ライフサイエンスコーパス: packing interaction

1 ing that this face is involved in a critical packing interaction.

2 stacking, loop-helix interaction, and helix packing interaction.

3 metry is not simply a consequence of crystal-packing interactions.

4 is associated with loop dynamics and crystal-packing interactions.

5 rogen bonds but locally disrupted side-chain packing interactions.

6 idues participate in favorable van der Waals packing interactions.

7 to visualize directly the goodness-of-fit of packing interactions.

8 bdomain and likely contains some native-like packing interactions.

9 cal structure, apparently due to the loss of packing interactions.

10 His in the crystals is influenced by crystal packing interactions.

11 in the molecule or complex and/or by crystal packing interactions.

12 de possible by a series of changes in steric packing interactions.

13 lyproline II structure, and lacks pronounced packing interactions.

14 ndicating significant tertiary or quaternary packing interactions.

15 y structure that permit inter-helix tertiary packing interactions.

16 to identify RNAs that form extensive helical packing interactions.

17 ifferent C-X...NR3 (X = I, Br) distances and packing interactions.

18 at it also engages in tertiary or quaternary packing interactions.

19 rface recognition and favorable intersubunit packing interactions.

20 changes that could be suppressed by crystal packing interactions.

21 vironment appear to be mainly due to crystal packing interactions.

22 terogeneity and often have extensive crystal packing interactions.

23 ments of orientation dependence in molecular packing interactions.

24 gen bonding, buried hydrophobic surface, and packing interactions.

25 sult from signal propagation through crystal packing interactions.

26 , and are more important than specific tight packing interactions.

27 lightly from exact symmetry, possibly due to packing interactions.

28 nal domain, as well as in the inter-filament packing interactions.

29 ared with a region lacking native side-chain packing interactions.

30 transient disruption of lipid and/or protein packing interactions.

31 Likely, strong crystal packing interactions account for this observation.

32 We conclude that AS2/AS2' packing interactions alone can play an important role in

33 Packing interactions also play a significant role in the

34 stabilize the N- and C-terminal interhelical packing interactions also reduce viral infectivity.

35 wever, with additional mutations that affect packing interactions, an IL-8 variant specific for recep

36 imer showed most of the predicted side-chain packing interactions and a main-chain conformation indis

37 egulate receptor function are linked through packing interactions and a network of hydrogen bonds, su

38 Crystal-packing interactions and AlphaFold predictions suggest h

39 re more straightforward to predict than core-packing interactions and can be selected to avoid affect

40 es a further compaction, additional tertiary packing interactions and further uptake of magnesium ion

41 results suggest that a detailed interplay of packing interactions and interactions with water determi

42 e two crystal forms exhibit mostly unrelated packing interactions and local crystallographic disorder

43 as revealed by the unusual crystallographic packing interactions and other biochemical analysis.

44 Fine-tuning of the packing interactions and the final condensation of the s

45 gy function based primarily on Lennard-Jones packing interactions and the Lazaridis-Karplus implicit

46 the structural and energetic basis of helix packing interactions and their role in folding, we prepa

47 lone does not dominate function; helix-helix packing interactions appear to also contribute.

48 ane proteins are more tightly packed and the packing interactions are more diverse than those found i

49 stability of the I form, specific side-chain packing interactions are not.

50 rks of canonical knobs-into-holes side-chain packing interactions are observed at each helical interf

51 are segments of b2 within that region where packing interactions are quite loose.

52 The results demonstrate that crystal packing interactions are the molecular basis for the for

53 s as a homodimer using beta-sheet/beta-sheet packing interactions as observed for several other PAS d

54 where classically described knobs-into-holes packing interactions at interhelical contact surfaces ar

55 nts can be explained primarily by changes in packing interactions at the protein-protein interface.

56 y uncharacterized type of "knobs-into-holes" packing interaction between interfacial Trp side chains,

57 et conformation of the protofilament and the packing interaction between them that underlie the fibri

58 Importantly, we obtained evidence for a packing interaction between Val-335 in M4 and Gln-783 in

59 of the side chain conformation allowing for packing interactions between adjacent helices, which sug

60 t odorant selectivity is controlled by tight packing interactions between an odorant and an odorant r

61 Packing interactions between AQP0 tetramers in the cryst

62 ng to probe the fold within the core and the packing interactions between beta-sheets.

63 ulfonate binding sites and two for examining packing interactions between bound ligands and the bindi

64 lso examined hydrogen bonding and side chain packing interactions between D44 and R55 and between F47

65 show that the structural interplay of helix-packing interactions between HAMP and the adjoining meth

66 r around the active site, a set of conserved packing interactions between helices alpha(2) and alpha(

67 lvent exposure of residue 108 and heightened packing interactions between M108 and helices alpha2, al

68 he hydrophobic effect, hydrogen bonding, and packing interactions between residues in the protein int

69 The study shows that the packing interactions between the alpha2 and alpha1 helic

70 dues are important determinants of conserved packing interactions between the amino- and carboxyl-ter

71 These results identify conserved packing interactions between the N and C helices of gp41

72 es upon complexation and, possibly, enhanced packing interactions between the protein and DNA in the

73 proteins depend in part on a precise set of packing interactions between transmembrane helices.

74 These structures reveal the details of the packing interactions by which the constituent beta-stran

75 ins, detailed structural features, including packing interactions, cannot be designed a priori.

76 pi-pi, Cation-pi, and hydrophobic packing interactions contribute specificity to protein f

77 The large hydrophobic packing interactions contributed by all the helices of b

78 nd AahI and with combining loops involved in packing interactions, denoting expulsion of the bound an

79 the solid state, where a myriad of different packing interactions exist.

80 pairs (UBPs), which rely on hydrophobic and packing interactions for pairing and which are well repl

81 it is the ability to establish differential packing interactions for the helix segments, rather than

82 importance of tyrosine hydrogen-bonding and packing interactions for the stability of FIS and demons

83 Together, helix alpha6 and its packing interactions function as a simple central proces

84 NMR measurements also show that a packing interaction in rhodopsin between Trp265(6.48) an

85 ps underpinning direct carbohydrate-aromatic packing interactions in aqueous solution have been diffi

86 nstead, it comprises in excess of 50% of all packing interactions in crystals of A-form RNA and has a

87 ors are among the most widespread long-range packing interactions in large ribozymes.

88 e the importance of optimizing van der Waals packing interactions in protein design but demonstrate t

89 CH-pi interactions to carbohydrate-aromatic packing interactions in proteins.

90 he asymmetric unit and devoid of significant packing interactions in regions involved in the alloster

91 ary structure (1D/3D) together with pairwise packing interactions in the core (threading).

92 transient disruption of lipid and/or protein packing interactions in the course of particle fusion an

93 Packing interactions in the crystal structure suggest ho

94 strongly suggest that conserved interhelical packing interactions in the F protein fusion core are im

95 strong evidence that conserved interhelical packing interactions in the gp41 core are important dete

96 ts suggest the possibility of non-native B/E packing interactions in the kinetic intermediate.

97 t is noteworthy that one of the intersubunit packing interactions in the MJ0796 crystal involves anti

98 to be primarily the result of the perturbed packing interactions in the native state of the Ile -->

99 dynamics of the side chain as well as on the packing interactions in the solid state of peptides.

100 f 45 transmembrane (TM) helices and 88 helix packing interactions in three independent transmembrane

101 of alpha-helicity and decreased interhelical packing interactions in transmembrane regions are promot

102 Both solution studies and crystal packing interactions indicate that the TRPV2-ARD does no

103 To test the hypothesis that a close-packing interaction involving this patch is important fo

104 Crystal packing interactions involving a highly conserved, expos

105 th the monomer and dimer due to intrahelical packing interactions involving the beta-methyl groups, a

106 , is called into question by the presence of packing interactions involving the Na(+) site and the ac

107 Packing interaction is a critical driving force in the f

108 he overall conclusion is that improvement of packing interactions is a mechanism to confer stability

109 demonstrates that the inclusion of specific packing interactions is necessary for the design of nati

110 re modest and might simply represent crystal packing interactions, it is interesting to speculate tha

111 lex structures are similar, although crystal-packing interactions lead to differences between identic

112 Here, we test whether rigid side-chain packing interactions like those in holomyoglobin persist

113 ion selectivity defects, suggesting that the packing interaction may be conformation-sensitive.

114 Our results also suggest that needle-packing interactions may be different among these bacter

115 These results suggest that crystal packing interactions may influence their stability.

116 s often condensed through long-range helical packing interactions mediated by loop-receptor motifs.

117 cleosome complex consistent with key crystal packing interactions mediated by RCC1.

118 Both end-to-end and end-to-groove packing interactions occur in the crystal lattice, the l

119 is suggests that native-like helix B/helix C packing interactions occur in the folding intermediate.

120 ve and Ag+-sensitive and suggests a possible packing interaction of TMH1 with TMH2 and TMH3.

121 The interfacial elastic packing interactions of different galactosylceramides (G

122 of the Tsr homodimer interact mainly through packing interactions of hydrophobic residues at a and d

123 ture and revealed the importance of nonpolar packing interactions of the fifth sugar.

124 These data together suggest that the packing interactions of the hydrophobic core determine I

125 fibrils is likely the result of stabilizing packing interactions of the protofilaments.

126 can be related to differences in the crystal packing interactions of the two monomers in the asymmetr

127 viding models that delineate potential close packing interactions on the cell surface.

128 gle crystal showing the influence of crystal packing interactions on the course of enzymatic reaction

129 he results reveal the importance of specific packing interactions on the kinetics of amyloid formatio

130 two populations of b subunits with different packing interactions or to helical bending within this r

131 rring in the G/U shallow groove pocket--like packing interactions (P-interactions) and some phosphate

132 In these locations, nonbonded van der Waals packing interactions predominate over hydrogen bonding a

133 rt to successfully capture specific tertiary packing interactions produced specific three-dimensional

134 These altered packing interactions propagated subtle changes between t

135 the stability of the dimer, indicating that packing interactions rather than hydrogen-bonding provid

136 A crystal packing interaction replicates the lateral contacts betw

137 Crystal packing interactions suggest that lattice contacts with

138 These packing interactions suggest that the protofilament subu

139 th the crystal structures found with crystal-packing interactions that are effectively equivalent to

140 apparently reflecting particularly favorable packing interactions that are possible for the most comm

141 side surface of the membrane affects lateral packing interactions that cause perturbations in the org

142 hat A-minor motifs are integral to the helix packing interactions that define the 5'-splice site of t

143 t the design method is sensitive to the core packing interactions that specify the protein structure.

144 rative analysis of the atomic details of the packing interactions that surround the evolutionarily co

145 ink can facilitate the formation of tertiary packing interactions that would otherwise not be possibl

146 rnase; bs, barstar), deletes a van der Waals packing interaction; the second complex, bnLys27-->Ala-b

147 ld focus on the reduction of pai-pai crystal packing interactions to reduce the strong crystalline in

148 Sequence divergence and crystal packing interactions under low pH conditions are likely

149 The data further show that while packing interactions unique to triple and quadruple muta

150 er arises from transient disruption of lipid packing interactions upon disk-to-vesicle fusion.

151 ly disrupting a known and persistent crystal packing interaction, we have crystallized the poliovirus

152 espective of the degree of native side-chain-packing interactions, we anticipate that overpacking rep

153 Aromatic packing interactions were completely lost, although hydr

154 ecific helix-helix contacts via knob-in-hole packing interactions were identified in the adaptation,

155 n close proximity to each other via aromatic packing interactions, whereas the positively charged res

156 pe structure stabilized by aromatic-aromatic packing interactions with extended N- and C-termini.

157 G25A) and to promote native-like hydrophobic packing interactions with helix G (in the mutant H24L/H1

158 al helix is well formed and is stabilized by packing interactions with residues in the hydrophobic co

159 e active site that modify hydrogen bonds and packing interactions with substrate, as well as disrupt

160 e motions, apparently due to modification of packing interactions with the chameleon peptide.

161 the inhibitory helix without perturbing its packing interactions with the ETS domain.

162 s that disrupt side-chain hydrogen bonds and packing interactions with the iNOSox C-terminus (N83, D9

163 ntain a helical conformation even though the packing interactions with the remainder of the protein a

164 ion structures show impressively well-fitted packing interactions, with some regions thoroughly inter

165 whereby stimulus-induced changes in lateral packing interactions within an array of receptor-sensing

166 ns of the substrate protein compete with the packing interactions within the aggregate.

167 Here, we used packing interactions within the core of a protein to sta

168 imic effects, most likely by contributing to packing interactions within the HAMP bundle.

169 the hydrophobic surface of A2AR, increasing packing interactions within the receptor and stiffening

170 ur data suggest that cross-strand side chain packing interactions within the same beta-sheet may play