ライフサイエンスコーパス: pM

1 -A(165a):VEGFR1 and VEGF-A(165a):VEGFR2, 1.0 pM and 10 pM respectively, and validated the known affin

2 determination of Cl(-) was found at the 1.0 pM level for both sensing systems.

3 of the sequence were linear varying from 1.0 pM to 400.0 pM (I(p) nu log C) and 0.5-400.0 pM (DeltaR(

4 s an excellent linear dynamic range of 100.0 pM to 10.0 nM Hg(2+) concentration with R(2) = 0.982.

5 e level for quantification purposes is 100.0 pM.

6 model target miRNA-21 in the 100 fM to 25.0 pM range.

7 d minimal effective dose 50% (MED50%) of 3.0 pM at a constant amount of DT (4x minimal cytopathic dos

8 pM to 400.0 pM (I(p) nu log C) and 0.5-400.0 pM (DeltaR(ct) nu log C) with a limit of detection of 0.

9 nce were linear varying from 1.0 pM to 400.0 pM (I(p) nu log C) and 0.5-400.0 pM (DeltaR(ct) nu log C

10 iRNA can detect in a range from 0.1 to 500.0 pM with a relatively low detection limit of 84.3 fM.

11 the target miRNA ranging from 2.0 fM to 8.0 pM, and the detection limit was 0.6 fM.

12 peroxide anion in the range from 4 to 40 000 pM with a detection limit (S/N = 3) of 1.2 pM, which was

13 by LDI-MS were found to be 0.07 pM and 0.02 pM for putrescine and cadaverine, respectively.

14 1)) with a limit of detection (LOD) of 0.033 pM (7.5 pg mL(-1)) of MUC1.

15 th a limit of detection of 0.06 pM and 0.035 pM, at the signal to noise ratio of 3sigma.

16 nu log C) with a limit of detection of 0.06 pM and 0.035 pM, at the signal to noise ratio of 3sigma.

17 coated side by LDI-MS were found to be 0.07 pM and 0.02 pM for putrescine and cadaverine, respective

18 ude and a limit of detection of 1 pM and 0.1 pM respectively for 15 and 18-cycle amplified synthetic

19 limit of 5.2 fM (a linear range of from 0.1 pM to 10 nM), as well as a high selectivity that discrim

20 ble of ultra-low (limit of quantitation: 0.1 pM) detection.

21 Exposure to 0.1 pM, 10 pM, and 1 nM 17 beta-estradiol (E2) resulted in m

22 oltammetry in the concentration range of 0.1 pM-10 nM (25 pg mL(-1) - 2500 ng mL(-1)) with a limit of

23 ement in LOQ by a factor of 140, down to 0.1 pM.

24 hat achieved a limit of detection of about 1 pM or 50 amol/measurement, well within the reported usef

25 th detection limits of 1.2 nM, 1.3 muM and 1 pM, respectively.

26 e method offers to detect HRP-II as low as 1 pM without any interference from some common salts and t

27 ted based on 3sigma and attained as low as 1 pM, which is tremendously low compared to real CRP conce

28 achieved with a detection limit as low as 1 pM.

29 t 1 pM 22-OH-MaR1 and approximately 25% at 1 pM 14-oxo-MaR1, whereas 14-oxo-MaR1 was less active than

30 phage phagocytosis of approximately 75% at 1 pM 22-OH-MaR1 and approximately 25% at 1 pM 14-oxo-MaR1,

31 A concentrations in cell lysates are below 1 pM.

32 peptidases whose concentrations are below 1 pM.

33 librium dissociation constants K(D) of ca. 1 pM, 1000-fold tighter than the native RNA complexes (ca.

34 selectivity with a wide dynamic range from 1 pM to 100 nM.

35 0.85 pM in 60min with a dynamic range from 1 pM to 1000 pM, and could discriminate target DNA from mi

36 concentration range with detection limits <1 pM in 150 mM buffer and cell culture media, as well as <

37 assay demonstrates that ultrasensitivity (<1 pM) and high selectivity can be achieved on a direct rea

38 rgets has been carried out in the range of 1 pM - 1 uM.

39 s of magnitude and a limit of detection of 1 pM and 0.1 pM respectively for 15 and 18-cycle amplified

40 eveloped biosensor has detection limits of 1 pM and 10 pM of thrombin in phosphate buffered saline an

41 or with extremely different EC50 values of 1 pM and 50 nM, respectively.

42 er biomarker with the low concentration of 1 pM has been detected by controlling oxygen from 1 to 15

43 c acid amplification, a detection limit of 1 pM is achieved within 2 h.

44 7 pM to 100 nM with the detection limit of 1 pM.

45 strated with a limit of detection (LOD) of 1 pM.

46 finities with a limit of detection down to 1 pM, regardless of the analyte size.

47 iosensor has detection limits of 1 pM and 10 pM of thrombin in phosphate buffered saline and mimic se

48 EGFR1 and VEGF-A(165a):VEGFR2, 1.0 pM and 10 pM respectively, and validated the known affinity VEGF-A

49 surface-adsorbed mass, and approximately 10 pM for the glycan/lectins studied here.

50 probe response can be readily detected at 10 pM target in true color and in red-to-green ratio images

51 his approach, as little as 500 attomoles (10 pM) could be detected with single nucleotide resolution.

52 sis to achieve a limit of detection below 10 pM.

53 re allows detection of low concentration (10 pM) biomarkers as well as specific capture of single ant

54 its limit of quantification (LOQ) exceeds 10 pM while miRNA concentrations in cell lysates are below

55 detection in human serum solution is from 10 pM to 1 muM, with a regression coefficient of 0.98.

56 of the target miRNA-21 in the range from 10 pM to 100 nM in phosphate-buffered saline (PBS); the lim

57 or 69-base single-stranded DNA targets is 10 pM (about 10 million copies for our sample volume) with

58 ffer and cell culture media, as well as < 10 pM in artificial CSF.

59 Both nanogels exhibited K(d) <10 pM for their respective target protein and low cross-rea

60 atic reactions and with a sensitivity of <10 pM target RNA.

61 (2) sensing with the low concentration of 10 pM as well as prostate cancer biomarker is detected, whi

62 cting DJ-1 in urine at a concentration of 10 pM in 1 min.

63 tant of the beta-clamp is of the order of 10 pM in buffers of moderate ionic strength.

64 otein concentration in a dynamic range of 10 pM to 10 nM with a detection limit of 5.9 pM.

65 form demonstrated a limit of detection of 10 pM with a dynamic range of at least 4 orders of magnitud

66 sensitivity down to the concentration of 10 pM, which is four orders of magnitude lower than the det

67 Exposure to 0.1 pM, 10 pM, and 1 nM 17 beta-estradiol (E2) resulted in monotoni

68 ptimal conditions, a broad dynamic range (10 pM to 2 muM) with an excellent detection limit (down to

69 own to a concentration of 30 pM, near the 10 pM limit of detection (LOD), encompassing four orders of

70 xhibits a large linear range from 1 fM to 10 pM, with a limit of detection (LOD) of 152.93 aM.

71 in an appreciable signal/noise ratio, was 10 pM of alpha-thrombin in presence of 500 muM HSA.

72 achieving DNA quantification in the 0.1-100 pM range for 5 muL samples analyzed within 5 min under c

73 ethod indicated a good linear range from 100 pM to 1000 pM and a limit of detection (LOD) of 29.2 pM

74 it of 100 pM with a detection range from 100 pM to 3.5nM for norovirus was obtained.

75 d" inhibitor 1 (XAV939)(5), i.e., IC50 = 100 pM vs TNKS2 and IC50 = 6.5 muM vs PARP1 for 14.

76 d the desired profiles (EC50 (hGLP-2R) < 100 pM, CL in rat <0.3 mL/min/kg, selective vs hGLP-1R and h

77 The minimum detection level (MDL; 100 pM) of the aptasensors was determined, and their MDL was

78 tammetric analysis, a detection limit of 100 pM with a detection range from 100 pM to 3.5nM for norov

79 w 1 nM with a minimum detection level of 100 pM.

80 ntrations in a broad range from 10 aM to 100 pM and a limit of detection (LOD) of 10 aM was obtained,

81 centrations in aqueous solutions down to 100 pM could be measured by the differential adhesion betwee

82 e unprecedented voltammetric response to 100 pM dopamine was obtained with open CNPs.

83 ensor responded linearly in the range 1-1000 pM of miRNA-21, with a limit of detection of 0.3 pM, goo

84 ated a good linear range from 100 pM to 1000 pM and a limit of detection (LOD) of 29.2 pM was obtaine

85 60min with a dynamic range from 1 pM to 1000 pM, and could discriminate target DNA from mismatched se

86 biosensor for 17beta-estradiol in the 0.9-11 pM range.

87 PDGF-AA:R2 KD = 530 nM, PDGF-AB:R2 KD = 110 pM, PDGF-BB:R2 KD = 40 nM, and PDGF-CC:R2 KD = 70 pM.

88 achieved a limit of detection (LOD) of 0.12 pM (3.0 attomoles) for the synthetic target and showed a

89 or GCSF, GCSF-Fc and PEG-GCSF were 37 +/- 12 pM, 75 +/- 13.5 pM and 46 +/- 5.5 pM, respectively.

90 ertain cell lines [e.g., Tb32 with IC50 = 12 pM against MES SA (uterine sarcoma) cell line and 2 pM a

91 A detection limit of 12 pM fluorescein was achieved when sampling 20 droplets, a

92 f this nanobiosensor indicated the LOD of 12 pM which revealed high rate sensitivity.

93 in saliva with a detection limit down to 12 pM.

94 gher alphavbeta6 integrin affinities (23-120 pM) than the monomers (260 pM), the best results-that is

95 gher alphavbeta6 integrin affinities (23-120 pM) than the monomers (260 pM), the best results-that is

96 itive determination (limit of detection, 120 pM) of Escherichia coli O111:B4 lipopolysaccharide (LPS)

97 ions yielded a detection limit of 613 +/- 13 pM for CE of fluorescein disodium salt solution in borat

98 of quantification (LLOQ) was obtained as 148 pM with a relative standard deviation of 0.16%.

99 sed 3-fold in response to LPS, to 116 +/- 15 pM, but remained below the approximate threshold for eli

100 ch, we have achieved a detection limit of 15 pM in LRET assays of human immunodeficiency viral DNA.

101 0 pM to 1000 nM with a detection limit of 15 pM.

102 50 values over a wide range of potencies (15 pM to 9 mM).

103 concentration (S/N approximately 4.6 at 150 pM).

104 BSA at concentrations in the range from 150 pM to 15 muM (down to 3 orders of magnitude lower than t

105 A in a wide linear dynamic range of 0.1-1500 pM.

106 The LLOQ ranged from 0.03 to 0.16 pM, intra- and inter-assay precision were <27% and truen

107 cells in vitro with an affinity of 45 +/- 16 pM.

108 ensitive assays that can detect as low as 16 pM Ebola Virus DNA, 0.01ng/mL carcinoembryonic antigen (

109 st potent compound (ML10) has an IC50 of 160 pM in a PfPKG kinase assay and inhibits P. falciparum bl

110 ear dynamic range for Cyt c from 175 to 1750 pM with a detection limit of 32.7 pM.

111 The significantly low detection limit (42.18 pM) demonstrates the ultrasensitivity of the proposed me

112 achieving very low limits of detection of 18 pM and 76 pM, respectively, while no matrix effects were

113 owed submicromolar activity, including a 180-pM subtype-selective agonist of the D(4) dopamine recept

114 The LOD value achieved was 0.2 pM (5 amol in 25 muL).

115 were replaced with lower concentrations (1-2 pM) of hydrophilic ferrioxamine siderophores.

116 0 pM with a detection limit (S/N = 3) of 1.2 pM, which was 5000-fold lower than those of the chemilum

117 limits of detection (LODs) of 23.0 and 13.2 pM, respectively, without any target DNA amplification.

118 00 pM and a limit of detection (LOD) of 29.2 pM was obtained.

119 affinities (Kd, Adnectin1 approximately 6.2 pM vs Kd, Adnectin2 approximately 46 nM).

120 detect uPA in spiked serum samples up to 9.2 pM.

121 nst MES SA (uterine sarcoma) cell line and 2 pM against HEK 293T (human embryonic kidney) cell line],

122 (LOD) for a synthetic influenza target of 2 pM after 45 min of RCA, which is comparable to the corre

123 he new LoD being 1.2 fmol (or 26 fg/muL or 2 pM).

124 r of natural EEEV infection with potent (<20 pM) inhibitory activity of EEEV.

125 A detection limit (DL) of 20 pM (20 femtomoles, 1 mL) is estimated from the sigmoidal

126 could be performed on-chip with an LOD of 20 pM after 45 min of RCA.

127 ated in terms of sensitivity and a LOD of 20 pM was achieved on fluorescent glass microarray.

128 served in the same cells treated with 20-200 pM EGF in vitro.

129 3 immunosensor was found between 0.2 and 200 pM with a calculated limit of detection of 22.8 fM.

130 mits of detection in both concentration (200 pM of beta-ionone) and in molecular weight of VOCs (100

131 rleukin-2 concentrations from <20 fM to >200 pM were demonstrated, surpassing the conventional NWFET

132 relevant concentration range from 50 to 2000 pM.

133 ith a limit of detection (LOD) as low as 209 pM.

134 50 pM to 2.5 nM, LOD of 64 pM and LOQ of 215 pM Excellent selectivity towards one base mismatch (1-MM

135 rying binding affinities (K(D) as low as 216 pM), co-crystallized it with the receptor, and confirmed

136 gh sensitivity (with a detection limit of 22 pM for Hg(2+) and 20 nM for Pb(2+)) and selectivity with

137 h an excellent detection limit (down to 7.23 pM) was achieved.

138 pyoS2 (pyoS2(NTD)) bound to FpvAI (Kd = 240 pM) reveals that the pyocin mimics Fe-Pvd, inducing the

139 ts of alpha-synuclein in the range from 0.25 pM to 25 nM.

140 ers were determined to be 0.3 uA/nM and 0.25 pM, respectively.

141 5) that have anti-HIV potencies of around 25 pM, which is more than four orders of magnitude higher t

142 tion of rhodopsin to 11CR and opsin has a 25-pM equilibrium dissociation constant, which corresponds

143 Rs in water and concentrations as low as 250 pM in the circulation of living mice.

144 e genoassay provided a linear range from 250 pM to 2.5 nM, LOD of 64 pM and LOQ of 215 pM Excellent s

145 d detection limits of 500 fg of protein (250 pM) while simultaneous baseline separation resolution wa

146 current response (83 pA) and frequency (0.26 pM(-1) s(-1)) were on the same order of magnitude as the

147 biosensor offered a detection limit of 0.26 pM, with a nice analytical reproducibility by CV (coeffi

148 ffinities (23-120 pM) than the monomers (260 pM), the best results-that is, low background uptake and

149 ffinities (23-120 pM) than the monomers (260 pM), the best results-that is, low background uptake and

150 with a limit of detection (LOD) as low as 27 pM.

151 mit of detection (LoD) based on 3sigma is 28 pM Hg(2+), while the lowest detectable level for quantif

152 ical measurements achieve a detection of 280 pM RNP in reaction buffer and 8 nM RNP in biologically r

153 tx1 & stx2 with picomolar K(d) (~47 pM & ~29 pM, respectively) were successfully used to fabricate vo

154 ct cocaine in serum with a LOD as low as 293 pM.

155 f miRNA-21, with a limit of detection of 0.3 pM, good reproducibility (Relative Standard deviation (R

156 ic evaluation software, and found to be 15.3 pM (KD) and 81.02m degrees (Bmax) with probe 1 and 54.9p

157 ls (49.2 +/- 13.4 compared with 20.2 +/- 2.3 pM; P = 0.04).

158 M-500microM at pH=7.4 and LOD is 2.8 and 3.3 pM at pH=7.4 and 9.0, respectively, which were reported

159 A limit of detection of 0.2 ng/mL (3.3 pM) capsid proteins was achieved with convenient UV abso

160 tor alpha with a detection limit as low as 3 pM.

161 orescence spectroscopy (limit of detection 3 pM) and on surfaces at the single-particle level using t

162 st NTS2 affinity described to date (K(i) = 3 pM) and good NTS1 affinity (K(i) = 4 nM), providing a >1

163 FP, have very high affinities of about 10-30 pM, and extremely slow off-rates.

164 BRD4 protein at concentrations as low as 30 pM in the RS4;11 leukemia cell line, achieves an IC50 va

165 del revealed "cascade amplification" from 30 pM levels of intrinsic tenase to 15 nM prothrombinase to

166 rom 0.1 to 2 nM with a detection limit of 30 pM and for Cu(2+) from 2.0 to 50.0 nM with a detection l

167 binding curve down to a concentration of 30 pM, near the 10 pM limit of detection (LOD), encompassin

168 inear dynamic concentration range was 30-300 pM, and the limit of detection was 22 fM.

169 miR-21 at concentrations between 30 and 300 pM from the same sample.

170 ections, with detection limits of 70 and 300 pM, respectively.

171 with an experimental detection limit of ~300 pM in aqueous buffer solution.

172 xcellent limit of detection, i.e., 32 pM, 31 pM, 64 pM, and 9 pM for DA, 5-HT, Epn, and Norepn, respe

173 ion steps, with a limit of detection of 1.32 pM that enabled the identification of DILI.

174 th an excellent limit of detection, i.e., 32 pM, 31 pM, 64 pM, and 9 pM for DA, 5-HT, Epn, and Norepn

175 showed a limit of detection smaller than 33 pM of PSA and a wide detection range from 0.033 to 330 n

176 interaction for the first time with KD = 340 pM.

177 us assays could detect 5.2 mug L(-1) MPO (35 pM) via a faster cycle.

178 er and serum-matrix at a concentration of 35 pM.

179 with a dissociation constant of less than 35 pM, as measured by surface plasmon resonance.

180 se against EIS from 0.1 to 100pg/ml 3.5-3500 pM.

181 8, 25.08), fasting proinsulin (betaPFOS=1.37 pM; 95% CI: 0.50, 2.25; betaPFOA=1.71 pM; 95% CI: 0.72,

182 pled with a high binding affinity (K(i) = 38 pM).

183 d with a picomolar binding affinity (Ki = 38 pM), coupled with a single-digit micromolar activity aga

184 M) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor.

185 ited STAT3 DNA-binding ability (IC(50) = 2.4 pM), blocked the constitutive and IL-6-induced STAT3 act

186 maximal effective concentration (EC50) of 4 pM in vitro, representing an approximately 330-fold high

187 regular Fe medium (10(-17.6) M Fe(3+)) to 4 pM in low iron medium (10(-19.0) M Fe(3+)); a 500-fold i

188 most potent inhibitor (K(i,app) = 130 +/- 40 pM) for NTMT1 to date, displaying more than 3000-fold se

189 th sub-nanomolar activity (K(i) = 370 +/- 40 pM) and a high stability (t(1/2) > 5 days in plasma), al

190 in-house developed NPM-ALK ELISA; LOD of 40 pM) as compared to the ubiquitous beta-actin protein (ca

191 a limit of detection (LOD) of 10 ng/mL (400 pM), attributed to the significant reduction of the net

192 o-4H-chromene-3-carboxamide (20) (IC50 = 403 pM) and N-(3',4'-dimethylphenyl)-4-oxo-4H-chromene-3-car

193 ifference of SD of residuals: Abeta40, -7.42 pM; P < .001; Abeta42, -3.72 pM; P < .001).

194 y high binding affinity by 2 (41-nt, KD = 45 pM) and high specificity by 10, was used successfully to

195 ith a limit of detection (LOD) as low as 450 pM.

196 icol with a limit of detection as low as 451 pM.

197 current response (75 pA) and frequency (0.47 pM(-1) s(-1)) of single Escherichia coli collisions.

198 against stx1 & stx2 with picomolar K(d) (~47 pM & ~29 pM, respectively) were successfully used to fab

199 ates for the detection of miRNA222 (LOD: 485 pM), paving the way for the application of the developed

200 ectable concentration of HSA and HIgG at 1.5 pM.

201 and PEG-GCSF were 37 +/- 12 pM, 75 +/- 13.5 pM and 46 +/- 5.5 pM, respectively.

202 y revealed a limit of detection (LOD) of 3.5 pM for atrazine, which, to the best of our knowledge, is

203 37 +/- 12 pM, 75 +/- 13.5 pM and 46 +/- 5.5 pM, respectively.

204 lished with a limit of detection as low as 5 pM.

205 iscovery of AB680, a highly potent (K(i) = 5 pM), reversible, and selective inhibitor of CD73.

206 ation of FXIa became prominent and reached 5 pM FXIa at >500 sec in the simulation, consistent with a

207 o all Ln(III)s, with apparent K(d)s of 10-50 pM but only weak response to other common divalent and t

208 reaction limits of detection ranged from 50 pM to 250 nM with the average being 50-100 nM.

209 of 0.1 nM), a biomarker (thrombin, LOD of 50 pM), and a drug (cocaine, LOD of 5 nM).

210 and investigations resulted in an LOD of 50 pM.

211 , MAIT cell activation potencies (EC50 3-500 pM), and chemical stabilities are described.

212 interactions with Kds ranging from below 500 pM to above 300 muM.

213 iting binding affinities in the range of 500 pM-500 nM.

214 emia cell line, achieves an IC50 value of 51 pM in inhibition of RS4;11 cell growth and induces rapid

215 to be approximately 16 and approximately 53 pM, respectively.

216 ith limits of detection of 0.793 pM and 1.54 pM, respectively.

217 ompetitive inhibitor with an affinity of 545 pM for thrombin and is 4 orders of magnitude more select

218 dissociation constant was estimated to be 55 pM.

219 ust 5 min, achieving a detection limit of 55 pM (1.1 fmol), and the combined competitive-amplificatio

220 on curve displayed a detection limit of 2.57 pM.

221 ction limit of the proposed strategy is 0.58 pM, which is about 3 orders of magnitude better than the

222 ted CCC-initiating C1q protein (K(D)~140-580 pM) in vitro, and C1q-ApoE complexes emerged as markers

223 toward the trypanosomal protease (K(i) = 0.6 pM) and a submicromolar antiparasitic activity (EC(50) =

224 aline (PBS); the limit of detection was 14.6 pM.

225 ntum yield of 27%, and binds Zn(2+) with 4.6 pM affinity, which decreases by over 4 orders of magnitu

226 with limits of detection of 16.7 pM and 48.6 pM in spiked buffer and serum samples, respectively.

227 for ALP was estimated to be 0.02 units/L (~6 pM; 1 ng/mL).

228 ific detection of MC-LR in the range from 60 pM to 1000 nM with a detection limit of 15 pM.

229 oligomer concentration in the range from 60 pM to 150 nM.

230 dissociation constant K(d) values down to 60 pM and, together with a newly developed workflow, allow

231 otein expression at low doses in vitro (<600 pM) and in vivo (1 mg kg(-1) ).

232 l in milk and serum with LODs of 697 and 601 pM, respectively.

233 ith a limit of detection of 20 pg mL(-1) (63 pM), the competitive ULISA is well applicable to the det

234 terms of low detection limit (8.75 +/- 0.64 pM) and high sensitivity (39.56 +/- 0.41 muA nM(-1)) val

235 inear range from 250 pM to 2.5 nM, LOD of 64 pM and LOQ of 215 pM Excellent selectivity towards one b

236 t limit of detection, i.e., 32 pM, 31 pM, 64 pM, and 9 pM for DA, 5-HT, Epn, and Norepn, respectively

237 he molecular receptors exhibited a K(d) < 65 pM for their respective target protein and low cross-rea

238 o-4H-chromene-3-carboxamide (27) (IC50 = 669 pM), acting as competitive and noncompetitive reversible

239 prefers VEGFR2 binding at an affinity = 0.67 pM while binding VEGFR1 with a weaker affinity-K(D) = 1.

240 n at a low concentration of 0.1 ng/mL (~1.67 pM) is also demonstrated through real-time monitoring of

241 itions, the limit of detection (LOD) was 0.7 pM miR-221 (15% RSD).

242 V) across a range from nearly 27.4 fM to 1.7 pM using the described collection method.

243 ow limits of detection down to 240 amol (1.7 pM) of microRNA and 123 amol (0.88 pM) of DNA.

244 0 fM -10 nM with limits of detection of 16.7 pM and 48.6 pM in spiked buffer and serum samples, respe

245 75 to 1750 pM with a detection limit of 32.7 pM.

246 mpi detection was in the linear range from 7 pM to 100 nM with the detection limit of 1 pM.

247 criminated at picomolar detection limits (<7 pM) "perfect-match" from mismatched sequences, down to a

248 of c, nM) and a low limit of detection of 7 pM (S/N = 3).

249 ity for quantum dot quantification down to 7 pM.

250 nm diameter with a binding constant of k=1.7(pM)(-1), sensitivity of 6.9nm/ng/mm(2) and limit of dete

251 DGF-BB:R2 KD = 40 nM, and PDGF-CC:R2 KD = 70 pM.

252 fied by relatively small increases (15 to 70 pM) in plasma insulin concentrations.

253 S=1.37 pM; 95% CI: 0.50, 2.25; betaPFOA=1.71 pM; 95% CI: 0.72, 2.71), and glycated hemoglobin (HbA1c)

254 k and serum samples with LODs of 740 and 710 pM, respectively.

255 Abeta40, -7.42 pM; P < .001; Abeta42, -3.72 pM; P < .001).

256 tained to be 100.82 Omega nM(-1) and a of 74 pM, respectively.

257 ing 100-fold more active (IC50 values, 50-75 pM vs. 7 nM; HCT116), and that are now accessible becaus

258 very low limits of detection of 18 pM and 76 pM, respectively, while no matrix effects were observed.

259 hole blood with limits of detection of 0.793 pM and 1.54 pM, respectively.

260 c range of concentrations from 1.2 fM to 1.8 pM).

261 for both ENRO and CIPRO were achieved at 2.8 pM.

262 ion of 63 fM and a dynamic range of 200 fM-8 pM was observed for the assay.

263 oltammograms revealed a detection limit of 8 pM, while a linear range was found between 10 nM-250 nM.

264 The limit of detection is as low as 80 pM.

265 and decent response linearity range (10-800 pM, R(2) = 0.9943).

266 serum sample with a limit of detection of 81 pM This work demonstrates the use of the MPT64 aptamer a

267 target DNA at the concentration down to 0.85 pM in 60min with a dynamic range from 1 pM to 1000 pM, a

268 amol (1.7 pM) of microRNA and 123 amol (0.88 pM) of DNA.

269 roved sensitivity (limit of detection of 0.9 pM for the short synthetic oligomer) using a much simple

270 50 nM, and a lower limit of detection of 1.9 pM (S/N = 3), with a high sensitivity of 1.65 x 103 Omeg

271 The sensor possesses 18.9 pM as the limit of detection (LOD) which is lowest of th

272 10 pM to 10 nM with a detection limit of 5.9 pM.

273 detection, i.e., 32 pM, 31 pM, 64 pM, and 9 pM for DA, 5-HT, Epn, and Norepn, respectively.

274 trations in iron-deficient waters averaged 9 pM, up to fivefold higher than in iron-rich coastal and

275 trated along with a limit of detection of 90 pM in PBS.

276 en cell entry (with IC(50) values down to 95 pM), but only partially block DC-SIGNR-mediated virus in

277 avy chain germlines generated high affinity (pM) antibodies that neutralize the two IsdB NEAT domains

278 ic current are linear from 1 to 30 ng/mL and pM concentrations can be detected without the need for m

279 proach has been explored to detect beta-A at pM levels within 30-40 min compared to 6-8h of ELISA tes

280 EBOV immunosensing can detect virus level at pM concentration within approximately 40min compared to

281 ing concept could even prove its exceptional pM sensitivity in combination with a superior discrimina

282 surements showed that this platform exhibits pM-range sensitivity, high specificity and good reproduc

283 m samples at clinically relevant levels (low pM range) was also demonstrated, thus illustrating the p

284 lectroanalytical measurements of ultralow (<=pM) concentrations of analytes in environmental and biom

285 With this setup, we can measure pM concentrations, corresponding to zeptomole (10(-21) m

286 mitters in the human body is very low (nM or pM level) and it is extremely difficult to detect the fl

287 LacO) in vitro with a Kd about 10 picomolar (pM), it is often assumed that LacI also has high affinit

288 vorable simultaneous detection of picomolar (pM) insulin and nanomolar (nM) cortisol concentrations i

289 limits of detection (LODs) in the picoMolar (pM) range.

290 A sub-pM concentration of plasminogen (but not plasmin) acting

291 We achieved sub-pM quantification of different miRNAs in about 1.5 h, th

292 ed, featuring very low LOD values at the sub-pM level.

293 We have achieved a LOD in the pM order and have assessed the feasibility of directly m

294 -based assays showed detection limits in the pM range and polymer-coated microplates are stable to st

295 lifecycle at effective concentrations in the pM to nM regimes, while the majority of CIs target a sin

296 specific detection of mRNA fragments in the pM-nM concentration range, reducing quantification error

297 imits of detection and quantification in the pM-nM range.

298 quantification can be estimated in the nM to pM range.

299 catalyst and substrate (S) are ultradilute (pM-low muM) and the oxidant is very dilute (high nM-low

300 the potassium channels Kv1.1 and Kv1.3 with pM affinity.