ライフサイエンスコーパス: paracetamol

1 gested an increased risk with acetaminophen (paracetamol).

2 68 for NSAIDs, 19 for opioids, and three for paracetamol).

3 sumed a 200-mL liquid meal (400 kcal + 1.5 g paracetamol).

4 ds, nonsteroidal anti-inflammatory drugs and paracetamol.

5 g from drug-induced liver injury, often from paracetamol.

6 4 and not observed with other metabolites of paracetamol.

7 rkers to stratify patients who overdose with paracetamol.

8 on the voltammetric response of caffeine and paracetamol.

9 3) were 0.79muM for caffeine and 0.45muM for paracetamol.

10 chemically generated reactive metabolites of paracetamol.

11 ompaction behavior of the monoclinic form of paracetamol.

12 plus ibuprofen 400 mg (n = 136; PCM + IBU), paracetamol 1000 mg plus matched placebo (n = 142; PCM),

13 4, 2.24 to 9.21, P<0.001), prescriptions for paracetamol (3.68, 2.86 to 4.74, P<0.001), renal failure

14 hed placebo (n = 141; IBU), or half-strength paracetamol 500 mg plus ibuprofen 200 mg (n = 140; HS-PC

15 Paracetamol 750 mg was provided as the number of rescue

16 ent; and N-acetyl-para-aminophenol (APAP, or paracetamol), a hepatotoxic analgesic drug.

17 ter-sized crystals of the monoclinic form of paracetamol-a widely used analgesic known for its partic

18 Participants were randomized to receive paracetamol (acetaminophen) 1000 mg plus ibuprofen 400 m

19 nd environmental influences, with a study of paracetamol (acetaminophen) administered to rats.

20 %, it was possible to predict the depth of a paracetamol (acetaminophen) inclusion within a turbid ma

21 n the identification of batches of analgesic paracetamol (acetaminophen) tablets using nitrogen-14 nu

22 per group that evaluated NSAIDs, opioids, or paracetamol (acetaminophen) to treat osteoarthritis.

23 mesalazine, and 4-aminophenol - precursor to paracetamol (acetaminophen).

24 ntly associated with being female and taking paracetamol (acetaminophen).

25 o xenobiotic-derived substructures including paracetamol/acetaminophen mercapturate and dimethylpyrog

26 d the extent of liver damage sustained after paracetamol administration.

27 ndividuals with at least one prescription of paracetamol, aged between 60 and 90 years, was identifie

28 y reduced morphine consumption compared with paracetamol alone in the first 24 hours after surgery; t

29 led groups receiving ibuprofen alone vs with paracetamol alone.

30 recovery area, all patients received 1000 mg paracetamol and 50 mg diclofenac, orally, to be continue

31 egioisomer of the well-known pain medication paracetamol and a promising analgesic and an anti-arthri

32 disruptor as reported for fellow analgesics paracetamol and aspirin.

33 uterine and ovarian atrophy at high doses of paracetamol and decreased ovarian-cyst formation at lowe

34 tudy focuses on predicting the solubility of paracetamol and density of solvent using temperature (T)

35 were performed with ascorbic acid, dopamine, paracetamol and epinephrine.

36 observed that the oxidation products of both paracetamol and ethoxyquin form two isomeric conjugates,

37 Solid dispersion between Paracetamol and Eudragit E was formed and that proved by

38 Tablets of paracetamol and hyproxypropyl methylcellulose (HPMC) and

39 ommonly interfering compounds such as urate, paracetamol and l-ascorbate.

40 All patients had access to paracetamol and metoclopramide.

41 nti-inflammatory drugs such as acetaminophen/paracetamol and nonsteroidal anti-inflammatory drugs (NS

42 The pain was severe and unresponsive to paracetamol and nonsteroidal anti-inflammatory drugs.

43 f-reported prescribing of both acetaminophen/paracetamol and opiates in 97% of patients and gabapenti

44 aches like HPLC, and was applied to the drug paracetamol and the controversial feed preservative etho

45 o variations of the amount of the inclusion (paracetamol) and to the overall thickness of the turbid

46 d a prescription of naproxen, acetaminophen (paracetamol), and pantoprazole; a limited rescue prescri

47 Paracetamol (APAP) has been known to induce hepatotoxici

48 The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastroin

49 mol/kg), diethyl maleate (DEM; 4.2 mmol/kg), paracetamol (APAP; 3.5 and 1.0 mmol/kg), or carbon tetra

50 nd systemic administration of acetaminophen (paracetamol) are lost in Trpa1(-/-) mice.

51 Here, using paracetamol as paradigm compound, mathematical modelling

52 racetamol or Co-dydramol (dihydrocodeine and paracetamol) as required; they completed linear analogue

53 replacement therapy, statins, acetaminophen/paracetamol, aspirin, tea drinking, history of general a

54 ed the effect of pH on the redox reaction of paracetamol at the both electrodes in Britton-Robinson b

55 Certain fragments (including paracetamol) bind in a consistent mode to different brom

56 terfered by electroactive substances such as paracetamol, caffeine, acetylsalicylic acid, aspartame,

57 ings (e.g., sweetener, detergent, sugar, and paracetamol-caffeine-based analgesic drugs), common ions

58 , sugar, acetylsalicylic acid (aspirin), and paracetamol-caffeine-based analgesic drugs.

59 nt (n = 53), stratified according to whether paracetamol caused ALF.

60 for extracting drugs, including amoxicillin, paracetamol, ciprofloxacin, and cefixime.

61 Paracetamol clearance, determined from elimination rate

62 ing of several other analgesics (co-codamol, paracetamol, codeine, co-dydramol, tramadol, oxycodone,

63 ostoperative use of intermittent intravenous paracetamol compared with continuous morphine resulted i

64 y exhibited statistically significant higher paracetamol consumption (p < 0.001) and need for additio

65 Effervescent formulations of paracetamol containing sodium bicarbonate have been repo

66 The analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been wid

67 icals and lifestyle-related chemicals (e.g., paracetamol, diclofenac, nicotine, UV filters) and other

68 e status of 170 women with self-administered paracetamol-diclofenac with or without TAP blocks.

69 nents to allow the probe to melt through the paracetamol down to the underlying HPMC.

70 by elucidating the oxidation pathways of the paracetamol drug.

71 the relative intensity of two Raman bands of paracetamol exhibiting differential absorption by the ma

72 ed for the non-sodium-based and sodium-based paracetamol exposure groups, respectively (mean age: 74

73 in concentration from 9.8 nM to 280 muM for paracetamol, from 13.3 nM to 157 muM for tryptophan, and

74 (interquartile range, 99-264) mug/kg in the paracetamol group (n = 33) and 357 (interquartile range,

75 ean age 55 +/- 13 yr, 24% female): 49 in the paracetamol group and 50 in the placebo group.

76 One-third (30%) of patients in the paracetamol group did not respond to treatment.

77 The paracetamol group exhibited a moderate decrease in systo

78 5 minutes (interquartile range 0-290) in the paracetamol group vs. 0 minutes (0-5) in the placebo gro

79 that was 66% (95% CI, 34%-109%) lower in the paracetamol group.

80 Paracetamol has been used for decades to relieve mild-to

81 Acetaminophen (paracetamol) has many pharmacological effects that might

82 ntial hepatotoxicity of therapeutic doses of paracetamol have been highlighted in the last 18 months.

83 mical detection of the hydrolysis product of paracetamol, i.e., 4-aminophenol (4-AP), and two antibac

84 rmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluor

85 standard solutions and food supplements, and paracetamol in a pain killer.

86 0-125muM were obtained for both caffeine and paracetamol in acetate buffer solution of pH 4.5 with a

87 has prompted a reassessment of the safety of paracetamol in certain groups of patients.

88 e quantitative determination of caffeine and paracetamol in Coca-Cola, Pepsi-Cola and tea samples.

89 ts from short-term use of sodium bicarbonate paracetamol in routine clinical practice.

90 the B:CNW electrode for the determination of paracetamol in the artificial urine sample using differe

91 was linearly related to the concentration of paracetamol in the range from 0.065 uM to 32 uM for BDD

92 f-care (POC) determination of acetaminophen (paracetamol) in plasma and finger-prick whole blood was

93 and many were reduced by use of prophylactic paracetamol, including pain, feeling feverish, chills, m

94 rognostic model of outcome for patients with paracetamol induced acute liver injury based on admissio

95 patients suffering from acetaminophen (APAP, paracetamol)-induced acute liver failure (ALF) showed si

96 Acetaminophen (APAP, paracetamol)-induced hepatotoxicity, although treatable

97 njury in the context of acetaminophen (APAP; paracetamol)-induced liver injury is an important predic

98 spective initial sample of 103 patients with paracetamol-induced acute liver failure and applied to a

99 teria for emergency liver transplantation in paracetamol-induced acute liver failure are widely used,

100 Patients with paracetamol-induced acute liver failure managed at inten

101 tions for emergency liver transplantation in paracetamol-induced acute liver failure require re-evalu

102 al is central to management of patients with paracetamol-induced acute liver failure to identify thos

103 rately identifies patients who will die from paracetamol-induced acute liver failure.

104 to support decision making in patients with paracetamol-induced acute liver failure.

105 m 640 adult patients admitted to the ICU for paracetamol-induced ALF were extracted from the MIMIC-II

106 ong paracetamol-induced ALF; 79.4% among non-paracetamol-induced ALF) (P < 0.001).

107 02 patients had transplantation (41.0% among paracetamol-induced ALF; 79.4% among non-paracetamol-ind

108 sible to strong association between maternal paracetamol intake and autism or ADHD or both in offspri

109 indings suggest that the analgesic effect of paracetamol is mediated mainly by direct AM404-induced i

110 Paracetamol is most often administered as first-line tre

111 New Zealand ICUs suggest that acetaminophen/paracetamol is the most common first-line analgesic (49.

112 Acetaminophen (paracetamol) is a widely used analgesic and antipyretic

113 Acetaminophen (paracetamol) is the most commonly used medication for pa

114 Acetaminophen (paracetamol) is the most frequently used analgesic and a

115 Importance: Acetaminophen (paracetamol) is used by a large proportion of pregnant w

116 In the responder group paracetamol lowered the mean CT by 1 degrees C.

117 combination of ibuprofen and acetaminophen (paracetamol) may represent a viable nonopioid alternativ

118 the thermodynamic stability among competing paracetamol molecular crystal polymorphs.

119 Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise kn

120 ical rating scale, required at least step 1 (paracetamol) of the WHO ladder and were randomised to th

121 A typical anti-pain/fever drug paracetamol often causes hepatotoxicity due to peroxynit

122 receptor antagonist (ranitidine), analgesic (paracetamol), opiate (codeine), and aromatase inhibitor

123 (eg, non-steroidal anti-inflammatory drugs, paracetamol, opioids, anti-convulsant drugs, skeletal mu

124 in most cases, symptoms resolved after oral paracetamol or a short course of prednisone.

125 Patients took paracetamol or Co-dydramol (dihydrocodeine and paracetam

126 Patients received paracetamol or placebo (only one IV administration).

127 Acetaminophen (APAP; ie, Paracetamol or Tylenol) is generally self-medicated to t

128 cytotoxic model compounds (sodium azide and paracetamol) or subjected to freeze-thaw cycles to induc

129 53 activation in response to irradiation and paracetamol- or CCl(4)-induced liver regeneration.

130 Paracetamol overdose (POD) is common, with approximately

131 el is able to identify patients who die from paracetamol overdose fulminant hepatic failure as accura

132 ded intravenous acetylcysteine treatment for paracetamol overdose had circulating biomarkers measured

133 Paracetamol overdose is common but patient stratificatio

134 We randomly allocated patients with acute paracetamol overdose to either the standard intravenous

135 ts who required acetylcysteine treatment for paracetamol overdose were recruited (985 in the MAPP coh

136 nts transplanted for other causes of FHF (11 paracetamol overdose, 2 idiosyncratic drug reaction, 3 W

137 /=16 years in Scotland), were diagnosed with paracetamol overdose, and gave written informed consent.

138 rrors of metabolism, n = 2) and 34 with ALF (paracetamol overdose, n = 6; viral infections, n = 3; mu

139 phate (COD) determination in the presence of paracetamol (PAR) and caffeine (CAF).

140 dustrial small molecules (including the drug paracetamol), paving the way for a general strategy to b

141 n terms of the electrocatalytic detection of paracetamol (PCM).

142 Among patients undergoing THA, paracetamol plus ibuprofen significantly reduced morphin

143 o 2.6 (95% confidence interval 1.5 to 4.5)), paracetamol plus sustained release tramadol (2.4 (1.5 to

144 5 to 3.8)), baclofen (2.3 (1.5 to 3.4)), and paracetamol plus tramadol (2.1 (1.3 to 3.4)) compared wi

145 Paracetamol poisoning is common worldwide.

146 In patients with paracetamol poisoning, a 12 h modified acetylcysteine re

147 Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver

148 t molecular ion for each drug (theophylline, paracetamol, prednisolone) showed their distribution ran

149 In patients with paracetamol-related ALF, the 6-month survival rate was 6

150 Sodium-based paracetamol showed a positive association with all-cause

151 rkedly differing thermal responses, with the paracetamol showing a sharp melting accompanied by a pro

152 Paracetamol significantly reduced CT in febrile brain-in

153 ped and validated using experimental data on paracetamol solubility as well as density.

154 dence of the efficacy of gentle brushing and paracetamol, substantiating the need for randomised cont

155 hylline, caffeine, ibuprofen, acetaminophen (paracetamol), sulindac and indomethacin, was also achiev

156 crimination between the different batches of paracetamol tablets.

157 our follow-up was significantly lower in the paracetamol than placebo group: 38.4 +/- 0.5 vs. 39.0 +/

158 n (as trihydrate) and the analgesic medicine Paracetamol, that the latter design gives NQR signal int

159 for synthesizing 2-aminobenzoate-subtituted paracetamol through a decarboxylation route.

160 n two of the five sites allowed prophylactic paracetamol to be administered before vaccination.

161 announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminoph

162 steine (NAC) is widely used in patients with paracetamol toxicity with limited evidence of benefit in

163 N-acetylcysteine (NAC) used in patients with paracetamol toxicity with limited evidence of benefit in

164 Causes of acute liver failure include paracetamol toxicity, hepatic ischaemia, viral and autoi

165 Sensors for simultaneous determination of paracetamol, tryptophan, and caffeine have not been repo

166 ak currents during separate determination of paracetamol, tryptophan, and caffeine increased linearly

167 showed high activity toward the oxidation of paracetamol, tryptophan, and caffeine with significant d

168 mit (3sigma/ S) was 7.5, 7.8, and 4.4 nM for paracetamol, tryptophan, and caffeine, respectively.

169 tinuous morphine or intermittent intravenous paracetamol up to 48 hours postsurgery.

170 l analyses (fully adjusted) were for current paracetamol use (1.80; 1.75-1.86), cooking on an open fi

171 l analyses (fully adjusted) were for current paracetamol use (odds ratio = 2.06; 95% confidence inter

172 ividual-level associations were with current paracetamol use (odds ratio [OR] = 1.45, 95% confidence

173 = 1.41, 95% CI = 1.34-1.48), and early-life paracetamol use (OR = 1.28, 95% CI = 1.21-1.36), with th

174 ns at the individual level were with current paracetamol use (OR = 1.57, 95% CI = 1.51-1.63) and open

175 ally significant inverse association between paracetamol use and ovarian cancer risk.

176 oss sectional studies that reported maternal paracetamol use during pregnancy and the diagnosis of au

177 ting evidence does not clearly link maternal paracetamol use during pregnancy with autism or ADHD in

178 n, cognitive impairment, strong opiates, and paracetamol use in patients in the community after the f

179 rs (maternal characteristics, indication for paracetamol use, and familial factors) and unmeasured co

180 Several studies suggest that acetaminophen (paracetamol) use during pregnancy may increase risk of n

181 r simultaneous determination of caffeine and paracetamol using square-wave voltammetry.

182 sed for the electrochemical determination of paracetamol using the cyclic voltammetry and the differe

183 s (flunitrazepam, scopolamine, ketamine) and paracetamol via direct immersing into a spirit shot.

184 ibuprofen was 1.03 (0.64-1.64), and that for paracetamol was 0.52 (0.31-0.86), after adjusting for ag

185 Taste masking of paracetamol was achieved by preparing amorphous solid di

186 eduction of nitrobenzene to the synthesis of paracetamol was achieved by the acetylation of N-phenylh

187 Acute liver failure not caused by paracetamol was associated with greater 6-month patient

188 chemically generated reactive metabolites of paracetamol was mimicked by their adduct formation with

189 lower risk of ovarian cancer associated with paracetamol was more apparent for use on a daily basis,

190 Also, Paracetamol was released after 2 min in 0.1 N hydrochlor

191 Paracetamol was used as the model drug, and its crystall

192 stances in the determination of caffeine and paracetamol were also studied and their interferences we

193 Outcomes in patients taking sodium-based paracetamol were compared with those taking non-sodium-b

194 Glucose, sulfathiazole, and paracetamol were impregnated with bis-nitroxide biradica

195 doxycycline, nonaromatic antiepileptics, and paracetamol were often tolerated.