ライフサイエンスコーパス: painful

1 pain causes a painful stimulus to feel less painful.

2 from strong adhesion is hard, and sometimes painful.

3 uli that reach the brain may be perceived as painful.

4 However, intra-TMJ injections are painful.

5 or inflammation in the area perceived to be painful.

6 t with humans' experience of this drug being painful.

7 characteristics: sensory disturbances at the painful abdominal area (78%), a positive pinch sign (78%

8 twisting, repetitive movements or sometimes painful abnormal postures.

9 postsynaptic current and to the detection of painful acidosis.

10 rgeries associated to a new onset of sudden, painful AHP with normal ocular exam).

11 ough acetaldehyde has been implicated in the painful alcoholic neuropathy, the mechanism by which the

12 repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal d

13 ns of siRNA into skin, though effective, are painful and cover small surface areas and thus are not s

14 inensis, or human Guinea worm (GW), causes a painful and debilitating infection.

15 0%-40% of cases, CHIKV also causes long-term painful and debilitating muscle and joint pain, the path

16 Digital ulcers are a painful and disabling visible manifestation of digital v

17 (and 19 confederates) to equally unpleasant painful and disgusting stimulations, as well as unfair m

18 s have to undergo unnecessary but physically painful and expensive procedure such as prostate biopsie

19 Electrophysiological studies are painful and expensive.

20 as meloxicam, are the mainstay for treating painful and inflammatory conditions in animals and human

21 at risk for postherpetic neuralgia (PHN), a painful and long-lasting complication.

22 The painful and non-painful stimuli can be differentiated ba

23 hese sodium channels have been implicated in painful and painless channelopathies and there has been

24 tion and have been implicated in a number of painful and painless disorders.

25 histopathology of biopsy specimens that are painful and permanently scar.

26 y effective, but streptomycin injections are painful and potentially harmful.

27 the major challenge is that this approach is painful and the effects are restricted to the injection

28 Injury of the tooth pulp is excruciatingly painful and yet the receptors and neural circuit mechani

29 ral mucositis (OM) is among the most common, painful, and debilitating toxicities of cancer regimen-r

30 gioedema (HAE) is associated with recurrent, painful, and potentially lifethreatening attacks charact

31 Moreover, not all tumors are painful, and the occurrence of pain is often unrelated t

32 ith dynamic facial expressions, specifically painful, angry, happy, and neutral facial expressions an

33 epeated intravitreal injections which may be painful, are incompletely efficacious, and represent a s

34 Gout is a painful arthritic inflammatory disease caused by buildup

35 ed orthopedic procedure for the treatment of painful arthritis, osteonecrosis, or fracture.

36 One of the most painful aspects of this pandemic is the irremediable sep

37 uscular hypertonic saline injection) and non-painful (baseline, isotonic saline, post-pain) contracti

38 tional disorders (i.e. interstitial cystitis/painful bladder syndrome and irritable bowel syndrome) a

39 toms characteristic of interstitial cystitis/painful bladder syndrome, which manifests due to cross-s

40 children, who develop symptoms ranging from painful blisters around their mouths and hands to neurol

41 n shown to be effective in the management of painful bone tumors.

42 skin reaction to prolonged sun exposure (for painful burn with blisters vs. practically no reaction,

43 ontact with skin or is ingested, it causes a painful burning sensation.

44 ed contexts with and without the threat of a painful, but tolerable, shock.

45 1.6 years +/- 11.6; range, 24-69 years) with painful calcific tendinopathy diagnosed at US were prosp

46 rma (FNEPPK, OMIM:613000), which each entail painful calluses on palmar and plantar skin.

47 ous cell carcinoma (OSCC) is one of the most painful cancers, which interferes with orofacial functio

48 ous cell carcinoma (OSCC) is one of the most painful cancers.

49 For patients with painful chronic pancreatitis, surgical treatment is post

50 Hidradenitis suppurativa is a painful, chronic inflammatory skin disease with few opti

51 upport its use for patients with established painful CIPN.

52 ctions by herpes simplex viruses (HSV) cause painful cold sores or genital lesions in many people; le

53 2015, the patient experienced relapse, with painful collapse of L3 vertebral body.

54 Patients with painful compared to painless DN, had comparable neurophy

55 scharge rates decreased significantly in the painful condition (baseline vs. pain: 12.7 (1.1) Hz to 1

56 onic disease that results in a disabling and painful condition as it progresses to destruction of the

57 afflicted with shingles risk developing the painful condition of postherpetic neuralgia (PHN), which

58 formation, which has been implicated in the painful condition of postherpetic neuralgia, is regulate

59 nd suggests new strategies for treating this painful condition.

60 (13.4% vs 3.1%), depression (17.3% vs 9.1%), painful conditions (15.4% vs 8.4%) and dyspepsia (10.9%

61 hereas in the Taiwan NDCMP, a combination of painful conditions and alcohol problems had the largest

62 allow the exertion of high forces in acutely painful conditions but could eventually lead to greater

63 The generation of such painful conditions by small quantities of simultaneously

64 Painful conditions contribute to the risk of prescriptio

65 ytic-like and ability to relieve neuropathic painful conditions evaluated in CCI and STZ murine model

66 indicating its benefit in numerous potential painful conditions have increased.

67 Polyneuropathy is one of the most common painful conditions managed within general and specialty

68 Given that other painful conditions of the distal extremities (ie, neurop

69 mal anatomy of the hip and to discuss common painful conditions of the hip that affect the general ad

70 This is found in many painful conditions, particularly arthritis.

71 n low- and high-threshold motor units during painful conditions.

72 Toothache is a common painful consequence of damage to the teeth, particularly

73 Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases

74 n the pain type or underlying mechanism (eg, painful cramps, nociceptive pain, or neuropathic pain).

75 Patients may experience acute painful crises as well as chronic pain.

76 ate of vaso-occlusive crisis, a composite of painful crisis or acute chest syndrome.

77 SCA-related clinical outcome (vaso-occlusive painful crisis, dactylitis, acute chest syndrome, spleni

78 based chemical warfare agent known to induce painful cutaneous inflammation and blistering.

79 its diagnosis suggested by the presence of a painful cutaneous ulcer showing rapid progression.

80 5% of the general population and leads to a painful decrease in joint range of motion (ROM) and loss

81 Pain referred to the perianal region, painful defecation and weight loss have predictive value

82 tivariate regression analysis perianal pain, painful defecation and weight loss were significantly as

83 th a history of lumbar and perineal pain and painful defecation.

84 e density were demonstrated in patients with painful diabetic neuropathy compared with healthy contro

85 Participants who had painful diabetic neuropathy had a higher percentage of n

86 nerve lesions were greater in patients with painful diabetic neuropathy than in those with painless

87 arallel, new guidelines for the treatment of painful diabetic neuropathy using distinct classes of dr

88 elp identify patients with spinally mediated painful diabetic neuropathy who may respond optimally to

89 er of spinal inhibitory dysfunction in human painful diabetic neuropathy.

90 may contribute to the clinical phenotype in painful diabetic neuropathy.

91 ic symptoms and reduced QoL in patients with painful diabetic neuropathy.

92 Painful diabetic peripheral neuropathy (DPN) is difficul

93 rption (TR) in domestic cats is a common and painful disease characterised by the loss of mineralised

94 Endometriosis is a chronic painful disease highly prevalent in women that is define

95 itis (NIU) is an intractable, recurrent, and painful disease that is a common cause of vision loss.

96 Osteoarthritis (OA) is a common, painful disease.

97 s, we included data for non-gastrointestinal painful disorders and specific symptoms of pain, nausea,

98 y of life (QoL) in patients with and without painful DN.

99 received intravenous lidocaine treatment for painful DPN were screened.

100 for individualizing therapy in patients with painful DPN.

101 y cortex and how this relates to the various painful DSP clinical phenotypes.

102 Subjects with painful DSP insensate have the lowest somatosensory cort

103 siological relationship between a clinically painful DSP phenotype and alterations in the somatosenso

104 e, typically presenting with gait ataxia and painful dysaesthesiae in the legs evolving over 2-5 year

105 sed either financial penalty or demonstrably painful electric shock to their co-participant, thereby

106 eural basis as participants learned to avoid painful electric shocks for themselves and a stranger.

107 off decisions combining monetary rewards and painful electric shocks, administered to the participant

108 Participants could administer painful electrical shocks to a 'victim' in exchange for

109 years or younger who received sedation for a painful emergency department procedure were enrolled in

110 ing to blood vessel occlusion accompanied by painful episodes and even death.

111 of limited clinical significance to multiple painful episodes of ureteral obstruction with eventual k

112 s a worldwide hematological disorder causing painful episodes, anemia, organ damage, stroke, and even

113 However, injections are painful, especially considering that they have to be giv

114 Painful events are suggested to elicit two opponent resp

115 Memories of painful events protect us from danger.

116 onal principles by which the brain creates a painful experience from nociception are still unknown.

117 iated with stronger brain responses, whereas painful experiences (e.g., skin punctures, tube insertio

118 Our empirical results show that sharing painful experiences produces "identity fusion" - a visce

119 enucleation or evisceration due to a blind, painful eye.

120 a difficulty disinhibiting attention towards painful faces.

121 tive reversal, such as the "hedonic flip" of painful feelings.

122 r treating chronic gastrointestinal pain and painful FGIDs and serotonin noradrenergic reuptake inhib

123 ts horn bud growth through cauterization, is painful for calves.

124 cancer is cystoscopy, which is invasive and painful for patients.

125 Colonic diverticulitis is a painful gastrointestinal disease that recurs unpredictab

126 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation.

127 y was low for most questions except those on painful gums and tooth mobility.

128 nvestigate the association between FGM/C and painful gynecologic and obstetric complications in women

129 ly screened studies reporting prevalences of painful gynecologic and obstetric sequelae resulting fro

130 tion findings were unremarkable except for a painful hard and fixed mass measuring approximately 5 x

131 e and specific to nociceptive pain, mediated painful heat effects on pain report largely similarly in

132 participants observed a demonstrator undergo painful heat stimulations paired with a "control" cream

133 ned pain-predictive cues before experiencing painful heat.

134 direction for development of treatments for painful herpes zoster.

135 y inform development of novel treatments for painful herpes zoster.

136 is the modality of choice for investigating painful hip conditions due to its multiplanar capability

137 tial modality used to evaluate patients with painful hip joints.

138 hanisms and treatment.SIGNIFICANCE STATEMENT Painful HIV-associated sensory neuropathy is a neurologi

139 Mast cells were upregulated in painful human IVD tissue and induced an inflammatory, ca

140 a differential ability of painful versus non-painful human schwannomatosis tumor cells to secrete fac

141 sium channels, a potential mechanism for the painful hypersensitivity (that we term "noxacusis" to di

142 , whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK an

143 studied the role of IKD in damage-triggered painful hypersensitivity to innocuous cold.

144 of immune cells that naturally accumulate in painful inflamed areas.

145 umatoid arthritis (RA) is a debilitating and painful inflammatory autoimmune disease characterised by

146 Acute pancreatitis (AP) is a painful inflammatory disorder of the exocrine pancreas,

147 reatment of acute gout flare, alleviates the painful inflammatory response to MSU crystals.

148 Arsenicals are painful, inflammatory and blistering causing agents deve

149 and the same motor units were tracked across painful (intramuscular hypertonic saline injection) and

150 Painful IVD degeneration is associated with an acidic in

151 Degeneration is a hallmark of painful joint disease and is mediated by many proteases

152 Clinical studies in individuals with painful knee and hip osteoarthritis have revealed that N

153 w decreased attention to some stimuli on the painful limb and increased attention to others, a parado

154 spasticity after nervous system injuries and painful low back spasm affect more than 10% of global po

155 enting with regular menses, dysmenorrhea and painful lump in hypogastric region on the left side of m

156 nce, the molecular mechanisms underlying the painful manifestations of PN are poorly understood, and

157 how somatosensory neurons transduce acutely painful mechanical forces is largely unknown and remains

158 emales; median age, 58 years) diagnosed with painful meningoradiculitis (Bannwarth syndrome) who were

159 escents and young women, is characterized by painful menstrual cramps.

160 monitor their own actions in order to avoid painful mistakes, which are often associated with harsh

161 f traumatic peripheral nerve injury, causing painful mononeuropathy.

162 a brain disorder causing involuntary, often painful movements.

163 Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are depe

164 type 2 (n = 86) diabetes were evaluated with painful (n = 64), painless (n = 37), or no (n = 30) DPN.

165 30 controls and patients with painful (n = 78) and painless (n = 62) DN underwent asse

166 Trigeminal neuralgia is a very painful neurological condition with severe, stimulus-evo

167 tween all CCM parameters and the severity of painful neuropathic symptoms, depression score and QoL.

168 or sources of disability and often result in painful neuropathies or the impairment of muscle movemen

169 at the extreme, viral infections can induce painful neuropathies that can last for decades.

170 levels can contribute to the development of painful neuropathies.

171 D in diabetic rodents exhibiting features of painful neuropathy and the translational potential of th

172 al of modulating NK cell function to resolve painful neuropathy through the clearance of partially da

173 ility and familial episodic pain disorder or painful neuropathy, while mutations evoking larger membr

174 ronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predo

175 somatosensory neurons that are activated by painful (noxious) stimuli.

176 odynia - the misperception of light touch as painful - occurs when inhibition is compromised.

177 ations paired with a "control" cream and non-painful ones paired with a "treatment" cream, which actu

178 communication, neurons specialized to detect painful or otherwise noxious stimuli can respond to bact

179 Painful or threatening experiences trigger escape respon

180 ffects millions of people worldwide, causing painful oral and genital lesions, in addition to a multi

181 vestigate the histopathology associated with painful oral cancers in a preclinical model.

182 phigus vulgaris, which often originates with painful oral erosions, and pemphigus foliaceus, which is

183 mon candidal infection that may give rise to painful oral symptoms, as well as be a reservoir for inf

184 In this study, we observed that specific painful outcomes are significantly more common in partic

185 als refraining from actions that resulted in painful outcomes, whereas others favor actions that help

186 with distinct forms of striatal responses to painful outcomes.

187 Painful palmar-plantar keratoderma (PPK) severely impair

188 he likelihood that external events evoke the painful paroxysm typical of this condition.

189 ed frontolateral theta-band connectivity for painful percepts.

190 widely used chemotherapeutic agent, produces painful peripheral neuropathy.

191 rmatoses presenting with variable degrees of painful phototoxicity that markedly affects quality of l

192 ensitivity thresholds to painful thermal and painful pressure stimulation.

193 Surgery and painful procedural interventions in vulnerable preterm n

194 Observation Tool scores between baseline and painful procedures (mean difference, 3.13 +/- 1.56; p <

195 s of gestation) are exposed to stressful and painful procedures during neonatal intensive care.

196 Procedural sedation for children undergoing painful procedures is standard practice in emergency dep

197 gesics to treat pain in their children after painful procedures.

198 ation treatment, she experienced progressive painful pruritic breast fullness, skin dimpling, and ski

199 o a PTM or radiotherapy was development of a painful PTM within the radiotherapy field that required

200 The most common clinical symptoms were painful radiculitis (65.9%), cranial nerve palsy (43.4%)

201 ms is key for developing therapies to reduce painful recovery times for nerve-injury patients, by acc

202 The procedure is painful, requiring local anaesthetic, and is less effect

203 56), asthma (OR 1.23, 95% CI 1.06-1.44), and painful respiration (OR 1.28, 95% CI 1.14-1.44).

204 The outcome of interest was painful response measured through tactile, cold, and air

205 of weight-loss, fatigue, hematuria, dysuria, painful right inguinal ulceration, and right scrotal abs

206 nts, characterized by an intense, unpleasant/painful sensation occurring rapidly and reproducibly in

207 e response of the esophagus is an unpleasant/painful sensation, unrelated to dysphagia, occurring imm

208 Molecules that initiate painful sensations are intensively sought as therapeutic

209 h compromised or exaggerated TRPA1-dependent painful sensations in the skin.

210 decrease in frontoparietal connectivity for painful sensations was also identified in the gamma-band

211 Symptoms include painful sensations, an urge to move and involuntary leg

212 Why some individuals develop an acute painful sensory neuropathy on sustained cold exposure is

213 amily with a dominantly inherited late-onset painful sensory neuropathy.

214 r damage is associated with the evolution of painful sensory symptoms in diabetic polyneuropathy.

215 es describing the incidence or prevalence of painful sequelae associated with FGM/C.

216 ensitive sensory neurons: G1662S reported in painful SFN; and T790A, which underlies increased pain b

217 h encountering either sucrose, cocaine, or a painful shock-delivering object.

218 induced maladaptive attractions, even to the painful shock-rod, recruit mesocorticolimbic incentive-r

219 essing during anticipation of unpredictable, painful shock.

220 flammation, with symptoms defining the acute painful sickle-cell crisis.

221 Patients showed inattention to the painful side for visual processing of body parts but not

222 Peripheral neuropathy is a debilitating and painful side-effect that can severely impact an individu

223 tosis that presents with rapidly developing, painful skin ulcers hallmarked by undermined borders and

224 Painful small fiber neuropathy (SFN) may be caused by ga

225 ritable pain disorders, and in patients with painful small-fibre neuropathy.

226 perature range for classifying a stimulus as painful, specifically through a lowering of pain thresho

227 heumatoid arthritis (RA) is characterised by painful, stiff and swollen joints.

228 Uncontrollable, compared with controllable, painful stimulation can lead to increased pain perceptio

229 After tissue damage, sensitivity to painful stimulation develops in undamaged areas (seconda

230 Processing of painful stimulation occurs in the dorsal horn (DH), an a

231 ual sensitivity to pain without applying any painful stimulation, as might be valuable in patients wh

232 annels in sensory neurons are integrators of painful stimuli and heat, yet how they integrate diverse

233 The painful and non-painful stimuli can be differentiated based on their sig

234 We hypothesized that early exposure to painful stimuli during a period of rapid brain developme

235 96 male human participants learned to avoid painful stimuli either for themselves or for another ind

236 itive teeth were tested using nonpainful and painful stimuli in a clinical setting.

237 es autonomic cardiovascular responses during painful stimuli in humans.

238 hat peripheral nerves were more sensitive to painful stimuli in Neanderthals than in modern humans.

239 sential role in initiating pain by detecting painful stimuli in the periphery.

240 cts on pain inhibition, in which response to painful stimuli is reduced by subsequent non-painful sti

241 g some patients with the ability to localize painful stimuli or to fixate on or track visual stimuli.

242 By contrast, responses to painful stimuli remained unaltered.

243 especially important to do in the context of painful stimuli since most animals in these studies cann

244 a nonselective cationic channel activated by painful stimuli such as capsaicin and noxious heat, and

245 al transducers of sensory stimuli, including painful stimuli, from the periphery to central sensory a

246 ot ganglion neurons specialized in detecting painful stimuli, termed nociceptors.

247 and weak pain signals; however, upon strong painful stimuli, the recruitment of endogenous opioids w

248 ns, and on adult DRG neuron sensitization to painful stimuli.

249 neurons specialized in detecting noxious and painful stimuli.

250 painful stimuli is reduced by subsequent non-painful stimuli.

251 vation is believed to reduce transmission of painful stimuli.

252 nurses at baseline and after nonpainful and painful stimuli.

253 he transduction and transmission of noxious (painful) stimuli and innocuous stimuli that do not reach

254 In visceral organs of mammals, most noxious (painful) stimuli as well as innocuous stimuli are detect

255 ch as walking or withdrawing the limb from a painful stimulus rely upon integrative multimodal sensor

256 analgesia, where expecting low pain causes a painful stimulus to feel less painful.

257 ecies related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, p

258 Most of these pigs routinely undergo painful surgical procedures (surgical castration, tail d

259 ogy department for neck ultrasound (US) with painful swelling in the right parotid gland region.

260 n presented to the emergency department with painful swelling of the third finger on her right hand,

261 that conditioned medium (CM) collected from painful SWN tumors, but not that from nonpainful SWN tum

262 chronic autoimmune disease characterized by painful swollen joints and significant disabilities.

263 ammatory autoimmune disease characterized by painful, swollen joints that can severely impair physica

264 Spasticity is a painful symptom and can severely restrict everyday life,

265 Painful symptomatology was reported less frequently in t

266 d The pathophysiologic mechanisms underlying painful symptoms in diabetic polyneuropathy (DPN) are po

267 Neuropathy (DPN) typically is accompanied by painful symptoms.

268 cystic duct and sphincter of Oddi can cause painful syndromes is attractive and popular, at least in

269 aV1.7 subunit found in patients with chronic painful syndromes, by the implementation of a dedicated

270 ental pain sensitivity to risk of developing painful temporomandibular disorder (TMD).

271 to identify risk factors for development of painful temporomandibular disorder (TMD).

272 randomized controlled trial of patients with painful temporomandibular disorder (TMD).

273 AL was lower than a single RBL, HAL was more painful than RBL.

274 Stapled haemorrhoidopexy was less painful than traditional excisional surgery in the short

275 ention session via sensitivity thresholds to painful thermal and painful pressure stimulation.

276 ng memory task (2-back task) while receiving painful thermal stimulations.

277 markedly reduced when participants received painful thermal stimuli following hypnotic analgesia on

278 integration mechanism is sufficient to evoke painful thermal TCE, an essential step in transforming t

279 of pressure or friction become inflamed and painful, thus significantly impacting quality of life.

280 injury was strongly associated with elevated painful TMD risk, and the risk was amplified in subjects

281 CL, 3.4,25.6) predicted greater incidence of painful TMD than events perceived as noninjurious (IOR =

282 Injury-associated risk of painful TMD was elevated in people with high sensitivity

283 Injury and subsequent onset of painful TMD were monitored prospectively for <=5 y in a

284 Study examiners classified incident painful TMD, yielding 233 incident cases and 176 matched

285 ation between injury and subsequent onset of painful TMD.

286 PPERA) nested case-control study of incident painful TMD.

287 ransmit information about both innocuous and painful touch and inhibitory populations that serve as a

288 ly-life experiences (e.g., supportive versus painful touch) interact to shape the development of the

289 In 22 subjects with painful trigeminal neuropathy and 44 pain-free controls,

290 , or the ventral trigeminothalamic tracts in painful trigeminal neuropathy subjects compared with con

291 As a response to painful trigeminal stimulation, activation of the hypoth

292 re also detected at higher levels in CM from painful tumors.

293 ciated stimulus (reliefCS) presented after a painful US was varied from immediately (Study1), 3 secon

294 of the relief following the termination of a painful US.

295 ited blood disorder that is characterized by painful vaso-occlusive crises, for which there are few t

296 Painful vaso-occlusive crisis (VOC) is the most common c

297 r data demonstrate a differential ability of painful versus non-painful human schwannomatosis tumor c

298 ve and therapeutic approaches to combat this painful viral disease in humans.

299 ost-operative-day, she presented with sudden painful, visual loss.

300 ent pain perception in humans, we contrasted painful with nonpainful sensations delivered at the indi