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1 or agonist-induced zymogen activation in the pancreatic acinar cell.
2 rt and exocytosis of zymogen granules in the pancreatic acinar cell.
3 ase relevant to the secretory process in the pancreatic acinar cell.
4 rn the differentiated phenotype of the adult pancreatic acinar cell.
5 the aberrant signaling of Ca(2+) within the pancreatic acinar cell.
6 ling and the pathogenesis of pancreatitis in pancreatic acinar cells.
7 dramatically modifies autophagy in infected pancreatic acinar cells.
8 n of the effects of intracellular trypsin on pancreatic acinar cells.
9 associated with zymogen granule membranes in pancreatic acinar cells.
10 of active trypsin determines its effects on pancreatic acinar cells.
11 we analyzed the Bmi1-labeled cell lineage of pancreatic acinar cells.
12 es that may maintain the stable phenotype of pancreatic acinar cells.
13 ng digestive enzyme and fluid secretion from pancreatic acinar cells.
14 P(3)-induced Ca(2+) release (IICR) to ATP in pancreatic acinar cells.
15 uated agonist-induced Ca(2+) signaling in WT pancreatic acinar cells.
16 ach to determine the plasticity potential of pancreatic acinar cells.
17 nges of NO concentration in acutely isolated pancreatic acinar cells.
18 focal microscopy of isolated perfused murine pancreatic acinar cells.
19 the pathologic activation of zymogens within pancreatic acinar cells.
20 exocytosis are highly polarized functions of pancreatic acinar cells.
21 s and the underlying signaling mechanisms in pancreatic acinar cells.
22 uring zymogen granule exocytosis in exocrine pancreatic acinar cells.
23 mechanism for mesotrypsinogen activation in pancreatic acinar cells.
24 on with membrane-bound secretory vesicles in pancreatic acinar cells.
25 Kras transgene, which targets expression to pancreatic acinar cells.
26 ns of [Ca(2+)](c) oscillations are shaped in pancreatic acinar cells.
27 ing protein we find prominently expressed in pancreatic acinar cells.
28 nts also may lead to NF-kappaB activation in pancreatic acinar cells.
29 g cascade of terminally differentiated mouse pancreatic acinar cells.
30 in regulating digestive enzyme secretion in pancreatic acinar cells.
31 nucleotide phosphate (NAADP) release Ca2+ in pancreatic acinar cells.
32 is selectively transcribed to high levels in pancreatic acinar cells.
33 toimmunity or in preserving the integrity of pancreatic acinar cells.
34 s and matrix metalloproteinase expression in pancreatic acinar cells.
35 cohol and accelerates disorders of the ER in pancreatic acinar cells.
36 fic phosphoregulation of Ca(2+) signaling in pancreatic acinar cells.
37 the exocyst in polarized Ca(2+) signaling in pancreatic acinar cells.
38 modification in secretagogue-stimulated rat pancreatic acinar cells.
39 published values for the volume of the ER in pancreatic acinar cells.
40 by Ins(1,4,5)P3, as originally discovered in pancreatic acinar cells.
41 R and CCK to induce cytosolic Ca2+ spikes in pancreatic acinar cells.
42 mice that over-express Rab3D specifically in pancreatic acinar cells.
43 , intestinal and bronchiolar epithelial, and pancreatic acinar cells.
44 cium concentration ([Ca2+]i) in isolated rat pancreatic acinar cells.
45 ores of submandibular salivary gland but not pancreatic acinar cells.
46 reactive oxygen species generation in mouse pancreatic acinar cells.
47 f almost all islet beta cells and subsets of pancreatic acinar cells.
48 nohistochemistry showed TNFalpha presence in pancreatic acinar cells.
49 after stimulation of secretion from isolated pancreatic acinar cells.
50 ccurs at the site of Ca2+ wave initiation in pancreatic acinar cells.
51 ation of fluid secretion and exocytosis from pancreatic acinar cells.
52 ial changes also underlie the paligenosis of pancreatic acinar cells.
53 amino acids, particularly L-Lys, on isolated pancreatic acinar cells.
54 d for taurocholate-induced necrosis in mouse pancreatic acinar cells.
55 led that CB2R protein was expressed in mouse pancreatic acinar cells.
56 A recruits KDM6A to genomic binding sites in pancreatic acinar cells.
57 Ca(2+) ([Ca(2+)]i) overload and necrosis of pancreatic acinar cells.
58 e pancreatic duct and subsequent exposure to pancreatic acinar cells.
59 ressed with KIAA1967 in the nuclei of normal pancreatic acinar cells.
60 rticipate in the regulation of exocytosis in pancreatic acinar cells.
61 uction of the neutrophil attractant CXCL1 in pancreatic acinar cells.
62 ed whether Bcl-2 affects Ca(2+) extrusion in pancreatic acinar cells.
63 ation and fibrosis-associated genes in adult pancreatic acinar cells.
64 d with atypical localization of claudin-2 in pancreatic acinar cells.
65 and carbachol-regulated Ca(2+) signaling in pancreatic acinar cells.
66 tor, thapsigargin, activated Ca2+ entry into pancreatic acinar cells, a process known as capacitative
70 e key signalling events driving secretion in pancreatic acinar cells after stimulation by the secreta
71 of intracellular Ca(2+) signals may protect pancreatic acinar cells against Ca(2+) overload, intrace
72 receptor (CCKR) in its native milieu in the pancreatic acinar cell and in a Chinese hamster ovary (C
73 roteolytic activation of zymogens within the pancreatic acinar cell and initiate acute pancreatitis.
74 serves a major intracellular role within the pancreatic acinar cell and may be functionally active af
75 tionship between the events occurring in the pancreatic acinar cell and the vascular, neural, and imm
76 x-loop-helix transcription factor complex of pancreatic acinar cells and critical to acinar cell fate
77 CEL gene, which is specifically expressed in pancreatic acinar cells and encodes the digestive enzyme
78 GRP inhibited protein synthesis in AR42J rat pancreatic acinar cells and HuTu 80 human duodenal adeno
79 g/kg) induced a wave of DNA synthesis in the pancreatic acinar cells and in the proximal tubular epit
80 present in a subpopulation of self-renewing pancreatic acinar cells and is expressed in response to
81 lator of actin cytoskeleton and autophagy in pancreatic acinar cells and is potently protective again
82 s transfected with plasmids and in AR42J rat pancreatic acinar cells and isolated mouse pancreatic ac
83 on inside the endoplasmic reticulum store of pancreatic acinar cells and monitored the cytoplasmic Ca
85 pancreatic ductal cannulas, and in isolated pancreatic acinar cells and pancreatic lobules in vitro.
86 genic mice showed increased proliferation of pancreatic acinar cells and severely perturbed acinar di
87 presence of ARC channels in both parotid and pancreatic acinar cells and shown that, again, they are
88 sitive palmitoyl-CoA-sensitive Ca2+ store in pancreatic acinar cells and suggest that palmitoyl-CoA m
89 that SHA can bind to normal murine and human pancreatic acinar cells and that SHA-binding glycans are
90 e advanced understanding of the functions of pancreatic acinar cells and the mechanisms by which thes
92 n to play a role in amylase secretion by rat pancreatic acinar cells and to specifically dephosphoryl
93 sease that causes progressive destruction of pancreatic acinar cells and, ultimately, loss of pancrea
94 erleukin-6, interleukin-1, and chemokines by pancreatic acinar cells and/or transmigrated leukocytes.
95 ractivation, IgG-type autoantibodies against pancreatic acinar cells, and IgM-type autoantibodies aga
96 tophagy gene Atg5 is specifically deleted in pancreatic acinar cells, and show that coxsackievirus B3
97 GFR1/KLB) complexes expressed in adipocytes, pancreatic acinar cells, and the nervous system in mice.
99 ts show that key pathologic responses of the pancreatic acinar cell are regulated by PI3K gamma and s
106 nist-evoked cytosolic Ca(2+) spikes in mouse pancreatic acinar cells are specifically initiated in th
107 that adult intestinal cells, hepatocytes and pancreatic acinar cells are supplied physiologically fro
109 inogen induced apoptosis of HEK293 cells and pancreatic acinar cells, as indicated by histology, DNA
110 duce Ca(2+) signals and necrosis in isolated pancreatic acinar cells but the effects of bile acids on
111 eak pathways in the endoplasmic reticulum of pancreatic acinar cells by directly measuring Ca(2+) in
112 1 mutant R122H (R122H_mPRSS1) is targeted to pancreatic acinar cells by fusion to the elastase promot
114 the regulation of potassium channels in rat pancreatic acinar cells by the cyclic AMP-mediated agoni
115 TP53(+/+) or TP53(f/f) specifically in adult pancreatic acinar cells by using a full-length pancreati
117 nduced cytosolic Ca2+ oscillations in single pancreatic acinar cells by whole-cell patch-clamp monito
119 elevation of the Ca(2+) concentration inside pancreatic acinar cells ([Ca(2+)]i), due to excessive re
120 n conclusion, changes in intracellular pH in pancreatic acinar cells can profoundly alter cytosolic [
125 We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in
127 ethyl Urea (NMU) results in abnormal foci in pancreatic acinar cells characterized by increased level
128 e previously reported phosphorylation of the pancreatic acinar cell cholecystokinin (CCK) receptor an
131 close binding proximity of PTF1 and MIST1 in pancreatic acinar cell chromatin implies extensive colla
135 TGF-beta isoforms in primary hepatocyte and pancreatic acinar cell cultures generated from transgeni
137 human SPINK1, die perinatally due to massive pancreatic acinar cell death, precluding investigation o
139 rming growth factor alpha (TGF-alpha) in the pancreatic acinar cells develop tubular metaplasia, a po
141 entify a rare TERT-positive subpopulation of pancreatic acinar cells dispersed throughout the exocrin
142 erved by fluorescence microscopy in isolated pancreatic acinar cells, dissociated hepatocytes, rod ph
145 dings include those demonstrating that human pancreatic acinar cells do not respond to cholecystokini
147 ments of TNFalpha indicated its release from pancreatic acinar cells during incubation in primary cul
148 nvestigated by monitoring Ca(2+) dynamics in pancreatic acinar cells evoked by the flash photolysis o
149 gate the kinetics of ACh-evoked secretion in pancreatic acinar cells, exocytosis of zymogen granules
151 ed a direct function of insulin receptors on pancreatic acinar cells expressing a KRASG12D mutation i
153 mice, substance P levels in the pancreas and pancreatic acinar cell expression of NK1R are both incre
156 hat ANO1/TMEM16A is a significant pathway in pancreatic acinar cells for HCO3 (-) secretion into the
157 ies of human pancreatitis, directly protects pancreatic acinar cells from oxidant-induced cytosolic C
158 nger RNA population and PTF1 target genes in pancreatic acinar cells from these and wild-type mice.
160 f epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for th
161 The intracellular mechanisms regulating pancreatic acinar cell function are more complex than pr
162 eing made in understanding the regulation of pancreatic acinar cell function by receptor-activated in
164 Recent investigations into the regulation of pancreatic acinar cell function have led to a more detai
165 Understanding the mechanisms that regulate pancreatic acinar cell function is contributing to knowl
166 Understanding the mechanisms that regulate pancreatic acinar cell function is contributing to our k
168 rocess of acinar-to-ductal metaplasia (ADM), pancreatic acinar cells give rise to pancreatic intraepi
169 luding missense variants in genes related to pancreatic acinar cells (GP2) and insulin secretion (GLP
171 d cytosolic Ca(2+) ([Ca(2+)](i)) overload in pancreatic acinar cells have been implicated as the card
172 of the brain-gut peptide cholecystokinin on pancreatic acinar cells have indicated that NAADP and cA
173 ylene diamine (TPEN), we demonstrate that in pancreatic acinar cells, hepatocytes, and a variety of m
174 TG16L2, plays a critical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation
175 hondrial alterations also occur in untreated pancreatic acinar cells; however, the underlying mechani
177 1A on the specialized phenotype of the adult pancreatic acinar cell in vivo Transcriptome sequencing
179 based upon experiments with intact mice and pancreatic acinar cells in culture, that ZnT2 participat
183 poptosis and death signaling pathways in rat pancreatic acinar cells, including caspase activation, c
185 ively inactivated CCK-evoked Ca2+ signals in pancreatic acinar cells, indicating that NAADP may funct
186 irst evidence that insulin directly protects pancreatic acinar cell injury induced by bona fide pancr
194 calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-i
195 unclear, phospholipase A2 (PLA2) produced by pancreatic acinar cells is a known pathogenic trigger.
196 dings indicate that signaling specificity in pancreatic acinar cells is aided by polarized expression
197 endocytosis at the apical plasma membrane in pancreatic acinar cells is coupled to ductal bicarbonate
198 cretion of luminal glycoprotein 2 (GP2) from pancreatic acinar cells is induced in a TNF-dependent ma
200 ed that cholecystokinin stimulation of human pancreatic acinar cells is likely regulated by an indire
201 uggest that the fibroinflammatory program in pancreatic acinar cells is suppressed under normal physi
202 s of nicotine were also evaluated in primary pancreatic acinar cells isolated from wild-type, nAChR7a
203 A but not wild-type K18-overexpressing mice, pancreatic acinar cell keratin filaments retracted from
204 own to activate signaling kinase cascades in pancreatic acinar cells, leading to the activation of ex
207 d gastrin (Gly-G) stimulates growth of a rat pancreatic acinar cell line; however, the effect of Gly-
208 inct groups of mitochondria in normal living pancreatic acinar cells, located (i) in the peripheral b
212 eurotransmitter cholecystokinin (CCK) in rat pancreatic acinar cells may be an important signaling ca
214 eutrophil sequestration in the pancreas, and pancreatic acinar cell necrosis were significantly reduc
218 Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreas
221 enhancer drives high level transcription to pancreatic acinar cells of transgenic mice and in transf
222 Ca(2+) release-activated Ca(2+) currents in pancreatic acinar cells offers remarkable protection aga
223 we show that microRNA-26a (miR-26a) inhibits pancreatic acinar cell (PAC) store-operated Ca(2+) entry
224 nd 19 were tested in freshly isolated murine pancreatic acinar cells (PACs) to determine inhibition o
225 ated current has been previously reported in pancreatic acinar cells (PACs), the role of TRPM4 in the
230 perimental approaches with acute dissociated pancreatic acinar cells prepared from wild type, CB1R-kn
233 the critical role of the PI3K/Akt pathway in pancreatic acinar cell proliferation, IGF-1-mediated cel
235 To study the role of palmitoyl-CoA in the pancreatic acinar cell, rat pancreatic acini were isolat
236 lysis of fecal samples from 1795 volunteers, pancreatic acinar cell, rather than duct cell, function
237 aracterized the pH-dependent interactions of pancreatic acinar cell-regulated secretory proteins (zym
238 ressed in the exocrine pancreas, and whether pancreatic acinar cells release and respond to TNFalpha.
241 ent with high levels of IL-22RA1 expression, pancreatic acinar cells responded to IL-22 signaling via
242 tor kappaB transcriptional program in normal pancreatic acinar cells, resulting in acinar-ductal meta
243 Functional mapping of Ca2+ signaling in pancreatic acinar cells revealed that the M3, cholecysto
245 in 2 (VAMP 2) and VAMP 8 in Ca(2+)-regulated pancreatic acinar cell secretion, however, their coordin
246 stress has not been studied in CP, although pancreatic acinar cells seem to be especially vulnerable
247 n cerulein-induced pancreatitis samples from pancreatic acinar cell-specific Kras knock-in (Ptf1aCre(
250 nals and NADH responses were investigated in pancreatic acinar cells stimulated with calcium-releasin
251 and intracellular chymotrypsin activation in pancreatic acinar cells, suggesting that the modulation
252 Orai complexes contributes to the disease in pancreatic acinar cells, supporting a role for endoplasm
253 ults provide insights into the mechanisms in pancreatic acinar cells that link tumor necrosis factor
254 induced by muscarinic receptor activation of pancreatic acinar cells that reside within intact pancre
256 ool of heavy metal ions (> or = 12 microM in pancreatic acinar cells) that does not rapidly exchange
260 Thus, infusion of purified Gbetagamma into pancreatic acinar cells through a patch pipette evokes [
261 s suggest that acid challenge sensitizes the pancreatic acinar cell to secretagogue-induced zymogen a
264 tically, IL-22 acts directly at the level of pancreatic acinar cells to decrease expression of the pa
265 th the CHO-CCKR cells and agonist-stimulated pancreatic acinar cells to provide direct evidence for t
266 r level acute alcohol exposure can sensitize pancreatic acinar cells to secretagogue stimulation, res
267 tic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechan
268 mal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic duc
269 method for in vivo conversion of adult mouse pancreatic acinar cells toward beta cells, we show that
272 resent study describes a novel phenomenon in pancreatic acinar cells undergoing regulated exocytosis.
273 Phosphorylation of rpS6 was increased in pancreatic acinar cells upon implantation of the chemica
274 R sensitivity of different regions of intact pancreatic acinar cells using local uncaging of caged Ca
275 W) in agonist-induced Ca(2+) oscillations in pancreatic acinar cells using multiple experimental appr
276 small fluorescent probes in the ER lumen of pancreatic acinar cells, using confocal microscopy, loca
277 in InsP3-evoked Ca2+ release in single mouse pancreatic acinar cells, using high-speed (approximately
279 rise in the cytosolic Ca2+ concentration of pancreatic acinar cells was triggered by stimulation wit
282 oreover, using 3D explant culture of primary pancreatic acinar cells, we show that PKD1 acts downstre
285 Finally, NAADP-evoked Ca(2+) oscillations in pancreatic acinar cells were identical in wild-type and
290 microsomes [5] and triggers Ca2+ signals in pancreatic acinar cells, where it is proposed to mediate
291 This is in marked contrast to the related pancreatic acinar cells, where the distribution of mitoc
292 fication had no effect on [Ca2+]i in resting pancreatic acinar cells, whereas cytosolic alkalinizatio
293 e primary receptors for basement membrane in pancreatic acinar cells, which function to synthesize an
294 ced enhancement of Ca(2+) signaling in mouse pancreatic acinar cells, which suggests a potential cell
297 calcium dependence of calcium extrusion from pancreatic acinar cells with preserved intracellular env
299 re-lox recombination strategy in adult mouse pancreatic acinar cells (Yap1fl/fl;Tazfl/fl;Ela1-CreERT2