ライフサイエンスコーパス: oxytocin receptor

1 tant had all the activities of the wild type oxytocin receptor.

2 tine along with a novel caged agonist of the oxytocin receptor.

3 O2.1 is inhibited by oxytocin binding to the oxytocin receptor.

4 s ability to enter the brain and bind to the oxytocin receptor.

5 Rs and that this effect does not involve the oxytocin receptor.

6 pette, suggesting activation of postsynaptic oxytocin receptors.

7 gestation, and delayed induction of uterine oxytocin receptors.

8 n genes that regulate beta(2) adrenergic and oxytocin receptors.

9 reatment suppresses intake through action at oxytocin receptors.

10 nents of the signalling pathway that couples oxytocin receptor activation to changes in chemoreceptor

11 We found that an oxytocin receptor agonist decreases the amplitude of spo

12 entricular administration of oxytocin or the oxytocin receptor agonist PF-06655075, which does not cr

13 The oxytocin receptor agonist WAY267464 (10 mg/kg) inhibited

14 The effects of oxytocin, selective oxytocin receptor agonists, antagonists, and vehicle inj

15 Knocking-out either of the Oxytocin receptors also led to increased group spacing a

16 Oxytocin receptor and connexin-43 mRNA expression were r

17 ression of the contraction-associated genes, oxytocin receptor and connexin-43, and block oxytocin-in

18 e generated specific antibodies to the mouse oxytocin receptor and examined receptor expression throu

19 otection, especially the interaction between oxytocin receptor and GABAA receptor (GABAAR), remains t

20 polarization is sensitive to blockade of the oxytocin receptor and is mediated by a voltage-dependent

21 positive (SST(+)) interneurons expressed the oxytocin receptor and were activated by oxytocin in V1.

22 Here, we show that SEG/GRP neurons express oxytocin receptors and are activated by oxytocin during

23 sociated with an increase in the quantity of oxytocin receptors and of somatostatin interneurons in b

24 plasticity and memory in rats via acting on oxytocin receptors and regulating ERK activity.

25 ance of social behavior is influenced by the Oxytocin receptors and that the effects are not just pro

26 ating adrenal steroids affect the density of oxytocin receptors and the angiotensin receptor subtypes

27 d intraspecies variation of the geography of oxytocin receptors and vasopressin V1a receptors in the

28 potency in vitro (Ki = 4.1 nM, cloned human oxytocin receptor) and in vivo (intravenous AD50 = 0.71

29 or, human vasopressin 1b receptor, and human oxytocin receptor), and pharmacokinetic profiles in rode

30 he oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor

31 s, downregulation of neuronal and astrocytic oxytocin receptors, and impaired oxytocin-driven GABAerg

32 Mouse blastocysts express oxytocin receptors, and oxytocin induced delayed implant

33 th agonist-activated neurotensin-1 receptor, oxytocin receptor, angiotensin II type 1A receptor, and

34 end of the injection and (b) injection of an oxytocin receptor antagonist ([d(CH2)5-Tyr (Me)2-Orn8]-V

35 by injection into the fourth ventricle of an oxytocin receptor antagonist [d(CH(2))(5), Tyr (Me)(2),

36 Nolasiban is an orally active oxytocin receptor antagonist being developed to increase

37 to immobilization, whereas injections of an oxytocin receptor antagonist blocked the effects of the

38 II type 1 receptor antagonist losartan, the oxytocin receptor antagonist desGly-NH2 , d(CH2 )5 [D-Ty

39 Administration of a peripherally restricted oxytocin receptor antagonist did not reverse the effect

40 ist SR121463B, but not by treatment with the oxytocin receptor antagonist GW796679X.

41 Finally, we used a highly selective oxytocin receptor antagonist in the SuM to examine the i

42 juvenile and adult female prairie voles, and oxytocin receptor antagonist infused into the nucleus ac

43 tivity in the anterior cingulate cortex, and oxytocin receptor antagonist infused into this region ab

44 Additionally, the oxytocin receptor antagonist L-368,899 inhibited the oxy

45 Intrathecal injection of oxytocin receptor antagonist not only attenuates ejacula

46 ing with their male partner with a selective oxytocin receptor antagonist or vehicle.

47 cular administration of saline, oxytocin, or oxytocin receptor antagonist was used to measure the eff

48 In contrast, the oxytocin receptor antagonist WAY162720 (10 mg/kg) inhibi

49 omethacin and decorated with clinically used oxytocin receptor antagonist were designed and evaluated

50 Atosiban, an oxytocin receptor antagonist, is a registered tocolytic

51 ckling before and after administration of an oxytocin receptor antagonist.

52 GABAA receptor antagonists as well as by an oxytocin receptor antagonist.

53 Oxytocin receptor antagonists (OTR-A) have been develope

54 Next we examined the effects of two oxytocin receptor antagonists, (d(CH2)5(1),Tyr(Me)(2),Or

55 In the last few hours of pregnancy, oxytocin receptors appear in high concentrations in the

56 Ascope), we have established that Magel2 and oxytocin receptor are co-expressed in the dentate gyrus

57 us subcortical regions where vasopressin and oxytocin receptors are adjacently expressed and which ar

58 , but it is unknown precisely when and where oxytocin receptors are expressed or which neural circuit

59 Expression of oxytocin, oxytocin receptor, arginine vasopressin, arginine vasopr

60 red by the blockade of spinal vasopressin or oxytocin receptors at T1-T4.

61 twork comprising regions expected to express oxytocin receptors, based on histologic evidence, and in

62 in the paraventricular nucleus and increased oxytocin receptor binding in the central amygdala.

63 Oxytocin receptor binding in the MPOA and LS was reduced

64 duced exploratory behavior, maternal LG, and oxytocin receptor binding in the offspring of high LG mo

65 TAMOX and EE increased oxytocin receptor binding in the ventromedial nucleus of

66 hment enhanced exploration, LG behavior, and oxytocin receptor binding of low LG offspring.

67 Natural variation in oxytocin receptor binding predicted individual variation

68 ein kinases before assaying for behavior and oxytocin receptor binding.

69 nandamide degradation offsets the effects of oxytocin receptor blockade on both social place preferen

70 o uncontrollable stress and is enriched with oxytocin receptors, but their interactive influences on

71 on-associated and progestin-sensitive genes (oxytocin receptor, connexin 43, and cyclooxygenase-2) an

72 Although the nucleus accumbens receives oxytocin-receptor-containing inputs from several brain r

73 ntral tegmental area of ASD mice, but not in oxytocin receptor-deficient mice.

74 Oxytocin receptor densities are known to be higher in mu

75 the functional relationship between accumbal oxytocin receptor density and social behavior in prairie

76 to demonstrate a direct relationship between oxytocin receptor density in the nucleus accumbens and v

77 Oxytocin receptor density in the nucleus accumbens is po

78 ot only upon release of oxytocin but also on oxytocin receptor distribution within the brain, becomes

79 release GABA resulting in the inhibition of oxytocin receptor-expressing interneurons (OxtrINs) and

80 In this study, we provide evidence that oxytocin receptor-expressing neurons are a specific grou

81 Instead, oxytocin affects oxytocin receptor-expressing neurons in the dorsal raphe

82 As a result, we postulate that oxytocin receptor-expressing neurons in the paraventricu

83 al agranular insular cortex on GABAergic and oxytocin receptor-expressing neurons.

84 chiasmatic supraoptic nucleus (SOR(OXT)) and oxytocin-receptor-expressing cells in the anterior subdi

85 We found that oxytocin-receptor-expressing neurons in the parabrachial

86 tion of glutamatergic neurotransmission, and oxytocin receptor expression in both suicide and depress

87 es in female prairie voles, and suggest that oxytocin receptor expression in the accumbens is not suf

88 tion of observational fear and downregulates oxytocin receptor expression in the amygdala.

89 In contrast, dopamine controlled tonic oxytocin receptor expression in the central nucleus of t

90 Thus, individual variation in oxytocin receptor expression in the striatum may contrib

91 n neurons in the murine olfactory bulb, with oxytocin receptor expression peaking during activity-dep

92 We reveal spatial and temporal enrichment of oxytocin receptor expression within adult-born neurons i

93 in dependent rats and humans with increased oxytocin receptor expression.

94 eclinical studies have demonstrated that the oxytocin receptors foster accurate fear discrimination b

95 Oxytocin receptor function also contributed to the maint

96 hesis is based primarily on manipulations of oxytocin receptor function, leaving open the question of

97 ng female prairie voles lacking a functional oxytocin receptor gene (Oxtr(1-/-)).

98 Several common alleles in the oxytocin receptor gene (OXTR) are associated with altere

99 the extent to which genetic variants in the oxytocin receptor gene (OXTR) are associated with pair-b

100 -allele of a common variant (rs53576) in the oxytocin receptor gene (OXTR) has been associated with p

101 A common variant (rs53576) in the oxytocin receptor gene (OXTR) has been implicated in soc

102 The oxytocin receptor gene (OXTR) has been studied as a risk

103 n of the neurons in the PFC that express the oxytocin receptor gene (Oxtr) impairs the ability to dis

104 Epigenetic modification to the oxytocin receptor gene (OXTR) in ASD could be an informa

105 The oxytocin receptor gene (OXTR) polymorphism rs53576, whic

106 le mice with Cre-recombinase directed to the oxytocin receptor gene (Oxtr), we revealed that oxytocin

107 cts as its receptor, which is encoded by the oxytocin receptor gene (OXTR).

108 l stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a cor

109 pulation differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in f

110 studies have reported interaction effects of oxytocin receptor genotype (rs53576) and environmental f

111 Ablation of the oxytocin receptor in aromatase-expressing neurons of the

112 These data confirm a role for oxytocin receptor in the accumbens in the regulation of

113 Adult female prairie voles that overexpress oxytocin receptor in the nucleus accumbens displayed acc

114 d resistance to stress-induced modulation of oxytocin receptors in amygdala nuclei, which is indicati

115 Here we show a pronounced upregulation of oxytocin receptors in brain tissues of alcohol-dependent

116 Here, we explored the role of oxytocin receptors in selective peer attachment using fe

117 more, prairie voles have higher densities of oxytocin receptors in the accumbens than nonmonogamous r

118 Oxytocin receptors in the nucleus accumbens have been im

119 this critical period requires activation of oxytocin receptors in the nucleus accumbens, and is reca

120 fluorescence in situ hybridization to label oxytocin receptors in the SuM and determined that they a

121 We hypothesized that oxytocin receptors in the ventral tegmental area (VTA) m

122 more rewarding than males and activation of oxytocin receptors in the VTA is critical for social rew

123 We conclude that oxytocin receptors in the VTA play a physiologic role in

124 l behaviors that are especially enriched for oxytocin receptors, including the piriform cortex, the l

125 c disorders, and genetic polymorphism of the oxytocin receptor influence the effect of oxytocin on th

126 Together, these data indicate that oxytocin receptors influence the formation, persistence,

127 We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female

128 in nonmonogamous meadow voles by introducing oxytocin receptor into the nucleus accumbens.

129 ructural similarity, yet in many species the oxytocin receptor is only 30 to 50% homologous with vaso

130 1 residues from the COOH terminus of the rat oxytocin receptor is required for interaction with G(q/1

131 cial preference is accelerated if one of the Oxytocin receptors is knocked-out and that the knock-out

132 Here, we used a zebrafish oxytocin receptor knockout line to investigate how the g

133 Last, oxytocin receptor-knockout embryos transferred into wild

134 Blockade of oxytocin receptors largely attenuated activation in thes

135 no published reports describing activity of oxytocin receptor ligands on mammalian circadian rhythms

136 Non-peptide oxytocin receptor ligands that cross the blood brain bar

137 our in vitro constructs did not express any oxytocin receptors, meaning that the observed interactio

138 ter ovary cells expressing marmoset or human oxytocin receptors (mOTRs or hOTRs, respectively) were u

139 Oxytocin receptor mRNA levels were higher in the nucleus

140 ion-a localized volume transmission-to reach oxytocin receptors on GRP neurons and facilitate male se

141 Oxytocin receptor (OTR) activates the GTP-binding protei

142 first high-affinity fluorescent ligands for oxytocin receptor (OTR) are described.

143 Although oxytocin (OT) and oxytocin receptor (OTR) are known for roles in parturiti

144 amic OT levels and a concomitant increase of oxytocin receptor (OTR) binding in the lateral septum an

145 as sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal

146 was shown to be a potent full agonist at the oxytocin receptor (OTR) in vitro with good selectivity a

147 The oxytocin receptor (OTR) is differentially expressed in t

148 autoradiography to assess whether forebrain oxytocin receptor (OTR) or vasopressin V1a receptor (V1a

149 The oxytocin receptor (OTR) plays critical roles in social b

150 ifferences in vasopressin receptor (V1aR) or oxytocin receptor (OTR) related to social recognition.

151 when developing tocolytics targeting the OT/oxytocin receptor (OTR) system.

152 The oxytocin receptor (OTR), a member of the seven-transmemb

153 is nearly identical to the E2 region of the oxytocin receptor (OTR), we set out to ascertain whether

154 essing either ER also coexpress mRNA for the oxytocin receptor (OTR).

155 , spinal, and supraspinal levels through the oxytocin receptor (OTR).

156 s associated with a specific upregulation of oxytocin receptor (OTR, oxtr) and vasopressin V1a recept

157 Oxytocin receptors (OTR) and vasopressin V1a receptors (

158 Oxytocin receptors (OTR) have been found in the paravent

159 of endogenous sources of OT and signaling at oxytocin receptors (OTR) in brain or in the periphery.

160 In the nucleus accumbens (NAc) activation of oxytocin receptors (OTR) promotes social approach (time

161 (at RAIC) of the following: (1) L-368899 (an oxytocin receptor [OTR] antagonist) or by (2) bicucullin

162 ith the aim of imaging and quantification of oxytocin receptors (OTRs) in living brain using positron

163 er magnitude boost in G-protein signaling of oxytocin receptors (OTRs) in vitro and a 100- and 40-fol

164 f [Arg(8)]-vasopressin receptors (AVPRs) and oxytocin receptors (OTRs) suggests that G protein-couple

165 tabotropic glutamate receptor 5 (mGluR5) and oxytocin receptor (Oxtr) affect social affiliation and s

166 s assayed from adults who were genotyped for oxytocin receptor (OXTR) and CD38 risk alleles associate

167 croarray analysis, including upregulation of oxytocin receptor (Oxtr) and FBJ osteosarcoma oncogene (

168 fferences in salivary DNA methylation of the oxytocin receptor (OXTR) between CM and Non-CM groups of

169 e analogous to the optogenetic excitation of oxytocin receptor (OXTR) expressing neurons in the PFC t

170 followed by reduced P4 levels and increased oxytocin receptor (Oxtr) expression at 18.25 in uteri re

171 rocesses, with animal models indicating that oxytocin receptor (OXTR) expression patterns in the brai

172 g region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the

173 ed on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously

174 sly, we showed that the V281M variant in the oxytocin receptor (OXTR) gene impairs OXTR trafficking t

175 as9 strategy that is predicted to target the oxytocin receptor (Oxtr) gene in >80 rodent species.

176 The oxytocin receptor (OXTR) has a vital role in regulating

177 oxytocin (OXT) in 29 primate species and the oxytocin receptor (OXTR) in 21 of these species.

178 rginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brai

179 ological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of

180 Oxytocin receptor (Oxtr) signaling in neural circuits me

181 Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological r

182 The OXT/oxytocin receptor (OXTR) system, through the lateral sep

183 invasive nature of resistant cells, and the oxytocin receptor (OXTR), a potential new therapeutic ta

184 stigate epigenetic and genetic regulation of oxytocin receptor (OXTR), dopamine transporter (DAT1) an

185 ig contains at least 36 genes, including the oxytocin receptor (OXTR), hOGG1, the von Hippel-Lindau t

186 n levels and with genetic alterations of the oxytocin receptor (OXTR).

187 gement and subsequent endocytosis toward the oxytocin receptor (OXTR).

188 r of social behaviors via activation of both oxytocin receptors (OXTR) and vasopressin (AVP) 1a recep

189 Social cognition is facilitated by oxytocin receptors (OXTR) in the hippocampus, a brain re

190 Its central effects are exerted via oxytocin receptors (OXTR).

191 is study we investigated the role of the two oxytocin receptors, Oxtr and Oxtrl, in the development a

192 egular spiking interneurons that express the oxytocin receptor (OxtrINs).

193 ence of long-term SRM.SIGNIFICANCE STATEMENT Oxytocin receptors (OXTRs) are abundantly expressed in h

194 tocin receptor gene (Oxtr), we revealed that oxytocin receptors (OXTRs) are expressed on glutamatergi

195 Activation of oxytocin receptors (OXTRs) facilitates neuronal excitabi

196 As the oxytocin receptor plays a key role in parturition and la

197 nt, we explored the behavioral expression of oxytocin receptor polymorphism (OXTR) rs53576, a gene pr

198 l motoneurones showed an increased number of oxytocin receptors present on GABAergic terminals of CRF

199 gamous rodent species, and blocking accumbal oxytocin receptors prevents mating-induced partner prefe

200 on-specific levels of Oxtr messenger RNA and oxytocin receptor protein with established neuroanatomic

201 naturally occurring genetic variation of the oxytocin receptor relates to both empathy and stress pro

202 e tested how a polymorphism (rs53576) of the oxytocin receptor relates to two key social processes re

203 lamus (VMH), estrogen-dependent induction of oxytocin receptors required protein kinase C activation,

204 A common SNP in the oxytocin receptor (rs237887) was strongly associated wit

205 studies suggest that stimulation of central oxytocin receptors selectively suppresses carbohydrate i

206 However, how Oxytocin receptor signaling affects the development and

207 ssion relies on the de novo coupling between oxytocin receptor signaling and endocannabinoid receptor

208 ions, including the nucleus accumbens, where oxytocin receptor signaling facilitates social attachmen

209 It is believed that oxytocin receptor signaling in the brain is critical for

210 pharmacological manipulations, we show that oxytocin receptor signaling is crucial for entrainment o

211 ward and social selectivity, aggression, and oxytocin receptor signaling pathways in rodents that nat

212 l type-specific RNA-seq, we demonstrate that oxytocin receptor signaling promotes synaptic maturation

213 Pharmacological blockade of oxytocin receptors stops this response, whereas chemogen

214 e, NAc-targeted approaches to activate local oxytocin receptors sufficiently rescued their social def

215 in and V1a vasopressin receptors but not the oxytocin receptor) to stimulate adenylyl cyclase.

216 We previously showed that the rat oxytocin receptor transfected into Chinese hamster ovary

217 t glutamate-releasing ARC neurons expressing oxytocin receptor, unlike ARC(POMC) neurons, rapidly cau

218 al profile at AVP V(2)R, V(1a)R, V(1b)R, and oxytocin receptor was measured by binding assay and func

219 presumably Galpha1-coupled M1 muscarinic and oxytocin receptors was completely inhibited by pretreati

220 nalysis of the cerebral cortex revealed that oxytocin receptors were mainly expressed at synapses, as

221 spinal iGLURs, and 4) spinal vasopressin and oxytocin receptors were not involved in the mediation of

222 by oxytocin in the left auditory cortex, and oxytocin receptors were preferentially expressed in the

223 , CD9, activating transcription factor 3 and oxytocin receptor, were dominantly regulated by histone

224 of estrogen receptor alpha and beta and the oxytocin receptor (when LG is assessed across the light-

225 re, we investigate the sex-dependent role of oxytocin receptors within the ventral tegmental area (VT