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1 presentative CRM confirmed that a conserved, palindromic Alx1-binding site was essential for expressi
2 in Escherichia coli, or Sae2 in eukaryotes, palindromic amplifications arise and propagate in cells.
4 uity at the central nucleotide in the pseudo-palindromic cis-element CAATNATTG that is recognised by
5 ts(7-9), and it has been suggested that this palindromic consensus arises as a consequence of the str
9 within the 5'-leader of the RNA, including a palindromic dimer initiation signal (DIS) that has been
10 e state the genome remains a monomer, as the palindromic dimerization initiation site (DIS) is seques
11 of DNA libraries enriched with tumor-derived palindromic DNA (Genome-wide Analysis of Palindrome Form
12 ssor and two complexes each bound to a 20-bp palindromic DNA duplex containing its consensus operator
19 ough the mechanism that repeatedly generates palindromic DNA, such as Breakage-Fusion-Bridge cycles.
20 y shift assays, and we identified a specific palindromic DNA-binding site 5'-TTGATN4ATCAA-3' in these
21 o)2 (Chro = chromomycin A3) to stabilize the palindromic duplex d(TTGGCGAA) DNA with two G:G mismatch
22 , a mechanism characterized by the inverted (palindromic) duplication of genomic segments, in HER2-po
23 e IIP restriction endonuclease, recognizes a palindromic eight base pair (bp) symmetric sequence, 5-A
24 lemented FimA variants with reversed, pseudo-palindromic extensions, we demonstrate that the high sta
25 s GRIP1 toward GR binding sites dominated by palindromic GC response elements (GRE), suggesting a non
27 he ERBB2 oncogene at 17q12 is susceptible to palindromic gene amplification, a mechanism characterize
29 MITF bound to the CLEAR-box reveals how the palindromic nature of this motif induces symmetric MITF
30 e as a consequence of the existence of a non-palindromic nucleotide motif that occurs in approximatel
31 el electrophoresis and repetitive extragenic palindromic-PCR), multilocus sequence type (MLST) analys
33 thwart clustered regularly interspaced short palindromic repeat (CRISPR) adaptive immune systems.
34 as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protei
35 /Cas9 (clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome
41 tly, pooled clustered regularly interspersed palindromic repeat (CRISPR) mutagenesis screens of nonco
42 e-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen that a total of 273 g
43 e-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen, we identified key pa
44 he bacterial clustered regularly interspaced palindromic repeat (CRISPR) system and its subsequent ad
45 type V clustered regularly interspaced short palindromic repeat (CRISPR) system with both RNase and D
46 ryotic clustered regularly interspaced short palindromic repeat (CRISPR) system, recently harnessed f
47 ntly, clustered regulatory interspaced short palindromic repeat (CRISPR)-associated protein (Cas) (CR
48 ent of clustered regularly interspaced short-palindromic repeat (CRISPR)-based biotechnologies has re
49 ogy to clustered regularly interspaced short palindromic repeat (CRISPR)-based knockout by analysis o
53 e II clustered, regularly interspaced, short palindromic repeat (CRISPR)-Cas9 nucleases, along with t
54 lls by clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 revealed that it is ess
55 sing a clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system and measured the
56 used a clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 technology, gene-specif
57 using clustered regularly interspaced short palindromic repeat (CRISPR)-caspase 9 (Cas9) gene-editin
58 ryotic clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated (Cas) immu
59 using clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated protein 9
60 pe III clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) syst
61 The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas
62 uch as clustered regularly interspaced short palindromic repeat (CRISPR)-derived genome editing provi
63 using clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene editing and ac
64 llular clustered regularly interspaced short palindromic repeat (CRISPR)/Cas loci and dual viral and
66 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
67 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
68 n with clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
69 The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
70 ent of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9
71 evelop clustered regularly interspaced short palindromic repeat interference (CRISPRi) to repress gen
72 tance, clustered regularly interspaced short palindromic repeat technology was used to create EPHA5-d
73 RISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront o
74 RISPR (Clustered Regularly Interspaced Short Palindromic Repeat) machinery, have paved the way for th
75 RISPR (clustered regularly interspaced short palindromic repeat) systems have been broadly adopted fo
76 RISPR (clustered regularly interspaced short palindromic repeat)-associated Cas proteins have recentl
77 RISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR associated protein 9) k
78 RISPR (clustered regularly interspaced short palindromic repeat)/Cas9 editing (including regional del
79 RISPR (clustered regularly interspaced short palindromic repeat)/Cas9-mediated genome editing coupled
80 aCas9 (clustered regularly interspaced short palindromic repeat-associated 9 from Staphylococcus aure
83 ied by clustered regularly interspaced short palindromic repeat-Cas9 (CRISPR-Cas9) to determine wheth
85 ans of clustered regularly interspaced short palindromic repeat/CRISPR-associated 9 gene editing elic
86 used clustered regularly interspersed short palindromic repeat/CRISPR-associated nuclease 9 to gener
87 y, the clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR-associated nucleas
88 work, clustered regularly interspaced short palindromic repeats (CRISPR) /CRISPR associated protein
90 termed clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas)
91 we use clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated prote
92 n vivo clustered regularly interspaced short palindromic repeats (CRISPR) and RNA interference (RNAi)
94 used a clustered regularly interspaced short palindromic repeats (CRISPR) approach and created a LNJ-
95 ons of clustered regularly interspaced short palindromic repeats (CRISPR) as an accurate gene editing
99 geting clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas13a (previously
100 ughput clustered regularly interspaced short palindromic repeats (CRISPR) engineering and GPCR ligand
101 at the clustered regularly interspaced short palindromic repeats (CRISPR) genes as well as several hy
102 e-wide clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi) scre
103 -scale clustered regularly interspaced short palindromic repeats (CRISPR) knockout or activation (CRI
105 e-wide clustered regularly interspaced short palindromic repeats (CRISPR) loss-of-function screen for
107 ugh a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochon
108 -scale clustered regularly interspaced short palindromic repeats (CRISPR) screening in 3D lung cancer
109 e-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endoc
110 ltiple clustered regularly interspaced short palindromic repeats (CRISPR) single guide RNAs (sgRNAs)
111 A) and clustered regularly interspaced short palindromic repeats (CRISPR) studies did not reveal any
112 terial clustered regularly interspaced short palindromic repeats (CRISPR) system for genome editing i
113 The clustered regularly interspaced short palindromic repeats (CRISPR) system, an immune system an
114 using clustered regularly interspaced short palindromic repeats (CRISPR) techniques in human excitat
116 ionary Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology holds enormous p
117 t uses clustered regularly interspaced short palindromic repeats (CRISPR) technology to enable the di
119 e used clustered regularly interspaced short palindromic repeats (CRISPR) to knock out two key genes
123 ryotic clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 (Cas9) endonuc
125 diated clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease (Ca
126 hod is Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated nuclease (Cas)-b
127 ics of clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9)
128 lease termed clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9)
129 The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated protein Cas9 fro
130 using clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein-9 nuclea
131 sed on clustered regularly interspaced short palindromic repeats (CRISPR)-associated proteins (Cas) t
132 s, and clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing to chara
133 ons of clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing can be
135 ised a clustered regularly interspaced short palindromic repeats (CRISPR)-based tissue-specific knock
136 The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas nuclease system is a po
139 by the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 method caused profound
140 s) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nucleases are the most
141 RA), a clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 platform for in situ h
142 by the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system and a transposo
143 er the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system to the mdx mous
145 using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, sensitized P9 pups to
146 ins by clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9-mediated homology-dire
149 The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cpf1 system has been succes
150 ial of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9
151 on and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9
152 terial clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) sys
153 e-wide clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9
154 ats by clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9
155 on and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9
156 ced by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-Associated Protein 9
157 use of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9
158 er via clustered regularly interspaced short palindromic repeats (CRISPR)-enzymatically inactive Cas9
159 lasts, clustered regularly interspaced short palindromic repeats (CRISPR)-generated mutant fetal kera
160 eloped clustered regularly interspaced short palindromic repeats (CRISPR)-mediated base editing to en
161 ition, clustered regularly interspaced short palindromic repeats (CRISPR)-mediated knockout of FABP4
162 ncy of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated mutagenesis in pla
163 wn and clustered regularly interspaced short palindromic repeats (CRISPR)-mediated transcriptional ac
165 of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a (Cpf1) system, have
166 first clustered regularly interspaced short palindromic repeats (CRISPR)/Cas13a-powered microfluidic
167 using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and non-homologous end
168 cells using Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 did not abolish the in
169 r with clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing can knock
170 on and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing in RGCs i
171 ed the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing system to
172 nd the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, are systematiz
173 eloped clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology to knock ou
174 ingly, clustered regularly-interspaced short palindromic repeats (CRISPR)/Cas9-mediated deletion of t
175 one by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated editing rescu
176 cus by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editin
177 The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR associated (Cas)9 pr
178 plying clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9
179 The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) nuc
180 The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) sys
181 plexed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas9) sy
182 nd the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9)
183 The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
184 ted by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
185 on and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
187 sing a clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
188 e used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9
189 based, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9
190 using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9
191 ng the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9
192 -3 via clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9
193 r nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins
194 es for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-Associated-9 (Cas9)-
196 d with clustered regularly interspaced short palindromic repeats (CRISPR-Cas9)-mediated gene editing.
197 ) or clustered, regularly interspaced, short palindromic repeats (CRISPR/Cas9), resulted in a much gr
198 ms use Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas
199 ) with clustered regularly interspaced short palindromic repeats (CRISPRs) and the CRISPR-associated
200 Clustered, regularly interspaced, short palindromic repeats - CRISPR-associated (CRISPR-Cas) sys
201 erapy, clustered regularly interspaced short palindromic repeats -based genetic editing systems, immu
202 Mammalian sex chromosomes contain multiple palindromic repeats across the non-recombining region th
203 ces in clustered regularly interspaced short palindromic repeats and clustered regularly interspaced
204 y of clustered, regularly interspaced, short palindromic repeats and the Cas9 RNA-guided nuclease (CR
205 with some variant of the phrase "these short palindromic repeats and their associated endonucleases (
208 PRLR (clustered regularly interspaced short palindromic repeats or small hairpin RNA), were incubate
210 didate clustered regularly interspaced short palindromic repeats regions from bacterial genomic or me
213 lowing clustered regularly interspaced short palindromic repeats with Cas9 (CRISPR-Cas9)-mediated kno
214 term 'clustered regularly interspaced short palindromic repeats' (CRISPR) has recently become synony
215 RISPR (clustered regularly interspaced short palindromic repeats) and the nearby Cas (CRISPR-associat
216 RISPR (clustered regularly interspaced short palindromic repeats) and then transplanted back into the
217 RISPR (clustered regularly interspaced short palindromic repeats) array locus in a C. coli isolate.
218 RISPR, clustered regularly interspaced short palindromic repeats) gene editing system often require v
219 RISPR, Clustered Regularly Interspaced Short Palindromic Repeats) has revolutionized various fields o
220 RISPR (clustered regularly interspaced short palindromic repeats) immune system has been adapted for
221 RISPR (clustered regularly interspaced short palindromic repeats) knockouts of individual 15q13.3 mic
222 RISPR (clustered regularly interspaced short palindromic repeats) loci and their associated (cas) gen
223 RISPR (clustered regularly interspaced short palindromic repeats) mechanism allows bacteria to adapti
224 RISPR (clustered regularly interspaced short palindromic repeats) repair and demonstrated a rescue of
225 RISPR (clustered regularly interspaced short palindromic repeats) RNA (tracrRNA)-independent CRISPR-C
226 RISPR (clustered regularly interspaced short palindromic repeats) system protects archaea and bacteri
227 RISPR (clustered regularly interspaced short palindromic repeats) systems that serve as defence mecha
228 RISPR (clustered regularly interspaced short palindromic repeats) technology for therapeutic applicat
229 SPR (clustered, regularly interspaced, short palindromic repeats) to build mapping panels with target
230 RISPR (clustered regularly interspaced short palindromic repeats)-associated (Cas) protein Cas9 begin
231 RISPR (clustered regularly interspaced short palindromic repeats)-based genome editing technology is
233 RISPR (clustered regularly interspaced short palindromic repeats)-based screening system for combinat
234 PR (clustered, regularly, interspaced, short palindromic repeats)-Cas (CRISPR-associated) systems as
235 RISPR (clustered regularly interspaced short palindromic repeats)-Cas-mediated adaptive immune system
237 SPR (clustered, regularly interspaced, short palindromic repeats)-Cas9 targeting to delete DNA region
238 RISPR (clustered regularly interspaced short palindromic repeats)-have opened novel avenues to experi
239 RISPR (clustered regularly interspaced short palindromic repeats)-induced deletion of the NBM-encodin
240 RISPR (clustered regularly interspaced short palindromic repeats)-mediated genome editing on dystroph
241 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated gene 9) sys
242 ISPR (clustered regularly interspersed short palindromic repeats)/Cas9 (CRISPR-associated protein 9)
243 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9)
244 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9)
245 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 depletion of the CoREST core m
247 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 system, first identified in ba
249 RISPR (clustered regularly interspaced short palindromic repeats)/Cas9 to introduce indels in exon 3
250 SPR (clustered, regularly interspaced, short palindromic repeats)/CRISPR-associated protein 9 (Cas9)
251 es and clustered regularly interspaced short palindromic repeats, provide a platform to delete endoge
252 ts and clustered regularly interspaced short palindromic repeats-associated 9 technology, the impact
253 guided clustered regularly interspaced short palindromic repeats-associated protein 9 endonuclease-me
254 epeats/clustered regularly interspaced short palindromic repeats-associated protein 9 gene editing.
255 epeats/clustered regularly interspaced short palindromic repeats-associated protein 9 genome editing
256 used clustered, regularly interspaced, short palindromic repeats-associated protein 9 to introduce a
257 -Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) genome editing
258 es, or clustered regularly interspaced short palindromic repeats-based nucleases) raise prospects for
259 ons of clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) and transposon ve
261 /Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR associated protein 9) system
262 -Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated 9) system, transcr
263 geting clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Ca
264 ion of clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins (CRISPR-C
265 R-Cas (Clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) is a pro
266 uch as clustered regularly interspaced short palindromic repeats/Cas9 and effecting alterations in pr
268 e used clustered regularly interspaced short palindromic repeats/Cas9-mediated genomic modification t
269 /Cas9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced shor
270 using clustered regularly interspaced short palindromic repeats/clustered regularly interspaced shor
271 ts and clustered regularly interspaced short palindromic repeats/clustered regularly interspaced shor
272 /Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9) gene-ed
273 of the clustered regularly interspaced short palindromic repeats/CRISPR-associated (CRISPR/Cas) syste
274 using Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated gene9 (CRISPR/Cas9
275 NA and clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/
276 gence of new clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9 (CRISPR/
277 ng the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/
278 The clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/
279 /Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) genome
280 -Cas9 (clustered regularly-interspaced short palindromic repeats/CRISPR-associated protein 9) to corr
281 CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9)-based D
282 CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated) homology-directed
283 RISPR [clustered regularly interspaced short palindromic repeats]/Cas9 [CRISPR-associated protein 9])
284 In this Review, we explore the concept of palindromic rheumatism as part of the RA continuum and p
285 hermore, the pattern of inflammation seen in palindromic rheumatism has interesting parallels with th
286 The observation that most patients with palindromic rheumatism have RA-related autoantibodies an
289 d that many eventually develop RA has led to palindromic rheumatism often being viewed as a relapsing
290 ever, the clinical and imaging phenotypes of palindromic rheumatism suggest important distinctions fr
291 P restriction endonuclease AgeI recognizes a palindromic sequence 5-A/CCGGT-3 and cuts it ('/' denote
292 e site-specific m6A modifications in the non-palindromic sequence GACGmAG within the genomes of Bacil
293 The Nte of FimA, which exhibits a pseudo-palindromic sequence, is inserted in an antiparallel ori
294 fically recognize the 5'-TTGTACAN6AGTACAA-3' palindromic sequence, resulting in transcriptional repre
295 Our results also showed that the pseudo-palindromic sequences of the donor strands in all FimA p
298 Here we present the first evidence of large palindromic structures in a plant sex chromosome, based