ライフサイエンスコーパス: oxylipin

1 had alterations in hepatic lipids, including oxylipins.

2 lism of PU-NAEs through the formation of NAE-oxylipins.

3 polyunsaturated fatty acids to corresponding oxylipins.

4 difying or eliminating the function of these oxylipins.

5 tems and the other to form novel NAE-derived oxylipins.

6 e tissue specific synthesis of divinyl ether oxylipins.

7 P analysis was used to identify and quantify oxylipins.

8 fatty acids in seed oils and jasmonate-like oxylipins.

9 Fatty acids are precursors of inflammatory oxylipins.

10 rgy substrates or as lipid mediators such as oxylipins.

11 moderately decrease arachidonic acid-derived oxylipins.

12 se was observed for all EPA- and DHA-derived oxylipins.

13 zed metabolites, i.e., eicosanoids and other oxylipins.

14 in diet-induced obesity-C18 epoxide and diol oxylipins.

15 uces physiologically important lipids called oxylipins.

16 carotenoids, flavonoids, glucosinolates and oxylipins.

17 ic cascade responsible for the regulation of oxylipins.

18 Oxylipin 10-HOME was found to be immunogenically capable

19 ied compound and also glycosylated two other oxylipins, 11-hydroxy-7,9,13-hexadecatrienoic acid (11-H

20 pounds, 7 carotenoids, 39 acylcarnitines, 76 oxylipins, 13 sterols, and 566 lipids/lipid species.

21 ne), and lipid oxidation products (i.e., the oxylipin 13S-hydroperoxylinolenic acid).

22 an endogenously produced and secreted fungal oxylipin, 5,8-diHODE, induces fungal cellular differenti

23 Several oxylipins (8-HEPE, 5-HEPE, 11-HEPE, 9-HEPE, 18-HEPE, 9-H

24 poA is responsible for the production of the oxylipins 8R-hydroperoxyoctadecadienoic acid and 5S,8R-d

25 p had increased plasma concentrations of the oxylipins 9(S)-HpOTrE, 9(S)-HOTrE, 13(S)-HpOTrE, and 9,1

26 and pathogen defense (volatile aldehydes and oxylipins), a mechanism of unmolested nitrogen and carbo

27 Here, we propose that oxylipins, a group of oxidised metabolites derived from

28 The oxylipins, a large family of oxygenated lipid derivative

29 Our studies demonstrate that 12/15-LOX oxylipins act in concert, dampening inflammation in vivo

30 d oxygenation, resulting in the formation of oxylipins activating plant defense against hemibiotrophi

31 We additionally explored whether A. nidulans oxylipins affect seed LOX gene expression during Aspergi

32 ormone-like signaling activity for a major 9-oxylipin alpha-ketol.

33 arina grazing on P. tricornutum to exogenous oxylipins also decreased grazing rates, which is consist

34 Here, we show that oxylipins also facilitate infestation of Arabidopsis tha

35 significant changes were observed for other oxylipins among groups.

36 ipins, and challenges and considerations for oxylipin analysis including potential clinical utility.

37 Our objectives were to compare the plasma oxylipin and endocannabinoid profiles, and the platelet

38 ify (based on chromatographic peak area) the oxylipin and fatty acid content of biological samples wh

39 im of our work was to assess the fatty acid, oxylipin and phenolic composition using gas chromatograp

40 n UHPLC run enables the quantification of 43 oxylipins and 5 PUFAs, covering pro and anti-inflammator

41 fluence of sex on the effect of ibuprofen on oxylipins and COX products showed that approximately 27%

42 the infection became stronger an increase of oxylipins and diacylglycerols was revealed.

43 Oxylipins and endocannabinoids are classes of bioactive

44 upled to early generation of ~12 monohydroxy-oxylipins and enzymatically oxidized phospholipids (eoxP

45 mputational method for the identification of oxylipins and fatty acids.

46 ranching response is specific to a subset of oxylipins and is signaled through G-protein coupled rece

47 cept that the pyroptotic secretome possesses oxylipins and metabolites with tissue repair properties

48 supernatants identified the presence of both oxylipins and metabolites, linking them to pro-wound-hea

49 systemic concentrations of n-3 PUFA-derived oxylipins and moderately decrease arachidonic acid-deriv

50 IMS in LC-HRMS workflows for the analysis of oxylipins and oxidized complex lipids.

51 te the fatty acid oxidation pathway creating oxylipins and plant hormone jasmonate both have a key ro

52 Moreover, increased levels of oxylipins and salicylic acid favored closure of stomata

53 ss spectrometry (UHPLC-MS) assay to quantify oxylipins and their PUFA precursors in 100 muL of human

54 ns were collected every 3 mo for fatty acid, oxylipin, and DNA methylation (DNAm) analyses.

55 tructures and nomenclature, complex forms of oxylipins, and challenges and considerations for oxylipi

56 wledge of the involvement of FAs, FA-derived oxylipins, and enzymes catalyzing FA metabolism in plant

57 high levels of polyunsaturated fatty acids, oxylipins, and glutathione.

58 OF MS for semi-polar metabolites, LC-MRM for oxylipins, and headspace GC-MS for volatile compounds.

59 cluding genes related to halogen metabolism, oxylipins, and multicellularity (microRNA processing and

60 med cocktails of terpenoids, benzoxazinoids, oxylipins, and phenylpropanoids contribute to plant defe

61 , specifically the synthesis of pigments and oxylipins, and the metabolism of carbohydrates, amino ac

62 Within these oxylipins, arachidonic and linoleic acid derived do not

63 Oxylipins are a class of low-abundance lipids formed via

64 Oxylipins are a group of bioactive fatty acid metabolite

65 Among the microbial oxylipins, the fungal oxylipins are best characterized and function as hormone

66 Oxylipins are bioactive lipid mediators derived from pol

67 e fatty acids, recent evidence suggests that oxylipins are components of plastid-localized polar comp

68 Among these, 23 oxylipins are detectable in the majority of healthy wild

69 ive to drought, indicating that LOX6-derived oxylipins are important for the responses to abiotic and

70 Cyclooxygenase (COX)-derived oxylipins are important mediators of inflammation.

71 result provides genetic evidence that fungal oxylipins are involved in plant LOX gene expression chan

72 Oxylipins are key lipid mediators of important brain pro

73 Oxylipins are oxidized lipids that act as key upstream d

74 Importantly, oxylipins are responsive to therapeutic interventions an

75 Plant oxylipins are structural analogs of animal prostaglandin

76 In Aspergillus nidulans, oxylipins are synthesized by the dioxygenase enzymes Ppo

77 Structurally similar oxylipins are synthesized in seeds via the action of lip

78 cific signatures of ox-lipids, like those of oxylipins, are indicative of their functions.

79 Several recent studies have implicated oxylipins as a novel class of host-microbe signalling mo

80 amples were carried out to investigate these oxylipins as well as related phytohormones using a quadr

81 s that orchestrate redox responses, and GPCR/oxylipin-based signal transduction further suggests a br

82 Meanwhile, oxylipin beta-oxidation is uncoupled from oxidative phos

83 Lipid and oxylipin biomarker screening through adduct hierarchy se

84 identification of lipid, oxidized lipid, and oxylipin biomarkers in high-mass-accuracy HPLC-MS data.

85 a surface, which enables spatial mapping of oxylipin biosynthesis and migration within the tissue.

86 (PLA2) plays an important role in regulating oxylipin biosynthesis in mammals, but the molecular and

87 operoxides in roots, and that this branch of oxylipin biosynthesis is regulated by the jasmonate sign

88 d in photosynthesis, protein ubiquitination, oxylipin biosynthesis, autophagy, and response to biotic

89 pids being the primary products of plastidic oxylipin biosynthesis.

90 Herein, we explored whether a plant oxylipin biosynthetic gene (ZmLOX3) could substitute fun

91 These results indicate that oxylipin biosynthetic genes were present in the last com

92 links sequential catalytic activities in an oxylipin biosynthetic pathway.

93 ic acid and methyl jasmonate, as well as the oxylipin-biosynthetic intermediates 13-hydroperoxylinole

94 ns to ensure best practices when quantifying oxylipins by LC-MS.

95 Analysis of oxylipins by liquid chromatography mass spectrometry (LC

96 (teleomorph: Emericella nidulans) endogenous oxylipins, called psi factor, serve as hormone-like sign

97 first time, an in-depth profile of up to 52 oxylipins can be obtained from the brains of awake movin

98 Although oxylipins can be synthesized from free fatty acids, rece

99 and OPDA-18:3 DGDG, each containing a single oxylipin chain, rose 2- to 9-fold.

100 GDG, and OPDA-OPDA DGDG, each containing two oxylipin chains, increased 200- to 1,000-fold.

101 Using oxylipin chemical treatments, lipidomic analysis and fun

102 ted eoxPL belonged to subfamilies defined by oxylipin composition.

103 Oxylipins comprise a family of oxygenated fatty acid-der

104 re is no information on the dose-response of oxylipin concentrations after n-3 PUFA intake.

105 Our study provides first insights in the oxylipin concentrations of our daily food, indicating a

106 roach successfully eliminates the changes in oxylipin concentrations routinely observed during the an

107 also annotated features as potentially novel oxylipins, confirming its ability in providing further i

108 oAC strain that was reduced in production of oxylipins, conidia and the mycotoxin sterigmatocystin.

109 In unwounded leaves, the levels of these oxylipin-containing complex lipid species were low, betw

110 e complex polar lipid species, 17 species of oxylipin-containing phosphatidylglycerols, monogalactosy

111 their fatty acid precursors; therefore these oxylipins could be promising as not only diet-dependent

112 es the first genetic evidence for reciprocal oxylipin cross-talk in the Aspergillus-seed pathosystem.

113 (Ephx2)(-/-) mice, which have elevated epoxy-oxylipins, demonstrated opposing effects to epoxI-treate

114 Plasma concentrations of biologically active oxylipins derived from n-3 PUFAs, including epoxy-PUFAs

115 ly rescued by exogenous supplementation with oxylipins derived from the 13-LOX-peroxygenase pathway.

116 Here we show that oxylipins derived from this activity inhibit flagellum-d

117 OX products showed that approximately 27% of oxylipins detected were influenced by sex.

118 Our findings reveal an oxylipin-directed growth program-possibly arisen through

119 ion as a regulatory metabolic checkpoint for oxylipins during inflammation.

120 nvolvement of EPHX2-associated lipidomic and oxylipin dysregulations in AN, and reveal their potentia

121 al function and energy metabolism, including oxylipins, endocannabinoids, bile acids, and steroid hor

122 enase, lipoxygenase, and epoxygenase derived oxylipins, especially eicosanoids, play important roles

123 To examine LHC mRNA regulation by oxylipin exposure, the diatom Phaeodactylum tricornutum

124 In Candida albicans, exposure to the oxylipin farnesol causes the regulation of specific gene

125 indicated strong and early responses of many oxylipins following root-knot nematode infection.

126 Some of these oxylipins, for example jasmonic acid (JA), are important

127 Cytochrome P450 pathway oxylipins from arachidonic acid, linoleic acid, alpha-li

128 iral-induced elevation of 39 fatty acids and oxylipins from COX, LOX and P450 pathways, which suggest

129 Oxylipins function as signaling molecules in plant growt

130 f an increase in JA levels and expression of oxylipin genes during leaf senescence, and indicates tha

131 ion of P450s in phenylpropanoid, carotenoid, oxylipin, glucosinolate, and brassinosteroid biosynthese

132 These findings demonstrate that epoxy-oxylipins have a critical role in monocyte lineage recru

133 Over the last decade oxylipins have become more recognized for their involvem

134 The biological roles of oxylipins have been extensively studied in animals, plan

135 s of jasmonic acid (JA), the best-understood oxylipin hormone in herbivory defense.

136 n plant photoprotection and the synthesis of oxylipin hormones as regulators of development and defen

137 ion, enzyme elaboration, and a sophisticated oxylipin host crosstalk associated with a quorum-like de

138 ensitivity to routinely detect low-abundance oxylipins; however, new multiple-reaction-monitoring (MR

139 Atg7-deficient adipose tissues exhibited an oxylipin imbalance, driven through an NRF2-mediated upre

140 roles of cytochrome P450 (CYP)-derived epoxy-oxylipins in a well-characterized model of sterile resol

141 To investigate the role of these oxylipins in anther and pollen development, we character

142 demonstrating the importance of root-derived oxylipins in colonization of aboveground organs by an in

143 The aim of this study was to quantify oxylipins in human plasma samples from an intervention s

144 However, the roles of 9-LOX-derived oxylipins in insect resistance remain unclear.

145 These data support an important role for oxylipins in integrating mitotic and meiotic spore devel

146 d 31 fatty acids, 53 triacylglycerols and 37 oxylipins in one hundred commercial UHT milks by chromat

147 These experiments implicate oxylipins in pathogen development and suggest that Delta

148 her studies that implicate a role for fungal oxylipins in pathogenesis by Aspergillus and Candida spp

149 ass spectrometer (DESI-MRM) to spatially map oxylipins in pulmonary tissue.

150 sterified and non-esterified fatty acids and oxylipins in TGRL were quantified by mass spectrometry.

151 we investigated the fate of ALA and product oxylipins in the course of down-stream processing of see

152 we investigated the fate of ALA and product oxylipins in the course of down-stream processing of see

153 r study thus uncovers a role for prokaryotic oxylipins in the physiology and pathogenicity of bacteri

154 The occurrence of oxylipins in this species is reported for the first time

155 th elevated levels of JAs, suggest a role of oxylipins in tomato flower/seed development.

156 ygenase (COX) enzymes, but how NSAIDs affect oxylipins, in addition to COX products, in animal tissue

157 f several compounds, including camalexin and oxylipins, in two independent pae9 mutants.

158 s accurate measurement of several esterified oxylipins--in particular hydro(pero)xyeicosatetraenoic a

159 Phospholipid-esterified oxylipins include newly described families of bioactive

160 Oxylipins including jasmonates are signaling compounds i

161 Mammalian oxylipins, including the prostaglandins (PGs), mediate m

162 In parallel, levels of LOX5-derived oxylipins increased in roots and in petiole exudates of

163 nes of evidence indicated that 9-LOX-derived oxylipins induce BR synthesis and signaling to activate

164 cks 9-LOX activity, and noxy2-2, which shows oxylipin insensitivity and mitochondrial dysfunction.

165 biosynthesis of the cyclopentanone class of oxylipins is catalyzed by allene oxide cyclase (AOC) tha

166 One possible explanation for the elevated oxylipins is that frataxin deficiency results in increas

167 abundance of oxygenated metabolites of PUFA, oxylipins, is altered in TGRL postprandially, and how th

168 that plays a key role in the biosynthesis of oxylipin jasmonates, which are involved in signal and de

169 y previously showed lipid hydroperoxides and oxylipin levels are elevated in response to loss of skel

170 Last, dampening oxylipin levels by beta-oxidation is suggested to impact

171 In liver, esterified oxylipin levels decreased during acute inflammation and

172 ression of Cyp2c/Cyp2j subfamily members and oxylipin levels during LPS-induced inflammation and reso

173 We measured oxylipin levels using tandem mass spectrometry and ELISA

174 Low oxylipin levels were found in foods with high amounts of

175 In this study, we developed an extensive oxylipin library containing information on retention tim

176 ges of the analyzed standards are flagged as oxylipin-like species, which can be further characterize

177 edients were mainly polar lipids, comprising oxylipins, lysophosphatidylethanolamines, and lysophosph

178 PUFA and oxylipin markers were tested as potential biomarkers for

179 propose that Ppo products, PG, and/or other oxylipins may serve as activators of mammalian immune re

180 ed, hormone-like lipogenic molecules, called oxylipins, mediate the balance of asexual to sexual spor

181 hytodienoic acid (OPDA), both members of the oxylipin messenger family.

182 Genes putatively encoding oxylipin metabolic proteins, subtilisin-like proteases,

183 patial organization of these two branches of oxylipin metabolism.

184 acid hydroperoxides to different branches of oxylipin metabolism.

185 Our study highlights the relevance of oxylipins metabolism in stomatal regulation and indicate

186 identify a specific, bioactive ethanolamide oxylipin metabolite of NAE18:2, different from those of

187 lated by 12-oxo-phytodienoic acid (OPDA), an oxylipin metabolite produced through enzymatic oxygenati

188 ns of these fatty acids and their derivative oxylipin metabolites and produced differential DNAm prof

189 Quantification of oxylipin metabolites in lox mutants demonstrated altered

190 Here, we identify and quantify endogenous oxylipin metabolites of N-linolenoylethanolamine (NAE 18

191 correlation between obesity and hepatic C18 oxylipin metabolites of omega-6 (omega6) and omega-3 (om

192 Changes in several novel oxylipin metabolites were detected, including arabidopsi

193 Detectable levels of endogenous NAE-oxylipin metabolites were identified in FAAH fatty acid

194 tegral part of the plant's defense response, oxylipins might be placed as important signaling molecul

195 hese results suggest that host and microbial oxylipins might interfere with the metabolism, perceptio

196 hen stressed or wounded, diatoms can produce oxylipin molecules known to inhibit the reproduction and

197 Seventy-three oxylipins, mostly hydroxy-, dihydroxy-, and epoxy-PUFAs,

198 catrienoic acid-insensitive nonresponding to oxylipins (noxy) mutants showed the importance of the ce

199 Previous studies using nonresponding to oxylipins (noxy), a series of Arabidopsis (Arabidopsis t

200 xo-phytodienoic acid (OPDA) was the dominant oxylipin occurring nearly exclusively in the seed coat t

201 We suggest that NAE oxylipins of linolenic acid represent a newly identified

202 turated cyclopropane- and lactone-containing oxylipins of marine origin has been designed and applied

203 The oxylipins of these polar complex lipid species include o

204 tectable increase in JA may indicate that an oxylipin other than JA regulates basal resistance and sy

205 ulation are governed, in part, by endogenous oxylipins (oxygenated, polyunsaturated fatty acids and m

206 on of regulatory and structural genes of the oxylipin pathway and by studying nonlinearities in gene-

207 The oxylipin pathway generates not only prostaglandin-like j

208 induced systemic resistance, showed that the oxylipin pathway is differentially regulated.

209 Two members of the 9-lipoxygenase (9-LOX) oxylipin pathway, 9-hydroxyoctadecatrienoic acid and 9-k

210 arly the allene oxide synthase branch of the oxylipin pathway, responsible for production of jasmonic

211 ith the induction of the first enzyme of the oxylipin pathway, the lipoxygenase (LOX), leading to a f

212 insect suppression of the HPL branch of the oxylipin pathway.

213 further investigated the stimulation of the oxylipin pathway: metabolites and enzymes of the pathway

214 Large differential increases in oxylipin-pathway lipoxygenases and auxin-responsive tran

215 gesting that this molecule and its effect on oxylipin pathways play a key role in prey selection.

216 eased from membranes and is converted to the oxylipins phytodienoic acid and jasmonic acid through th

217 Jasmonates are oxylipin phytohormones critical for plant resistance aga

218 In this work, six new bioactive oxylipins -phytoprostanes - were detected in gulupa shel

219 Bioactive oxylipins play multiple roles during inflammation and in

220 Oxygenated fatty acids, or oxylipins, play an essential role in physiological signa

221 root) and radial (cell-to-cell) transport of oxylipins plays a major role in the wound response.

222 up to 1200 ug/g, 80 mg per serving) and high oxylipin/precursor-PUFA ratios were found in fried falaf

223 ication of 9-hydroxyoctadecadienoic acid (an oxylipin produced by the LOX5 enzyme) to roots restored

224 all, our results revealed associations among oxylipins produced across several biosynthetic pathways,

225 We also demonstrate that oxylipins produced by P. aeruginosa promote virulence in

226 S)-lipoxygenase (12-LOX), a highly expressed oxylipin-producing enzyme in the human platelet, is an e

227 dicate that pPLAIIalpha negatively regulates oxylipin production and suggest a role in the removal of

228 xpression, biofluid oxylipin profile, tissue oxylipin production capacity, and blood pressure.

229 These results suggest that NO and oxylipin production help to structure diatom communities

230 Oxylipin production in this fungus is dependent on devel

231 These results indicate that oxylipin production is important for host colonization a

232 We further provide evidence of H(2)O(2) and oxylipin production that, as in plants and animals, may

233 The expression of genes involved in oxylipin production was also higher in the pPLAIIalpha-d

234 ting levels of NO also resulted in increased oxylipin production, and lower overall grazing rates.

235 somes, whereas LOX, responsible for NAE 18:2-oxylipin production, was distributed in cytosol-enriched

236 type evaluating protein expression, biofluid oxylipin profile, tissue oxylipin production capacity, a

237 nutum and pronounced change in its dissolved oxylipin profile.

238 dividuals undergoing a fasting intervention; oxylipin profiles highlighted significantly altered PUFA

239 y, the validated method was used to evaluate oxylipin profiles in lipopolysaccharide-exposed mice, an

240 hat chewing insects differentially alter the oxylipin profiles produced by the two main and competing

241 at wounding and drought differentially alter oxylipin profiles, particularly the allene oxide synthas

242 Herein, comprehensive oxylipin profiling of tomato roots, performed using LC-M

243 Oxylipin profiling of xylem sap from T. virens-treated p

244 Comprehensive oxylipin profiling together with genetic and pharmacolog

245 Consequently, these oxylipins promote bacterial organization in microcolonie

246 plants, thus confirming that a LOX5-derived oxylipin promotes infestation of the foliage by GPAs.

247 Focusing specifically on the oxylipin prostaglandin E(2) (PGE(2)), we find that its s

248 on of AA pathway inhibitors, and analysis of oxylipins provided evidence that, following heparin, agg

249 he biosynthesis of the linoleic acid derived oxylipin psiBalpha.

250 Oxylipin ratios were calculated as proxy markers of in v

251 In this study, four oxylipin receptors were characterised using immunohistoc

252 In plants, oxylipins regulate developmental processes and defense r

253 nctions and the biosynthesis of hydroxylated oxylipins remains scarce.

254 ipopolysaccharide (LPS) dynamically enhances oxylipin removal via mitochondrial beta-oxidation.

255 Oxylipins represent a vast and diverse family of seconda

256 ool for the evaluation of complex regulatory oxylipin responses in in vitro or in vivo studies.

257 B60 as transcriptional integrator of ABA and oxylipins responses in guard cells.

258 Breast adipose oxylipins showed dose-dependent increases in DHA and EPA

259 erance in A. fumigatus whereby the inducible oxylipin signal 5,8-diHODE confers protection against ti

260 Hormone measurements showed that the oxylipin signal must precede subsequent increases in eth

261 Oxylipin signalling is central in biology, mediating pro

262 provide evidence that nitric oxide (NO) and oxylipin signalling pathways in diatoms respond to proti

263 Jasmonates are oxylipin signals that play important roles in the develo

264 rabidopsis thaliana) ecotypes to examine the oxylipin signature in response to specific stresses and

265 pidemic subjects produces TGRL with a unique oxylipin signature that promotes a pro-atherogenic endot

266 Oxylipin signatures of wounded opr3 leaves revealed the

267 a PN biosynthetic gene, thus suggesting that oxylipin species regulate secondary metabolites at the t

268 ention time (RT), m/z, and CCS values for 74 oxylipin standards using LC-IM-QTOF-MS in positive and n

269 dentification of endogenous amide-conjugated oxylipins suggests potential significance of these metab

270 f the genes involved in the initial steps of oxylipin synthesis revealed that abrogation of the PLDal

271 frataxin leads to elevation of COX2-mediated oxylipin synthesis stimulated by increases in transcript

272 anscription factor ZfpA, required for normal oxylipin synthesis, regulates the morphology switch.

273 S), the cytochrome P450 that initiates plant oxylipin synthesis.

274 role for AtMYB60 as a negative modulator of oxylipins synthesis in stomata.

275 ethods offer a comprehensive coverage of the oxylipin synthetic cascade applicable to a wide range of

276 ry, 12/15-LOX generates abundant monohydroxy oxylipins that act together via PPARgamma.

277 ing herbivory, marine diatom species release oxylipins that impair grazer reproduction and serve as s

278 f solandelactones is proposed for these C 22 oxylipins that parallels a hypothesis put forward previo

279 olized by CYP74 cytochrome P-450s to various oxylipins that play important roles in plant growth and

280 Jasmonates are oxygenated lipids (oxylipins) that control defense gene expression in respo

281 Among the microbial oxylipins, the fungal oxylipins are best characterized a

282 -MS/MS workflow for the quantification of 52 oxylipins to analyze mediator profiles in human monocyte

283 ave shown that exogenous application of seed oxylipins to Aspergillus cultures alters sporulation and

284 JA-deficient mutants confirmed shoot-to-root oxylipin transport.

285 Jasmonates, oxylipin-type plant hormones, are implicated in diverse

286 A panel of 5 oxylipins was then selected for DESI-MRM imaging derived

287 of oxygenated polyunsaturated fatty acids, "oxylipins." We employed three Arabidopsis (Arabidopsis t

288 Relative and absolute changes of individual oxylipins were calculated and concentrations were correl

289 library to mouse brain samples, 19 different oxylipins were identified by matching RT, m/z, and CCS v

290 Epoxide substrates of sEH and associated oxylipins were measured in ill AN, recovered AN and gend

291 Epoxy-oxylipins were produced in a biphasic manner during the

292 In 21 min, 39 oxylipins were quantified along with eight corresponding

293 Oxylipins were quantified in plasma after 3 and 12 mo.

294 f lipoxygenase- and cyclooxygenase-dependent oxylipins were unchanged.

295 s of polyunsaturated fatty acids (PUFAs) and oxylipins, which are strongly associated with chemical c

296 levels of polyunsaturated fatty acid-derived oxylipins, which control a range of outcomes related to

297 with 5-, 12-, and 15-lipoxygenases produced oxylipins, which were identified and characterized by li

298 ids (LComega3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic prop

299 exhibits a robust oxidative activity toward oxylipins with hydroxyl groups located at carbons C9 and

300 substrate to different classes of bioactive oxylipins within chloroplasts.