ライフサイエンスコーパス: palmitoyl

1 d either unsaturated dioleoyl PC (DOPC) or 1-palmitoyl 2-oleoyl PC (POPC).

2 pid (dioleoylphosphatidylcholine (DOPC) or 1-palmitoyl 2-oleoyl phosphatidylcholine (POPC)), and a lo

3 oleoyl-phosphatidylglycerol (POPG); and 5% 1-palmitoyl 2-oleoyl-diphosphatidylglycerol/cardiolipin (C

4 in phospholipid bilayers consisting of: 1) 1-palmitoyl 2-oleoyl-phosphatidylcholine (POPC); 2) 1-palm

5 yl 2-oleoyl-phosphatidylcholine (POPC); 2) 1-palmitoyl 2-oleoyl-phosphatidylethanolamine (POPE); and

6 (POPE); and 3) a mixture of 75% POPE, 20% 1-palmitoyl 2-oleoyl-phosphatidylglycerol (POPG); and 5% 1

7 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine

8 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine

9 -2-arachidonoyl-GPE (P-18:0/20:4), 1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4), sulfate, an

10 ylcarnitine, creatine, kynurenate, 1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4), 1-(1-enyl-s

11 tudied at both triolein/water and triolein/1-palmitoyl, 2-oleoylphosphatidylcholine/water interfaces

12 Mixed micelles of STC and 1-palmitoyl, 2-oleyl phosphatidylcholine, a phospholipid p

13 mit transmembrane oxygen permeability of a 1-palmitoyl,2-oleoylphosphatidylcholine phospholipid bilay

14 nes, and oxidized phospholipids, including 1-palmitoyl-2-(5'-oxovaleroyl)-sn-glycero-3-phosphocholine

15 ve oxidized phospholipids (OxPLs), such as 1-palmitoyl-2-(5'-oxovaleroyl)-sn-glycero-3-phosphocholine

16 EI can form as a phospholipase product of 1-palmitoyl-2-(5,6-epoxyisoprostane E2)-sn-glycero-3-phosp

17 ecule quantitated within plaque material, [1-palmitoyl-2-(5-oxo-valeroyl)-sn-glycero-3-phosphocholine

18 elevated basal levels of several products [1-palmitoyl-2-(5-oxovaleroyl)- sn-glycero-phosphocholine (

19 of this homo-association upon addition of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine

20 The truncated tail phospholipids, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine

21 l)-sn-glycero-3-phosphocholine (POVPC) and 1-palmitoyl-2-(9'-oxononanoyl)-sn-glycero-3-phosphocholine

22 lycero-phosphocholine, lysophosphocholine, 1-palmitoyl-2-(9-oxo-nonanoyl)- sn-glycero-3-phosphocholin

23 hatidylcholine-containing OxPL, including (1-palmitoyl-2-[9-oxo-nonanoyl] PC), representing a major p

24 Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox

25 helial cell (EC) response, the products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PA

26 (HAECs) with inflammatory lipids (oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine [Ox

27 rted that oxidized phospholipids (oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine [Ox

28 RATIONALE: Oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine

29 n products of the unsaturated phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-phosphocholine.

30 ic peptides: i) inhibited LPS and oxidized 1-palmitoyl-2-arachidonoyl-sn-phosphatidylcholine (oxPAPC)

31 xo-nonanoyl)- sn-glycero-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-glycero-3-phosphocholine, O-1-O

32 eroyl)- sn-glycero-phosphocholine (POVPC), 1-palmitoyl-2-glutaroyl- sn-glycero-phosphocholine, lysoph

33 l)-sn-glycero-3-phosphocholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC)

34 yl)-sn-glycero-3-phosphocholine (POVPC) or 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine, two o

35 aleroyl)-sn-glycero-3-phosphocholine], and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine, were

36 xed lipid membranes of the oxidized lipid, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC),

37 Treatment of the purified Vo sector with 1-palmitoyl-2-hydroxy-sn-glycero-3-[phospho-rac-(1-glycero

38 he structure and dynamics of human tBid in 1-palmitoyl-2-hydroxy-sn-glycero-3-[phospho-RAC-(1-glycero

39 D derived from Shaker potassium channel in 1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycero

40 azelaoyl- sn-glycero-3-phosphocholine, O-1-O-palmitoyl-2-O-(5,8-dioxo-8-hydroxy-6-octenoyl)-l-glycero

41 yl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the

42 used to explore behavior of capsaicin in a 1-palmitoyl-2-oleoyl phosphatidylcholine bilayer and with

43 ys, we show that the anionic phospholipid, 1-palmitoyl-2-oleoyl phosphatidylglycerol (POPG), preferen

44 monium transporter AmtB specifically binds 1-palmitoyl-2-oleoyl phosphatidylglycerol (POPG).

45 mitoyl-2-oleoylglycerol (POP) (8.6-17.7%), 1-palmitoyl-2-oleoyl-3-stearoyl-glycerol (POS) (12.6-19.6%

46 tions of Kv 1.2-VSD in LPPG micelles and a 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) bilay

47 y anionic phosphoglycerides and found that 1-palmitoyl-2-oleoyl-phosphatidic acid or 1-palmitoyl-2-ol

48 .Galphai1beta1gamma2 complex embedded in a 1-palmitoyl-2-oleoyl-phosphatidylcholine bilayer, using cr

49 able to release ATP from ATP-loaded lipid (1-palmitoyl-2-oleoyl-phosphatidylcholine) vesicles devoid

50 1-palmitoyl-2-oleoyl-phosphatidic acid or 1-palmitoyl-2-oleoyl-phosphatidylglycerol (</=15 mol %) in

51 By contrast, replacement with 1-palmitoyl-2-oleoyl-phosphatidylserine stimulated C1P tra

52 itoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero- 3-phosphoglycerol bilayer

53 nsaturation and polar headgroup size using 1-palmitoyl-2-oleoyl-sn-glycero- and 1,2-dioleoyl-sn-glyce

54 roduction of the negatively charged lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidic acid acid (

55 -glycero-3-phosphatidylglycerol (DMPG) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POP

56 acterial membranes containing zwitterionic 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylethanolamine

57 yl-sn-glycero-3-phosphatidylcholine (POPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (PO

58 hosphatidylethanolamine (POPE) and anionic 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (PO

59 negatively charged membrane lipids, POPG (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol

60 xidation reactions of 18:1 cardiolipin and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol

61 itoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol

62 od, to study the binding of TAT to anionic 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-1'-rac-glycerol

63 oyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS)

64 tion constant, K(Dapp), between Cu(2+) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS),

65 ho-(1'-rac-glycerol) (sodium salt)), POPS (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (sodium

66 ry of bacterial membranes with 20 mol % of 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-glycerol in

67 Two synthetic PC isomers, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (PC(16:0/

68 d bilayers via the enzymatic hydrolysis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (PC), a z

69 g amounts of the unsaturated phospholipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) an

70 MR indicates that in membranes composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) an

71 The interaction of humic acids (HAs) with 1-palmitoyl-2-oleoyl-Sn-glycero-3-phosphocholine (POPC) la

72 phospho-1'-rac-glycerol (POPG) and neutral 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) li

73 significant influence on the structure of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) me

74 ieved that Na(+) ions specifically bind to 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) me

75 e perform multi-microsecond simulations in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) of

76 , whereas for the unsaturated phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) th

77 yl-sn-glycero-3-phosphocholine (DPPC), and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)),

78 mitoyl-sn-glycero-3-phosphocholine (DPPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), a

79 eoyl-sn-glycero-3-phosphocholine (DOPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), b

80 ined data modeling, we show that the ApoA1-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)-ba

81 a suggest that the size and composition of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)-co

82 ave been made using exchangeable mimics of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and 1,2-d

83 layer lipid distribution in both symmetric 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and asymm

84 r dynamics simulations in a fully hydrated 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayer e

85 ics in the interaction between pHLIP and a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayer.

86 In a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine lipid bil

87 n and bovine rhodopsins were inserted into 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine lipid nan

88 an in vitro assay based on solid-supported 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine membranes

89 In nanodiscs formed with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine or choles

90 Studies with membranes containing POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) yielded

91 oyl-sn-glycero-3-phosphocholine) and POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine).

92 icantly stronger than its association with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, in bilay

93 sn-glycero-3-phosphocholine and asymmetric 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1,2-dimyr

94 our barrel-stave pores in a fully hydrated 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmito

95 ge in the polarity of local environment in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmito

96 to 20 mol %) on the lipid polymorphism of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POP

97 ere, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) a

98 Interestingly, the common phospholipid 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18

99 cardiolipin, bradykinin fragment 1-8, and 1-palmitoyl-2-oleoyl-sn-glycerol.

100 yl-sn-glycero-3-phosphocholine (DOPC), and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC).

101 ed and tested for Cl(-)/NO3(-) exchange in 1-palmitoyl-2-oleoylphosphatidylcholine/cholesterol large

102 hosphatidylcholine (PC; dipalmitoyl PC and 1-palmitoyl-2-stearoyl PC (DPPC and PSPC, respectively)) s

103 n by lipoteichoic acid (TLR2/6 activator) or palmitoyl (3)-Cys-Ser-Lys(4)-OH (TLR2/1 activator) but n

104 demonstrate that pretreatment of LSECs with palmitoyl-3-cysteine-serine-lysine-4 (P3C; TLR1/2 ligand

105 AD family members possess both stearoyl- and palmitoyl-ACP Delta(9) desaturase activity, including th

106 The identification of two Delta9 palmitoyl-ACP desaturases responsible for omega-7 FA bio

107 athway proceeds via Delta(9) desaturation of palmitoyl-ACP followed by elongation of the product.

108 Knockdown of the palmitoyl acyl transferase DHHC21 eliminates activation

109 13(skc4) mice with a deficiency in DHHC13, a palmitoyl-acyl transferase encoded by Zdhhc13.

110 lso called Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse.

111 own as DHHC17), a single member of the broad palmitoyl acyltransferase (PAT) family, produces marked

112 4 palmitoylation, we set out to identify the palmitoyl acyltransferase (PAT) involved.

113 The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expres

114 Our results also suggest that zDHHC3, a palmitoyl acyltransferase (PAT), catalyzes the palmitoyl

115 duced in mice with a genetic deletion of the palmitoyl acyltransferase (Zdhhc23) that controls S-acyl

116 report that the recycling endosome-resident palmitoyl acyltransferase DHHC2 interacts with and palmi

117 We identified the plasma membrane-localized palmitoyl acyltransferase DHHC5 as an important mediator

118 The cell surface palmitoyl acyltransferase DHHC5 regulates a growing numb

119 post-translational modification mediated by palmitoyl acyltransferase enzymes, a group of Zn(2+)-fin

120 ne residues C466 and C473 by the DHHC family palmitoyl acyltransferase Pfa4.

121 We identified DHHC-12 as the principal palmitoyl acyltransferase that palmitoylates gephyrin.

122 We further identified ZDHHC19 as a palmitoyl acyltransferase that regulates STAT3.

123 ng 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected bart

124 nt brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmi

125 e report a novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endotheli

126 However, knowledge of the roles of specific palmitoyl acyltransferases (PATs), which catalyze palmit

127 takes place at membranes and is mediated by palmitoyl acyltransferases (PATs).

128 enzymes are evolutionarily conserved protein palmitoyl acyltransferases (PATs).

129 Overexpression of selected DHHC palmitoyl acyltransferases increased palmitoylation of A

130 le N-myristoyltransferase (NMT) and multiple palmitoyl acyltransferases, and these enzymes and their

131 the Asp-His-His-Cys (DHHC) motif-containing palmitoyl acyltransferases.

132 ere identified on over half of the family of palmitoyl-acyltransferases (PATs) that mediate protein p

133 ort on a novel permeation enhancer, Dimethyl palmitoyl ammonio propanesulfonate (PPS), with excellent

134 Lipid anchors composed of palmitoyl and farnesyl moieties in H-, N-, and K-Ras are

135 xtensive molecular dynamics simulations on N-palmitoyl and N-stearoyl sphingomyelin.

136 ve examined how saturated sphingomyelin (SM; palmitoyl and stearoyl SM (PSM and SSM, respectively)) a

137 n complex with 1-lauroylglycerol, myristoyl, palmitoyl, and stearoyl substrate analogs enable identif

138 Herein, palmitoyl ascorbate (PA) as a prooxidant for hydrogen pe

139 rocarbon lengths ranging from formyl (C1) to palmitoyl (C16) as well as negatively charged dicarboxyl

140 fat, HMFS is characterized by enrichment of palmitoyl (C16:0) groups specifically at the middle (sn-

141 )-CoA inhibited synthesis of 11cROL, whereas palmitoyl (C16:0)-CoA promoted synthesis of 11cROL.

142 levels of the fatty acid transport molecule palmitoyl carnitine.

143 oduction in red gastrocnemius in response to palmitoyl carnitine.

144 , and 1 long-chain acylcarnitine metabolite (palmitoyl carnitine; median change, 7.83 [-5.64 to 26.99

145 timulated IS, showing that beta-oxidation of palmitoyl-carnitine is not required for its stimulation

146 This is associated with increased palmitoyl-carnitine oxidation and increased reactive oxy

147 A nonhydrolyzable ether analog of palmitoyl-carnitine stimulated IS, showing that beta-oxi

148 rate of mitochondrial respiration fueled by palmitoyl-carnitine that correlated with blood glucose d

149 ility of ordered domains formed by SM analog/palmitoyl ceramide (PCer) interactions.

150 C) or other lysophospholipids (lyso-PLs) and palmitoyl ceramide (PCer) or other ceramide analogs in d

151 sisting of palmitoyl sphingomyelin (PSM) and palmitoyl ceramide (PCer).

152 bilayers also influenced the segregation of palmitoyl ceramide and dipalmitoylglycerol into an order

153 of saturated phospholipids, cholesterol, and palmitoyl ceramide mixtures.

154 The ordered, palmitoyl ceramide-rich phase started to form above 2 mo

155 hysical state by introducing a perdeuterated palmitoyl chain in either molecule.

156 , we comparatively analyze beta-oxidation of palmitoyl CoA (PCoA) in isolated heart mitochondria from

157 d lipids, primarily oleoyl-CoA (18:1n-9) and palmitoyl-CoA (16:1n-7), the major monounsaturated fatty

158 resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and sub

159 , alleviates negative regulation of L-serine:palmitoyl-CoA acyltransferase, upregulating production o

160 g acyl donor palmitate and a nonhydrolyzable palmitoyl-CoA analog.

161 2 (At3g19260)-encoded ceramide synthase uses palmitoyl-CoA and dihydroxy LCB substrates.

162 toward long-chain fatty acyl-CoA substrates (palmitoyl-CoA and eicosapentaenoyl-CoA) than toward shor

163 8-unsaturated acyl-CoA and low activity with palmitoyl-CoA and ricinoleoyl (12-hydroxyoctadec-9-enoyl

164 ion, and substrate affinity studies revealed palmitoyl-CoA as the most likely ligand for these LTPs,

165 Palmitoyl-CoA competes with Atg30 for Atg37 binding.

166 yl-CoA, which serves as the acceptor for M+4 palmitoyl-CoA in chain elongation.

167 Furthermore, palmitoyl-CoA levels were maintained, whereas the levels

168 The enzyme transfers a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring link

169 almitoylation, palmitate is transferred from palmitoyl-CoA to the PAT, creating a palmitoyl:PAT inter

170 the endoplasmic reticulum (ER) enzyme serine palmitoyl-CoA transferase (SPT), the rate-limiting enzym

171 NAD(P)H:Quinone Oxidoreductase 1, Carnitine Palmitoyl-CoA Transferase and mitochondrial respiratory

172 lyase (Sply) and by upregulating the serine palmitoyl-CoA transferase catalytic subunit gene lace, t

173 rivatives (oleoyl-CoA and, to lesser extent, palmitoyl-CoA) modulate RaaS binding to DNA and expressi

174 eased by the addition of its lipid substrate palmitoyl-CoA, a treatment that results in autoacylation

175 While TgACAT1 preferentially utilizes palmitoyl-CoA, TgACAT2 has broader fatty acid specificit

176 PT catalyses the condensation of serine with palmitoyl-CoA, the initial step in sphingolipid biogenes

177 of a fatty acyl chain, usually derived from palmitoyl-CoA, to specific cysteine residues on target p

178 palmitoyltransferase 1b and 2) catalyze the palmitoyl-CoA-dependent incorporation of (14)C from [2-(

179 the ninth and tenth carbons of stearoyl- or palmitoyl-CoA.

180 (CoA) in addition to its canonical substrate palmitoyl-CoA.

181 biosynthesis: the condensation of serine and palmitoyl-CoA.

182 ly formed by the conjugation of l-serine and palmitoyl-CoA.

183 We further demonstrated that palmitoyl coenzyme A is a ligand for the PvrA, enhancing

184 6 was found to be essential for PvrA to bind palmitoyl coenzyme A.

185 ylation, N6-acetyllysine, methyl-arginine, S-palmitoyl-cysteine, pyrrolidone-carboxylic-acid and SUMO

186 ion in a ternary bilayer of unsaturated PL/N-palmitoyl-D-erythro-sphingomyelin and cholesterol.

187 eoyl glycerol, docosahexaenoyl ethanolamide, palmitoyl ethanolamide, and oleoyl ethanolamide.

188 olesterol depletion test, demonstrating that palmitoyl-gB limits outward cholesterol diffusion.

189 veal that one of the major species produced, palmitoyl-glycerophosphocholine, is generated by iPLA2be

190 membrane-binding fluorophore-cysteine-lysine-palmitoyl group (mCLING), which labels the plasma membra

191 (2-aminothiazol-4-yl-LIGRL-NH(2)) bound to a palmitoyl group (Pam) via polyethylene glycol (PEG) link

192 -charged amino acids, which could facilitate palmitoyl group transfer to substrate cysteine.

193 In contrast, the palmitoyl group was mostly preserved during electron tra

194 ally stable bioisosteres of the ester-linked palmitoyl group.

195 g the pore-lining helix to the membrane with palmitoyl groups.

196 he first step, autopalmitoylation, an enzyme-palmitoyl intermediate is formed.

197 tion, including active site thioester-linked palmitoyl intermediates.

198 observation that even in the absence of the palmitoyl, K-Ras4A can be active at the plasma membrane.

199 ization of individual peaks, we identified N-palmitoyl-l-leucine as a new splicing inhibitor that blo

200 olamide (4) stearoyl-L-valinolamide (5), and palmitoyl-L-valinolamide (6) were investigated in mice a

201 t PRCD is post-translationally modified by a palmitoyl lipid group at the cysteine residue linked wit

202 challenging task because of the tendency of palmitoyl loss during sample preparation and tandem MS a

203 ion-induced dissociation often led to facile palmitoyl loss, and electron capture dissociation freque

204 carbonate buffer could result in significant palmitoyl losses.

205 e modifications, such as succinyl lysine and palmitoyl lysine.

206 Here, a charged, chiral amphiphile (palmitoyl-lysine, C(16)-K(1)) is used to elucidate the p

207 Binary complexes containing palmitoyl lyso-PC and ceramide were prepared, and these

208 er, it appeared that the association between palmitoyl lyso-PC and PCer was equimolar in nature.

209 In the presence of 20 mol% palmitoyl lyso-PC in the DOPC bilayer, the lateral segre

210 ty of the PCer-rich phase in the presence of palmitoyl lyso-PC was also increased compared to that in

211 s between palmitoyl lysophosphatidylcholine (palmitoyl lyso-PC) or other lysophospholipids (lyso-PLs)

212 - or 3-deoxy-PCer) were also associated with palmitoyl lyso-PC, similarly to PCer, suggesting that th

213 l segregation of PCer in a similar manner as palmitoyl lyso-PC.

214 increased compared to that in the absence of palmitoyl lyso-PC.

215 Other saturated lyso-PLs (e.g., palmitoyl lyso-phosphatidylethanolamine and lyso-sphingo

216 The mode of interactions between palmitoyl lysophosphatidylcholine (palmitoyl lyso-PC) or

217 tradecylcarbamyl chain to mimic the native N-palmitoyl moiety and various small amino acids residues

218 the sequence c16-xyL3K3-CO2H where c16 is a palmitoyl moiety and xy represents the heme binding regi

219 The enzyme transfers a palmitoyl moiety from palmitoyl-CoA to the 6-position of

220 The palmitoyl moiety is then transferred to a protein substr

221 During the second step, the palmitoyl moiety is transferred to a protein substrate,

222 ainly through the N-terminal peptide and the palmitoyl moiety of ShhN(p) and the other through the Ca

223 RPE65 is post-translationally modified by a palmitoyl moiety, but this is not universal (about 25% o

224 s known, and this gene encodes the plastidic palmitoyl-monogalactosyldiacylglycerol Delta7 desaturase

225 A conserved palmitoyl-motif is necessary and sufficient to target LI

226 in (TPLENK) were coated with the polymer - N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-

227 o N-Ras in a farnesyl-dependent, but neither palmitoyl- nor guanosine triphosphate (GTP)-dependent, f

228 sphingomyelin (PSM), cholesterol, and either palmitoyl oleoyl phosphatidyl choline or dioleoyl phosph

229 itol 4,5-bisphosphate (PIP2)) PLs containing palmitoyl-oleoyl and dimyristoyl fatty acid chains.

230 phatidylcholine/dioleoyl-phosphatidylcholine/palmitoyl-oleoyl-phos phatidylcholine/cholesterol (DSPC/

231 ng one to six peptides that were embedded in palmitoyl-oleoyl-phosphatidylcholine (POPC) lipid bilaye

232 we solved the structures of ELIC embedded in palmitoyl-oleoyl-phosphatidylcholine- (POPC-) only nanod

233 present in the pulmonary surfactant complex, palmitoyl-oleoyl-phosphatidylglycerol (POPG) and phospha

234 was identified which confers specificity for palmitoyl- or stearoyl-CoA, respectively, in both yeast

235 the palmitoylation reaction occurs through a palmitoyl-PAT covalent intermediate that involves the co

236 ed from palmitoyl-CoA to the PAT, creating a palmitoyl:PAT intermediate and releasing reduced CoA.

237 making it the ideal fragmentation method for palmitoyl peptide analysis.

238 rge difference in hydrophobicity between the palmitoyl peptides and their unmodified counterparts cou

239 wing them to be simultaneously analyzed with palmitoyl peptides for relative quantification of palmit

240 stability of palmitoylation in several model palmitoyl peptides under different incubation and fragme

241 Triacylated palmitoyl-PG species were diminished in strains deleted

242 l (OOL), 1,2,3-trioleyl (OOO), 1,2-dioleyl-3-palmitoyl (POO), 1,2-dilinoleoyl-3-oleyl (OLL) and 1-ole

243 tative enzyme activity measurements of human palmitoyl protein thioesterase (PPT1) and tripeptidyl pe

244 used by a deficiency of the lysosomal enzyme palmitoyl protein thioesterase 1 (PPT1).

245 s in the CLN1 gene, which encodes the enzyme Palmitoyl protein thioesterase-1 (PPT-1).

246 al storage disease caused by a deficiency in palmitoyl protein thioesterase-1 (PPT1).

247 rage disease (LSD) caused by a deficiency in palmitoyl protein thioesterase-1 (PPT1).

248 Mutation of the depalmitoylating enzyme palmitoyl-protein thioesterase 1 (PPT1) causes infantile

249 or CLN1 disease) is due to mutations in the palmitoyl-protein thioesterase 1 (PPT1) gene and severel

250 CLN1 encodes a lysosomal enzyme, palmitoyl-protein thioesterase 1 (PPT1).

251 tivating mutations in the CLN1 gene encoding palmitoyl-protein thioesterase-1 (PPT1) cause INCL, thos

252 t is caused by inactivating mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene.

253 utations in the gene (CLN1 or PPT1) encoding palmitoyl-protein thioesterase-1 (PPT1).

254 ble variation between the sets of identified palmitoyl-proteins and so there remains some uncertainty

255 rce to help researchers prioritise candidate palmitoyl-proteins for investigation.

256 The palmitoyl-proteins identified from each method by mass s

257 axons, although long-distance trafficking of palmitoyl-proteins is important for axon integrity and f

258 t least some of the variability in published palmitoyl proteomes is due to methodological differences

259 domain (TMD) as well as via covalently bound palmitoyl residues.

260 , cholesterol association with fluid dihydro-palmitoyl SM bilayers was stronger than seen with palmit

261 toyl SM bilayers was stronger than seen with palmitoyl SM under similar conditions.

262 We have compared the properties of oleoyl or palmitoyl SM with comparable dihydro-SMs, because the hy

263 SXXS-containing CD3delta segment in LPPG (1-palmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium

264 hosphocholine (PC(16:0/18:1)) and 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine (PC(18:1/16:0)), w

265 and 1-(4-hydroxy-3,5-dimethoxy) cinnamoyl-2-palmitoyl-sn-glycero-3-phosphocholine exhibited good ant

266 Compound 1-(4-hydroxy-3-methoxy) cinnamoyl-2-palmitoyl-sn-glycero-3-phosphocholine exhibited good ant

267 us (2)H NMR study on membranes consisting of palmitoyl sphingomyelin (PSM) and palmitoyl ceramide (PC

268 gated in a model membrane system composed of palmitoyl sphingomyelin (PSM), cholesterol, and an unsat

269 n data are presented for ternary mixtures of palmitoyl sphingomyelin (PSM), cholesterol, and either p

270 e spontaneous radius of curvature for pure N-palmitoyl sphingomyelin bilayers is estimated to be 43-1

271 l-ceramide interaction can exist either with palmitoyl sphingomyelin or with dipalmitoyl phosphatidyl

272 lar, saturated, long-chain C16:0 ceramide (N-palmitoyl sphingosine) and nonsaturated, very long chain

273 The role of the cav-1 palmitoyl tail is less clear and appears to increase the

274 embrane-interacting domains and a C-terminal palmitoyl tail.

275 due to inhibition of the activity of serine-palmitoyl transferase (SPT) and the expression of its SP

276 rst time that Chlamydomonas expresses serine palmitoyl transferase (SPT), the first enzyme in (phyto)

277 in strain W83) predicted to encode a serine palmitoyl transferase (SPT)-the enzyme that catalyzes th

278 yslipidemia, we pursued inhibitors of serine palmitoyl transferase (SPT).

279 of lipids through the key molecule carnitine palmitoyl transferase 1 (CPT1), it is possible to revers

280 e, up-regulated gene expression of carnitine palmitoyl transferase 1, and down-regulated sterol regul

281 Because the carnitine palmitoyl transferase 1a (CPT1a) is a protein that catal

282 Levels of carbamyl-palmitoyl transferase 1a and ATP synthase subunit ATP5G1

283 ts: increases in cyclophylin F and carnitine palmitoyl transferase 1A and reductions in mitofusin1, p

284 treatment increased expression of carnitine palmitoyl transferase 1a, the rate-limiting enzyme of FA

285 sion of the fatty-acid transporter carnitine palmitoyl transferase 1c, which was recently linked to r

286 We used myriocin (a serine palmitoyl transferase antagonist) and two SK inhibitors

287 r-activated receptor (PPAR)-alpha, carnitine palmitoyl transferase I (CPT1)a, peroxisomal membrane pr

288 d hearts coincides with a shift of carnitine palmitoyl transferase I from muscle to increased liver i

289 Acutely increased carnitine palmitoyl transferase I in normal rodent hearts has been

290 athway of sphingolipids by inhibiting serine palmitoyl transferase in response to elevated ceramide l

291 el cell polyomavirus(-) cells express serine palmitoyl transferase subunits and sphingosine kinase (S

292 la bronchiseptica PagP (PagPBB) is a lipid A palmitoyl transferase that is required for resistance to

293 of fatty acid oxidation, including carnitine palmitoyl transferase-1, and the integral transcriptiona

294 te acyltransferase and an increase in serine palmitoyl transferase.

295 hway by one of these genes, PFA4, encoding a palmitoyl transferase.

296 utation in the neuronal isoform of carnitine palmitoyl-transferase (CPT1C) gene.

297 hondrial acylcarnitine carrier and carnitine-palmitoyl-transferase 1 gene expression, two key compone

298 HSAN1 is due to dominant mutations in serine palmitoyl-transferase subunit 1 (SPT1).

299 itoylation is mediated by the Golgi-resident palmitoyl transferases zDHHC9/14/18 and is followed by d

300 n by lowering the steady state amount of the palmitoyl-zDHHC9 intermediate.