ライフサイエンスコーパス: oxysterol

1 he only macrophage-synthesized and -secreted oxysterol.

2 ication of ergosterol endoperoxide, a B-ring oxysterol.

3 reactive, giving rise to biologically active oxysterols.

4 Th1 cells, preferentially produce these two oxysterols.

5 s C, i.e., rich in hydroperoxides but low in oxysterols.

6 roteins that form adducts with ozone-derived oxysterols.

7 Smoothened-/- mouse embryonic fibroblasts to oxysterols.

8 homeostasis of cholesterol, bile acids, and oxysterols.

9 owed earlier that NPC1 binds cholesterol and oxysterols.

10 required for the known regulatory actions of oxysterols.

11 NPC2 bound cholesterol, but not oxysterols.

12 y lead to increased levels of LXR-activating oxysterols.

13 e pathways of metabolism that generate novel oxysterols.

14 icles in response to its endogenous ligands, oxysterols.

15 shown to lead to accumulation of neurotoxic oxysterols.

16 lining fluid, generating chemically reactive oxysterols.

17 n of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol (24S-HC) in a pancreatic

18 Binding of both sterols was competed by oxysterols (24-, 25-, and 27-HC).

19 with additive effects on serum levels of the oxysterol, 24S-hydroxycholesterol, a substrate of the en

20 e (Ch25h) and that are unable to produce the oxysterol 25-hydroxycholesterol (25-HC) overproduce infl

21 ere we report that in vitro additions of the oxysterol 25-hydroxycholesterol (25-HC), exogenous cytos

22 The oxysterol 25-hydroxycholesterol (25HC) plays multiple ro

23 Here we show that a lipid, oxysterol 25-hydroxycholesterol (25HC), directly binds t

24 ore formation requires the production of the oxysterol 25-hydroxycholesterol (25HC), inhibition of ch

25 ulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC).

26 Here, we report that the oxysterol 25-hydroxycholesterol and geranylgeraniol comb

27 These findings identify an oxysterol, 25-HC, as a critical mediator in the negative

28 LC) separation of a closely eluting isomeric oxysterol, 25-hydroxycholesterol.

29 more recent studies have indicated that the oxysterol 27-hydroxycholesterol (27HC), and not choleste

30 The oxysterol 27-hydroxycholesterol (27HC), synthesized by t

31 led to decreased levels of the 7-DHC-derived oxysterol, 3beta,5alpha-dihydroxycholest-7-en-6-one.

32 in ECs, and that these cells accumulated the oxysterol 7-ketocholesterol (7-KC) when Abcg1(-/-) mice

33 nction of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critica

34 tion of LXRs a l so suppresses expression of oxysterol 7alpha-hydroxylase (Cyp7b1), which may lead to

35 Expression of liver oxysterol 7alpha-hydroxylase in the alternative bile aci

36 Conversely, inactivation of the CYP7B1 oxysterol 7alpha-hydroxylase, which degrades 25-hydroxyc

37 essive mutations in the gene CYP7B1 encoding oxysterol-7alpha-hydroxylase.

38 double blind interventional trial targeting oxysterol accumulation in serum of SPG5 patients.

39 ogical functions of sterol intermediates and oxysterols, acting through transcription factors such as

40 Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a centra

41 rs alpha and beta (LXRalpha and LXRbeta) are oxysterol-activated transcription factors that coordinat

42 l site 1 and site 2 phosphomutants supported oxysterol activation of SM synthesis in OSBP-deficient C

43 um membrane phospholipid remodeling inhibits oxysterol activity.

44 The mechanism by which O3-derived oxysterols affect molecular function is unknown.

45 ) induce only HAS3 transcription, whereas 22,oxysterol affects both HAS2 and HAS3.

46 ystems, as several other biologically active oxysterols also mobilize accessible cholesterol through

47 fects within two specific lipid (cholesterol/oxysterol and phosphatidylethanolamine) biosynthetic cas

48 epatic cholesterol and accumulation of toxic oxysterols and bile acids.

49 protein-2 is responsive to both sterols and oxysterols and has been shown to mediate the transcripti

50 The ability of oxysterols and lipoprotein-containing serum to suppress

51 ice by promoting efflux of cholesterol and 7-oxysterols and preserving active eNOS dimer levels.

52 Oxysterols and secosteroids regulate both innate and ada

53 (LXR) are stimulated by cholesterol-derived oxysterols and serve as transcription factors to regulat

54 ydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids.

55 uclear receptor family that are activated by oxysterols and synthetic high-affinity agonists.

56 ing ozone exposure through the generation of oxysterols and the formation of oxysterol-protein adduct

57 d to account for the formation of all of the oxysterols and the reaction progress profile.

58 oduction of endogenous bioactive sterols and oxysterols and their mechanisms of action in the immune

59 activity is crucial for the inactivation of oxysterols and their subsequent conversion into bile sal

60 relevant endogenous (e.g., cholestane 3,5,6 oxysterol) and exogenous (e.g., lipopolysaccharide) mole

61 eptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol

62 ivation of the UPR include oxidative stress, oxysterols, and high levels of intracellular cholesterol

63 ators of sterol metabolism, including serum, oxysterols, and synthetic liver X receptor (LXR) agonist

64 ous Smoothened activator is cholesterol, not oxysterols, and that vertebrate Hedgehog signaling contr

65 rol in breast cancer when the levels of this oxysterol are elevated.

66 EBI2; however, the cellular sources of this oxysterol are undefined.

67 Because oxysterols are agonists for Liver X Receptors (LXRs), we

68 procedure, the extraction and enrichment of oxysterols are combined in a unique step, reducing sampl

69 Side-chain oxysterols are enzymatically generated oxidation product

70 Oxysterols are increased in inflamed airways after aller

71 Certain oxysterols are known to have direct effects on membrane

72 Oxysterols are oxidized derivatives of cholesterol that

73 Oxysterols are oxygenated cholesterol derivates that are

74 port the contention that side chain-oxidized oxysterols are strong suppressors of cholesterol biosynt

75 which has serious implications for how these oxysterols are used as biomarkers.

76 Oxidation products of cholesterol, the oxysterols, are enzymatically produced molecules that pl

77 a previously unknown mechanism for selected oxysterols as immune modulators and a direct role for CY

78 t findings extend the biologic activities of oxysterols as ligands for nuclear receptors to a role in

79 viral entry and implicate membrane-modifying oxysterols as potential antiviral therapeutics.

80 dentification of several naturally occurring oxysterols as RORgammat agonists.

81 ular pathways for the rapid equilibration of oxysterols between membranes, direct imaging of oxystero

82 Oxysterols, bile acids (BAs), and steroids work primaril

83 Here, we show that oxysterol binding protein (OSBP) and its anchors at the

84 tion complex have been identified, including oxysterol binding protein (OSBP) and phosphatidylinosito

85 CV RNP complexes revealed the association of oxysterol binding protein (OSBP) as one of the component

86 The oxysterol binding protein (OSBP) is a storied protein in

87 lipid transfer proteins to the ER, including oxysterol binding protein (OSBP), which has been previou

88 The oxysterol binding protein homologue Kes1p has been impli

89 A homologue oxysterol binding protein of yeast (Osh4) peripherally b

90 Mesmin et al. show how a single molecule of oxysterol binding protein, which has a lipid binding dom

91 H-1 K289R mutation induced the expression of oxysterol binding protein-like 3 (OSBPL3), enhanced SREB

92 Two peptides matching to oxysterol binding protein-related protein 1L (ORP1L) and

93 Oxysterol binding protein-related proteins, including th

94 sfer protein CERT and several members of the oxysterol binding proteins.

95 sent the first molecular characterization of oxysterol binding to a 7TM receptor and identify positio

96 late a range of cellular processes, only few oxysterol-binding effector proteins have been identified

97 The oxysterol-binding groove in the Smo CRD is analogous to

98 t Sac1-mediated PI4P metabolism requires the oxysterol-binding homology (Osh) proteins.

99 Oxysterol-binding protein (OSBP) and OSBP-related protei

100 Oxysterol-binding protein (OSBP) exchanges cholesterol a

101 o the TGN by Osh1, a member of the conserved oxysterol-binding protein (OSBP) family of lipid transfe

102 intracellular lipid-transfer proteins of the oxysterol-binding protein (OSBP) family.

103 Ceramide transfer protein (CERT) and oxysterol-binding protein (OSBP) play a crucial role in

104 rane-protein-associated protein A (VAPA) and oxysterol-binding protein (OSBP) regulate intracellular

105 culum (ER)-Golgi sterol transfer activity of oxysterol-binding protein (OSBP) regulates sphingomyelin

106 PI 4-kinase and oxysterol-binding protein (OSBP) were inhibited using RN

107 ynamin-1, kinesin, beta-tubulin, beta-actin, oxysterol-binding protein (OSBP)-related protein 2 (ORP2

108 t two similar ER integral membrane proteins, oxysterol-binding protein (OSBP)-related protein 5 (ORP5

109 er of the evolutionarily conserved family of oxysterol-binding protein (OSBP)-related proteins (ORPs)

110 ecruits lipid transfer proteins (LTPs), like oxysterol-binding protein (OSBP).

111 -miR-885-5p levels correlated inversely with oxysterol-binding protein 2 (OSBPL2) expression (r = -0.

112 from multiple pools is delivered to Sac1 by oxysterol-binding protein and related proteins in exchan

113 erto unknown relationship between members of oxysterol-binding protein and VAP33 families of plant pr

114 flip at the TGN appears to be to control the oxysterol-binding protein homologue Kes1/Osh4 and regula

115 ction between ER-localized VAP and endosomal oxysterol-binding protein ORP1L, and is required for the

116 re, the RIDalpha pathway is regulated by the oxysterol-binding protein ORP1L.

117 se PP2A, the tyrosine phosphatase HePTP, the oxysterol-binding protein OSBP and cholesterol.

118 y a novel substrate of PKD at the Golgi, the oxysterol-binding protein OSBP.

119 Kes1, and other oxysterol-binding protein superfamily members, are invol

120 ol-binding properties of a small Arabidopsis oxysterol-binding protein, ORP3a.

121 asome, and OSBPL1A, which encodes a presumed oxysterol-binding protein, were both preferentially expr

122 red JAK2 and tyrosine 394 phosphorylation of oxysterol-binding protein-1.

123 e studies identify a previously unrecognized oxysterol-binding protein-mediated mode of activation of

124 The oxysterol-binding protein-related protein (ORP) family i

125 ab7-interacting lysosomal protein (RILP) and oxysterol-binding protein-related protein 1L (ORP1L) are

126 endoplasmic reticulum, a process mediated by oxysterol-binding protein-related protein 1L (ORP1L), a

127 Oxysterol-binding protein-related protein 2 (ORP2), a ch

128 Oxysterol-binding protein-related protein 8, which was r

129 OSBPL1 encodes the full-length oxysterol-binding protein-related protein ORP1L, which t

130 Oxysterol-binding protein-related proteins (ORPs) have b

131 In non-plant systems, oxysterol-binding proteins have been involved in sterol

132 There are at least twelve homologs of oxysterol-binding proteins in the Arabidopsis genome, bu

133 We show here that in yeast the oxysterol-binding proteins Osh1-Osh7 are collectively ne

134 These studies define Insigs as oxysterol-binding proteins, explaining the long-known ab

135 inery in the initial steps of steroid and/or oxysterol biosynthesis pathways are present and active i

136 SREBP)-dependent gene expression, side chain oxysterol biosynthesis, and cholesterol precursors in th

137 Cholesterol and oxysterols block COPII binding to MELADL by binding to d

138 Two classes of sterols, cholesterol and oxysterols, block export of sterol regulatory element-bi

139 response to loading with free cholesterol or oxysterol, but underlying mechanisms have not been eluci

140 We show that side chain oxysterols, but not steroid ring-modified oxysterols, ex

141 ol has allowed us to directly visualize this oxysterol by attaching an azide fluorophore through cycl

142 nification of the sample and purification of oxysterols by reversed phase C18-SPE followed by HPLC-MS

143 New studies now indicate that tumor-derived oxysterols can serve to subvert the immune system by rec

144 stent with experimental results showing that oxysterols can trigger cholesterol trafficking from the

145 Lower plasma levels of the oxysterol cholestenoic acid associate with increased mor

146 ion of disease severity and progression with oxysterol concentrations, and demonstrate in a randomize

147 res and to investigate postmortem changes in oxysterol concentrations.

148 Then human specimens were analyzed for oxysterol concentrations.

149 Maximum oxysterols concentrations were achieved at 20 min in nea

150 and that acute mobilization of this pool by oxysterols confers immunity to these pathogens.

151 acologic blockade or genetic inactivation of oxysterols controls pNET tumorigenesis by dampening the

152 fy an unanticipated protumor function of the oxysterol-CXCR2 axis and a possible target for cancer th

153 We demonstrate that interfering with the oxysterol-CXCR2 axis delays tumor growth and prolongs th

154 roteinase-14 cleavage site G-L prevented the oxysterol-dependent increase in arterial pressure and sE

155 th the SRE and nLXRE are required for normal oxysterol-dependent repression of this gene.

156 ch on sterol oxidation focuses mainly on the oxysterol derivatives formation to the exclusion of comp

157 in the cholesterol-biosynthetic pathway and oxysterol derivatives of cholesterol regulate diverse ce

158 Natural ligands that activate LXRs include oxysterol derivatives such as 25-hydroxycholesterol, 27-

159 est-7-en-6-one, a naturally occurring B-ring oxysterol derived from 7-DHC that also accumulates in Sm

160 Fifteen oxysterols derived from 7-DHC were isolated and characte

161 Furthermore, binding studies showed that oxysterols did not compete with fluorescently labeled cy

162 ss high baseline Gli activity, we found that oxysterols did not dramatically shift the IC50 concentra

163 ed U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.

164 zed Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyc

165 Oxysterols elicit profound effects on immune and inflamm

166 Oxysterols elicit profound effects on immune and inflamm

167 of vertebrate Smo and show that it binds to oxysterols, endogenous lipids that activate Hh signaling

168 lial cells to O3 results in the formation of oxysterols, epoxycholesterol-alpha and -beta and secoste

169 Side chain oxysterols exert cholesterol homeostatic effects by supp

170 in oxysterols, but not steroid ring-modified oxysterols, exhibit membrane expansion behavior in phosp

171 Results confirmed that compared to ATP, both oxysterols failed to reach the acceptable threshold bind

172 Besides, the roles of oxysterols, fatty acids, phospholipids, and lipid second

173 to pregnant female mice led to a decrease in oxysterol formation in brain and liver tissues of the ne

174 of FAME delayed PS degradation and postponed oxysterols formation.

175 7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques

176 body, the de novo production of steroids or oxysterols from cholesterol has not been examined.

177 ting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting t

178 CG1, which promote efflux of cholesterol and oxysterols from macrophages, has not been investigated.

179 Here we isolate oxysterols from porcine spleen extracts and show that th

180 se that the high reactivity of 7-DHC and the oxysterols generated from its peroxidation may play impo

181 cellular and molecular mechanisms governing oxysterol generation within tumor microenvironments rema

182 As expected, O3-derived oxysterols have a pro-inflammatory effect and increase N

183 Intriguingly, these oxysterols have also been detected in atherosclerotic pl

184 The biological effects of oxysterols have largely been credited to the activation

185 rall, these data demonstrate that O3-derived oxysterols have pro-inflammatory functions and form lipi

186 Oxysterols have recently been identified as natural liga

187 Tumor-derived oxysterols have recently been shown to favor tumor growt

188 Cholesterol-oxidized products, namely oxysterols, have been shown to favor tumor growth direct

189 uction of these receptors with ozone-derived oxysterols impaired ligand binding and corresponded with

190 in 24-hydroxycholesterol (24SOH), the major oxysterol in the brain.

191 use molecular dynamics simulations of these oxysterols in 1-palmitoyl 2-oleoyl phosphatidylcholine (

192 their potential to reduce formation of 7-DHC oxysterols in fibroblast from SLOS patients.

193 ies, studied dose-dependent neurotoxicity of oxysterols in human cortical neurons and performed a ran

194 trinsic, 'professional' role for sterols and oxysterols in macrophage and T-cell immunity.

195 idering the adverse effects of 7-DHC-derived oxysterols in neuronal and glial cultures and the positi

196 responsible for differential accumulation of oxysterols in organelle membranes.

197 Furthermore, CAR elevated toxic oxysterols in the brain of maternally exposed Dhcr7(+/-)

198 A role for oxysterols in the effects of Sonic hedgehog protein focu

199 human NPC1 and confirmed its ability to bind oxysterols, including those with a hydroxyl group on the

200 ne cell function, and it was found that this oxysterol increases the number of polymorphonuclear-neut

201 Cholesterol or oxysterols induced ABCA1 expression in wild type macroph

202 of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter dr

203 to M1 polarization, decreased autophagy and oxysterol-induced cell death whereas overexpression of M

204 onto HDL and in protecting these cells from oxysterol-induced cytotoxicity.

205 This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-

206 mitochondria and its DNA may be targets for oxysterol-induced oxidative stress and may play a role i

207 Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling b

208 This oxysterol is an efficient suppressor of cholesterol synt

209 The function of this oxysterol is unknown.

210 Furthermore, the effect of oxysterols is abolished in Smoothened mutants that retai

211 e believe that preventing formation of 7-DHC oxysterols is critical for countering the detrimental ef

212 When cell cholesterol is lowered, or oxysterols is introduced, the complex disassembles and p

213 t direct membrane perturbation by side-chain oxysterols is significant and suggests that these membra

214 ) DCs highly express EBI2 and migrate to its oxysterol ligand, 7alpha,25-OHC.

215 To determine whether oxysterol ligands for EBI2 are increased in asthma exace

216 for NOX4 in insulin-stimulated generation of oxysterol ligands for LXR, a key lipogenic factor.

217 analysis and studies of naturally occurring oxysterol ligands indicate that the transactivation and

218 reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B (SecoA an

219 f the UPR in response to free cholesterol or oxysterol loading in insulin-resistant macrophages.

220 programs upon their activation by endogenous oxysterols, LXRs have recently also been implicated in r

221 2) processing, and selectively attenuate the oxysterol-mediated repression of SREBP-2 processing.

222 To examine whether oxysterol-membrane interactions contribute to the regula

223 These studies implicate oxysterol-membrane interactions in acute regulation of s

224 w that these enzymes metabolize human immune oxysterol messengers.

225 etastatic effects of a high-fat diet via its oxysterol metabolite, 27-hydroxycholesterol.

226 , including roles for catechol estrogen- and oxysterol-metabolites of parasite origin as initiators o

227 T cell activation triggers induction of the oxysterol-metabolizing enzyme SULT2B1, consequent suppre

228 patients, indicating that elevated levels of oxysterols might be key pathogenic factors in SPG5.

229 In a cell viability test, the oxysterol mixture from 7-DHC peroxidation was found to b

230 genous modulator of NMDARs acting at a novel oxysterol modulatory site that also represents a target

231 GPR183) was shown to be activated by several oxysterols, most potently by 7alpha,25-dihydroxycholeste

232 also accounts for the formation of numerous oxysterol natural products isolated from fungal species,

233 ing cholesterol to 27-hydroxycholesterol, an oxysterol of multiple functions, including tissue-specif

234 les for metabolites of catechol estrogen and oxysterols of parasite origin as initiators of carcinoge

235 -rich domain (CRD) as the site of action for oxysterols on Smo, involving residues structurally analo

236 Using alkynyl surrogates of O3-derived oxysterols, our data demonstrate adduction of LXR with S

237 Oxysterols, oxidized metabolites of cholesterol, are end

238 se the intriguing possibility that targeting oxysterol pathways could serve as a novel therapeutic ap

239 BCG1 results in increased levels of specific oxysterols, phosphatidylcholines, and oxidized phospholi

240 esterol itself and other naturally occurring oxysterols present in brain do not modulate NMDARs at co

241 we report that specific, naturally occurring oxysterols, previously shown to direct pluripotent mesen

242 Using this unique oxysterol probe, we provide evidence that oxysterol regu

243 s CH25H, have essential roles in controlling oxysterol production in lymphoid tissues, and they sugge

244 SL-mediated steroidogenesis entails enhanced oxysterol production.

245 By comparing the oxysterol profile formed from 7-DHC and those formed fro

246 od hydrogen atom donor alpha-tocopherol, the oxysterol profile of 7-DHC peroxidation differed distinc

247 The oxysterol profile of the retina suggests that all known

248 Qualitatively, oxysterol profiles were similar in the bovine and human

249 How oxysterol-protein adduction modifies the function of lun

250 eneration of oxysterols and the formation of oxysterol-protein adducts on phagocytic receptors.

251 responses is not mediated by enantiospecific oxysterol-protein interactions.

252 udy demonstrated that lipopolysaccharide and oxysterols (PSC-related stressors) induced the expressio

253 resent study demonstrates a key role for the oxysterol receptor liver X receptor beta (LXRbeta) in th

254 We recently showed that tumor-derived oxysterols recruit neutrophils endowed with protumoral a

255 We report that tumor-derived oxysterols recruit protumor neutrophils in a liver X rec

256 ew insights into the mechanism through which oxysterols regulate cellular cholesterol balance.

257 uggesting a possible mechanism for how these oxysterols regulate cholesterol homeostasis.

258 y further the understanding of ways in which oxysterols regulate intracellular lipid transport.

259 k inhibition where the levels of sterols and oxysterols regulate the expression of cholesterologenic

260 ological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholestero

261 embrane perturbations may play a role in the oxysterol regulation of cholesterol homeostasis.

262 ue oxysterol probe, we provide evidence that oxysterol regulation of cholesterol homeostatic response

263 AT3 and relevant coregulatory factors to the oxysterol-responsive region of the profilin-1 promoter.

264 We show that these oxysterols reverse the inhibitory effect of an RORgammat

265 Unexpectedly, we found that this oxysterol selectively accumulates in the Golgi membrane

266 hat oxidative stress and the accumulation of oxysterols should be considered as two key factors in ch

267 in CYP27A1, a key enzyme in generating these oxysterols, showed significant reduction of IL-17-produc

268 geranylgeranyl pyrophosphate and a secondary oxysterol signal.

269 s) and hydroxylated cholesterol derivatives (oxysterols); Smo is also highly sensitive to cellular st

270 sed to O3 contained elevated levels of these oxysterol species.

271 ptional repression of rhotekin 2 (RTKN2), an oxysterol stress responder, to optimize cell survival.

272 has recently been challenged by reports that oxysterols such as lanosterol and 25-hydroxycholesterol

273 Recent work has shown that side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), alter

274 Related oxysterols, such as 5alpha,6alpha-epoxycholesterol (5,6-

275 nsively studied, fundamental questions about oxysterols, such as their subcellular distribution and t

276 sterols between membranes, direct imaging of oxysterols suggests that a vesicular pathway is responsi

277 ogenous regulator decreases lipogenesis, and oxysterol sulfation can be a key protective regulatory p

278 Oxysterol synergized with nonsteroid LXR ligand induced

279 m, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24

280 and beta are nuclear receptors activated by oxysterols that originated from the oxidation of cholest

281 GPCR known to bind and to be activated by an oxysterol, the goal of this study was to understand the

282 e show that the nuclear hormone receptor for oxysterols, the liver X receptor alpha (LXRalpha), regul

283 d the known immunological effects of certain oxysterols, thus uncovering a previously unknown role fo

284 al state through the production of a natural oxysterol to inhibit viral entry and implicate membrane-

285 Recent data expand the functional roles of oxysterols to fetal development and to the detoxificatio

286 oteins, explaining the long-known ability of oxysterols to inhibit cholesterol synthesis in animal ce

287 acellular receptors, cholesterol to Scap and oxysterols to Insig.

288 with rapid chromatographic separation of the oxysterols to permit accurate determination of plasma 24

289 abolome profiling of all naturally occurring oxysterols upon infection or IFN-stimulation, we reveal

290 t, 5-cholestenoic acid, is the most abundant oxysterol, varying up to threefold in different persons.

291 In the brain, the predominant oxysterol was 24S-hydroxycholesterol.

292 ygen species are related to the formation of oxysterols, we assessed the effect of 22-(R)-hydroxychol

293 Oxysterols were found to impair metabolic activity and v

294 7-DHC-derived oxysterols were measured in fibroblasts from SLOS patien

295 Levels of CAR, CAR metabolites, sterols, and oxysterols were measured in the brain of maternally expo

296 erial properties of the bilayer when certain oxysterols were present in the bilayer.

297 We observed that dense cells had increased oxysterols, which activated LXRbeta to upregulate ABCA1.

298 used by the presence of the second dipole of oxysterols, which reduces the energetic barrier for Abet

299 atic cells involves metabolism to side-chain oxysterols, which serve as transport forms of cholestero

300 cholesterol metabolites such as steroids or oxysterols within endocrine tissues are currently recogn