ライフサイエンスコーパス: p-cresol

1 hose associated with aromatic compounds like p-cresol.

2 ys503 to the p-hydroxybenzyl radical to form p-cresol.

3 2-dependent hydroxylation of toluene to form p-cresol.

4 sulfate (PCS) but no detectable unconjugated p-cresol.

5 -dependent hydroxylation of toluene to yield p-cresol.

6 es the hydroxylation of toluene to yield 96% p-cresol.

7 thylaniline, 3,4-dimethylphenol, and 2-amino-p-cresol.

8 )-dependent hydroxylation of toluene to form p-cresol.

9 ma, were 0.3 ug kg(-1) for phenol, o-cresol, p-cresol; 0.6 ug kg(-1) for eugenol, isoeugenol; and 1 u

10 Derivatives of p-cresol 1-4 were synthesized, and their photochemical r

11 r for butyric acid, 1 x 10(-4) mug/L air for p-cresol, 1 x 10(-5) mug/L air for indole, and 1 x 10(-5

12 ower than the pK(a) of tyrosine (10.1) or of p-cresol (10.2).

13 amounts (in %) are 2-methyladenine (60.6%), p-cresol (16.3%), adenine (12.5%), 2-(methylthio)adenine

14 umed 4 electron equiv/mol when titrated with p-cresol (2 electrons from p-cresol and 2 from 4-hydroxy

15 ophen, diclofenac, carbamazepine, clozapine, p-cresol, 4-ethylphenol, and 3-methylindole in human liv

16 e, derived from phenolic compounds including p-cresol, 4-hydroxybenzoate and numerous lignin monomers

17 seudomonas mendocina KR1 oxidizes toluene to p-cresol (96%) and oxidizes benzene sequentially to phen

18 p-Cresol, a microbial metabolite produced by the human m

19 Clostridioides difficile is known to produce p-cresol, a phenolic compound with selective antimicrobi

20 gues that contain the bases-2-methyladenine, p-cresol, adenine, and 2-(methylthio)adenine.

21 he infrared spectrum of 4-methylimidazole or p-cresol alone.

22 esol did not increase Tf saturation with Al. p-Cresol also increased Tf-Al uptake in Friend erythrole

23 In the presence of tyrosine or p-cresol, an unusual tricyclo[4.3.3.0] adduct has been c

24 rent Km value of 250 microM and produced 90% p-cresol and 10% m-cresol.

25 hen titrated with p-cresol (2 electrons from p-cresol and 2 from 4-hydroxybenzyl alcohol), PchF(C) ac

26 oxidation-labile aromatic compounds such as p-cresol and 2-naphthol with high yields, 95% and 85%, r

27 T4MO, in comparison, produces 97% p-cresol and 3% m-cresol.

28 Odorants such as p-cresol and a sweet-character unknown component were co

29 Examples of top prioritized compounds were p-cresol and chlorophene, based on human health end poin

30 The second-order rate constants for p-cresol and ferrocyanide reduction of the mutant compou

31 enerates myriad toxic metabolites, including p-cresol and indoxyl sulfate.

32 ure conditions suggesting the involvement of p-cresol and its impact on the biochemical composition o

33 Conversely, the A107T variant produced >98% p-cresol and p-nitrophenol from toluene and nitrobenzene

34 Interestingly, p-cresol and phenol, which are the lower ligand in Sporo

35 e enzyme HydG lyses free tyrosine to produce p-cresol and the CO and CN(-) ligands of the [2Fe](H) cl

36 the electronic and redox properties of bound p-cresol and the covalently bound FAD.

37 Our studies suggest that p-cresol and uremic fractions 4 to 8, 12, 14, and 15 inc

38 the higher acidity of the S1 states of these p-cresols and the ability for excited-state intramolecul

39 methylbenzimidazole, 5-methoxybenzimidazole, p-cresol, and phenol were determined.

40 l)phenylacetonitrile, cyclobutanone, phenol, p-cresol, aniline) to form ammonia and trans-(DMPE)(2)Ru

41 ogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into alpha-ribotides, which are i

42 alpha-amino group (the aromatic hydrogens of p-cresol are far less subject to exchange) and by imidaz

43 tion of biphenyl, naphthalene, m-xylene, and p-cresol are predicted to be distributed among 15 gene c

44 urally characterized cell permeable diformyl-p-cresol based receptor (HL) selectively senses the AsO3

45 ening addition and fragmentation reaction of p-cresol-based N-phenylbenzoxazine with aliphatic and ar

46 e identified compounds including 2,6-dinitro-p-cresol, bisphenol S, clonixin, and triclopyr.

47 functionalised with 2-(2'-benzothiazolylazo)-p-cresol (BTAC).

48 The degradation of the toxic phenol p-cresol by Pseudomonas bacteria occurs by way of the pr

49 steady-state rate constant for oxidation of p-cresol by various forms of PCMH and PchF; both nu(m) a

50 This study examined the form in which p-cresol circulates and quantified its removal by hemodi

51 We conclude that p-cresol circulates in the form of its sulfate conjugate

52 n (Cl(ind)), p-cresol sulfate (Cl(pcs)), and p-cresol (Cl(pc)) averaged only 5 +/- 1, 4 +/- 1, and 14

53 The sensor probe is characterized for p-cresol concentration range from 0microM (reference sam

54 s showed increased Al uptake and toxicity at p-cresol concentrations of 3 mg/dl in culture media.

55 lfatase resulted in recovery of this peak as p-cresol, confirming its identity.

56 p-Cresol did not increase Tf saturation with Al. p-Creso

57 determination of phenols (phenol, o-cresol, p-cresol, eugenol, isoeugenol and guaiacol) in smoked fo

58 Our findings indicated that while perinatal p-Cresol exposure did not affect gestational outcomes, p

59 r future epidemiological studies to quantify p-Cresol exposure during pregnancy and early childhood,

60 These results suggest that p-Cresol exposure selectively induces ASD-like behaviors

61 , BHA, creosol, isoeugenol and di-o-propenyl p-cresol, fewer radicals were trapped by a single phenol

62 yielded shifts of regiospecificity away from p-cresol formation, with F205I giving an approximately 5

63 ptake and cell toxicity were proportional to p-cresol from 1.5 mg/dl to 3 mg/dl in culture media.

64 Furthermore, G103S/A107T formed 100% p-cresol from toluene; hence, a better para-hydroxylatin

65 e involved in the fermentative production of p-cresol from tyrosine in clostridia.

66 nylacetyl glycine (from phenylalanine); (ii) p-cresol (from tyrosine) yielding p-cresol sulfate and p

67 oxyline, indole-3-acetic-acid-O-glucuronide, p-cresol glucuronide, and pregnanediol-3-glucuronide.

68 from tyrosine) yielding p-cresol sulfate and p-cresol glucuronide; (iii) 4-OH-phenyllactic acid (from

69 It was demonstrated that p-cresol has a charge-transfer interaction with FAD when

70 Elevated levels of p-Cresol have been consistently observed in patients wit

71 se reduced circulating p-cresol sulfate, and p-cresol impaired contractility and rhythm in human indu

72 in the product distribution, and gave o- and p-cresol in a 1:1 ratio.

73 chia coli in coculture to assess the role of p-cresol in modulating interspecies dynamics.

74 nalysis confirmed the structural identity of p-cresol in samples containing the product of hydroxylat

75 p-Cresol increased Tf-associated Al uptake only because

76 studies of the reaction of PCMH[Y384F] with p-cresol indicated that the K(m) for this substrate was

77 p-Cresol is a simple molecular model for the para phenol

78 p-cresol is produced by the conversion of para-Hydroxyph

79 as dihydroxyacetone, alanine, xanthine, and p-cresol-key metabolites in independent pathways.

80 rstanding how environmental factors, such as p-Cresol, may contribute to social impairments and neuro

81 exposure to environmental toxins, including p-Cresol, may disrupt essential physiological processes

82 The alpha(2)beta(2) flavocytochrome p-cresol methylhydroxylase (PCMH) from Pseudomonas putid

83 PchF) of the alpha(2)beta(2) flavocytochrome p-cresol methylhydroxylase (PCMH) from Pseudomonas putid

84 Each flavoprotein subunit (PchF) of p-cresol methylhydroxylase (PCMH) has flavin adenine din

85 protein component (PchF) of flavocytochrome, p-cresol methylhydroxylase (PCMH), and cytochrome-free P

86 The first enzyme in this pathway, p-cresol methylhydroxylase (PCMH), is a flavocytochrome

87 These proteins are (1) the flavocytochrome c p-cresol methylhydroxylase (rPCMH, 1.85 A resolution) an

88 ee variants of the flavoprotein component of p-cresol methylhydroxylase that contain noncovalently or

89 ybenzyl alcohol, the intermediate product of p-cresol oxidation by PCMH, reduced PchF(NC) fairly quic

90 relation was found between the efficiency of p-cresol oxidation by these proteins and E(CT), the ener

91 mg of protein were obtained for o-, m-, and p-cresol oxidation by wild-type T4MO, which are comparab

92 d also that 4-hydroxybenzaldehyde, the final p-cresol oxidation product, is an efficient competitive

93 styrene (S), o-cresol (o-C), phenol (PhAl), p-cresol (p-C), indole (ID), and skatole (SK)).

94 water at 25 degrees C for benzene, p-xylene, p-cresol, p-dicyanobenzene, and hydroquinone from statis

95 m PCS by decreasing intestinal production of p-cresol, prevented these metabolic derangements.

96 bitors of HpdBCA decarboxylase, which reduce p-cresol production and render C. difficile less able to

97 ibitor of HpdBCA decarboxylase, only reduced p-cresol production by 54.9 +/- 13.5%.

98 mpound, 4-Hydroxyphenylacetonitrile, reduced p-cresol production by 99.0 +/- 0.4%, whereas 4-Hydroxyp

99 This study has identified promising p-cresol production inhibitors whose development could l

100 In contrast, p-cresol rapidly reduced PchF with covalently bound FAD

101 ient coupling and high regiospecificity with p-cresol representing >96% of total products from toluen

102 entical to that of the natural isoform, with p-cresol representing 90-95% of the total product distri

103 , and a decrease in regiospecificity so that p-cresol represents approximately 60% of total products.

104 Its response time is also better than the p-cresol sensor currently available in the market for th

105 btained as compared to the recently reported p-cresol sensor.

106 ture, 4-methylimidazole covalently linked to p-cresol, show that a feature near 1540 cm(-1) is unique

107 iously, Siamwiza and co-workers investigated p-cresol solutions to identify Raman spectroscopic signa

108 0.16-fold), indoxyl sulfate (0.21-fold), and p-cresol sulfate (0.39-fold) were much lower than the ra

109 (108-fold), indoxyl sulfate (116-fold), and p-cresol sulfate (41-fold) were much greater than the co

110 sus 2.3 0.6 for patients with CKD; P<0.001), p-cresol sulfate (8.6 2.6 for controls versus 4.1 1.5 fo

111 the protein-bound solutes indican (Cl(ind)), p-cresol sulfate (Cl(pcs)), and p-cresol (Cl(pc)) averag

112 re enriched in gut-derived bacterial solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) that bot

113 eak whose mobility corresponded to synthetic p-cresol sulfate (PCS) but no detectable unconjugated p-

114 ic MDMs (uMDMs) phenylacetylglutamine (PAG), p-cresol sulfate (PCS), and indoxyl sulfate (IS) accumul

115 In cultured cells, indoxyl sulfate and p-cresol sulfate activated the EGF receptor and downstre

116 Although p-cresol sulfate and indoxyl sulfate are well studied ex

117 HPLC confirmed the colonic origin of p-cresol sulfate and indoxyl sulfate, but levels of hipp

118 ine); (ii) p-cresol (from tyrosine) yielding p-cresol sulfate and p-cresol glucuronide; (iii) 4-OH-ph

119 icrobiome formation of uremic toxins such as p-cresol sulfate and thereby their body exposure and nee

120 tomized mice treated with indoxyl sulfate or p-cresol sulfate as study models.

121 Low clearance of hippurate or p-cresol sulfate associated with greater risk of death i

122 g results suggested that indoxyl sulfate and p-cresol sulfate dock on a putative interdomain pocket o

123 Indoxyl sulfate and p-cresol sulfate have been suggested to induce kidney ti

124 In conclusion, indoxyl sulfate and p-cresol sulfate may induce kidney tissue remodeling thr

125 treatment: from no reduction in the level of p-cresol sulfate or asymmetric dimethylarginine to signi

126 Treatment of mice with indoxyl sulfate or p-cresol sulfate significantly activated the renal EGF r

127 plasma levels of these compounds (including p-cresol sulfate).

128 ecreted solute (hippurate, cinnamoylglycine, p-cresol sulfate, and indoxyl sulfate) clearance using l

129 amine, 5-hydroxyindole, indoxyl glucuronide, p-cresol sulfate, and indoxyl sulfate.

130 tes, the SGLT2i likewise reduced circulating p-cresol sulfate, and p-cresol impaired contractility an

131 ylphenylsulfate, oxindole, indolepropionate, p-cresol sulfate, catechol sulfate, and salicylate, are

132 abolites, including indole-3-propionic acid, p-cresol sulfate, hippuric acid, pyrocatechol sulfate, a

133 the secreted anions phenylacetyl glutamine, p-cresol sulfate, indoxyl sulfate, and hippurate confirm

134 c toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include

135 We then narrowed down to five metabolites [p-cresol sulfate, linoleic acid, glycocholic acid, lysoP

136 e recovery, and changes in indolelactate and p-cresol sulfate, metabolites that impact host inflammat

137 with GD (4-cresyl sulfate, cresol, glycine, P-cresol sulfate, phenylacetic acid, and stearoylcarniti

138 hotometric absorption of indoxyl sulfate and p-cresol sulfate.

139 c acid, pantothenic acid, hippuric acid, and p-cresol sulfate.

140 identified metabolites of bacterial origin (p-cresol sulphate, indoxyl sulphate and N-phenylacetylgl

141 group metabolites of bacterial origin (e.g. p-cresol sulphate, indoxyl sulphate and N-phenylacetylgl

142 ode resonance (LMR) based sensor for urinary p-cresol testing on optical fiber substrate is developed

143 etylene, cyclobutanone, aniline, phenol, and p-cresol, the reaction was observed to proceed via ion p

144 PCMH oxidizes p-cresol to 4-hydroxybenzyl alcohol, which is oxidized s

145 ylhydroquinone (9%), to oxidize m-cresol and p-cresol to 4-methylcatechol (100%), and to oxidize o-me

146 The enzyme first catalyzes the oxidation of p-cresol to p-hydroxybenzyl alcohol, utilizing one atom

147 interpret the Raman and infrared spectra of p-cresol vapor and extend the previous correlation to th

148 tudy, we exposed pregnant mice (C57BL/6J) to p-Cresol via drinking water from mid-gestation, through

149 icant Al uptake by MH was observed only when p-cresol was added together with Tf-Al.

150 p-Cresol was not toxic to MH in the absence of Tf-Al in

151 N-o-Vanillidine-2-amino-p-cresol was used as a chelating ligand and 1-undecanol

152 It was found that p-cresol was virtually incapable of reducing PchF with n

153 an amino acid-derived microbial metabolite, p-cresol, was supplemented along with WSD-ETPi diet, pri

154 substitution of 4-(fluoroethynyl)benzenes by p-cresol were determined by (1)H NMR spectroscopy, and t

155 otope distributions of 5'-deoxyadenosine and p-cresol were evaluated using deuterium-labeled tyrosine

156 mation of CYP2B4-specific benzyl alcohol and p-cresol were inhibited, whereas that of CYP1A2-specific

157 most extensively studied of these solutes is p-cresol, which has been shown to be toxic in vitro.

158 ons also show a clear preference for binding p-cresol with the hydroxyl group hydrated rather than in

159 proton transfer to this 4OB(*) radical forms p-cresol, with the conversion of this dehydroglycine lig

160 eviously from these ultrafiltrate fractions (p-cresol, xanthine, tryptophan, hippuric acid, and o-hyd

161 icotinate mononucleotide (NaMN) to phenol or p-cresol, yielding alpha-O-glycosidic ribotides.