ライフサイエンスコーパス: para position

1 onosubstituted benzenes predominantly at the para position.

2 troducing onium cationic substituents in the para position.

3 at CYP2A6 oxidized PCB 95 and PCB 136 in the para position.

4 a strongly electron-withdrawing group at the para position.

5 d was further diminished by moving it to the para position.

6 is systematically changed from the ortho to para position.

7 nable site-selective radical addition at the para position.

8 anilines bearing a donor substituent in the para position.

9 drawing properties of the substituent at the para position.

10 formation between two pyridine rings at the para position.

11 -) linker connecting the two moieties at the para position.

12 -yl are among the better substituents at the para-position.

13 ts such as F, NO(2), OMe, OH, and OAc at the para-position.

14 functionalized substituents on the meta- or para-position.

15 and electron-deficient substituents in their para-position.

16 ct of an electron-withdrawing substituent in para-position.

17 boronic acid and the dimethylamino groups in para positions.

18 electron-withdrawing in the ortho, meta, or para positions.

19 aryl groups from meta to either the ortho or para positions.

20 tal centers is enhanced relative to meta and para positions.

21 electron-donating groups in either ortho or para positions.

22 shifted from ortho to meta, and from meta to para positions.

23 the pyridyl nitrogen from ortho to meta and para positions.

24 tive toward electrophilic palladation at the para-positions.

25 ly feature bromo-substitutents in ortho- and para-positions.

26 hain was conjugated via an ether bond in the para-position (2,6-dinitro-4-(octyloxy)phenol), exhibite

27 quinoline-8-sulfonamide), rather than at the para position (4BP-TQS), display no allosteric agonist a

28 bearing directing heteroatom at the meta- or para-positions, affording unprecedented site-selectivity

29 ld still be tuned electronically through the para-position, allowing access to r.t., dynamic covalent

30 sis reveals a cooperative effect between the para-positioned amino groups through the electron-poor t

31 hydroxylates monosubstituted benzenes at the para position and toluene ortho-monooxygenase (TOM) of B

32 ongly decreasing the addition barrier in the para position, and it is shown that the calculated barri

33 igands (-SR) with different bulkiness at the para-position are synthesized and investigated.

34 es enhances the electronic coupling of those para-positioned atoms, forming restricted n-bonds on the

35 five hydroquinone rings linked through their para positions by methylene bridges, modifies the bindin

36 Here, we show that steric hindrance at the para position causes julolidine-derived dicyanomethyl ra

37 droxyl- and amino-substituents in ortho- and para-positions, causing 100% ClO(2)(-) and 0% FAC format

38 The methoxy substituent at the para position changes the direction of the ortho-cycliza

39 ith a halide or methyl halide in the meta or para position containing no strong hydrogen bond accepti

40 n-withdrawing CN substituent at the ortho or para position could slow down the tau torsion.

41 ers) that incorporate a siletane ring at the para position creates a deprotection pathway without aff

42 itution with electron-donating groups at the para position (e.g., the methoxy group in [(H3CO-C6H4-Im

43 with small hydrophobic groups in the meta or para position enhanced both antipolymerase and antimicro

44 ectron-donating substituents in the ortho or para positions favor formation of the allylic halide.

45 e selective for alkenylation at the meta and para positions, generally with approximately 2:1 selecti

46 The -N(2)(+) group in the para position has a similar effect.

47 rawing protonated dimethylamino group at the para position, hydrogen coordination is enhanced.

48 s the amidine at the phenyl shifted from the para position in DB921 to the meta position, has also be

49 tivity for electrophilic attack at the ortho/para positions in electron-rich substrates and at the me

50 th modifications at the carbonyl linker, the para-position in the C ring of SMART template, and modif

51 the presence of a substituent at the aniline para-position in these compounds.

52 ion, as long as a methoxy substituent is not para-positioned in the aromatic ring, relative to the su

53 unctionalization of phenols at the ortho and para position is generally facilitated by the electron-d

54 functionalization of C-H bonds at the arene para position is highly challenging using transition met

55 g tetragonally via alkynyl linkages from the para positions is described.

56 atic ring, whereas the hydroxyl group in the para-position is not essential, but strongly enhances th

57 chlorides having electron-donating group at para-position is reported.

58 e with aromatic carbons in ortho-, meta-, or para-positions is not feasible and that AKIEs of this re

59 (32) reveals that fewer methyl groups at the para-position lead to a stronger interligand pai...pai s

60 3.97 wt%) are coordinated with square-planar para-positioned nitrogen and phosphorus atoms in a hiera

61 bic residues, such as propyl or butyl in the para position (not ortho or meta) of the A-ring and a m-

62 by an alkyne-Co2(CO)6 complex bonded to the para position of a benzene ring.

63 haptens were synthesized by derivatizing the para position of a phenyl moiety of TCC.

64 s a choice between arylation at the ortho or para position of anisole substrates, we find that arylat

65 overy of a new catalytic C-N coupling to the para position of ArO. to form 4-amino-2,4,6-tri-tert-but

66 presence of a methoxy group in the ortho or para position of at least one phenyl ring is beneficial

67 achment of the tripeptide Gly-Glu-Glu to the para position of cinnamaldehyde resulted in an inhibitor

68 ) containing an isothiocyanate moiety at the para position of either Phe(3) or Phe(4) were prepared a

69 eric hindrance from tert-butyl groups in the para position of p-tert-butylcalix[4]arene (Bu(t)C4), th

70 In general, substitution at the para position of Phe(4) decreased binding affinity at bo

71 Substitution of H by Cl in the para position of tetraphenylborate leads to a 100-fold e

72 imide) electron acceptors is attached to the para position of the 20-phenyl group.

73 at attaching a large lipophilic group at the para position of the 4-(arylamino) ring results in impro

74 droxy group meta to the amino rather than in para position of the aniline moiety were prepared.

75 reaction of ((t)Bu)(2)ArP (1a-h), where the para position of the Ar group contains electron-donating

76 h a single electron-withdrawing group at the para position of the arene, but are formed when the fluo

77 ng (1) a single substitution at the ortho or para position of the aromatic A-ring, (2) a heteroaryl o

78 ligand presenting different Y groups in the para position of the aromatic N-substituent.

79 upon substitution of a methoxy group at the para position of the aromatic phenyl ring.

80 -analogous to the parent free nitrene-in the para position of the aromatic substituent, thus, clearly

81 presence of a -OMe or -F substituent at the para position of the aryl group, which helped to stabili

82 ies indicated that polar substituents at the para position of the B-ring are critical for potent acti

83 s 9m with water-solubilizing moieties at the para position of the B-ring inhibited the autophosphoryl

84 iation of electron-withdrawing groups at the para position of the benzyl chloride reagent.

85 protease inhibitors (PIs), decorated at the para position of the benzyl group in the P1' side with (

86 Paclitaxel was labeled with (19)F at the para position of the C-2 benzoyl substituent and with (1

87 inomethyl and aminoethyl substituents on the para position of the C-2 phenyl group retained the activ

88 rgy relationships indicate that changing the para position of the CDI substituents yields a similar e

89 g the introduction of a primary amine on the para position of the macrocyclic pyridine unit.

90 The substituent at the para position of the N-aryl group determines two diverse

91 ed the importance of the bromine atom in the para position of the N1 side chain phenyl ring for the i

92 s found that appropriate substitution at the para position of the P1' phenyl group of 1 resulted in t

93 The para position of the PCBM's phenyl ring was substituted

94 ngly, introduction of a chlorine atom at the para position of the pendant 5'-phenyl group of 6c not o

95 trophilic substitution of Cl at the ortho or para position of the phenol structure of THC-COOH was co

96 n-withdrawing groups are incorporated in the para position of the phenol substrate and decrease when

97 hobic, electron-donating substituents at the para position of the phenyl group (RBpT).

98 hile addition of hydrogen bond donors in the para position of the phenyl group enhanced NR1A/2B poten

99 e variation of the substituting group on the para position of the phenyl moiety, as supported by DFT

100 If a methoxy substituent is located in the para position of the phenyl ring adjacent to the ether o

101 Substitutions at the para position of the phenyl ring at C3 were generally we

102 on of an activated ferryl-oxo species at the para position of the side chain of the amino acid to for

103 Substituents at the para position of the single phenyl ring were either an e

104 In particular, the substitution of the para position of the terminal phenyl ring of GV150526 wi

105 esonance effect of the groups present in the para position of the terminal phenyl ring.

106 generation of aryl radicals at the ortho and para positions of aryl halides bearing PCET handles, des

107 on-withdrawing groups at the ortho, meta and para positions of both aromatic rings were evaluated.

108 various substituents at the ortho, meta and para positions of the aromatic core of phenols on the bo

109 th chiral auxiliaries placed at the meta and para positions of the benzoyl group have been examined b

110 h three hydroxymethyl arms at both ortho and para positions of the core unit, potentially releasing u

111 rawing functional groups at ortho, meta, and para positions of the diallylanilines.

112 For the diradical, in which all ortho and para positions of the m-phenylene are sterically shielde

113 ron acceptors are covalently attached at the para positions of the PerPh(4) phenyl groups to yield Pe

114 with different substituents at the ortho and para positions of the phenolate ring and substituents at

115 the aromatic COOH group was at the meta and para positions of the phthaloyl ring had IC(50) values o

116 mple procedure, the substitution of the free para positions of the propeller-shaped HPB with tert-but

117 rawing substituents such as fluorides in the para positions of the pyridine rings can reduce the pote

118 oth at the phenoxide oxygen and on ortho and para positions of the ring.

119 ely charged trimethylanilinium groups at the para positions of the tetraphenylporphyrin (TPP) phenyls

120 ne by sulfonate groups also installed in the para positions of the TPP phenyls.

121 emarkably, magnesiation of IPr occurs at the para-position of an aryl substituent, sodiation occurs a

122 henomenon that a subtle ligand effect in the para-position of benzenethiolate can significantly affec

123 stal imide group of one PDI is linked to the para-position of one ZnTPP phenyl group to yield ZnTPP-P

124 A fluorine atom introduced in the para-position of phenylalanine enhanced the binding affi

125 he hydrogen is transferred directly from the para-position of pyridine-AlMe(3) to C2 of allylbenzene.

126 The para-position of the 4-phenoxy group of the thieno[2,3-c

127 hydrophilic electron-donating groups at the para-position of the anilino ring enhance or maintain in

128 s that proceeds without a substituent at the para-position of the aromatic ring.

129 electronegative aromatic substituents in the para-position of the benzamide moiety of CDPPB increase

130 ing hydrophilic group (OH, NH2, COOH) at the para-position of the pendent 2-phenyl ring (8-16) or dif

131 to install a water-solubilizing group at the para-position of the phenoxy group to increase the aqueo

132 he phenylamine moieties were modified at the para-position of the two external rings by electron-with

133 hdrawing and donating functionalities in the para-position of their pyridine nitrogen were synthesize

134 inly attached via C-C bonds to the ortho- or para-positions of phenolic hydroxyl/amino groups and the

135 ng functionalities at the ortho-, meta-, and para-positions of the isothiocyanate moiety.

136 ntroducing bulky amido moieties to ortho- or para-positions of the meso-phenyl groups.

137 hain, alongside substituents at the meta- or para-positions of the phenylurea, increases ligand affin

138 methodology via mesityl substitution at the para-positions of tris(2,4,6-trichlorophenyl)methyl radi

139 prepared, where the functional groups at the para position on the coordinated pyridine ligand were va

140 substituents are placed at the ortho versus para position on the pyrylium cyclohexane ring.

141 signated mpAbc, has substituents at meta and para positions on the inner (azo-linked) and outer rings

142 Additionally, the para-position on the phenyl ring of several substrates w

143 stitution of electron donating groups at the para-position on the phenyl ring was the most favorable

144 ated by reducing the electron density at the para position or by placing substituents bearing lone pa

145 ols that differ in their substituents at the para position (P1, R = H and P2, R = NEt(2)) were design

146 dine units linked to the core either at para-para positions (para series 1-5) or meta-meta positions

147 rgies and that amino acids juxtaposed to the para position play a significant but not dominant role i

148 ship studies showed that substitution at the para position plays a crucial role.

149 adical, which contains a trityl group at the para position, prevents C-N coupling and diverts the rea

150 idines suggested that a methoxy group in the para position relative to the amino group in aminopyridi

151 ition relative to one acetylene linker and a para position relative to the other, destructive QI is a

152 A chloro and ethoxy group at the meta- and para-positions, respectively, produced the most active c

153 onating and relatively small substituents in para-position resulted in dramatically enhanced selectiv

154 tain strong pi-acceptors in the ortho and/or para position(s).

155 ups, namely -NMe(2), -NH(2), and -SMe in the para position, strongly favors the triplet state.

156 dimethylamino group at their para or pseudo-para positions, strongly depend on their substitution pa

157 When substituted in the para-position, the 1,4 and the 2,4-triazoles are cation-

158 Conversely, at the farther para-position, the larger alkyl groups were systematical

159 ith aryl boronic acids containing EWG at the para position, there are two competing forces: one direc

160 CoA, hydrolytic removal of chlorine from the para position to generate 4-hydroxybenzoyl-CoA, hydrolys

161 henyl PDI chromophores are attached at their para positions to both nitrogens and the 1 and 7 carbons

162 henyl PDI chromophores are attached at their para positions to both nitrogens and the 3 and 6 carbons

163 t the substrate requires a hydroxyl group in para-position to the acetate moiety.

164 samine rhodamine B fluorophore (in ortho and para positions) to AC42-NH(2).

165 acetylene-phenyl pai-spacer (ortho, meta, or para positions) upon oxidizing one of the phthalocyanine

166 With monosubstitution, the para position was most useful in increasing potency, wit

167 derivative lacking the chlorine atom in the para-position was found to enhance enzyme activity in li

168 electron-withdrawing groups in the ortho- or para-positions was high yielding.

169 This enhanced relaxivity arises from two para-positioned water coordination sites (q = 2) on the

170 ubstrates with different substituents at the para position were studied by molecular modeling using M

171 arious substituted (hetero)aryl rings in the para-position were prepared by palladium nanoparticle-ca

172 Substitution of the aromatic ring at the para position with methyl or NO2 groups abolished this e

173 enesulfonamide inhibitors substituted at the para position with positively charged, negatively charge

174 atom is also decisive, and when it is in the para position with respect to the N atom, the inductive

175 with -OMe substituents in the meta or ortho/para positions with respect to the C-F bonds.

176 lides, particularly those substituted in the para-position with electron-withdrawing groups, such as

177 razones at two selected positions, i.e., the para-position with regard to the proton-donating and pro

178 ependently substituted at ortho-, meta-, and para-positions with 11 different groups common to inhibi

179 ution strategy, of pi-acceptors in ortho and para positions, works in both cases to planarize and sta