ライフサイエンスコーパス: oxindole

1 dation undergoes further rearrangement to an oxindole.

2 in formation of an alpha,alpha-disubstituted oxindole.

3 ate molecules of the class isoindolinone and oxindole.

4 for the synthesis of chiral 3,3'-cyclopropyl oxindole.

5 shift on indole ring to ultimately produce 2-oxindole.

6 dominantly one enantiomer of the spirocyclic oxindole.

7 ucial and highly congested 3,3-disubstituted oxindole.

8 hods for the synthesis of 3,3'-disubstituted oxindoles.

9 eady access to N-carbamoyl-3-monosubstituted oxindoles.

10 aternary carbon in alpha,alpha-disubstituted oxindoles.

11 ioenriched N-unprotected 3-allyl-3-hydroxy-2-oxindoles.

12 ted spiro-pyrrolidinyl and spiro-piperidinyl oxindoles.

13 antioenriched spirocyclohexyl-indolines and -oxindoles.

14 ogically relevant quaternary carbon-centered oxindoles.

15 arious 5'-substituted spiro[pyrrolidine-3,3'-oxindoles].

16 d carbonate derivatives of the antirheumatic oxindole 1 were prepared and screened as potential prodr

17 The series of 3-monofunctionalized 2-oxindoles 2 were conveniently synthesized from reactions

18 benzenesulfonyl chloride 2, the N-protected oxindole 3, and protected dibromide 4.

19 Initial exposure of ynones and oxindole 3-oxy acrylates to K(2)CO(3) triggered a tandem

20 variety of enantioenriched 3,3-disubstituted oxindoles 3 and spirolactones 4 were generated in modera

21 paraformaldehyde generates 3,3-disubstituted oxindoles 3 bearing a hydroxymethyl group, while the rea

22 ized symmetric/unsymmetric 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indo

23 ubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and a-aryl oxi

24 formation facilitate a rapid access to spiro[oxindole-3,2'-pyrrolidines] in their optically active fo

25 A novel stereocontrolled assembly of spiro[oxindole-3,2'-pyrrolidines] via [3+2]-cycloaddition of d

26 In this article, we have demonstrated that 2-oxindole-3-acetic acid (oxIAA) is a major primary IAA ca

27 oxidation of IAA to its primary catabolite 2-oxindole-3-acetic acid (oxIAA) remains uncharacterized.

28 ansform IAA into the biologically inactive 2-oxindole-3-acetic acid (oxIAA), representing a new bacte

29 d in Zea seedlings: Indole-3-acetic acid --> Oxindole-3-acetic acid --> 7-Hydroxyoxindole-3-acetic ac

30 t is present at levels comparable to that of oxindole-3-acetic acid and indole-3-acetic acid (62 pico

31 Indole-3-acetic acid is oxidized to oxindole-3-acetic acid by Zea mays tissue extracts.

32 enzymic oxidation of indole-3-acetic acid to oxindole-3-acetic acid in higher plants.

33 ific showing no glucose ester formation with oxindole-3-acetic acid or 7-hydroxy-oxindole-3-acetic ac

34 Moreover, our data suggested that 2-oxindole-3-acetic acid production depends, at least in p

35 Radiolabeled oxindole-3-acetic acid was metabolized by roots, shoots,

36 ion with oxindole-3-acetic acid or 7-hydroxy-oxindole-3-acetic acid, and low activity with phenylprop

37 the kernel, more than 10 times the amount of oxindole-3-acetic acid.

38 2-oxindole-3-alkylcarboxylates, this direct alkynylations

39 Spiroannulation of oxindole-3-oxy acrylates with ynones involving two overl

40 l diazoesters 3, and acrylic ester/3-alkenyl oxindoles 5/6 provide various dihydroindolizines 7 to 9

41 Indole was strongly associated with oxindole, 5-HT, and tryptamine and the sum of Trp metabo

42 owth factor receptor 1 kinase inhibitor) and oxindole (a vascular endothelial growth factor receptor

43 It was found that 5-Br-3-oxindole, a precursor of the product 5-Br-3-oxindolenine

44 For methylene oxindoles, a thermodynamically driven Z-E isomerization

45 rm 3,3-disubstituted pyrrolidines, including oxindole alkaloids.

46 between the E and Z isomers of the starting oxindoles allowed a site-specific diastereoselective and

47 terestingly, (E)-3-(2-(aryl)-2-oxoethylidene)oxindole and (E)-3-ylidene oxindole give different diast

48 ooxygenated products were found to be 5-Br-2-oxindole and 5-Br-3-oxindolenine.

49 kylidene)indolin-2-ones in high yield from 2-oxindole and aryl/alkyl nitrile in the presence of LiOtB

50 s achieved by protecting the N-center of the oxindole and C5 alkylated product is furnished exclusive

51 ynurenic acid) and citrus honey (caffeine, 2-oxindole and indole-3-carbinol).

52 s forges two bonds en route to spirocyclized oxindole and indolenine products.

53 , and rearomatization steps lead to valuable oxindole and isoindoline-1-one motifs.

54 are broad in scope with respect to both the oxindole and nitroolefin substrates and provide the desi

55 tolerate a range of substitution on both the oxindole and the aryl/vinyl coupling partners.

56 hibited that two of the suitably substituted oxindole and triazatuxene may have atropisomerism at roo

57 ion that simultaneously constructs the spiro-oxindole and vinyl isonitrile moieties.

58 loped by employing 3-(2-oxo-2-arylethylidene)oxindoles and 1,4-benzoxazinone as starting materials.

59 atile route to enantiopure 3,3-disubstituted oxindoles and 3a-substituted pyrrolidinoindolines is des

60 liver direct access to 3-allyl-3-aminomethyl oxindoles and 5-silyl methyl spiro[pyrrolidine-3,3'-oxin

61 By the application of 3-olefinic oxindoles and benzofuranone, biologically relevant spiro

62 ectivity for a variety of unprotected 3-aryl oxindoles and benzylic methyl carbonates using chiral bi

63 construction of a C-C bond between 3-ylidene oxindoles and electron-rich arenes has been successfully

64 ion to engineer TrpB to accept 3-substituted oxindoles and form C-C bonds leading to new quaternary s

65 ethod provides access to 3-(fluoromethylene) oxindoles and gamma-lactams with excellent stereoselecti

66 ect construction of a range of spirocyclized oxindoles and indolenines in good to excellent yields.

67 report the palladium-catalyzed reactions of oxindoles and indoles, both functioning as bis-nucleophi

68 cturally diverse and valuable functionalized oxindoles and isoquinolinediones in moderate to good yie

69 selective domino reactions of spiroaziridine oxindoles and malononitrile have been developed using DB

70 Michael-aldol reaction between 3-substituted oxindoles and methyleneindolinones that affords complex

71 Starting from simple alkylidene oxindoles and nitroketones, a highly stereoselective met

72 lopentannulation has been devised, employing oxindoles and pyrazolones as prototypical platforms.

73 Both 3,3-bis(hydroxyaryl)oxindoles and spirooxindoles bearing a xanthene moiety s

74 s of biologically active 3,3-bis(hydroxyaryl)oxindoles and spirooxindoles bearing a xanthene moiety.

75 s been utilized in solid-phase approaches to oxindoles and tetrahydroquinolones.

76 in activity for alkylation of 3-substituted oxindoles and the ability to selectively form a new, all

77 This method provides alternative access to oxindoles and their biologically active derivatives.

78 Oxindoles and their indoline derivatives are common stru

79 d indazole, benzimidazole, pyrazole, indole, oxindole, and azaindole halides under mild conditions in

80 ore was accomplished in 13 steps using a new oxindole annulation and late-stage enamine oxidation.

81 ict an isatin-derived and 3,3'-disubstituted oxindole-appended epoxy-acrylate undergoing Cp(2)Ti(III)

82 alpha-Aryl oxindoles are accessed from isatin via a two-step proced

83 ric syntheses of diversely 3,3-disubstituted oxindoles are currently developed, this isomerization pr

84 All-carbon quaternary spirocyclic oxindoles are privileged frameworks.

85 In the reaction, 3,3'-disubstituted oxindoles are produced via a C-H alkylation and intramol

86 e spirocyclization reactions, isopropylidene oxindoles are the least explored to date.

87 icle describes our work regarding the use of oxindoles as carbon-based nucleophiles in a Pd-catalyzed

88 esent the first ever use of 3-isopropylidene oxindoles as electrophiles in vinylogous Michael initiat

89 d asymmetric benzylic alkylation with 3-aryl oxindoles as prochiral nucleophiles.

90 Here, we describe spiro-azetidine oxindoles as small molecule RSV entry inhibitors display

91 s, 3,3-di(indolyl)indolin-2-ones, and a-aryl oxindoles as valuable building blocks is further illustr

92 the late-stage diversification of bioactive oxindoles as well as facilitated the synthesis of quinol

93 ed catalyst system chemoselectively arylated oxindole at the 3 position, while arylation occurred exc

94 eloped a stereochemically paired spirocyclic oxindole aziridine covalent library and screened this li

95 Phe(B27)RLF (21%), D-Trp(B27) (26%), and the oxindole(B27)RLF (41%).

96 Walter Reed chemical database, we identified oxindole-based compounds as effective inhibitors of Pfmr

97 Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhy

98 proparyloxy-substituted indoles to generate oxindoles bearing allyl- or allenyl-substituted quaterna

99 cedure for the synthesis of spiro-polycyclic oxindoles bearing five contiguous stereogenic centers in

100 The gamma-functionalization of oxindoles bearing nonsymmetric 3-alkylidene groups via v

101 N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is rep

102 The novel fluoro-oxindoles BMS-204352 and racemic compound 1 are potent,

103 rates for a palladium-catalyzed synthesis of oxindoles by amide alpha-arylation.

104 ion-metal-free method to construct N-hydroxy oxindoles by an aza-Nazarov-type reaction involving azao

105 od to access unsymmetrical 3,3-disubstituted oxindoles by direct C-H functionalization where the oxin

106 hree-dimensional (3D) polyheterocyclic spiro-oxindoles by Lewis-acid-catalyzed Friedel-Crafts type C-

107 esis of beta-pyridone-alpha,beta-unsaturated oxindoles by the reaction of isatins and 2-chloropyridin

108 synthesizing a series of 3-functionalized 2-oxindoles by varying the isatin, amine, and alcohol comp

109 atalyst system, the corresponding 3-arylated oxindoles can be obtained in good to excellent yields (<

110 tion partners such as N-protected alkylidene oxindole carboxylates and pyridinium ylides to afford na

111 al benzylic ether serves as an auxiliary for oxindole carboxylation (dr 5.2:1.0) that sets C10 config

112 tive alpha-arylation and alpha-vinylation of oxindoles catalyzed by Pd and a biarylmonophosphine liga

113 ly provided a similar yield of 3-arylidene-2-oxindoles compared with more reactive aryl iodides.

114 bitors led to novel, chemically stable spiro-oxindole compounds bearing a spiro[3H-indole-3,2'-pyrrol

115 hane at 70 C, affords 3-alkyl-3-(hydroxyaryl)oxindole compounds with a high degree of selectivity.

116 s, whereas the moieties that extend from the oxindole contact residues in the hinge region between th

117 atalyst derived from Pd(OAc)(2) to construct oxindoles containing a diaryl-substituted all-carbon qua

118 OCl(3)-mediated direct cyclotrimerization of oxindoles containing electron-deficient substituents on

119 in the formation of 2-chloroindoles, whereas oxindoles containing electron-donating substituents gave

120 nhibitors was identified that is based on an oxindole core (indolinones).

121 tiated the adenine mimetic properties of its oxindole core.

122 ortance of our synthesized spiro-cyclopropyl oxindole core.

123 can be used to access biologically relevant oxindole cores.

124 ry carbon center are derived from alkylidene oxindole, coumarin, and malonate substrates with high st

125 rated challenging (i.e., alpha-substituted 2-oxindoles, cyanoesters, oxazolones, thiazolones, and azl

126 a model of precursors for Hartwig asymmetric oxindole cyclizations.

127 ymmetric organocatalytic cascade reaction of oxindole derivates with a,B-unsaturated aldehydes effici

128 Oxidation of the spirocyclic oxindole derivative, isamic acid 1, led to decarboxylati

129 biologically important phenol-substituted 2-oxindole derivatives directly without any skeleton rearr

130 roach for the synthesis of spiro-cyclopropyl oxindole derivatives has been developed.

131 -free catalytic system providing a series of oxindole derivatives having two contiguous stereocenters

132 c)(2).H(2)O provided succinimide-substituted oxindole derivatives in good to excellent yields.

133 bstrates led to the formation of spirocyclic oxindole derivatives in good yields with complete regios

134 provided the corresponding quaternary CF(3)-oxindole derivatives in good yields.

135 We have investigated several oxindole derivatives in the pursuit of a 5-HT7 receptor

136 form various C(3)-butyrolactone-substituted oxindole derivatives in very good yields.

137 e synthesis of biologically important 3-aryl oxindole derivatives is described.

138 iourea-catalyzed asymmetric 1,4-additions of oxindole derivatives to nitroolefins as a key step.

139 were used under mild conditions to construct oxindole derivatives with high enantiopurity and structu

140 ally relevant carbazoles, delta-lactams, and oxindole derivatives).

141 able synthesis of functionalized 3-alkenyl-2-oxindole derivatives.

142 nge of enantioenriched spiro[3,2'-morpholine-oxindole] derivatives which incorporate a tertiary stere

143 orts an asymmetric organocascade reaction of oxindole-derived alkenes with 3-bromo-1-nitropropane eff

144 iodinated hetero- and carbocycles including oxindoles, dihydrobenzofurans, indolines, a chromane, an

145 opure synthesis of spiro[dihydropyrrole-3,3'-oxindoles] (ee up to >99%).

146 Numerous 3-hydroxy-2-oxindoles effectively undergo azide transfer to afford a

147 The competing reactivity of isopropylidene oxindoles (electrophilicity vs nucleophilicity) in the p

148 cient direct alkynylations of 3-alkyl/aryl 2-oxindoles employing ethynyl-1,2-benziodoxol-3(1H)-one (E

149 The route to oxindoles employs the first Pummerer cyclizations on sol

150 such as an intriguing propellane hexacyclic oxindole encountered in the communesin F sequence, are d

151 alkylation of enantiopure ditriflate 10 with oxindole enolates is the central step.

152 e diones are tricyclic N-acyl-2-alkylidene-3-oxindole enones that readily engage in tertiary phosphin

153 ridged indole 35, and rearrangement of 35 to oxindole ent-6.

154 onalities and the formation of 3-fluorinated oxindoles exhibiting an array of four adjacent centers o

155 rmolytic skeletal rearrangement of 3-azide-2-oxindole for the synthesis of biologically important qui

156 heme-dependent enzyme, catalyzes a unique 2-oxindole-forming monooxygenation reaction from tryptopha

157 es by direct C-H functionalization where the oxindole fragment behaves as an electrophile.

158 igh-throughput crystallography identified an oxindole fragment bound to the S1 pocket of the protein

159 enantiomer and-as the reaction progresses-by oxindole fragmentation products blocking the binding sit

160 ted aziridine-fused spiro[imidazolidine-4,3'-oxindole] framework.

161 he selective functionalization of indole and oxindole frameworks employing an alternative strategy in

162 thod for the synthesis of 3-(chloromethylene)oxindoles from alkyne-tethered carbamoyl chlorides using

163 ical cyclizations to produce enantioenriched oxindoles from alpha-haloamides.

164 ll-carbon tetrasubstituted olefin containing oxindoles from readily accessible anilides has been deve

165 )-2-oxoethylidene)oxindole and (E)-3-ylidene oxindole give different diastereomers on nitration.

166 ulation of sulfonylphthalide with 3-olefinic oxindole has been performed.

167 The synthesis of dihydrobenzofuran-appended oxindoles has been accomplished taking advantage of an u

168 elective, one-pot synthesis of 3-arylidene-2-oxindoles has been accomplished via Heck-like carbocycli

169 of symmetrical and unsymmetrical 3-arylidene oxindoles has been described from diazoindolones and dip

170 hesis of highly functionalized spiro-oxetane oxindoles has been described.

171 Dimerization of 3-substituted 2-oxindoles has been developed under a mild electrochemica

172 Pathways for direct conversion of indoles to oxindoles have accumulated considerable interest in rece

173 w anticancer therapeutic strategy, and spiro-oxindoles have been designed as a class of potent and ef

174 linear and cross-conjugated trienamines with oxindoles have been studied with density functional theo

175 In particular, 3,3'-disubstituted oxindoles have one or more asymmetric quaternary carbon

176 The reaction affords a variety of 2-oxindoles having quaternary center at the pseudobenzylic

177 affold resulted in a potent arylsulfoanilide-oxindole hybrid, 27.

178 The cocrystal structure of the related oxindole hydrazide c-MET inhibitor 10 with a nonphosphor

179 An oxindole hydrazide hit 6 was identified during a c-MET H

180 The chemically labile oxindole hydrazide scaffold was replaced with a chemical

181 Treatment with the oxindole/imidazole derivative C16 rescued oHSV-1 replica

182 Reactivity with 5-Br-3-oxindole in the absence of H2O2 also yielded 5,5'-Br2-in

183 nacol rearrangement for the formation of the oxindole in the final step.

184 aternary stereocenter or trifluoromethylated oxindoles in a regioselective manner.

185 access to novel spiro-dihydronaphthoquinone-oxindoles in excellent yields with complete selectivity

186 K annulation to provide spiro-isoquinolinone-oxindoles in excellent yields.

187 complex by azoles afforded 3,3-disubstituted oxindoles in good yields with excellent enantioselectivi

188 the synthesis of a wide range of 3-alkenyl-2-oxindoles in good yields with excellent functional group

189 diverse 1,3-diazaspiro[bicyclo[3.1.0]hexane]oxindoles in isolated yields up to 81% under mild condit

190 ides to give corresponding 3,3-disubstituted oxindoles in moderate to good yields.

191 ide rapid access to a variety of spirocyclic oxindoles in one operation.

192 able steric bulk, can be introduced at C3 of oxindoles in this way (Table 4).

193 al of these, including 4-ethylphenylsulfate, oxindole, indolepropionate, p-cresol sulfate, catechol s

194 own to provide direct access to an important oxindole intermediate, could be applied to the total syn

195 nother transformation of 3-(nitroalkylidene) oxindole into 3-(tosylalkylidene) oxindole was performed

196 The conversion of the beta-nitro oxindole into the corresponding beta-amino derivative di

197 3-Azido oxindole is employed to synthesize 3-amino- and 3-triazo

198 Access to N-unsubstituted oxindoles is demonstrated by DPA cleavage with Et(2)NH.

199 ichael addition of nitroalkanes to 3-ylidene oxindoles is described, mediated by thiourea-based bifun

200 ted spiro-pyrrolidinyl and spiro-piperidinyl oxindoles is described.

201 y C3-(sp(3)-carbon) center of spiroaziridine oxindoles is developed using inexpensive trimethylsilyl

202 and allenoates to functionalized 3-alkenyl-2-oxindoles is disclosed.

203 o quaternary C-acetylated and C-carboxylated oxindoles is observed, even for substrates containing br

204 amides, including benzanilide, acetanilide, oxindole, isatin, quinolinone, and maleimide, affording

205 catalyzed multicomponent reaction of 3-diazo oxindole, isocyanide, and aniline has been developed.

206 by employing differently substituted 3-diazo oxindoles, isocyanides, and anilines as starting materia

207 We identify a conserved oxindole isostere, shared between three structurally div

208 ic compounds containing amide, indanone, and oxindole moieties in good to excellent yields with high

209 nd allows for the direct introduction of the oxindole moiety onto a range of aromatic compounds inclu

210 key feature of these molecules is the spiro-oxindole moiety that lends a strained three-dimensional

211 ive cyclization of an N-Boc aniline onto the oxindole moiety to form a pentacyclic framework containi

212 , efficient, and sustainable generation of 2-oxindole motifs, which are already known for a plethora

213 These oxindole motors offer attractive prospects for functiona

214 The oxindole occupies the site in which the adenine of adeno

215 otifs of highly functionalized spiro-oxetane oxindoles of pharmaceutical relevance.

216 catalyzed sequential Michael addition of bis-oxindole onto nitroethylene (up to 93% ee and >20:1 dr).

217 s wherein the first nucleophilic unit on the oxindole or indole reacts with an allenyl-palladium spec

218 ith the second nucleophilic component of the oxindole or indole.

219 counterion coordination controls whether an oxindole or N-hydroxyindole product is formed.

220 s, such as N-CF(3) decorated alkenyl amides, oxindoles, or quinolones, all of which were inaccessible

221 Herein, we focused on oxindole (OX), a small rigid molecule with four known po

222 ans and the multipotent therapeutic value of oxindole pharmacophores.

223 y, the variants that could use 3-substituted oxindoles preferentially formed N-C bonds on N(1) of the

224 the resulting palladium enolate to form the oxindole product.

225 xazoline catalysts were employed to generate oxindole products with 100% conversion and up to 92% ee.

226 olyheterocycles are skillfully embraced with oxindole, pyrrole, and coumarin scaffolds, which are wel

227 llows the formation of chiral bispirocyclic [oxindole-pyrrolidine-pyrazolones] in high yields (up to

228 An initial subdeck screen revealed that the oxindole-pyrrolo[2,1- f][1,2,4]triazine lead 2a displaye

229 es and 5-silyl methyl spiro[pyrrolidine-3,3'-oxindoles], respectively.

230 ylides of 1,3-dicarbonyls and 3-alkylidene-2-oxindoles results in 3H-spiro[furan-2,3'-indolin]-2'-one

231 Heck cyclization for the installation of the oxindole ring system as well as a directed hydrosilylati

232 of MIAs with a unique spiro[pyrrolidine-3,3'-oxindole] ring system.

233 l quinine-derived thiourea with a 3,3-diaryl-oxindole scaffold is reported.

234 indole-3-lactic acid, together with skatole, oxindole, serotonin, and indoleacrylic acid.

235 it has been developed for the synthesis of 2-oxindoles sharing vicinal all-carbon quaternary stereoce

236 xperiments using enantioenriched 3-hydroxy-2-oxindole show that the reaction proceeds through in situ

237 n the synthesis of a short library of chiral oxindoles, showing activity almost comparable to that of

238 ess to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-pot three-component [3 + 2]

239 s such as 3-spiro[1-azabicyclo[3.2.0]heptane]oxindoles spiro-conjugated or fused to a succinimide moi

240 cycloadditions with isatins 2a-2f to form 2-oxindole spirolactones 3a-3l.

241 Oxindoles substituted at N-1 by electron-withdrawing gro

242 aternary peroxyoxindoles afforded C2 or C4 2-oxindole-substituted phenol derivatives.

243 C-H functionalization event involving a keto oxindole substrate to introduce the tetrahydrofuran ring

244 The synthesis of 3,3-difluoro-2-oxindoles through a robust and efficient palladium-catal

245 the preparation of functionalized 3-alkenyl-oxindoles through a Suzuki-Miyaura reaction.

246 changed the reaction outcome to yield solely oxindoles through an unprecedented dioxygen-transfer rea

247 Pd-catalyzed asymmetric prenylation of oxindoles to afford selectively either the prenyl or rev

248 les in a Pd-catalyzed asymmetric addition of oxindoles to allenes (Pd-catalyzed hydrocarbonation of a

249 lactic acid, but decreased the production of oxindole, tryptamine, and serotonin.

250 d a wide variety of 3-alkynyl-3-alkyl/aryl 2-oxindole under transition-metal free condition.

251 of diverse heterocycles onto spirocyclobutyl oxindoles under mild, operationally simple conditions, m

252 owed that some of our first-generation spiro-oxindoles undergo a reversible ring-opening-cyclization

253 Further, it provides an opportunity to merge oxindole units with clinically used drugs like norethind

254 Among the various alkylidene oxindoles used in enantioselective spirocyclization reac

255 selective azidations of beta-keto esters and oxindoles using a readily available N3-transfer reagent

256 ckel-catalyzed C-3-selective alkylation of 2-oxindoles using a wide variety of secondary alkyl alcoho

257 or the union of amides, imides, ketones, and oxindoles using soluble copper(II) or iron(III) salts as

258 rted for the synthesis of 3-(aminoalkylidene)oxindoles via a sequential condensation-hydrolysis- nucl

259 ure for the synthesis of 3,3-disubstituted 2-oxindoles via cross-dehydrogenative coupling (CDC) is re

260 demanding unsymmetrical 3,3-disubstituted 2-oxindoles via reductive cyclization of alpha-ketoamides

261 ployed to synthesize 3-amino- and 3-triazole oxindoles via Staudinger reduction and click chemistry,

262 he cascade transformation of 3-(2-azidoethyl)oxindoles via Staudinger/aza-Wittig/Mannich reactions.

263 lkylidene) oxindole into 3-(tosylalkylidene) oxindole was performed through metal and oxidant-free to

264 Regioselective N-carbamoylation of oxindoles was achieved through the use of imidazole carb

265 biologically relevant spiro-dihydropyridine oxindoles was described via readily available isatin, ma

266 A series of 3-substituted 3-amino-2-oxindoles was obtained with excellent results (up to 99%

267 biologically relevant spiro[pyrrolidine-3,3'-oxindoles] was developed on the basis of the cascade tra

268 to a stereogenic carbon and an N-coordinated oxindole were synthesized by the reaction of alkenyl ary

269 and stereoselective synthesis of 3-arylidene oxindoles were also demonstrated in good yield.

270 zine]- and 3-spiro[3-azabicyclo[3.1.0]hexane]oxindoles were prepared in moderate to high yields via o

271 Oxadiazole substituted oxindoles were subsequently converted to pyrroloindoline

272 Molecular rotary motors based on oxindole which can be driven by visible light are presen

273 and selective synthesis of (E)-3-alkylidene oxindole, which is a highly valuable framework due to it

274 trated in the synthesis of 3,3-disubstituted oxindoles, which are prevalent motifs seen in numerous b

275 Replacement of the C4 oxindole with 2-methyl-5- N-methoxybenzamide aniline 9 g

276 pseudobenzylic position of two partners of 2-oxindoles with a broad substrate scope.

277 his transformation allows the preparation of oxindoles with a quaternary carbon stereocenter using no

278 formal [3 + 2]-annulation of spiro-aziridine oxindoles with allylsilanes have been demonstrated to de

279 for the allylation reactions of 3-hydroxy-2-oxindoles with allyltrimethylsilane has been developed.

280 the cross-coupling reactions of unprotected oxindoles with aryl halides, Pd- and Cu-based catalyst s

281 um-catalyzed monoselective C3 arylation of 2-oxindoles with aryl tosylates is described.

282 rnish synthetically viable enantioenriched 2-oxindoles with C-3 quaternary stereocenters.

283 tions for the exclusive synthesis of 3-azido oxindoles with excellent yield and enantioselectivity (e

284 uted highly enantioenriched spirocyclopropyl oxindoles with excellent yield and stereoselectivities.

285 ee conditions afforded 3-allyl-3-aminomethyl oxindoles with good stereoselectivity (ee up to 80%).

286 allenols to efficiently afford 3-halodienyl-oxindoles with good yield and total selectivity.

287 cyclization cascade reaction of 3-alkylidene oxindoles with isatins and o-quinones.

288 rein we disclose a novel aminooxygenation of oxindoles with nitrosobenzene catalyzed by a newly desig

289 annulative coupling of spirovinylcyclopropyl oxindoles with p-quinone methides has been accomplished

290 A cascade reaction of 3-ylidene oxindoles with phenols and beta-naphthol resulted in 2,3

291 N-alkylation and C-alkylation reactions of 2-oxindoles with secondary alcohols.

292 thesized a series of second-generation spiro-oxindoles with symmetrical pyrrolidine C2 substitution.

293 ation of the beta C-H bond of 3-alkylidene-2-oxindoles with tert-butyl nitrite (TBN) has been explore

294 construct a C-O bond at the C(3) position of oxindoles with the creation of an oxygen-containing tetr

295 tion unpredictably affords 3,3-disubstituted oxindoles with the formal reduction of the nitro group u

296 reoselective synthesis of spiro(cyclopentene)oxindoles with trisubstituted cyclopentene units.

297 e 3,4-dihydrospiro[benzo[b][1,4]oxazine-2,3'-oxindole] with excellent enantiopurity (ee up to >99%).

298 ilic ring opening of spiro[cyclopropane-1,3'-oxindoles] with the azide ion.

299 A series of new spiro[pyrrolidine-3,3'-oxindoles] with various (het)aryl substituents at the C2

300 all yield of 65% or by direct bromination of oxindoles (yield of 65-86%).