ライフサイエンスコーパス: palmitoylation

1 hibitors that shift levels of importin alpha palmitoylation.

2 cysteine residue that undergoes LPS-induced palmitoylation.

3 ioning, namely TMD surface area, length, and palmitoylation.

4 knock-out cells decreased endogenous IFITM3 palmitoylation.

5 identify the structural determinants of NCX1 palmitoylation.

6 in adipose tissue and muscle decreased Glut4 palmitoylation.

7 e of the helix significantly reduced FL-NCX1 palmitoylation.

8 large intracellular loop that controls NCX1 palmitoylation.

9 cortex is mediated by the N-terminus, likely palmitoylation.

10 beta-dependent fashion and decreased Galphaq palmitoylation.

11 -terminal side of Cys-739 abolished YFP-NCX1 palmitoylation.

12 t a DHHC7 catalytic mutant, enhances JAM-C S-palmitoylation.

13 tly screen for small molecular inhibitors of palmitoylation.

14 erapeutic benefit by activating MC1R protein palmitoylation.

15 rmacological tools to interfere with protein palmitoylation.

16 ha-helix whose properties facilitate Cys-739 palmitoylation.

17 in of Dsg2 that, when mutated, eliminate its palmitoylation.

18 led to rapidly increased Galphas and Galphai palmitoylation.

19 olgi to the plasma membrane due to enzymatic palmitoylation.

20 id palmitate; the building block for protein palmitoylation.

21 in ZDHHC21 expression and attenuated 5-HT1AR palmitoylation.

22 e fatty acid palmitate, via a process called palmitoylation.

23 epression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the tre

24 Cysteine palmitoylation, a form of S-acylation, is a key posttran

25 IFITM3 is activated by palmitoylation, a lipid posttranslational modification.

26 Here, we show that Nav1.5 is subject to palmitoylation, a reversible post-translational lipid mo

27 tant mice resulted in lower levels of Drp1 S-palmitoylation accompanied by altered mitochondrial dyna

28 ses of mutant proteins, we propose that Drd3 palmitoylation acts as a molecular switch for Drd3-biase

29 ever, details regarding the mechanism of how palmitoylation affects cilia protein localization and fu

30 Mutation of Cys that blocked ENaC palmitoylation also reduced channel open probability.

31 The role of S-palmitoylation (also referred to as S-acylation), a reve

32 ampal neurons, we find that ZDHHC14 controls palmitoylation and AIS clustering of PSD93 and also of K

33 ransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation.

34 oyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5

35 Protein palmitoylation and depalmitoylation alter protein functi

36 Silencing ZDHHC19 blocks STAT3 palmitoylation and dimerization, and impairs the cytokin

37 ways, including the downstream viral protein palmitoylation and double-membrane vesicles formation, t

38 rons, Zdhhc5/8 shRNA knockdown reduced Gp130 palmitoylation and even more markedly reduced Gp130 surf

39 age-gated sodium channels are subjected to S-palmitoylation and exhibit altered functions in differen

40 t a pharmacological approach to inhibit TEAD palmitoylation and have important implications for targe

41 ly lacking ZDHHCs 1-24 and found that IFITM3 palmitoylation and its inhibition of influenza virus inf

42 d reciprocal relationship between C-terminal palmitoylation and N-terminal phosphorylation.

43 iously unrecognized effect of NAC on Galphaq palmitoylation and phospholipase C beta-mediated signali

44 ered in 4CA mice despite the lack of BACE1 S-palmitoylation and reduced lipid raft association.

45 pable of identifying novel inhibitors of DLK palmitoylation and signalling that may have considerable

46 tightly controlled through the regulation of palmitoylation and stability via the orchestration of FA

47 Myristoylation often primes for subsequent palmitoylation and stable membrane attachment, however,

48 ts cilia localization, and one that prevents palmitoylation and thus membrane binding, in assays of t

49 n polymorphism S738F, which enhanced FL-NCX1 palmitoylation, and D741A, which modestly reduced it.

50 Altered R-Ras trafficking, increased R-Ras palmitoylation, and fibronectin retention were found in

51 Here, we re-examined RPE65 palmitoylation, and its functional consequence in the vi

52 GODZ is involved in palmitoylation, and we found that UL20 is palmitoylated

53 translationally modified by phosphorylation, palmitoylation, and, possibly, ubiquitination.

54 ate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chlo

55 se of AKAP79/150, indirect CaMKII effects on palmitoylation are more important than the effects of di

56 reveal that fatty-acid- and ZDHHC19-mediated palmitoylation are signals that regulate STAT3, which pr

57 We recently identified protein palmitoylation as a mechanism regulating desmosome dynam

58 Therefore, our study reveals S-palmitoylation as a potential isoform-specific mechanism

59 A palmitoylation assay with purified components revealed t

60 appreciated role for acute posttranslational palmitoylation at defined circuit components to regulate

61 BACE1 is modified by S-palmitoylation at four juxtamembrane cysteine residues.

62 E2 recruitment to the DRM, are regulated by palmitoylation at NS2/C113.

63 Furthermore, we showed that eliminating S-palmitoylation at specific sites alters Nav1.6-mediated

64 ne interaction can be partly attributed to S-palmitoylation, but the existence of RPE65 palmitoylatio

65 Further, we show that palmitoylation by App functions antagonistically to phos

66 proxy readout to identify inhibitors of DLK palmitoylation by High Content Screening (HCS).

67 Blocking NS2 palmitoylation by introducing an NS2/C113S mutation redu

68 Cytokine stimulation increases STAT3 palmitoylation by promoting the association between ZDHH

69 Here, we found that blocking EGFR palmitoylation, by either knocking down the palmitoyltra

70 Our data indicate that alterations in palmitoylation can substantially control Nav1.5 function

71 oyltransferase, ZDHHC16, revealing the first palmitoylation cascade.

72 allosteric modulation both influence GLP-1R palmitoylation, clustering, nanodomain signaling, and in

73 c PATs and reveal a novel mechanism by which palmitoylation controls axonal retrograde signaling.

74 newly revealed information suggests that NS2 palmitoylation could serve as a promising target to inhi

75 Compounds that inhibit DLK palmitoylation could thus reduce neurodegeneration, but

76 Together, these studies validate the palmitoylation cycle as a promising therapeutic target i

77 ER stress in primary beta-cells perturbs the palmitoylation cycle controlling GAD65 endomembrane dist

78 Furthermore, palmitoylation-deficient C112 mutants are significantly

79 ted with wild-type Lyn, but not a kinase- or palmitoylation-deficient Lyn mutant.

80 Palmitoylation-deficient TEAD4 mutant is unstable and de

81 This palmitoylation-depalmitoylation cycle enhances STAT3 act

82 interaction is unique to KRAS4A because the palmitoylation-depalmitoylation cycle of this RAS isofor

83 To evaluate the palmitoylation/depalmitoylation cycle as a candidate dru

84 Specifically, inhibiting the palmitoylation/depalmitoylation cycle is an appealing st

85 n that some proteins undergo extremely rapid palmitoylation/depalmitoylation cycles after cellular st

86 localization in non-neuronal cells is highly palmitoylation-dependent and can thus serve as a proxy r

87 ontrast, we find that the inhibition of CD82 palmitoylation disrupts the formation and organization o

88 This work indicates that palmitoylation drives their encounter in specific domain

89 Palmitoylation enhances the hydrophobicity of proteins,

90 Palmitoylation enzymes have been assumed to select their

91 Trafficking of palmitoylation enzymes via Rab27a regulates mVEGFR1 stab

92 nding the signalling functions of numerous S-palmitoylation events.

93 our study allows for a systematic view of S-palmitoylation for identification of ZDHHC13 substrates

94 subunit a1 of the V0 sector (V0a1) requires palmitoylation for interacting with adaptor protein-2 (A

95 nd efficient in vivo strategy to induce MC1R palmitoylation for therapeutic benefit.

96 ifferences in associated PAT specificity and palmitoylation function.

97 Furthermore, gamma subunit palmitoylation had a dominant role over beta subunit pal

98 nds of human proteins are known to undergo S-palmitoylation, how this modification is regulated to mo

99 Therefore, targeting protein palmitoylation in AML blasts could block MDSC accumulati

100 ese findings indicate that targeting protein palmitoylation in AML could interfere with the leukemoge

101 ted cysteine string region of CSPalpha loses palmitoylation in ANCL mutants.

102 Stx1a was accelerated likely through reduced palmitoylation in ATGL deficient INS1 cells.

103 Stx1a was accelerated likely through reduced palmitoylation in ATGL-deficient INS1 cells.

104 important mediator of the stimulus-dependent palmitoylation in cardiomyocytes.

105 mistry analyses demonstrated increased R-Ras palmitoylation in cells with APT-1 deficiency.

106 d reveal a previously unappreciated role for palmitoylation in control of neuronal excitability.

107 the involvement of DHHC21-mediated PLCbeta1 palmitoylation in endothelial inflammation.

108 imary screen, dose-dependently inhibited DLK palmitoylation in follow-up biochemical assays.

109 Modulation of importin alpha palmitoylation in human cells similarly affected nuclear

110 ilarly, NAC treatment also decreased Galphaq palmitoylation in ischemic and nonischemic hindlimbs in

111 ystrophic neurites in the absence of BACE1 S-palmitoylation in mouse models of AD amyloidosis.

112 he results highlight a central role for MC1R palmitoylation in pigmentation and protection against me

113 optosis through Fas is dependent on receptor palmitoylation in primary immune cells, and Fas may prev

114 istent with differential regulation of PSD95 palmitoylation in PSDs resulting from the clustering of

115 lation had a dominant role over beta subunit palmitoylation in regulating ENaC.

116 The role of endogenous N-RasG12D palmitoylation in signal transduction, hematopoietic dif

117 ge assay showed that Nav1.6 is modified by S-palmitoylation in the mouse brain and in a Nav1.6 stable

118 mistry analyses demonstrated increased R-Ras palmitoylation in the setting of hyperglycemia.

119 investigated the functional role of barttin palmitoylation in vivo in Zdhhc7 (-/-) mice.

120 can directly activate STAT3 by enhancing its palmitoylation, in synergy with cytokine stimulation.

121 acyltransferases (PATs) that mediate protein palmitoylation, including active site thioester-linked p

122 Alternatively, blocking palmitoylation increased the association of EGFR with th

123 In contrast, blocking palmitoylation increases closed-state channel inactivati

124 striction occurred independently of IFITM3 S-palmitoylation, indicating a restrictive capacity distin

125 rmat and is sensitive to known, non-specific palmitoylation inhibitors.

126 Palmitoylation is a critical post-translational modifica

127 S-palmitoylation is a dynamic posttranslational modificati

128 tudy suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, ma

129 Palmitoylation is a reversible post-translation modifica

130 S-Palmitoylation is a reversible post-translational lipid

131 Protein S-palmitoylation is a reversible post-translational modifi

132 Palmitoylation is a reversible post-translational protei

133 S-palmitoylation is a reversible posttranslational modific

134 Palmitoylation is a reversible, posttranslational modifi

135 Palmitoylation is a widespread, reversible lipid modific

136 t-hairpin RNA knockdown/rescue, we find that palmitoylation is critical for DLK-dependent retrograde

137 These results suggest that NS2 palmitoylation is critical for HCV RNA replication by pr

138 so have demonstrated that GODZ-mediated UL20 palmitoylation is critical for UL20 membrane targeting a

139 NCX1 palmitoylation is governed by a distal secondary structu

140 veral oncogenes of the Ras and Src families, palmitoylation is indispensable for protein function.

141 Palmitoylation is involved in several neuropsychiatric a

142 Cys-265 S-palmitoylation is mediated by the Golgi-resident palmito

143 lly-regulated palmitoylated protein and that palmitoylation is necessary for regulating its membrane

144 Studies in cultured neurons suggest that S-palmitoylation is required for dendritic spine localizat

145 UL20 is palmitoylated by GODZ, and this UL20 palmitoylation is required for HSV-1 infectivity.

146 e activity per se, ZDHHC5-mediated Furin/PC7 palmitoylation is required for the cleavage of the anthr

147 Since S-palmitoylation is reversible, NS2 palmitoylation likely

148 In this study, we discovered that NS2 palmitoylation is the master regulator of its multiple f

149 S-Palmitoylation is the only reversible post-translational

150 Protein S-acylation (also called palmitoylation) is a common post-translational modificat

151 Protein S-acylation (palmitoylation) is a reversible lipid modification that

152 Cysteine palmitoylation (S-palmitoylation) is a reversible post-translational modif

153 toyl acyltransferases (PATs), which catalyze palmitoylation, is incomplete.

154 Finally, we show that RPE65 palmitoylation level is highly regulated by lecithin:ret

155 Moreover, DHHC7 knockdown decreases the S-palmitoylation level of JAM-C.

156 Since S-palmitoylation is reversible, NS2 palmitoylation likely allows NS2 to fine tune both HCV R

157 Pharmacological manipulation of protein palmitoylation may be a strategy to alter cilia function

158 that the sensitivity of ARL13b stability to palmitoylation may be exploited by the cell to accelerat

159 Finally, the lack of BACE1 S-palmitoylation mitigates cognitive deficits in 5XFAD mic

160 Including a palmitoylation motif at the N terminus of CaV2.2 I-II lo

161 Distinct palmitoylation motifs and site topology were identified

162 Utilizing a palmitoylation mutant form of CD82 with disrupted membra

163 ng the intracellular domain of Fat, and that palmitoylation negatively regulates Fat function.

164 Despite these observations, palmitoylation-null beta1-p.C162A modulated sodium curre

165 r, and in vivo studies, we found that ARL13b palmitoylation occurs in vivo in mouse kidneys and that

166 Using these mutants, we determined that TF palmitoylation occurs primarily in the N terminus.

167 reased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefro

168 sitol 4,5-bisphosphate and is facilitated by palmitoylation of a single cysteine at position 739 with

169 This is the first demonstration of S-palmitoylation of a VGSC beta subunit, establishing prec

170 monstrate that intrinsic posttranslational S-palmitoylation of BACE1 has a significant impact on amyl

171 Although palmitoylation of barttin in kidneys of Zdhhc7 (-/-) ani

172 Strikingly, defective palmitoylation of BMPR1a modulates NSC function within t

173 face or of helix-breaking prolines impaired palmitoylation of both YFP-NCX1 and FL-NCX1.

174 Trafficking of myomaker is regulated by palmitoylation of C-terminal cysteine residues that allo

175 ta indicates that N-linked glycosylation and palmitoylation of CD82 are both critical modifications t

176 Basal S-palmitoylation of Cys-265 is negligible, but agonist-ind

177 nhibition of depalmitoylation reveals that S-palmitoylation of Cys-265 may stabilize the receptor at

178 stably attached to the cell membrane through palmitoylation of cysteine residues.

179 of cardiomyocytes led to stimulus-dependent palmitoylation of downstream signaling proteins.

180 Diminished DHHC3-dependent palmitoylation of ERGIC3 protein likely played a key rol

181 Finally, we show that palmitoylation of Furin and PC7 promotes their associati

182 HC5 showed that this enzyme is necessary for palmitoylation of Galphas, Galphai, and functional respo

183 Palmitoylation of gamma2 and a second substrate, growth-

184 that this process is critically dependent on palmitoylation of Glut4 at Cys-223.

185 Altogether, these results uncover the palmitoylation of HCMV gB and its role in gB multimeriza

186 n cytomegalovirus (HCMV) gB depends on the S-palmitoylation of its endodomain for an efficient intera

187 These results suggest that S-palmitoylation of JAM-C can be potentially targeted to c

188 Palmitoylation of JAM-C promotes its localization to tig

189 S-palmitoylation of MBLAC2 is increased in cells when expr

190 Post-translational palmitoylation of mVEGFR1 is a binary stabilization swit

191 bility, as reduced levels of Rab27a impaired palmitoylation of mVEGFR1, decreased its stability, and

192 mpletely inactivated by mutations preventing palmitoylation of nsP1.

193 the main acetyltransferase required for the palmitoylation of PD-L1, and show that the inhibition of

194 Neither S-palmitoylation of PMP22 nor its putative cholesterol bin

195 Palmitoylation of proteins is primarily mediated by zinc

196 tify small molecules that interfere with the palmitoylation of Ras, a high value therapeutic target t

197 ygen species via NADPH oxidase, reducing the palmitoylation of receptor-associated Galphai in a JNK-d

198 re is a significant decrease in the level of palmitoylation of RPE65.

199 Palmitoylation of SP-C had an indirect effect on the ext

200 Here we show that palmitoylation of STING at the Golgi is essential for ac

201 Palmitoylation of STING was not required for RV-A16 repl

202 In this study, we show that the palmitoylation of TEAD, which controls the activity and

203 del where the C terminus of TF modulates the palmitoylation of TF at the N terminus, and palmitoylate

204 In this study, we show that the palmitoylation of TF regulates its localization to the p

205 Here we show that activity-dependent palmitoylation of the atypical AMPA receptor auxiliary t

206 FASN expression specifically impacts on the palmitoylation of the atypical GTPase RhoU.

207 ons from glycosylation of the N terminus and palmitoylation of the C terminus of CB(2).

208 lity of these mutant aggregates is linked to palmitoylation of the cysteine-string domain, however th

209 Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin varian

210 mically regulated by agonist binding through palmitoylation of the GLP-1R at its carboxyl-terminal ta

211 n synapses by proposing a mechanism by which palmitoylation of the immobilized scaffold protein PSD-9

212 cysteine (Cys) mutants to test differential palmitoylation of the Sindbis virus 6K and TF proteins.

213 , techniques have been developed to identify palmitoylation on a proteome-wide scale in order to reve

214 ator, STAT3(3,4), is subject to reversible S-palmitoylation on cysteine 108.

215 almitoylated, and investigate the effects of palmitoylation on SynDIG1 stability and localization.

216 Here, we show that JAM-C undergoes S-palmitoylation on two juxtamembrane cysteine residues, C

217 cell differentiation; perturbation of either palmitoylation or depalmitoylation negatively affects T(

218 rtical recruitment of Scrib does not require palmitoylation or polar phospholipid binding but instead

219 Together, the results show that palmitoylation plays a unique and critical role in contr

220 We hypothesized that blocking EGFR palmitoylation, previously shown to inhibit EGFR activit

221 C1R signaling is critically dependent on its palmitoylation primarily mediated by the ZDHHC13 protein

222 MC1R palmitoylation, primarily mediated by the protein-acyl t

223 In an unbiased palmitoylation proteomic screen of endothelial cells fro

224 ed mCCDcl1 cells with a general inhibitor of palmitoylation reduced ENaC-mediated Na(+) currents with

225 dominant-negative mutant and an inhibitor of palmitoylation reduced HSV-1 titers and altered the loca

226 idue in beta1, Cys-162, to alanine prevented palmitoylation, reduced the level of beta1 polypeptides

227 ment of IBD but also a model through which S-palmitoylation regulates cell signalling, which might be

228 Cys(1978) S-palmitoylation regulates current amplitude uniquely in N

229 iding new mechanistic insights into how UL20 palmitoylation regulates HSV-1 infectivity.IMPORTANCE HS

230 Our aim was to investigate whether and how S-palmitoylation regulates Nav1.6 channel function and to

231 Palmitoylation regulates the localization and function o

232 S-palmitoylation, but the existence of RPE65 palmitoylation remains a matter of debate.

233 in-acyl transferase, whether increasing MC1R palmitoylation represents a viable therapeutic target to

234 , we show that pharmacological activation of palmitoylation rescues the defects of Mc1r RHC variants

235 palmitoyltransferase DHHC20 or expressing a palmitoylation-resistant EGFR mutant, reduced activation

236 The functional importance of palmitoylation results in part from a dramatic increase

237 Cysteine palmitoylation (S-palmitoylation) is a reversible post-t

238 Cysteine targets for S-palmitoylation, S-glutathionylation, and S-nitrosylation

239 These data indicate that palmitoylation, SH2- and SH3-mediated intermolecular int

240 Mutation of C347 palmitoylation site and Y218 of a newly identified Chole

241 is palmitoylated and identified the likely S-palmitoylation site as Cys254.

242 proteins however, methods for comprehensive palmitoylation site characterization are lacking.

243 In contrast, a mutation in the nsP1 palmitoylation site completely inactivated CHIKV replica

244 but not the mutant D(1) R 347A that lacks a palmitoylation site.

245 Three S-palmitoylation sites (Cys(1169), Cys(1170), and Cys(1978

246 wn palmitoylated proteins and 102 individual palmitoylation sites are known from the literature.

247 ssABE allows the global identification of palmitoylation sites as well as measurement of the activ

248 ype ENaC and channels lacking beta and gamma palmitoylation sites co-immunoprecipitated with the five

249 54% of palmitoylation sites map to synaptic proteins including

250 me with TMT10-plex labelling, 400 (31%) of S-palmitoylation sites on 254 proteins were down-regulated

251 t allowed the identification of 906 putative palmitoylation sites on 641 proteins from mouse forebrai

252 es Nav1.6 channel function and to identify S-palmitoylation sites that can potentially be pharmacolog

253 extensive mutational studies we mapped the S-palmitoylation sites to residues C112 and C146.

254 Palmitoylation sites were identified on over half of the

255 ivation by DHHCs was lost when gamma subunit palmitoylation sites were mutated, whereas DHHCs 1, 2, a

256 ite specific mutagenesis of the three ZDHHC6 palmitoylation sites, experimental determination of kine

257 14 still activated ENaC lacking beta subunit palmitoylation sites.

258 are not normally palmitoylated, they became palmitoylation sites.

259 and exhibit altered functions in different S-palmitoylation states.

260 Modulation of the palmitoylation status of desmosomal cadherins can affect

261 nonical Cdc42 expression is dependent on the palmitoylation status of RhoU.

262 s was validated by direct myristoylation and palmitoylation studies, which indicated that the residue

263 e identify four cysteines as possible Nav1.5 palmitoylation substrates.

264 Moreover, T48A-DAT displayed increased palmitoylation, suggesting that phosphorylation/dephosph

265 In conclusion, DHHC3-mediated protein palmitoylation supports breast tumor growth by modulatin

266 so designed a competitive inhibitor of PD-L1 palmitoylation that decreases PD-L1 expression in tumour

267 l-molecule reversible inhibitor of TEAD auto-palmitoylation that directly occupies its lipid-binding

268 Barttin undergoes post-translational palmitoylation that is essential for its functions, but

269 Palmitoylation, the modification of proteins with the li

270 ly to cilia, multiple cilia proteins rely on palmitoylation, the post-translational attachment of a s

271 stigated the in vivo significance of BACE1 S-palmitoylation through the analysis of knock-in mice wit

272 ve site modification state of PATs, enabling palmitoylation to be studied at a systems level.

273 rovides evidence linking the deregulation of palmitoylation to inflammation and cancer.

274 For palmitoylation to occur, membrane association is a prere

275 lux, TMX1 requires its thioredoxin motif and palmitoylation to target to the MAM.

276 umvent membrane rigidity caused by defective palmitoylation turnover.

277 Blocking of palmitoylation using 2-bromopalmitate (2-BP) affected th

278 Inhibition of palmitoylation using 2-bromopalmitate and 2-fluoropalmit

279 PD-L1, and show that the inhibition of PD-L1 palmitoylation via 2-bromopalmitate, or the silencing of

280 beta subunit palmitoylation was increased by ENaC co-expression with

281 , dissection of the C terminus revealed that palmitoylation was not sufficient for complete fusogenic

282 Finally, gB palmitoylation was required for full fusogenic activity

283 The kinetics of palmitoylation was temporally consistent with the downst

284 n MAPK and PI3K signaling, modulated by EGFR palmitoylation, was only observed in the presence of onc

285 urther insights into the regulation of Glut4 palmitoylation, we set out to identify the palmitoyl acy

286 egments (OS) presumably anchored to discs by palmitoylation, whereas ARL3 is an inner segment cytopla

287 ectopic expression of DHHC7 increased Glut4 palmitoylation, whereas DHHC7 knockdown in 3T3-L1 adipoc

288 lmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon palmitate to specifi

289 we identified that Zdhhc13-dependent Drp1 S-palmitoylation, which acting alone or in concert, enable

290 ion of ENaC cytoplasmic cysteine residues by palmitoylation, which enhance channel activity by alteri

291 hippocampal slice culture increases SynDIG1 palmitoylation, which is consistent with our prior demon

292 roteins are modified post-translationally by palmitoylation, which is essential for their secretion,

293 ced beta2AR activation results in enhanced S-palmitoylation, which requires phosphorylation by the cA

294 three novel cellular and molecular roles of palmitoylation, which targets DLK to trafficking vesicle

295 sport receptor importin alpha is modified by palmitoylation, which targets it to the plasma membrane

296 increases Nav1.6 current, whereas blocking S-palmitoylation with 2-bromopalmitate reduces Nav1.6 curr

297 oltage clamp, we discovered that enhancing S-palmitoylation with palmitic acid increases Nav1.6 curre

298 on lipid, is shown to largely substitute for palmitoylation with regard to cilia localization of ARL1

299 the ZDHHCs were capable of increasing IFITM3 palmitoylation with ZDHHCs 3, 7, 15, and 20 having the g

300 e of Cys-739 in YFP-NCX1 did not affect NCX1 palmitoylation, with the exception of the rare human pol