ライフサイエンスコーパス: oxoglutarate

1 nteractions are modulated by ADP, ATP, and 2-oxoglutarate.

2 oxylases via enzyme-catalysed oxidation to 2-oxoglutarate.

3 e, which is an analogue of the cosubstrate 2-oxoglutarate.

4 c acid, N-acetylglucosamine, and decreased 2-oxoglutarate.

5 mall effectors, most notably glutamine and 2-oxoglutarate.

6 es not prevent the binding of the cofactor 2-oxoglutarate.

7 hylase activity dependent on both iron and 2-oxoglutarate.

8 carbon/nitrogen and depleted in starch and 2-oxoglutarate.

9 the oxidative deamination of glutamate to 2-oxoglutarate.

10 ino-terminal GAF domain of NifA that binds 2-oxoglutarate.

11 the release of 14CO2 from labeled [1-14C]-2-oxoglutarate.

12 le oxidative deamination of L-glutamate to 2-oxoglutarate.

13 ate, Ala:glyoxylate, Glu:pyruvate, and Ala:2-oxoglutarate.

14 trimethylamine N-oxide (TMAO), citrate and 2-oxoglutarate.

15 gar phosphate levels, and lower content of 2-oxoglutarate.

16 xy-d-GlcNAc to form UDP-4-amino-FucNAc and 2-oxoglutarate.

17 2-oxoglutarate (2-OG or alpha-ketoglutarate) relates mitoc

18 eir ability to bind the effector molecules 2-oxoglutarate (2-OG) and ATP or ADP.

19 These 2-oxoglutarate (2-OG) and non-heme iron-dependent oxygenas

20 co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including

21 lytic domain in complex with the substrate 2-oxoglutarate (2-OG) and the inhibitor N-oxalylglycine (N

22 thetase/glutamate synthase system requires 2-oxoglutarate (2-OG) as a carbon precursor.

23 ctor and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII-N

24 Levels of 2-oxoglutarate (2-OG) reflect nitrogen status in many bact

25 oglutarate dehydrogenase (2-OGDH) converts 2-oxoglutarate (2-OG) to succinyl-CoA concomitant with the

26 Recently, members of the 2-oxoglutarate (2-OG)-dependent dioxygenase family have be

27 s (JBP1 and JBP2) homologous to the Fe(2+)/2-oxoglutarate (2-OG)-dependent dioxygenase superfamily wh

28 sigE and that this binding is enhanced by 2-oxoglutarate (2-OG).

29 ch was corrected by provision of exogenous 2-oxoglutarate (2-OG).

30 f the enzyme in complex with the substrate 2-oxoglutarate (2-OG).

31 2-Oxoglutarate (2OG) and Fe(II)-dependent oxygenase domain

32 ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic ac

33 nge of Bacteria and Archaea sense cellular 2-oxoglutarate (2OG) as an indicator of nitrogen limitatio

34 NrpR, nifOR(1), nifOR(2), and the effector 2-oxoglutarate (2OG) combine to regulate nif expression, l

35 human homologues belong to a subfamily of 2-oxoglutarate (2OG) dependent oxygenases (2OG oxygenases

36 The human 2-oxoglutarate (2OG) dependent oxygenases belong to a fami

37 mber of the Jumonji C family of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases.

38 presence of NifI(1) and NifI(2), and that 2-oxoglutarate (2OG), a potential signal of nitrogen limit

39 e MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that cat

40 anslocation (TET) proteins are Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenases that successiv

41 cherichia coli DNA repair enzyme AlkB is a 2-oxoglutarate (2OG)-dependent Fe(2+) binding dioxygenase

42 FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic acid demet

43 C domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various

44 ber of the mononuclear nonheme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily.

45 te/asparagine-beta-hydroxylase (AspH) is a 2-oxoglutarate (2OG)-dependent oxygenase that catalyzes th

46 2-Oxoglutarate (2OG)-dependent oxygenases catalyze a wide

47 Mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large

48 2-Oxoglutarate (2OG)-dependent oxygenases have important r

49 ome sequences predict the presence of many 2-oxoglutarate (2OG)-dependent oxygenases of unknown bioch

50 The JmjC KDMs are Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which a

51 prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first ident

52 on hydroxylation as catalyzed by iron- and 2-oxoglutarate (2OG)-dependent prolyl and asparaginyl hydr

53 The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in euka

54 lyze the interconversion of isocitrate and 2-oxoglutarate (2OG).

55 tosolic alpha-ketoglutarate, also known as 2-oxoglutarate (2OG).

56 ression increased levels of the metabolite 2-oxoglutarate (2OG).

57 corbate, and the Kreb's cycle intermediate 2-oxoglutarate (2OG).

58 Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) encodes the only ly

59 ion of the crosslinker procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), in sarcomas has re

60 PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residu

61 lpha-ketoglutarate (alphaKG, also known as 2-oxoglutarate), a metabolite that also serves as an oblig

62 nhibition is antagonised by the binding of 2-oxoglutarate, a key metabolic signal of the carbon statu

63 The electron acceptor for 2-oxoglutarate:acceptor oxidoreductase was determined to b

64 rate respiration is mediated by the enzyme 2-oxoglutarate:acceptor oxidoreductase; mutagenesis of thi

65 lly vulnerable, as it employs pyruvate and 2-oxoglutarate:acceptor oxidoreductases (Por and Oor), whi

66 One such enzyme is the 2-oxoglutarate (alpha-ketoglutarate) oxidoreductase (OOR),

67 OGDDs all require oxygen, reduced iron and 2-oxoglutarate (also known as alpha-ketoglutarate) to func

68 Mutation of gltB (encoding glutamate oxoglutarate amidotransferase or GOGAT) in RU2307 increa

69 ss experienced by enzymes, such as glutamine oxoglutarate amidotransferase, that contain redox active

70 he urea and glutamine synthetase/glutamine 2-oxoglutarate aminotransferase pathways and redirected to

71 , nitrate/nitrite reductases and glutamine:2-oxoglutarate aminotransferase.

72 in phosphotransferase, and diaminobutyrate-2-oxoglutarate aminotransferase.

73 4S-containing ferredoxin-dependent glutamine oxoglutarate aminotransferases declined significantly in

74 With the carbon skeleton provided by 2-oxoglutarate, ammonia/ammonium (NH(4)(+)) is assimilated

75 n using the isoquinolone Roxadustat or the 2-oxoglutarate analog dimethyloxalylglycine (DMOG).

76 olyl hydroxylase inhibitors are lipophilic 2-oxoglutarate analogues (2OGAs) that are widely taken up

77 A set of human 2-oxoglutarate analogues were screened using a unified ass

78 an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that medi

79 shunt is a major contributor to flux from 2-oxoglutarate and glutamate to succinate in Synechocystis

80 rs (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzym

81 Unlike classical 2-oxoglutarate and iron-dependent dioxygenases, which incl

82 asmic reticulum and belong to the group of 2-oxoglutarate and iron-dependent dioxygenases.

83 nguish between the C5-carboxylate group of 2-oxoglutarate and the epsilon-ammonium group of l-lysine.

84 ounds (iron, ascorbate, hydrogen peroxide, 2-oxoglutarate, and succinate) influenced by cellular oxid

85 ta-Phe, (R)-3-amino-5-methylhexanoic acid, 2-oxoglutarate, and the inhibitor 2-aminooxyacetic acid, w

86 form that contained iron, the co-substrate 2-oxoglutarate, and the reaction product of EctD, 5-hydrox

87 tudies, including galN, N-acetylglucosamine, oxoglutarate, and urocanic acid, enhancing metabolome co

88 Both Tet and AlkB enzymes are 2-oxoglutarate- and Fe(II)-dependent dioxygenases.

89 hat Jumonji domain-containing 4 (Jmjd4), a 2-oxoglutarate- and Fe(II)-dependent oxygenase, catalyzes

90 roxymethyl-cytosine (hmC) by the action of 2-oxoglutarate- and Fe(ii)-dependent oxygenases of the TET

91 e Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II)-dependent oxygenases.

92 boxyl-terminal domain corresponding to the 2-oxoglutarate- and iron-dependent dioxygenase domains sim

93 (the flavin-dependent KDM1 enzymes and the 2-oxoglutarate- and oxygen-dependent JmjC KDMs, respective

94 Our data suggest that an Fe(II)-, oxoglutarate-, and oxygen-dependent enzyme may directly

95 ishes AmtB/GlnK association, and sites for 2-oxoglutarate are evaluated.

96 reviously described TET enzymes, which use 2-oxoglutarate as a co-substrate(4), CMD1 uses L-ascorbic

97 s depends on iron as the activating metal, 2-oxoglutarate as a co-substrate, and ascorbic acid as a c

98 sing flavin (amine oxidases) or Fe(II) and 2-oxoglutarate as cofactors (2OG oxygenases) has changed t

99 alpha-ketoglutarate (alternatively termed 2-oxoglutarate) as a co-substrate in so many oxidation rea

100 sume the metabolite alphaKG (also known as 2-oxoglutarate) as an obligate cosubstrate and are inhibit

101 AML-associated mutations in the Fe(2+) and 2-oxoglutarate-binding residues increased the Km values fo

102 dependent dioxygenases, putative iron- and 2-oxoglutarate-binding residues, typical of such enzymes,

103 ids, AOX1A and AOX1D are both activated by 2-oxoglutarate, but only AOX1A is additionally activated b

104 mical carbon-carbon bond formation to make 2-oxoglutarate by coupling CO(2) with a succinyl group.

105 mitochondrial transport of 2OG through the 2-oxoglutarate carrier (OGC) participates in control of nu

106 nicotinamide, methionine, acetylcarnitine, 2-oxoglutarate, choline, and creatine.

107 tic iron center is exposed to solvent, the 2-oxoglutarate co-substrate likely adopts an inactive conf

108 These enzymes use an Fe(II) cofactor and 2-oxoglutarate co-substrate to oxidize organic substrates.

109 e 8 or 5-carboxy-8-hydroxyquinoline 9, two 2-oxoglutarate competitive templates developed for JmjC in

110 -42041935, was a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhi

111 s should be amenable to the assay of other 2-oxoglutarate-consuming enzymes and to the discovery of i

112 Severe decreases were also seen in 2-oxoglutarate content, a key indicator of cellular carbon

113 r primary substrates while decomposing the 2-oxoglutarate cosubstrate to form succinate and CO(2).

114 es that orchestrate nitrogen flow, such as 2-oxoglutarate decarboxylase (KGD).

115 022 and combinations thereof, deficient in 2-oxoglutarate decarboxylase (Sll1981), succinate semialde

116 Genes encoding a novel 2-oxoglutarate decarboxylase and succinic semialdehyde deh

117 Independent of the 2-oxoglutarate decarboxylase bypass, the gamma-aminobutyra

118 The Deltasll1981 strain, lacking 2-oxoglutarate decarboxylase, exhibited a succinate level

119 ite flux to succinate than the pathway via 2-oxoglutarate decarboxylase.

120 The tricarboxylic acid cycle enzyme 2-oxoglutarate dehydrogenase (2-OGDH) converts 2-oxoglutar

121 ccinyltransferase (Dlst), a subunit of the 2-oxoglutarate dehydrogenase (alpha-KGDH) complex.

122 (a) Functionally competent 2-oxoglutarate dehydrogenase (E1o-h) and dihydrolipoyl suc

123 arker glutarylcarnitine and demonstrate that oxoglutarate dehydrogenase (OGDH) is responsible for thi

124 ogenase E1 component subunit beta (PDHB) and oxoglutarate dehydrogenase (OGDH) required dual phosphor

125 However, the 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-oxoa

126 edundancy with the ubiquitous OGDH-encoded 2-oxoglutarate dehydrogenase (OGDH).

127 ire the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH).

128 mplete in many other anaerobes (absence of 2-oxoglutarate dehydrogenase activity), isotopic labeling

129 cid as a cofactor (pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and glycine decarboxylase).

130 to succinate and thus functionally replace 2-oxoglutarate dehydrogenase and succinyl-CoA synthetase.

131 boxylic acid (TCA) cycle because they lack 2-oxoglutarate dehydrogenase and thus cannot convert 2-oxo

132 The 2-oxoglutarate dehydrogenase complex (OGHDC) (also known a

133 ependent E1o component (EC 1.2.4.2) of the 2-oxoglutarate dehydrogenase complex catalyses a rate-limi

134 of the gene encoding the E1 subunit of the 2-oxoglutarate dehydrogenase complex in the antisense orie

135 A traditional 2-oxoglutarate dehydrogenase complex is missing in the cya

136 -oxo-acid dehydrogenase, and E2 subunit of 2-oxoglutarate dehydrogenase complex.

137 We report that the intact pyruvate and 2-oxoglutarate dehydrogenase complexes specifically copuri

138 h engineered variants of the E2 subunit of 2-oxoglutarate dehydrogenase indicate that binding sites f

139 re reported unique properties of the human 2-oxoglutarate dehydrogenase multienzyme complex (OGDHc),

140 interactions with other components of the 2-oxoglutarate dehydrogenase multienzyme complex.

141 to enzymes of the tricarboxylic acid cycle (oxoglutarate dehydrogenase, isocitrate dehydrogenase) an

142 s and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two key enzymes that determi

143 ine diphosphate-dependent Escherichia coli 2-oxoglutarate dehydrogenase, which is a key component of

144 ficient PDAC cells through the inhibition of oxoglutarate dehydrogenase-an enzyme of the tricarboxyli

145 OPN knockout or AAV9-mediated delivery of 2-oxoglutarate dehydrogenase-like (Ogdhl) to the heart.

146 ing domain of a large multienzyme complex, 2-oxoglutarate dehydrogenase.

147 Pyruvate and 2-oxoglutarate dehydrogenases are substituted by 'ancient'

148 and small molecule inhibitors of MAPK and 2-oxoglutarate dependent collagen IV modifying enzymes res

149 Feruloyl-CoA 6'-hydroxylase (F6'H), a 2-oxoglutarate dependent dioxygenase (2OGD), catalyzes a p

150 Three mononuclear nonheme iron and 2-oxoglutarate dependent enzymes, l-Ile 4-hydroxylase, l-L

151 The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-be

152 The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to

153 amma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the fina

154 nserved eukaryotic subfamily of Fe(II) and 2-oxoglutarate dependent oxygenases; their catalytic domai

155 ion catalyzed by the nonheme iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase, AsqJ.

156 Iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases generate iron

157 d gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is li

158 d heterologous expression, we identified a 2-oxoglutarate-dependent dioxygenase (BX13) that catalyzes

159 The protein level of a probable 2-oxoglutarate-dependent dioxygenase 2-ODD2, involved in g

160 ioxygenase (HtxA) is a novel member of the 2-oxoglutarate-dependent dioxygenase enzyme family.

161 The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and comprise t

162 s, homozygous mutations in the Fe(II)- and 2-oxoglutarate-dependent dioxygenase family gene F6'H1 and

163 Tpa1 is a member of the Fe(II) and 2-oxoglutarate-dependent dioxygenase family, and we show t

164 O and VEGF), certain members of the oxygen/2-oxoglutarate-dependent dioxygenase family, including the

165 In a mutant screening, we identified 2-oxoglutarate-dependent dioxygenase Feruloyl-CoA 6'-Hydro

166 -hydroxylation catalyzed by the Fe(II) and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 prot

167 er of the non-heme-containing iron(II) and 2-oxoglutarate-dependent dioxygenase superfamily and is ev

168 xidase cluster of the Arabidopsis thaliana 2-oxoglutarate-dependent dioxygenase superfamily tree.

169 nalysis revealed it to be a member of the Fe-oxoglutarate-dependent dioxygenase superfamily.

170 identified six pathway enzymes, including an oxoglutarate-dependent dioxygenase that closes the core

171 ein (JMJD6) is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates his

172 lso known as Egl nine homolog 1 (EGLN1), a 2-oxoglutarate-dependent dioxygenase that hydroxylates HIF

173 AlkB is a bacterial Fe(II)- and 2-oxoglutarate-dependent dioxygenase that repairs a wide r

174 bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylat

175 ICU11 encodes a 2-oxoglutarate-dependent dioxygenase, an activity associat

176 coli that DES has the characteristics of a 2-oxoglutarate-dependent dioxygenase.

177 -hydroxylase isoform 1 (PHD1), an iron and 2-oxoglutarate-dependent dioxygenase.

178 2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a super

179 oxalylglycine, an inhibitor of Fe(II)- and 2-oxoglutarate-dependent dioxygenases also inhibited AhR-d

180 synthases, cytochrome P450 monooxygenases, 2-oxoglutarate-dependent dioxygenases and UDP-dependent gl

181 The Fe(II)/2-oxoglutarate-dependent dioxygenases are a catalytically

182 Iron- and 2-oxoglutarate-dependent dioxygenases are a diverse family

183 amin C serves as a cofactor for Fe(II) and 2-oxoglutarate-dependent dioxygenases including TET family

184 ription factor alpha subunit by oxygen and 2-oxoglutarate-dependent dioxygenases promotes decay of th

185 erated by a series of non-haem Fe(II)- and 2-oxoglutarate-dependent dioxygenases that catalyse the po

186 ignal is generated by a series of iron and 2-oxoglutarate-dependent dioxygenases that catalyze post-t

187 he oxygen-sensitive signal is generated by 2-oxoglutarate-dependent dioxygenases that deploy molecula

188 l 4-hydroxylases are a family of iron- and 2-oxoglutarate-dependent dioxygenases that negatively regu

189 Like other iron/2-oxoglutarate-dependent dioxygenases, AlkB employs a two-

190 The FNSI class comprises soluble Fe(2+)/2-oxoglutarate-dependent dioxygenases, and FNSII enzymes a

191 Gibberellin (GA) 3-oxidase, a class of 2-oxoglutarate-dependent dioxygenases, catalyzes the conve

192 ometabolites and competitive inhibition of 2-oxoglutarate-dependent dioxygenases, particularly, hypox

193 ow amino acid sequence homology with known 2-oxoglutarate-dependent dioxygenases, putative iron- and

194 kinetic parameters of two bacterial Fe(II)/2-oxoglutarate-dependent dioxygenases.

195 it will be a valuable tool to study Fe(II)/2-oxoglutarate-dependent dioxygenases.

196 hese levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases.

197 The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA de

198 generated by the TET family of Fe(II) and 2-oxoglutarate-dependent enzymes through oxidation of 5-me

199 uctural characteristics of non-heme Fe(II) 2-oxoglutarate-dependent enzymes, although key enzymatic r

200 bstantiated by the pioneering discovery of 2-oxoglutarate-dependent flavone demethylase activity in b

201 While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases (2ODHs) have been fou

202 umors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzym

203 irectly decreased the activity of a Fe(II)-2-oxoglutarate-dependent histone H3K9 demethylase in nucle

204 dependent aromatic amino acid hydroxylase, 2-oxoglutarate-dependent hydroxylase, Rieske dioxygenase,

205 TH domain related to the family of Fe(2+)/2-oxoglutarate-dependent hydroxylases.

206 JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues i

207 The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitumo

208 ort that recombinant PHF8 is an Fe(II) and 2-oxoglutarate-dependent N(epsilon)-methyl lysine demethyl

209 2-Oxoglutarate-dependent nucleic acid demethylases are of

210 C synthase (DAOC/DACS) is an iron(II) and 2-oxoglutarate-dependent oxygenase involved in the biosynt

211 The AlkB family of nonheme Fe(II)/2-oxoglutarate-dependent oxygenases are essential regulato

212 A widely used generic assay for 2-oxoglutarate-dependent oxygenases relies upon monitoring

213 lase domain enzymes (PHDs) are Fe(II)- and 2-oxoglutarate-dependent oxygenases that act as hypoxia-se

214 f the HIF system is provided by Fe(II) and 2-oxoglutarate-dependent oxygenases that catalyse the post

215 iron binding residues that are present in 2-oxoglutarate-dependent oxygenases.

216 TO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases.

217 cocontrolled by PHD2 and PHD3, oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regula

218 ed by using wild-type and variant forms of 2-oxoglutarate-dependent taurine dioxygenase.

219 2-Oxoglutarate-dependent versions appear to have further e

220 ly, Grob-type oxidative fragmentation of a 2-oxoglutarate-derived intermediate occurs to give ethylen

221 2-Oxoglutarate did not affect activity in DeltanifI(1)nifI

222 2-Oxoglutarate diminishes AmtB/GlnK association, and sites

223 nce comparisons suggest that hypophosphite:2-oxoglutarate dioxygenase (HtxA) is a novel member of the

224 DEFGHIJKLMN operon encodes a hypophosphite-2-oxoglutarate dioxygenase (HtxA), whereas the predicted a

225 Whereas the Fe-2-oxoglutarate dioxygenase core matches that in other supe

226 vitamin C, a potential cofactor for Fe(II) 2-oxoglutarate dioxygenase enzymes such as Tet enzymes.

227 hondrial poison cyanide or the nonspecific 2-oxoglutarate dioxygenase inhibitor dimethyloxalylglycine

228 er the tested conditions, a broad-spectrum 2-oxoglutarate dioxygenase inhibitor is a better mimic of

229 Ofd1, a prolyl 4-hydroxylase-like 2-oxoglutarate dioxygenase, controls the oxygen-dependent

230 ion of ATF3 under anoxia is independent of 2-oxoglutarate dioxygenase, HIF-1 and p53, presumably invo

231 also striking enrichment for the family of 2-oxoglutarate dioxygenases, including the jumonji-domain

232 e Arabidopsis DMR6 gene encodes a putative 2-oxoglutarate Fe(II)-dependent oxygenase (2OGO) and has b

233 This reaction is catalyzed by iron(II) and 2-oxoglutarate (Fe/2OG) dependent enzymes.

234 uncharacterized prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase, accelerates Sre1N degra

235 ese findings further highlight the role of 2-oxoglutarate/Fe(II) oxygenases in fundamental cellular p

236 morphine biosynthesis are catalyzed by the 2-oxoglutarate/Fe(II)-dependent dioxygenases, thebaine 6-O

237 DhpJ, a 2-oxoglutarate/Fe(II)-dependent enzyme, introduces the vin

238 port the identification of four paralogous 2-oxoglutarate/Fe(II)-dependent oxygenases in Arabidopsis

239 ium sulfide nanorods (CdS NRs) transfer to 2-oxoglutarate:ferredoxin oxidoreductase from Magnetococcu

240 icarboxylic acid cycle, ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and pyruvate:fer

241 acid directly competes with the substrate 2-oxoglutarate for binding within the active site of HCS.

242 logical function of NADH-GDH is to provide 2-oxoglutarate for the tricarboxylic acid cycle.

243 We examine the dependence of 2-oxoglutarate formation on a variety of factors and, usin

244 ti-correlation between 2-hydroxyglutarate, 2-oxoglutarate, fructose, hexadecanoic acid, hypotaurine,

245 a two-step mechanism in which oxidation of 2-oxoglutarate generates a highly reactive enzyme-bound ox

246 tate and reintroduced in the TCA cycle via 2-oxoglutarate/glutamate.

247 xykynurenine:xanthurenic acid ratio, and the oxoglutarate:glutamate ratio.

248 inine in a nonoxidized conformation and of 2-oxoglutarate in an unprecedented high-energy conformatio

249 ganisms includes demonstrating the role of 2-oxoglutarate in regulating the activity of the transcrip

250 and OGDH to oxidation of 2-oxoadipate and 2-oxoglutarate in vitro.

251 The P(II) effector 2-oxoglutarate, in the presence of Mg-ATP, inhibited DraT-

252 Extraction and quantification of 2-oxoglutarate indicated concentrations 10-fold higher in

253 , glutamate, and the anaplerotic substrate 2-oxoglutarate, inhibiting MM cell growth.

254 To determine pathways that convert 2-oxoglutarate into succinate in the cyanobacterium Synech

255 an alternative assay in which depletion of 2-oxoglutarate is monitored by its postincubation derivati

256 The iron and 2-oxoglutarate ligands are bound within the EctD active si

257 yruvate, orthophosphate dikinase, and the 2'-oxoglutarate/malate transporter are expressed in oat and

258 sphorylation pathway and those involved in 2-oxoglutarate metabolic processes.

259 eal that 2-hydroxyglutarate is oxidized to 2-oxoglutarate non-enzymatically, likely via iron-mediated

260 Deficiency in 2-oxoglutarate occurred despite increased citrate and mala

261 resonance upon reaction of the E1o-h with 2-oxoglutarate (OG) by itself or when assembled from indiv

262 s multiple oxygen-dependent enzymes called 2-oxoglutarate (OG)-dependent dioxygenases (2-OGDDs), but

263 However, the dicarboxylate (DIC) and 2-oxoglutarate (OGC) carriers localized to the inner mitoc

264 ial for function of the pyruvate (PDH) and 2-oxoglutarate (OGDH) dehydrogenases and thus for aerobic

265 ility to override the allosteric effect of 2-oxoglutarate on NifA activity.

266 ne, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen.

267 plant secondary metabolism are catalyzed by oxoglutarate- or cytochrome P450-dependent oxygenases.

268 In one branch, an apparently typical 2-oxoglutarate oxygenase reaction to give succinate, carbo

269 doplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and te

270 f 2-hydroxyglutarate-enabled activation of 2-oxoglutarate oxygenases, including prolyl hydroxylase do

271 at levels supporting in vitro catalysis by 2-oxoglutarate oxygenases.

272 ic flux using (13)C labelling; acetate and 2-oxoglutarate production was reduced in the light.

273 stimulated and inhibited, respectively, by 2-oxoglutarate, providing a mechanistic link between PII s

274 lizing the typical keto-acid cosubstrates, 2-oxoglutarate, pyruvate, and oxaloacetate, Ab-ArAT4 posse

275 GPR99, previously described as an oxoglutarate receptor (Oxgr1), showed both a functional

276 the adrenal release of adrenaline through 2-oxoglutarate receptor 1 (OXGR1) expressed in adrenal gla

277 variety of nitrogen assimilation genes by 2-oxoglutarate-reversible binding to conserved palindromic

278 Pyruvate and oxaloacetate bind to the 2-oxoglutarate site of HIF-1alpha prolyl hydroxylases, but

279 cycle intermediates (citrate, isocitrate, 2-oxoglutarate, succinate, fumarate, malate, and oxaloacet

280 annotation implicates a ferredoxin-dependent oxoglutarate synthase, isotopic evidence does not suppor

281 r yields slow but substantial oxidation of 2-oxoglutarate that is inefficiently coupled to nucleotide

282 ing for activity both molecular oxygen and 2-oxoglutarate that, under normoxia, selectively hydroxyla

283 f a novel enzymatic activity that converts 2-oxoglutarate to D-2-hydroxyglutarate.

284 fungi by condensing acetyl-coenzyme A and 2-oxoglutarate to form 3R-homocitrate and coenzyme A.

285 ersible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate, and thereby

286 on, but via the four-electron oxidation of 2-oxoglutarate to give ethylene in an arginine-dependent r

287 Pyl is also able to ligate 2-oxoglutarate to other 4-amino-sugar derivatives to form

288 Together, these two enzymes convert 2-oxoglutarate to succinate and thus functionally replace

289 rate dehydrogenase and thus cannot convert 2-oxoglutarate to succinyl-coenzyme A (CoA).

290 t, in the presence of ATP and Mg(II), adds 2-oxoglutarate to the 4-amino moiety of UDP-4-amino-FucNAc

291 tes that this mutation prevents binding of 2-oxoglutarate to the GAF domain.

292 Addition of 2-oxoglutarate to wild-type extracts enhanced activity up

293 samination enzymes, namely 4-aminobutyrate-2-oxoglutarate transaminase (GABA-T) and alanine-glyoxylat

294 ian transaminating enzymes 4-aminobutyrate-2-oxoglutarate transaminase and alanine-glyoxylate transam

295 ture quenching by solvent, which uncouples 2-oxoglutarate turnover from nucleobase oxidation.

296 d in the synthesis of UDP-FucNAc-4-amido-(2)-oxoglutarate (UDP-Yelosamine), a modified UDP-sugar not

297 e in counteracting the response of NifA to 2-oxoglutarate, under conditions that are inappropriate fo

298 le oxidative deamination of l-glutamate to 2-oxoglutarate using NAD(P)(+) as coenzyme.

299 ity that is counteracted by high levels of 2-oxoglutarate, which acts as a signal of nitrogen limitat

300 amination activity of GDH might regenerate 2-oxoglutarate, which is a cosubstrate that facilitates th