ライフサイエンスコーパス: palmitoleate

1 nduced M1-like polarization by administering palmitoleate.

2 a large hydrophobic pocket that accommodates palmitoleate.

3 ention studies that target circulating trans-palmitoleate.

4 ing by mediating the removal of an essential palmitoleate.

5 rinsically greater production and release of palmitoleate.

6 ning systemic concentrations of the lipokine palmitoleate.

7 alterations characterized by an increase in palmitoleate.

8 d in beta-cells exposed to palmitate but not palmitoleate.

9 esence of a buried 16-carbon fatty acid, cis-palmitoleate.

10 s repressed by treatment with oleate but not palmitoleate.

11 Palmitoleate (16:1(9Z)) is a major mammalian skin-produc

12 e oleate (18:1Delta9) were nontoxic, whereas palmitoleate (16:1Delta9) was a potent growth inhibitor.

13 release of the insulin-sensitizing lipokine palmitoleate (16:1n-7).

14 ty acids (MUFAs), mainly oleate (18:1n9) and palmitoleate (16:1n7) from saturated fatty acids (SFA),

15 ied 167 yeast mutants as sensitive to 0.5 mm palmitoleate, 45% of which define pathways that were con

16 o WNT7A, presumably via its covalently bound palmitoleate, a modification that is common to all WNTs

17 ction of active Wnt depends on attachment of palmitoleate, a monounsaturated fatty acid, to a conserv

18 synthesis of the monounsaturated fatty acids palmitoleate and oleate.

19 ependent determinants of plasma phospholipid palmitoleate and relations of palmitoleate with metaboli

20 c hypertrophy involving the lipokine C16:1n7 palmitoleate as a molecular co-mediator.

21 filing also led to identification of C16:1n7-palmitoleate as an adipose tissue-derived lipid hormone

22 The appearance of palmitoleate at 12 degrees C is accompanied by a decline

23 50BM3 (residues 73-84) which participates in palmitoleate binding was subjected to scanning chimerage

24 esize the monounsaturated fatty acids (MUFA) palmitoleate (C(16:1)) and oleate (C(18:1)), both of whi

25 The equivalent value for palmitoleate (C16:1 cis) was 3.1.

26 Post-translational attachment of palmitoleate (C16:1) to a conserved Ser in Wnt proteins

27 rated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane p

28 uced uniformly labeled palmitate (C16:0) and palmitoleate (C16:1).

29 statistically significant declines in muscle palmitoleate CoA (16:1), oleate CoA (18:1), or total LCA

30 trans-Palmitoleate concentrations correlated positively with s

31 After multivariable adjustment, trans-palmitoleate concentrations were associated with higher

32 tors and other potential confounders, higher palmitoleate concentrations were independently associate

33 anges-are associated with higher circulating palmitoleate concentrations.

34 h independent lifestyle correlates of higher palmitoleate concentrations.

35 d palmitoylated proteins to their respective palmitoleated derivatives.

36 Interestingly, cells treated with palmitoleate exerted a sustainable level of cIAP1, where

37 two monounsaturated fatty acids, oleate and palmitoleate, from the saturated fatty acids stearate an

38 ignaling through deacylation of an essential palmitoleate group on Wnt proteins.

39 ignaling through the removal of an essential palmitoleate group.

40 ndently related to plasma phospholipid trans-palmitoleate; how trans-palmitoleate related to major me

41 c electron microscopy (cryo-EM) structure of palmitoleated human WNT8A in complex with WLS.

42 c electron microscopy (cryo-EM) structure of palmitoleated human WNT8A in complex with WLS.

43 the independent determinants of circulating palmitoleate in free-living humans and whether palmitole

44 lipid profiles also displayed an increase in palmitoleate in HFD-Tg mice compared with controls.

45 The replacement of laurate with palmitoleate in lipid A may reflect the desirability of

46 type E. coli grown at 12 degrees C contained palmitoleate in place of laurate, whereas the lipid A of

47 While both palmitate and palmitoleate induced an overt ER stress response, lipoto

48 m L6 myotubes treated with palmitate-but not palmitoleate-induced THP1 monocyte migration across tran

49 Strains lacking lpxP fail to incorporate palmitoleate into their lipid A at 12 degrees C but make

50 Circulating trans-palmitoleate is associated with higher LDL cholesterol b

51 Circulating trans-palmitoleate is associated with lower insulin resistance

52 Palmitoleate is not present in lipid A isolated from Esc

53 lmitoleate in free-living humans and whether palmitoleate is related to lower metabolic risk and the

54 Circulating palmitoleate is robustly associated with multiple metabo

55 In consonance, the serum C16:1n7 palmitoleate level exhibited a significantly positive co

56 Higher trans-palmitoleate levels were associated with slightly lower

57 s most strongly associated with higher trans-palmitoleate levels.

58 The carboxylesterase Notum hydrolyzes a palmitoleate moiety from Wingless/Integrated(Wnt) ligand

59 a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitut

60 Among them are Wnt proteins, which carry a palmitoleate moiety that is essential for signalling act

61 tricts Wg signaling by cleaving an essential palmitoleate moiety.

62 We identified methyl palmitoleate (MPO), methyl oleate, and methyl palmitate

63 Transfer of palmitate, palmitoleate, or R-3-hydroxymyristate was very slow.

64 y compared to pre-surgery levels: myristate, palmitoleate, palmitate, linoleate, oleate, stearate and

65 Notably, 6-h incubation with palmitoleate (PO) reversed the proinflammatory gene expr

66 of these fragments were shown to bind in the palmitoleate pocket of Notum.

67 obic cavity in the GPCR-like domain, and the palmitoleate protrudes between two helices into the bila

68 a phospholipid trans-palmitoleate; how trans-palmitoleate related to major metabolic risk factors; an

69 major metabolic risk factors; and how trans-palmitoleate related to new-onset diabetes (304 incident

70 in vitro primary GC cultures with palmitate, palmitoleate, stearate, oleate, linoleate, and alpha-lin

71 ing endogenously synthesized oleate, but not palmitoleate, suggesting a clear mTORC1-mediated regulat

72 ) is a membrane-bound O-acyltransferase that palmitoleates the Wnts and hence is essential for their

73 Palmitoleate, the other main unsaturated fatty acid of S

74 dipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regu

75 ongates the 16 carbon unsaturated acyl chain palmitoleate to the 18 carbon unsaturated acyl chain, ci

76 Emerging evidence suggests that trans-palmitoleate (trans 16:1n-7), a fatty acid in dairy and

77 (15:0), heptadecanoic acid (17:0), and trans palmitoleate (trans 16:1n-7), were associated with lower

78 Trans-palmitoleate (trans-16:1n-7) represents a distinctly exo

79 d cells to death in response to the nontoxic palmitoleate treatment.

80 The mean (+/- SD) palmitoleate value was 0.49 +/- 0.20% (range: 0.11-2.55%

81 Trans-palmitoleate was also associated with a substantially lo

82 However, palmitoleate was also associated with higher triglycerid

83 In prospective analyses, trans-palmitoleate was independently associated with lower inc

84 Palmitoleate was not significantly associated with incid

85 required for the biosynthesis of oleate and palmitoleate, which are the major monounsaturated fatty

86 WNTs are modified with palmitoleate, which is critical for binding Frizzled (FZ

87 We investigated the association of trans-palmitoleate with metabolic risk and incident diabetes i

88 a phospholipid palmitoleate and relations of palmitoleate with metabolic risk factors were investigat