ライフサイエンスコーパス: p21-activated kinase

1 arth of inhibitors of their effectors (e.g., p21-activated kinases).

2 also prevented the interaction of Cdc42 with p21 activated kinase.

3 ects on Wiskott-Aldrich syndrome protein and p21-activated kinase.

4 gen-activated protein kinase kinase MKK4 and p21-activated kinase.

5 le mechanisms that are mediated, in part, by p21-activated kinase.

6 rylation target mediating this plasticity is p21-activated kinase.

7 reduced phosphorylation of the Rac effector p21-activated kinase.

8 was increased after the depletion of PAK3, a p21-activated kinase.

9 inhibition of Rac1, Rho-activated kinase, or p21-activated kinase.

10 the activation of Rac1 and its main effector p21-activated kinase.

11 PAK4 is a member of the group B family of p21-activated kinases.

12 ctin and by the concerted action of Rho- and p21-activated kinases.

13 selectivity over the related Ste-20 kinases, p21 activated kinase 1 (PAK1), and p21 activated kinase

14 fic integrin signaling and GTPase-dependent, p21-activated kinase 1 (PAK-1) activity.

15 required for matrix contraction converge on p21-activated kinase 1 (PAK1) and its downstream effecto

16 Although p21-activated kinase 1 (PAK1) and microtubule (MT) dynam

17 -bound Cdc42 binds to its effectors, such as p21-activated kinase 1 (PAK1) and N-WASP, a homolog of t

18 PH oxidase downstream of the Rho GTPases and p21-activated kinase 1 (PAK1) and oxidatively modified t

19 p21-activated kinase 1 (PAK1) and PAK3 belong to group I

20 We identified p21-activated kinase 1 (PAK1) as a kinase that permitted

21 g of a mammary gland cDNA library with human p21-activated kinase 1 (Pak1) as bait identified polyC-R

22 Here we report that p21-activated kinase 1 (Pak1) binds to htt in vivo and i

23 bolic pathways, whereby the signaling kinase p21-activated kinase 1 (Pak1) binds to, phosphorylates a

24 Autoinhibited p21-activated kinase 1 (Pak1) can be activated in vitro

25 ere we show that microRNA-7 (miR-7) inhibits p21-activated kinase 1 (Pak1) expression, a widely up-re

26 p21-activated kinase 1 (Pak1) has been shown recently to

27 As p21-activated kinase 1 (Pak1) has been shown to regulate

28 Here, we demonstrate a novel role for p21-activated kinase 1 (Pak1) in defining the size and s

29 p21-activated kinase 1 (Pak1) induces cytoskeleton reorg

30 p21-activated kinase 1 (Pak1) is a downstream mediator o

31 p21-activated kinase 1 (PAK1) is a serine/threonine kina

32 Activation of the p21-activated kinase 1 (PAK1) is achieved through a conf

33 P21-activated kinase 1 (PAK1) is activated by binding to

34 p21-activated kinase 1 (PAK1) regulates both the actin c

35 Here, we investigated the role of P21-activated kinase 1 (Pak1) signaling in the function

36 of breast cancer cells is also influenced by p21-activated kinase 1 (Pak1) signaling, we investigated

37 w-up studies using CDC42 inhibitor ML141 and p21-activated kinase 1 (PAK1) siRNA knockdown also resul

38 The inhibitory switch (IS) domain of p21-activated kinase 1 (PAK1) stabilizes full-length PAK

39 T cell receptor engagement activates p21-activated kinase 1 (PAK1) through a LAT-SLP-76-Nck-V

40 Mutation of two kinases (PKC-theta and p21-activated kinase 1 (PAK1)) confirmed critical roles

41 Emerging data suggest that p21-activated kinase 1 (Pak1), a downstream signaling mo

42 Recent evidence suggests that p21-activated kinase 1 (Pak1), a major signaling nodule

43 These studies tested the hypothesis that p21-activated kinase 1 (PAK1), a serine/threonine kinase

44 P21-activated kinase 1 (PAK1), a serine/threonine protei

45 DLC1 phosphorylation on Ser(88) by p21-activated kinase 1 (Pak1), a signaling nodule, promo

46 GEF-H1 as a binding target and substrate for p21-activated kinase 1 (PAK1), an effector of Rac and Cd

47 rtners include the serine/threonine kinases, p21-activated kinase 1 (PAK1), apoptosis signal-regulati

48 , and in particular, nuclear localization of p21-activated kinase 1 (PAK1), is associated with the pr

49 cribe a novel interaction between merlin and p21-activated kinase 1 (Pak1), which is dynamic and faci

50 n murine models, Duo and Cdc42 phosphorylate p21-activated kinase 1 (PAK1), which modifies the activi

51 DLC1), a component of the dynein motor, as a p21-activated kinase 1 (Pak1)-interacting substrate with

52 ionizing radiation or genotoxic drugs drives p21-activated kinase 1 (PAK1)-mediated phosphorylation o

53 and activation of its downstream modulator, p21-activated kinase 1 (PAK1).

54 epidermal growth factor receptor (EGFR) and p21-activated kinase 1 (Pak1).

55 iscs protein to bind to the kinase domain of p21-activated kinase 1 (PAK1).

56 ocesses that overlap with those regulated by p21-activated kinase 1 (PAK1).

57 new binding partners of NCAM and identified p21-activated kinase 1 (Pak1).

58 cogenic events (e.g. CD44-Cdc42 association, p21-activated kinase 1 activation, and p21-activated kin

59 eover, loss of CIB1 in these cells decreases p21-activated kinase 1 activation, downstream extracellu

60 ased tissue damage and significantly reduced p21-activated kinase 1 activation.

61 Because p21-activated kinase 1 also contributes to endothelial c

62 ontaining protein, modulates the activity of p21-activated kinase 1 in fibroblasts.

63 ctivated through a NF-kappaB-inducing kinase/p21-activated kinase 1 pathway.

64 We found that the PI3K through p21-activated kinase 1 regulates FRA-1 proto-oncogene in

65 PAK1 (p21-activated kinase 1) activation is induced by C albic

66 16 decreases Rac downstream effects of PAK1 (p21-activated kinase 1) activity and directed migration

67 of Rac1 and its cytoskeletal effectors PAK1 (p21-activated kinase 1) and cortactin.

68 nd maintains the activity of the cdc42-PAK1 (p21-activated kinase 1) complex, which triggers the acti

69 Pak1 (p21-activated kinase 1), a conserved, mammalian signalin

70 Ras-related C3 botulinum toxin substrate 1, p21-activated kinase 1, ADP-ribosylation factor 6, and c

71 were correlated with up-regulation of HER2, p21-activated kinase 1, and p38 protein expression.

72 ere at PP2A and PP1, as well as the upstream p21-activated kinase 1, in maladaptive pressure overload

73 tion, p21-activated kinase 1 activation, and p21-activated kinase 1-filamin complex formation) and tu

74 y regulated genes between wild-type (WT) and p21-activated kinase 1-null (PAK1-KO) mouse embryonic fi

75 Rac1 activations was the phosphorylation of p21-activated-kinase 1 (Pak1), and this phosphorylation

76 or (c-Met) to PI3 kinase --> c-Akt --> Pak1 (p21-activated kinase -1) --> NF-kappaB (nuclear factor-k

77 pendent kinase 5 (Cdk5), and upregulation of p21 activated kinase-1 (PAK-1) activity.

78 In the current study, we found that phospho-p21-activated kinase-1 (Pak1) and Pak1 expression was hi

79 esized that PKCzeta exists as a complex with p21-activated kinase-1 (Pak1) and protein phosphatase 2A

80 p21-activated kinase-1 (Pak1) is a serine/threonine kina

81 p21-Activated kinase-1 (Pak1) is frequently upregulated

82 ugh the Ras-Erk pathway can be influenced by p21-activated kinase-1 (Pak1), an effector of the Rho fa

83 Here we found that a signaling kinase, p21-activated kinase-1 (Pak1), interacts with and phosph

84 Insulin signaling in muscle requires p21-activated kinase-1 (PAK1), whose downstream signalin

85 Pak1 (p21-activated kinase-1) and the dynein light chain, LC8,

86 s-related C3 botulinum toxin substrate 1 and p21 activated kinases 2 as operational in these signalin

87 iency virus type 1 (HIV-1) Nef activation of p21-activated kinase 2 (PAK-2) was recapitulated in a ce

88 munodeficiency virus type 1 (HIV-1) Nef with p21-activated kinase 2 (Pak2) has been proposed to play

89 The P21-activated kinase 2 (Pak2) is an effector for the Rho

90 ermis by negatively regulating c-Myc through p21-activated kinase 2 (PAK2) phosphorylation.

91 r the actin cytoskeletal remodeling protein, p21-activated kinase 2 (Pak2), in Treg development and h

92 Herein, we report that the signaling kinase, p21-activated kinase 2 (Pak2), is essential for maintain

93 to known regulators, two truncated forms of p21-activated kinase 2 (PAK2), PAK2DeltaL(1-224) and PAK

94 on of individual Pak isoforms, in particular p21-activated kinase 2 (Pak2), the main Pak isoform expr

95 rt that the cytoskeletal remodeling protein, p21-activated kinase 2 (Pak2), was essential for NKT cel

96 which was dependent on signals downstream of p21-activated kinase 2 (PAK2).

97 ctivates the autophosphorylation activity of p21-activated kinase 2 (PAK2).

98 ocyte apoptosis by caspase-8, caspase-3, and p21-activated kinase 2 cleavage.

99 r virion incorporation efficiency, no PAK-2 (p21-activated kinase 2) activation, and no CD4 and major

100 ing molecules led to the discovery that Pak (p21-activated kinase)2 is a stress-responsive kinase loc

101 d protein kinase B (PKB; also known as Akt), p21-activated kinase-2 (PAK-2), and their downstream eff

102 p21-activated kinase-2 (PAK2) and activation of abelson

103 ction of Nef with an active subpopulation of p21-activated kinase-2 found only in the lipid rafts.

104 ominant-negative dynamin and is required for p21-activated kinase-2 kinase activity and the increased

105 f and key cellular partners (e.g., activated p21-activated kinase-2) into the immunological synapse m

106 otype is caused by a hypomorphic mutation in p21-activated kinase 2a (pak2a).

107 One suppressor region deleted p21-activated kinase 3 (pak3), which encodes a member of

108 This is the case of the Rac/Cdc42 effector p21-activated kinase 3 (PAK3).

109 in I (cTnI) is known to be phosphorylated by p21-activated kinase 3 (PAK3).

110 effector, the actin cytoskeleton-regulating p21-activated kinase 3, is known as PBD46.

111 downstream of Cdc42, we determined that the p21-activated kinase-3 (PAK3) phosphorylates S863 in vit

112 kinases, p21 activated kinase 1 (PAK1), and p21 activated kinase 4 (PAK4) and an almost 10-fold sele

113 ponents of the Rho family network, revealing p21 Activated Kinase 4 (PAK4) as another amplified gene

114 luated the biological and functional role of p21-activated kinase 4 (PAK4) and its potential as a new

115 nging key residues between the STE20 kinases p21-activated kinase 4 (PAK4) and Mammalian sterile 20 k

116 We have identified the p21-activated kinase 4 (PAK4) as a new substrate for met

117 We further demonstrate that p21-activated kinase 4 (PAK4) can phosphorylate ICAP1 at

118 Constitutive depletion of p21-activated kinase 4 (PAK4) in the mouse causes embryo

119 P21-activated kinase 4 (PAK4) is a Cdc42 effector protei

120 It has been reported that p21-activated kinase 4 (PAK4) is amplified in pancreatic

121 p21-activated kinase 4 (PAK4), a potential therapeutic t

122 rminal region to the serine-threonine kinase p21-activated kinase 4 (PAK4), an effector for Cdc42.

123 lation and activation of its upstream kinase p21-activated kinase 4 (PAK4).

124 We identified grade-dependent p21-activated kinases 4 (PAK4) upregulation in gliomas a

125 p21-activated kinase 5 (Pak5) is an effector for the sma

126 We show that Inca physically interacts with p21-activated kinase 5 (PAK5), a known regulator of the

127 Pak5 (p21-activated kinase 5) is a brain-specific isoform of t

128 tofusin2, metabotropic glutamate receptor 5, p21-activated kinase 7, and Ras-related protein 5A) bind

129 -) mutant is alleviated by dominant-negative p21-activated kinase a.

130 ivity depends on the activation state of the p21-activated kinase a.

131 PAK1 encodes the p21-activated kinase, a major driver of neuronal develop

132 Our results identify inhibition of Rac1/p21-activated kinase actin signaling pathways as an acti

133 We found that pak-1/Pak (p21-activated kinase), along with putative activators of

134 s upstream signaling partners LIM kinase and p21-activated kinase, an enzyme directly downstream of R

135 Additional experiments confirmed that p21 activated kinase and cofilin, two actin-regulatory p

136 ut abrogated phosphorylation of the effector p21-activated kinase and decreased NF2/merlin phosphoryl

137 on is required for centrosomal activation of p21-activated kinase and its downstream kinase Aurora A,

138 ting in the activation of downstream kinases p21-activated kinase and LIM kinase and phosphorylation

139 ing proteins have been identified, including p21-activated kinase and serum-inducible kinase, which m

140 wever, miR-377 led to reduced expressions of p21-activated kinase and superoxide dismutase, which enh

141 s requires DMoesin, the Rho1-GTPase, class-I p21-activated kinases and the Arp2/3 complex.

142 nduced proinflammatory signaling (NF-kappaB, p21-activated kinase) and gene expression (ICAM1, VCAM1)

143 (1) a complex of SCRIB, ARHGEF, GIT and PAK (p21-activated kinase), and (2) a complex of SCRIB, NOS1A

144 pathway as exemplified by enhanced AKT, Rac, P21-activated kinase, and IFN regulatory factor 3 activi

145 activation of Rho GTPase family members and p21-activated kinase, and is associated with increased B

146 Emc10 signaled through small GTPases, p21-activated kinase, and the p38 mitogen-activated prot

147 roxide production, whereas interactions with p21-activated kinase are necessary for fMLF-induced acti

148 Dictyostelium p21-activated kinase B (PakB) phosphorylates and activat

149 ac1 promotes eNOS gene transcription through p21-activated kinase but not NADPH oxidase, increases eN

150 Countering Fus3p, Cdk and a p21-activated kinase, Cla4p, maintain Fus2p's nuclear lo

151 p67(phox), and to the RAC-binding domain of p21-activated kinase, consistent with our earlier findin

152 In budding yeast, Cla4 and Ste20, two p21-activated kinases, contribute to numerous morphogene

153 esponses in cellular behavior, including the p21-activated kinase-dependent generation of active, lea

154 is due to activation of Cdc42, resulting in p21-activated kinase-dependent phosphorylation and activ

155 f alpha-catenin and focal adhesion kinase or p21-activated kinase eliminates basal cell protection as

156 The Saccharomyces cerevisiae PAK (p21-activated kinase) family kinase Ste20 functions in s

157 and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascad

158 Two closely related p21-activated kinases from Saccharomyces cerevisiae, Ste

159 As Group I p21-activated kinases (Group I Paks, PAK1/2/3) have been

160 ng: It emanates from transphosphorylation of p21-activated kinases in their evolutionary conserved ki

161 cells (BMMCs), gamma-tubulin interacts with p21-activated kinase interacting exchange factor beta (b

162 cytes with a knockout mutation in alpha-PAK (p21-activated kinase)-interacting exchange factor (PIX;

163 eceptor kinase-interacting protein) and PIX (p21-activated kinase-interacting exchange factor) family

164 n 4 (AIP4) with the GTP exchange factor beta-p21-activated kinase-interactive exchange factor (beta P

165 We found that beta-Pix (p21-activated kinase-interactive exchange factor), a gua

166 ctin phosphorylation was dependent on Ixodes p21-activated kinase (IPAK1)-mediated signaling.

167 Sole transphosphorylation of p21-activated kinases is not sufficient to activate Erk1

168 ting exchange factor beta) and class I PAKs (p21-activated kinases) is recruited to adherens junction

169 in kinase cascade that involves PI3K, Cdc42, p21-activated kinase, MEK1, and ERK1/2.

170 nlike and EGF-like domains 1/angiopoietin-1, p21-activated kinase, microRNA 21, and transforming grow

171 The binding of either PAK (p21-activated kinase) or Cbl (Casitas B-lymphoma) to the

172 ound in normal vessels suppress flow-induced p21 activated kinase (PAK) and nuclear factor (NF)-kappa

173 p21-activated kinase (PAK) 2, a member of the PAK family

174 phosphorylation at Thr-423 (an indication of p21-activated kinase (PAK) activation).

175 ubunit (MYPT1) and a significant increase in p21-activated kinase (PAK) activity compared with CCS.

176 d Dock180 is mediated by activation of Rac1, p21-activated kinase (PAK) and AKT/protein kinase B (AKT

177 0070 also resulted in the phosphorylation of p21-activated kinase (PAK) and extracellular signal-regu

178 ugh its ability to bind the Cdc42/Rac target p21-activated kinase (PAK) and has been implicated in ce

179 to Rac1 that disrupts its ability to bind to p21-activated kinase (Pak) and other Cdc42/Rac1 interact

180 GIT1 mediates the localization of the p21-activated kinase (PAK) and PAK-interactive exchange

181 all-molecule inhibitors for the RAC effector p21-activated kinase (PAK) are in late-stage clinical de

182 Defects in p21-activated kinase (PAK) are suspected to play a role

183 associated with abrogated phosphorylation of p21-activated kinase (PAK) as well as its substrates LIM

184 exchange factor (GEF) and a Cdc42p effector p21-activated kinase (PAK) associate with Bem1p.

185 Because mutation of p21-activated kinase (PAK) can lead to mental retardatio

186 The p21-activated kinase (PAK) family of serine/threonine ki

187 The p21-activated kinase (PAK) family of serine/threonine pr

188 Activation of p21-activated kinase (PAK) followed the same matrix-depe

189 ration signals through cascades that involve p21-activated kinase (Pak) function; however, the specif

190 ic spine size, as well as phosphorylation of p21-activated kinase (PAK) in cultured cortical neurons.

191 We examined a potential role for the p21-activated kinase (PAK) in the regulation of vascular

192 esign a potent and highly selective group II p21-activated kinase (PAK) inhibitor with a novel bindin

193 Previous work showed that p21-activated kinase (PAK) is a critical regulator of en

194 The Rac1/Cdc42 effector p21-activated kinase (PAK) is activated by various signa

195 Introduction of activated p21-activated kinase (PAK) is sufficient to release prim

196 The group I p21-activated kinase (PAK) isoforms PAK1 and PAK2 are ac

197 Two p21-activated kinase (PAK) kinases, Pak1 and Ste20, are

198 Signaling through p21-activated kinase (PAK) mediates several of the delet

199 bers of spines containing phosphorylated (p) p21-activated kinase (PAK) or its downstream target cofi

200 his mutation with an allosteric inhibitor of p21-activated kinase (Pak) or its genetic inactivation r

201 hosphatidylinositol 3-kinase (PI3K)/Akt, and p21-activated kinase (PAK) pathways.

202 We recently found that p21-activated kinase (PAK) regulates endothelial permeab

203 Here, we show that postsynaptic p21-activated kinase (Pak) signaling diverges into two g

204 cation between guanylyl cyclases and the Rac-p21-activated kinase (PAK) signaling pathway--which is e

205 It was previously shown that Rac-p21-activated kinase (PAK) signaling regulated the physi

206 lobe, loss of Limk abolishes the ability of p21-activated kinase (Pak) to alter glomerular developme

207 s between Raf-1, protein kinase A (PKA), and p21-activated kinase (PAK) to determine their roles in t

208 ity through its transient recruitment of the p21-activated kinase (PAK) to focal adhesions.

209 p21-activated kinase (PAK), a Cdc42 effector whose activ

210 P21-activated kinase (PAK), a downstream target of Rac1/

211 y an inhibition of the catalytic activity of p21-activated kinase (PAK), a kinase known to play a cri

212 hrough engaging downstream effectors such as p21-activated kinase (PAK), a serine/threonine protein k

213 p21-activated kinase (Pak), an effector for the Rho GTPa

214 p21-activated kinase (PAK), an effector molecule of the

215 cruitment, prevents association of Raf-1 and p21-activated kinase (PAK), and blocks phosphorylation o

216 onine-protein kinase proteins, also known as P21-activated kinase (PAK), and the mechanosensitive fac

217 IB) effectors, activated Cdc42 kinase (ACK), p21-activated kinase (PAK), and Wiskott-Aldrich syndrome

218 hesized that Rac1 and its downstream target, p21-activated kinase (PAK), are regulators of insulin-st

219 e experiment found that downstream of Cdc42, p21-activated kinase (PAK), but not Par6 or WASP, may be

220 m1 also increases GEF phosphorylation by the p21-activated kinase (PAK), Cla4.

221 vity and assembly, the role of its effector, p21-activated kinase (Pak), in oxidase function has not

222 -dense tissues when DOCK8, through CDC42 and p21-activated kinase (PAK), is unavailable to coordinate

223 An Akt scaffolding protein, p21-activated kinase (PAK), translocates to the membrane

224 d by the GTPase Rac1 and downstream effector p21-activated kinase (PAK), we further examined Shank3 r

225 We show that p21-activated kinase (PAK)-induced phosphorylation of se

226 p21-activated kinase (Pak)-interacting exchange factor (

227 n, following stimulation with LPA as well as p21-activated kinase (PAK)-mediated lamellipodia and fil

228 Rac activation, in turn, promotes the p21-activated kinase (PAK)-mediated phosphorylation of a

229 -regulated kinases depended on the status of p21-activated kinase (PAK).

230 tion of synaptic cofilin but not of synaptic p21-activated kinase (PAK).

231 that regulates cell migration by inhibiting p21-activated kinase (PAK).

232 ase cdc42 and its downstream binding partner p21-activated kinase (PAK).

233 proliferation in part by inhibiting Rac- and p21-activated kinase (Pak).

234 ntified a RhoGDI kinase from bovine brain as p21-activated kinase (Pak).

235 h modulation of actin cytoskeleton dynamics: p21-activated kinase (PAK).

236 nhibition led to a rapid suppression of Rac1/p21-activated kinase (PAK)/protein kinase C-RAF (C-RAF)/

237 Muscle-specific genetic ablation of p21-activated kinase (PAK)2, but not whole-body PAK1 kno

238 s further regulated by Rho-kinase (ROCK) and p21-activated kinase (PAK): ROCK inhibits ULF transport,

239 p21-activated kinases (PAK) are a family of serine/threo

240 The P21-activated kinases (PAK) are emerging antitumor thera

241 The p21-activated kinases (Pak) can regulate contractility i

242 f3a regulates localized cortical activity of p21-activated kinases (PAK), which in turn controls basa

243 ibiting its downstream effector kinases, the p21-activated kinases (Pak).

244 The p21-activated kinase PAK1 is implicated in tumorigenesis

245 We recently identified p21-activated kinase (PAK1) as a downstream effector mol

246 ecretion, signals downstream to activate the p21-activated kinase (PAK1), which then signals to Raf-1

247 ty by interaction with and inhibition of the p21-activated kinase (PAK1).

248 The class I p21-activated kinases (Pak1-3) regulate many essential b

249 control protein 42 homolog (CDC42) effector p21-activated kinase (Pak2) has been implicated in HSPC

250 P21 activated kinases (PAKs) are major downstream effect

251 ssociated with increased activity of Rac and p21-activated kinases (PAKs) and deregulation of cytoske

252 The p21-activated kinases (PAKs) are a family of six serine/

253 p21-activated kinases (Paks) are Cdc42/Rac-activated ser

254 The p21-activated kinases (PAKs) are immediate downstream ef

255 The p21-activated kinases (PAKs) are important effector prot

256 The type II p21-activated kinases (PAKs) are key effectors of RHO-fa

257 P21-activated kinases (Paks) are major effectors downstr

258 p21-Activated kinases (PAKs) are regulators of cell moti

259 The p21-activated kinases (Paks) are serine/threonine kinase

260 The p21-activated kinases (PAKs) are serine/threonine kinase

261 p21-activated kinases (PAKs) are serine/threonine kinase

262 p21-activated kinases (PAKs) are serine/threonine protei

263 rt ADP-ribosylation factor (ARF) GTPases and p21-activated kinases (PAKs) as its relevant host substr

264 p21-activated kinases (PAKs) become activated in cells w

265 The p21-activated kinases (Paks) can regulate the contractil

266 The p21-activated kinases (PAKs) contain an N-terminal Cdc42

267 p21-activated kinases (Paks) have been shown to regulate

268 m1 is required for the activation of group I p21-activated kinases (Paks) on centrosomes in prophase.

269 The p21-activated kinases (PAKs) play essential roles in div

270 p21-activated kinases (PAKs) regulate actin filaments an

271 p21-activated kinases (PAKs) regulate many cellular proc

272 The p21-activated kinases (Paks) serve as effectors of the R

273 Last, p21-activated kinases (PAKs) were downregulated in SAP10

274 P21-activated kinases (Paks), a family of serine/threoni

275 The p21-activated kinases (Paks), an evolutionarily conserve

276 In this paper, we show that p21-activated kinases (Paks), downstream effectors of th

277 we tested the effects of novel inhibitors to p21-activated kinases (PAKs), major targets of Rac1, on

278 In this work, the authors show that p21-activated kinases (Paks), previously best known for

279 We recently reported that the p21-activated kinases (PAKs), which are activated by GTP

280 Here, we focus on the group A p21-activated kinases (Paks), which have previously been

281 ctivates its downstream effectors, including p21-activated kinases (PAKs).

282 VIF are rapidly phosphorylated at Ser-38, a p21-activated kinase phosphorylation site.

283 g the content of Rac1 and in spines and PAK (p21-activated kinase) phosphorylation.

284 Integrin signaling promotes, through p21-activated kinase, phosphorylation and inactivation o

285 tivation (i.e., Rac1.GTP) was quantitated by p21-activated kinase pull-down assay.

286 We exploited the p21-activated kinase pulldown assay to identify proteins

287 could be rescued by depletion of ARHGEF7 and p21-activated kinase, Rac1-specific effector proteins re

288 Inhibiting p21-activated kinase reduces JNK activation in atheropro

289 tes formation of filopodia and activates the p21-activated kinase serine/threonine kinase.

290 ed on the laboratory advances in the Akt and p21-activated kinase signaling pathways, it is conceivab

291 We further demonstrate that a Rac-PAK (p21-activated kinase) signaling pathway mediates kinocil

292 n are largely mediated by the Cdc42 effector p21-activated kinase Ste20.

293 42p regulates cell polarity, and through the p21-activated kinase Ste20p, Cdc42p also regulates mitog

294 Simultaneous loss of Urm1p and Cla4p, a p21-activated kinase that functions in budding, is letha

295 ng CCL2-induced activation of the downstream p21-activated kinase that regulates the cytoskeleton and

296 ll GTPase Rac1 and that both act through the p21-activated kinase to promote the phosphorylation and

297 tical convergence signaling nodules, Akt and p21-activated kinase, two integral components of phenoty

298 the GTPases Rac and Cdc42 and their effector p21-activated kinase, which may explain why its acute ef

299 tivity, as shown by increased binding to the p21-activated kinase, which modulates actin cytoskeletal

300 m is controlled by the catalytic activity of p21-activated kinase, X-PAK1.