ライフサイエンスコーパス: oxo acid

1 The product is a novel 2-oxo acid.

2 tionally regulated by redox mechanisms and 2-oxo acids.

3 that is activated by redox mechanisms and 2-oxo acids.

4 or inhibition of 2OG oxygenase activity by 2-oxo acids.

5 dues, CysI and CysII, are both involved in 2-oxo acid activation, with AOX1A activity being more incr

6 e scope is observed with respect to both the oxo acid and arene coupling partners.

7 H2(18)O, we established synthesis of the C8-oxo acid and C12 aldehyde with the retention of the hydr

8 anion formed during decarboxylation of the 2-oxo acid and E1beta His128 to provide the proton require

9 acid substrate, (b) decarboxylation of the 2-oxo acid and reductive acetylation of the tethered lipoy

10 e is an acetylene analogue of a variety of 2-oxo acids and as such may have general utility as an inh

11 , Leu and Ile as well as the corresponding 2-oxo acids but also transaminates Met and its cognate ket

12 ich lack the ketolytic enzyme succinyl-CoA:3-oxo-acid CoA-transferase (SCOT), to demonstrate that ket

13 e specifically recognised by their cognate 2-oxo acid decarboxylase (E1p, E1o).

14 nzyme on all thiamin diphosphate-dependent 2-oxo acid decarboxylases.

15 fference in skeletal muscle branched-chain 2-oxo acid dehydrogenase (BCOADH) activity between groups.

16 irulence was not associated with a loss of 2-oxo acid dehydrogenase activity, as the wild-type pneumo

17 rogenase complex (PDC), the branched chain 2-oxo acid dehydrogenase complex (BCOADC), and the 2-oxogl

18 ngly, the E2 subunit of the branched chain 2-oxo acid dehydrogenase complex also remained intact in t

19 plex, the E2 subunit of the branched chain 2-oxo acid dehydrogenase complex, the E2 subunit of the ox

20 ot with any other enzyme components of the 2-oxo acid dehydrogenase complex.

21 dihydrolipoyl acyltransferase component of 2-oxo acid dehydrogenase complexes and will assist in furt

22 he two major classes of the superfamily of 2-oxo acid dehydrogenase complexes with different assembly

23 nase (in eukaryotic PDH and branched chain 2-oxo acid dehydrogenase complexes).

24 to the linker regions in the E2 chains of 2-oxo acid dehydrogenase complexes, and it is likely this

25 ) hetero-tetrameric E1 components of other 2-oxo acid dehydrogenase complexes, except that in E1o, th

26 en identified as subunits of the following 2-oxo acid dehydrogenase complexes: the pyruvate dehydroge

27 their pendant lipoyl groups in the parent 2-oxo acid dehydrogenase complexes; an important aspect of

28 These data suggest that each of the 2-oxo acid dehydrogenase enzymes has distinct antigenicity

29 We report that all three 2-oxo acid dehydrogenase enzymes share the ability to rema

30 sferase components (E2) from the family of 2-oxo acid dehydrogenase multienzyme complexes form large

31 crucial to the reactions catalysed by the 2-oxo acid dehydrogenase multienzyme complexes.

32 rolipoyl dehydrogenase (E3) components, of 2-oxo acid dehydrogenase multienzyme complexes.

33 ate dehydrogenase (PDC-E2), branched-chain 2-oxo-acid dehydrogenase (BCOADC-E2), and 2-oxo-glutarate

34 enase complex (PDC-E2), the branched-chain 2-oxo-acid dehydrogenase complex (BCOADC-E2), and the 2-ox

35 9 (45%), against PDC-E2 and branched-chain 2-oxo-acid dehydrogenase complex E2 (BCOADC-E2) in 4 of 49

36 19 patients (78.9%), to the branched-chain 2-oxo-acid dehydrogenase complex E2 (BCOADC-E2) in 6 of 19

37 r membrane of the mitochondria, called the 2-oxo-acid dehydrogenase complex represents the target of

38 re-absorption of the IgA using recombinant 2-oxo-acid dehydrogenase complex significantly diminished

39 The 2-oxo-acid dehydrogenase complexes and, in particular, the

40 utoantigens belong to E2 components of the 2-oxo-acid dehydrogenase family of mitochondrially located

41 equenced, and identified as members of the 2-oxo-acid dehydrogenase pathway, including the E2 subunit

42 of pyruvate dehydrogenase, branched chain 2-oxo-acid dehydrogenase, and 2-oxo-glutarate dehydrogenas

43 ainst PDC-E2, E2 subunit of branched chain 2-oxo-acid dehydrogenase, and E2 subunit of 2-oxoglutarate

44 octanoyl-ACP) to the lipoyl domains of the 2-oxo acid dehydrogenases and the H subunit of glycine cle

45 example of a non-hydrogenative DKR of a beta-oxo acid derivative.

46 talyzed borylative cyclizations of racemic B-oxo acid derivatives bearing tethered pro-nucleophilic o

47 2-Oxo acid derivatives have potential as drugs, for use in

48 rbon nucleophiles to racemic a-stereogenic B-oxo acid derivatives that deliver enantiomerically enric

49 orted protocol is applicable to a range of B-oxo acid derivatives, and the diastereomeric products ar

50 also catalyze the slow decarboxylation of 2-oxo acids) enabled the observation of the substrate-thia

51 d not contain activity of any of the known 2-oxo acid enzyme complexes.

52 aminotransferases in converting Met to its 2-oxo acid for glucosinolate chain elongation.

53 herefore, we propose a mechanism whereby the oxo acids generated after oxidation of the cysteine thio

54 he direct decarboxylative arylation of alpha-oxo acids has been achieved by synergistic visible-light

55 Importantly, we detected the signature 2-oxo-acid N-terminal peptide in tryptic digests of bronch

56 2OG oxygenases may be regulated by natural 2-oxo acids other than 2OG.

57 alkyl ketone architectures from simple alpha-oxo acid precursors via an acyl radical intermediate.

58 o small amounts of additional amino acid and oxo acid products through partitions of the main reactio

59 known to be involved in regulation by the 2-oxo acids pyruvate and glyoxylate) and propose that this

60 residues are involved in: (a) binding the 2-oxo acid substrate, (b) decarboxylation of the 2-oxo aci

61 ith AOX1A activity being more increased by 2-oxo acids than that of AOX1C and AOX1D.

62 y involved in the three-step conversion of 2-oxo acids to their respective acyl-CoA derivatives, but

63 us epidermidis reduces a broad spectrum of 2-oxo acids, which are difficult substrates for transition