and thermal rearrangement of

275 tivation for transforming 1-acyl-1-carbamoyl oximes to cyanoformamides.

276 arrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group

277 pling with alpha,beta-unsaturated O-pivaloyl oximes to provide substituted pyridines in good yield.

278 efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhi

279 on of cyclohexenone and tetralone O-pivaloyl oximes to the corresponding primary anilines and 1-amino

280 o assess the mechanism of the intramolecular oxime transfer reaction that leads to the formation of i

281 mines were synthesized from their respective oximes using a pulsed addition of excess NaBH(3)CN at pH

282 pid oxidation of various aliphatic amines to oximes using m-CPBA as an oxidant in ethyl acetate is de

283 products can be subsequently converted into oximes using SnCl2.2H2O in high yields.

284 omethanes and pyrrole to afford two isomeric oximes via conjugate addition followed by rearomatizatio

285 The oxime was employed as both a directing group (DG) and an

286 on of the (C8-S)-nitroso compound to the E/Z-oximes was approximately 8 times faster (at 40 degrees C

287 A small library of 57 low molecular weight oximes was prepared from fragrant aldehydes and ketones,

288 und IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) was found to be a potent, noncytotoxic inhibitor

289 H-indeno[1,2-b]quinoxalin-11-one-O-(2-furoyl)oxime]was a specific inhibitor of the c-Jun N-terminal k

290 Both oxime groups in these bis-oximes were attached to the same central, saturated hete

291 of camphor, menthone, piperitone and carvone oximes were fully resolved.

292 Amidine-oximes were tested in vitro, and reactivation rates for

293 Amidine-oximes were tested in vivo for protection against the to

294 s different oximes (formaldehyde and acetone oxime) were considered.

295 size an unprecedented type of Baylis-Hillman oxime, which underwent N-O coupling to produce new isoxa

296 reaction of O-methyl alpha,beta-unsaturated oximes with aldehydes and N-tosyl imines affords seconda

297 Condensation of oximes with boronic acids RB(OH)2 or B(OH)3 affords rema

298 alysis to couple readily available O-benzoyl oximes with cyanoarenes to synthesize primary amines wit

299 olves the reaction of beta,gamma-unsaturated oximes with electrophilic selenium and tellurium species

300 eased accessibility of the Y337A mutation to oximes within the space-impacted active center gorge wit