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1 he MLT1/MALT1 locus, which encodes the human paracaspase.
2 hoid tissue lymphoma translocation 1 (MALT1) paracaspase, a key component of the Carma1/Bcl10/MALT1 s
3 broad phylogenetic distribution of meta- and paracaspases across all kingdoms of life and large varia
4 ver, the biochemical and structural basis of paracaspase action remains largely unknown.
5 actor-kB, c-Jun N-terminal kinase, and MALT1 paracaspase activity in B and T cells.
6 d proteolytic cleavage is dependent on MALT1 paracaspase activity.
7                                  Thus, MALT1 paracaspase acts as a bifurcation point for enhancing tr
8                                              Paracaspase acts downstream of Bcl10 to induce NF-kappaB
9                                              Paracaspase and a ubiquitin-conjugating enzyme (UBC13) w
10                      MALT1 is the only known paracaspase and is a critical mediator of B- and T-cell
11                                          The paracaspase and the Ig domains appear as a single foldin
12 erfering RNAs that reduced the expression of paracaspase and UBC13 abrogated the effects of Bcl10.
13 n of NF-kappaB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO.
14                     Like caspases, meta- and paracaspases are multifunctional proteins regulating div
15                             Metacaspases and paracaspases are proteases that were first identified as
16 strate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-rece
17                                          The paracaspase domain adopts a fold that is nearly identica
18 MALT1 paracaspase region, which contains the paracaspase domain and an ensuing Ig-like domain.
19                                          The paracaspase domain of MALT1, in a protease-independent m
20  caspases, the active and mature form of the paracaspase domain remains a single uncleaved polypeptid
21 s inflammatory cytokine production via MALT1 paracaspase engagement.
22 or deciphering the function and mechanism of paracaspases exemplified by MALT1.
23 unctional connection between the caspase and paracaspase families to enable nonapoptotic processes.
24 ified two families of caspase-like proteins, Paracaspases (found in metazoans and Dictyostelium) and
25         Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1(TBM/TBM) (T
26 ing different aspects of caspases, meta- and paracaspases in various organisms, ranging from microbes
27                                        MALT1/paracaspase is a caspase-like protein that contains an N
28 cation and unified nomenclature of meta- and paracaspases is especially important to avoid frequent c
29                                          The paracaspase MALT 1 is a major player in lymphocyte activ
30                              We identify the paracaspase MALT-1 as a critical output of the pathway.
31 so called CARD11), the adaptor BCL10 and the paracaspase MALT1 (the CBM complex), linked to the inhib
32            The CARD domain protein BCL10 and paracaspase MALT1 are essential for the activation of Ik
33                                          The paracaspase MALT1 cleaves and removes negative checkpoin
34                                          The paracaspase MALT1 has gained increasing interest as a ta
35                                          The paracaspase Malt1 is a key regulator of canonical NF-kap
36                                          The paracaspase MALT1 plays an important role in immune rece
37 s a complex with B cell lymphoma 10 (BCL10), paracaspase MALT1, and the inhibitors of kappaB kinase (
38 n and regnase-1 proteins were cleaved by the paracaspase MALT1.
39  CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1.
40 ion, and this activation is dependent on the paracaspase MALT1.
41 mphocytic leukemia/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) (CBM) complex are associated with di
42                                              Paracaspase (MALT1), a member of an evolutionarily conse
43 ion fuses the BIR domains of c-IAP2 with the paracaspase/MALT1 (mucosa-associated lymphoid tissue) pr
44         Here we show that API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor p
45                   Our studies reveal a novel paracaspase-mediated oncogenic gain-of-function mechanis
46 velopment and abolishing activation of MALT1 paracaspase, NF-kB, and JNK activity.
47                                    The human paracaspase prodomain binds Bcl10, a protein involved in
48                                     Metazoan paracaspase prodomains contain a death domain and immuno
49 ain (CARD)-containing protein Bcl10, and the paracaspase (protease related to caspases) MALT1 as crit
50 rmal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and
51 -A resolution crystal structure of the MALT1 paracaspase region, which contains the paracaspase domai
52 pase recruitment domains (CARDs), MALT1 is a paracaspase with structural similarity to caspases.