ライフサイエンスコーパス: paramount

1 erative care for these youngest patients are paramount.

2 low survival after chemotherapy treatment is paramount.

3 regulate the replication stress response is paramount.

4 e modes of action for future insecticides is paramount.

5 nditions where control of T cell activity is paramount.

6 h risk of secondary CNS relapse is therefore paramount.

7 under operational and accident conditions is paramount.

8 actical test, with lower detection limit, is paramount.

9 njury to optimize neurocognitive function is paramount.

10 nologies, although clinical judgment remains paramount.

11 w HPAI viruses in different avian species is paramount.

12 Thus the need for alternative treatments is paramount.

13 lial sodium channel (ENaC), are regulated is paramount.

14 iquitin-26S proteasome system is also likely paramount.

15 y, where precise and accurate positioning is paramount.

16 chanisms by which these viruses reproduce is paramount.

17 xpensive molecular chromophores is therefore paramount.

18 atient Protection and Affordable Care Act is paramount.

19 low aging, although compliance issues remain paramount.

20 d selective delivery to cancer cells remains paramount.

21 n of the quality and constituents of meat is paramount.

22 for the detection and monitoring of IPF, is paramount.

23 d properly treated or modified woods will be paramount.

24 experimental inoculation in this species, is paramount.

25 s most prevalent where test affordability is paramount.

26 nd enable dynamic MSC bioactive function are paramount.

27 ese metallocenes in the presence of acids is paramount.

28 Respect for patient autonomy remains paramount, although physicians are not required to provi

29 Epidermal cell differentiation is a paramount and conserved process among plants.

30 Preparedness to manage complications remains paramount and recommendations for operators and institut

31 flucytosine and amphotericin B, in LMICs is paramount and the focus of this Personal View.

32 ich growth in information processing becomes paramount, and an Information Threshold, which once cros

33 ssociated with pregnancy, and postpartum, is paramount as both require urgent specific treatment.

34 the modality chosen, patient counselling is paramount, as recovery of the penis to its predisease st

35 nsient acquired risk factors for VTE remains paramount, as they have generally been shown to carry mo

36 Accurate diagnosis of these lesions is paramount because the clinical therapy can vary tremendo

37 Heart disease is a paramount cause of global death and disability.

38 in AD human trials and the disease remains a paramount challenge and a stigma in medicine.

39 selectivity with C(sp(3))-H bonds remains a paramount challenge.

40 Two paramount challenges are the lack of an adequate trainin

41 ses interconnect at the cellular level is of paramount clinical importance for optimizing treatment s

42 ore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgica

43 ern of sulfation on the PG sugar chains is a paramount determinant of a diverse and flexible set of o

44 e the dynamics of the deposition of H3.3 are paramount during reprogramming events that drive zygotic

45 its relative and absolute configurations-is paramount, enabling one to understand its biological act

46 Tuberculosis (TB) is a paramount example of a chronic infection in which antimi

47 lection advantages that have resulted in the paramount fixation of the ACKR1 rs2814778(G) polymorphis

48 rks of bundle shape similarities that can be paramount for automating quality control.

49 This topic is also paramount for comparative purposes, since some topologic

50 s for chemotherapy-driven metastasis will be paramount for designing novel mechanism-based treatments

51 al following Ebola virus (EBOV) infection is paramount for developing countermeasures.

52 the final elemental distribution, which are paramount for device optimization, are still poorly unde

53 Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell ma

54 Newborn screening is paramount for early diagnosis and enrolment of affected

55 acement on soil organic carbon (SOC) remains paramount for effectively managing ecosystems to mitigat

56 is available on autophagy in glia, but it is paramount for glia to perform their critical responses t

57 Optimal system design is paramount for imaging performance, but research systems

58 ased testing and contact-tracing capacity is paramount for mitigating the recent large-scale increase

59 ific gene knockouts to show that Slc30a10 is paramount for Mn excretion in the liver and small intest

60 This question is paramount for neurodevelopmental disorders arising from

61 e range expansions during climate warming is paramount for predicting population extirpations and pre

62 tion with canonical Wnt/beta-catenin signals paramount for promoting the ovary pathway.

63 advantages, which makes viral tool selection paramount for properly designing and executing experimen

64 Antithrombotic medications are paramount for secondary prevention and thus crucial to r

65 molecular testing with mutation analysis is paramount for selection of appropriate therapy.

66 ledge of liver anatomy and its variations is paramount for success in ALPPS.

67 erstanding and forecasting of Sahel drought, paramount for successful adaptation strategies in a chan

68 Precise spatiotemporal gene regulation is paramount for the establishment and maintenance of cell-

69 Yet, the time domain is paramount for the observation and study of complex biolo

70 king DNA double strand break (DSB) repair is paramount for the understanding and therapeutic developm

71 receptors in the plasma membrane of cells is paramount for their functionality.

72 c responses are evolutionarily conserved and paramount for tissue and organismal health.

73 Laboratory mouse studies are paramount for understanding basic biological phenomena b

74 Laboratory mice, while paramount for understanding basic biological phenomena,

75 these trimers and higher-order oligomers is paramount for understanding their role in neurodegenerat

76 safety of any new curative therapies will be paramount given the excellent safety of currently approv

77 fication of this cohort of NAFLD patients is paramount, given the associated poorer outcomes, in orde

78 tumors as summarized in this review will be paramount if Precision Oncology is ultimately to lead to

79 owever, the length of the glycol chain is of paramount importance and the present studies show that t

80 ety of volunteers in challenge studies is of paramount importance and treatment timing can affect pri

81 This is of paramount importance as preferential degradation of (S)-

82 tter interactions in many-body systems is of paramount importance both for fundamental understanding

83 g drug treatment in the critically ill is of paramount importance but challenging as the underlying c

84 At the same time, it is of paramount importance considering the limited capability

85 hanical behavior of molecular machines is of paramount importance for a rational design of superior n

86 notion that task-induced activations are of paramount importance for behavior.

87 ng remnants of native vegetation is still of paramount importance for biodiversity conservation in ag

88 These findings are of paramount importance for chaotic operation of quantum ca

89 ous identification of biothreat agents is of paramount importance for confirmation of the event and t

90 The Wnt signaling pathway is of paramount importance for development and disease.

91 fine details of PTIR analysis has become of paramount importance for extending complex IR analysis m

92 The repair of white matter damage is of paramount importance for functional recovery after brain

93 ypic plasticity in crops such as maize is of paramount importance for maintaining and increasing yiel

94 roving device efficiency and stability is of paramount importance for OLED technology.

95 ignals still remains challenging despite the paramount importance for practical applications.

96 While allostery is of paramount importance for protein regulation, the underly

97 nature and causes of their variability is of paramount importance for society.

98 egies to identify drug resistance remains of paramount importance for successful treatment.

99 The functionalization of MoS(2) is of paramount importance for tailoring its properties toward

100 The water gas shift (WGS) reaction is of paramount importance for the chemical industry, as it co

101 sis of release characteristics of CRFs is of paramount importance for the design and development of n

102 vents controlling melanoma progression is of paramount importance for the development of alternative

103 understanding of thin-film flexibility is of paramount importance for the rational design of MOF-base

104 and the end product, iPSCs, and are also of paramount importance for the reprogramming process.

105 intenance of DNA replication, seems to be of paramount importance for the survival of this parasite t

106 mperature) on crystallisation dynamics is of paramount importance for the synthesis of nanocrystals o

107 of non-precious-metal electrocatalysts is of paramount importance for their large-scale commercializa

108 materials with high chemical stability is of paramount importance for their practical application.

109 Awareness of one's own abilities is of paramount importance in adaptive decision making.

110 ny different organs and have proven to be of paramount importance in advancing our knowledge of norma

111 In situ evolution of electrocatalysts is of paramount importance in defining catalytic reactions.

112 and weak intermolecular interactions are of paramount importance in dictating the formation of their

113 onally accepted, reproducible criteria is of paramount importance in evaluating and comparing clinica

114 tion during postnatal development and are of paramount importance in guiding the development of brain

115 ndaries and discovery of cryptic taxa are of paramount importance in interpreting ecological and evol

116 ning due to internal stress generation is of paramount importance in living systems and is the founda

117 g and its detection and quantification is of paramount importance in many areas of current research.

118 ction of the "flowability" of powders are of paramount importance in many industries.

119 s through the introduction of fluorine is of paramount importance in medicinal chemistry.

120 iwavelength fluorescence measurements are of paramount importance in microfluidic analytics.

121 limit of detection and dynamic range are of paramount importance in obtaining experimental results t

122 These innovations are of paramount importance in order to facilitate efficient is

123 r survivors who have elevated CVD risk is of paramount importance in order to prevent CVD manifestati

124 edicting plant response to disturbance is of paramount importance in our changing world.

125 Sustaining agricultural productivity is of paramount importance in the current scenario of increasi

126 igh-throughput screening (HTS) methods is of paramount importance in the early stage of drug discover

127 Discovery of CRISPR-Cas systems is one of paramount importance in the field of microbiology.

128 annealing for the theory of cuts, a field of paramount importance in theoretical computer science.

129 ngle crystals of layered SnSe have created a paramount importance in thermoelectrics owing to their u

130 A question of paramount importance is how to control the formation of

131 Reinforcing the paramount importance of graft outcomes encompassed the p

132 atrial anatomy and function, underlying the paramount importance of the atria in optimal heart perfo

133 ent evolution of groups, and it stresses the paramount importance of the life cycle: only by evaluati

134 ome inference problems constitutes a task of paramount importance that continues to challenge the cur

135 ternative to chocolate milk drinks, being of paramount importance the study of the cold plasma proces

136 s of social distancing recommendations is of paramount importance to avoid further waves of COVID-19.

137 this (1)H NMR study provides information of paramount importance to design sound in vitro digestion

138 chemical methods for their preparation is of paramount importance to facilitate exploration of their

139 Understanding allosteric regulation is of paramount importance to guide therapeutic modulation of

140 The honey bee is of paramount importance to humans in both agricultural and

141 Thus, it is of paramount importance to identify novel causative variant

142 Calcium (Ca(2+)) signalling is of paramount importance to immunity.

143 It is of paramount importance to improve the control over large a

144 aining substrates and alumina surfaces is of paramount importance to industrial and academic catalysi

145 or the oxygen evolution reaction (OER) is of paramount importance to many chemical and energy transfo

146 of treatment-associated complications is of paramount importance to MS clinicians, but also of relev

147 Lightweight materials are of paramount importance to reduce energy consumption and em

148 Because practical implementation is of paramount importance to the eventual realization of usin

149 in interaction with tRNA fragments advocate paramount importance toward understanding BEX family inv

150 ressively failing disordered structure is of paramount importance when considering structural materia

151 Ferroelectrics (FEs) are materials of paramount importance with a wide diversity of applicatio

152 CE The development of an HIV-1 vaccine is of paramount importance, and broadly neutralizing antibodie

153 conformation of water around proteins is of paramount importance, as it determines protein interacti

154 e countries, reduction of transmission is of paramount importance, but social distancing is challenge

155 ucture of small-molecule binding sites is of paramount importance, but systematically designing arbit

156 ng dopamine neuron health and function is of paramount importance, but this alone fails to capture th

157 the management of such complications are of paramount importance, particularly in an era when TAVR e

158 aking structural elucidation is therefore of paramount importance, such that biologists and synthetic

159 here assessing duodenal mucosal health is of paramount importance.

160 egies to defeat Pseudomonas aeruginosa is of paramount importance.

161 hance the mechanical stability of MOFs is of paramount importance.

162 the chromosome association of the CPC is of paramount importance.

163 g of mouse visual circuit architecture is of paramount importance.

164 identifying novel therapeutic targets are of paramount importance.

165 ent of diabetes and its complications are of paramount importance.

166 e despite antiretroviral therapy (ART) is of paramount importance.

167 e to a fifth of the global population, is of paramount importance.

168 selection for antifungal prophylaxis are of paramount importance.

169 t) protein can activate microglia is thus of paramount importance.

170 ferentiating it from pancreatic cancer is of paramount importance.

171 y metal contamination in potable water is of paramount importance.

172 d manufacturing practice compatibility is of paramount importance.

173 e effective medical pH imaging methods is of paramount importance.

174 how much effort we should expend can assume paramount importance.

175 Determining these structures is thus of paramount importance.

176 to prioritize these variants is therefore of paramount importance.

177 s involved in CD20 regulation seems to be of paramount importance.

178 to manage excess body weight is therefore of paramount importance.

179 iers, where it exerts a protective effect of paramount importance.

180 sitive and rapid detection of proteins is of paramount importance.

181 ntial to discriminate mutated strands, is of paramount importance.

182 ing fair and unbiased classifiers becomes of paramount importance.

183 rcise capacity is regulated is a question of paramount importance.

184 of innovative control measures has become of paramount importance.

185 emission trends for urban environments is of paramount importance.

186 rgeting these pathogens in the vector are of paramount importance.

187 ntification of non-narcotic analgesics is of paramount importance.

188 obes such as proteins and small molecules is paramount in decoding the molecular basis of gene functi

189 Long-term temporal genetic monitoring is paramount in determining future viability of cosmopolita

190 robes active against multiple phenotypes, is paramount in drug discovery.

191 ontraction, assessment of sarcomere order is paramount in evaluation of cardiac and skeletal myocytes

192 work establishes the prenylation pathway as paramount in KRAS membrane association, reveals a regula

193 hese disorders, a high index of suspicion is paramount in making the correct diagnosis, which can inv

194 The need to assess autonomic function is paramount in many experimental paradigms because of the

195 high spatio-temporal resolution are becoming paramount in neuroscience.

196 counseling and access to specialist care are paramount in optimizing disease management.

197 Knowledge of these interactions is paramount in optimizing the success of antiviral therapy

198 ts in switching time and switching energy is paramount in order to design nanoscale structures with e

199 Inflammation is paramount in pancreatic oncogenesis.

200 to random imperfections in periodic media is paramount in photonics research.

201 the ecological response of nitrification is paramount in predicting impacts of oil spills on the nit

202 cose control in individuals with diabetes is paramount in reducing the morbidity and mortality associ

203 pplications with the hardware itself will be paramount in successfully using quantum computers in the

204 Paramount in the clot's capability to stem haemorrhage a

205 -reported outcomes (PROs) in surgery remains paramount in the current medical climate.

206 the controlled experiment, a feature that is paramount in the derivation of the corrected methylation

207 Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologically relevant mole

208 Accurately characterizing exposure is paramount in these studies to ensure valid estimates of

209 ecedented specificity and precision has been paramount in this endeavor.

210 he need for greater research transparency is paramount, inadequate reporting hinders assessment of th

211 tions in which minimized size and weight are paramount, including emerging in situ characterization t

212 tention to the burden of patient symptoms is paramount, including pruritus and fatigue.

213 f proponents who advocate for their cause as paramount, increasingly, given limited resources, by dow

214 Hence, there is a paramount interest in understanding the regulation of vi

215 utes to emissive solid-state materials is of paramount interest, and in this report we describe the b

216 n structures and dynamics of C domains is of paramount interest.

217 non-invasive delivery approaches are also of paramount interest.

218 Paramount is a patient-centered treatment paradigm that

219 Where absolute sensitivity is not paramount, it is advantageous to switch from a highly se

220 isms able to improve energy metabolism is of paramount medical importance because such mechanisms can

221 been recently implicated in a vast array of paramount pathogenic conditions in humans, including mul

222 lites succinate and citrate and hence are of paramount physiological importance.

223 and cancer stem cell (CSC) formation are two paramount processes driving tumor progression, therapy r

224 of cell-associated nanoparticles (NPs) is a paramount question in both nanomedicine and nanotoxicolo

225 nd binding toward its molecular target is of paramount relevance in drug design.

226 ultidrug-resistant profiles, is certainly of paramount relevance, given its obvious effect on the cha

227 e representations that can be generalized, a paramount requirement of linguistic rules.

228 Autophagy plays a paramount role in mammalian antiviral immunity including

229 Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry

230 We have found that dynamic effects have a paramount role in the selectivity observed for these rea

231 This study demonstrates the paramount role of Cyp26b1 in regulating retinoid homeost

232 Our investigation reveals the paramount role played by internal double bonds on the se

233 the dilation of the pulmonary arteries as a paramount sign of PAH, we hypothesized that the ascendin

234 aving group combinations were found to be of paramount significance for achieving successful glycosyl

235 The kynurenine pathway is a paramount source of several immunoregulatory metabolites

236 opy unevenness problem and show that the two paramount sources of bias are the synthesis and amplific

237 rials for the last five decades, which offer paramount technological importance.

238 is almost always associated with pain, it is paramount that the administered pain medication does not

239 es as low-cost colorimetric detectors, it is paramount that they interface with flexible software tha

240 It is paramount that we elucidate which anatomic compartments

241 ularly high pathogenicity of the virus makes paramount the identification and development of promisin

242 differential diagnosis of parkinsonism is of paramount therapeutic and prognostic importance.

243 to-metal charge transfer (LMCT) character is paramount to account for their distinct electron configu

244 ous disease, and stratification of tumors is paramount to achieve better clinical outcomes.

245 heterojunction (BHJ) organic solar cells is paramount to achieve high-efficiency devices.

246 Fast and accurate diagnosis of CDI is paramount to achieve immediate infection control initiat

247 these severely affected children, it is also paramount to address the larger proportion of ZIKV-expos

248 lerate and thrive in diverse environments is paramount to all living organisms, and many organisms sp

249 It is paramount to apply a strong level of scientific rigor to

250 nes by an informed, experienced clinician is paramount to arrive at a correct Stage and Grade.

251 rapid growth of biomedical literature, it is paramount to build tools that facilitate speed and maint

252 r basis for viral latency and persistence is paramount to controlling or eliminating HCMV infection.

253 s reinforces gender and other stereotypes is paramount to creating a culture of inclusivity.

254 accine and therapeutic discovery efforts are paramount to curb the pandemic spread of this zoonotic v

255 steric factors and associated mechanisms are paramount to deepen our understanding of the complex dyn

256 covariates and environmental predictors, are paramount to develop a more complete understanding of th

257 the causes of these persistent illnesses is paramount to develop appropriate therapeutic protocols.

258 ete class-switched neutralizing antibody are paramount to effective immunity.

259 ental evidence that self-organization can be paramount to enhancing ecosystem persistence.

260 Removal of harmful chemicals from water is paramount to environmental cleanliness and safety.

261 of efficacy and potential adverse effects is paramount to formulating the optimal treatment regimen f

262 nd its multiple nonhistone substrates, it is paramount to fully characterize these dynamic changes in

263 d of prognostic factors for complications is paramount to guide therapeutic decisions.

264 to cellular and organismal survival and are paramount to health.

265 area and reduced water availability make it paramount to identify and develop strategies to allow cr

266 Early diagnosis and management are paramount to improve patient outcomes.

267 ing and cellular targets of this cytokine is paramount to inform the design of clinical studies.

268 enoid cyclase as a template for catalysis is paramount to its function, and protein engineering can b

269 To counteract the spread of AR, it is paramount to know which organisms harbor mobile AR genes

270 nt representation of these data is therefore paramount to lessen the burden of storage and facilitate

271 hogens and other environmental challenges is paramount to maintain normal health, and individuals lac

272 ICANCE STATEMENT Predicting future reward is paramount to optimal behavior.

273 reatable feature, on neuro-axonal injury, is paramount to optimize neuroprotective strategy in MS.

274 ccurate risk stratification in this group is paramount to optimize the use of preventive therapies.

275 g receptor tyrosine kinases has proven to be paramount to overcoming chemotherapy resistance in sever

276 Predicting future reward is paramount to performing an optimal action.

277 Rapid reduction of HIV viral load is paramount to prevent peripartum transmission in women di

278 als that pi-donating dialkylamide groups are paramount to successful phosphinidene transfer; poorer p

279 arameters of the employed DrewPhos ligand is paramount to suppressing isomerization and promoting eff

280 discovery of new drugs with novel targets is paramount to the continued success of tuberculosis (TB)

281 Paramount to the development of microbiota-based therape

282 defence-arousal system and its integrity is paramount to the expression of survival behaviours.

283 een aquatic ecosystems and the human host is paramount to the pathogenic success of V. cholerae The t

284 Postexercise nutrition is paramount to the restoration of muscle energy stores by

285 factors that affect explosive sensitivity is paramount to the safe handling and development of new ex

286 Effective mitigation of such pollution is paramount to the safeguarding of human health, animal an

287 es coupled with reduced drug prices has been paramount to the VA's success in curing HCV infection.

288 Reducing surgical costs is paramount to the viability of hospitals.

289 Paramount to these efforts is reducing pregnant women an

290 types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate

291 Thus, it is paramount to understand how salinity drives both microbi

292 abilities of proteins and their complexes is paramount to understanding their biological functions in

293 helial progenitor cells (OEPCs) is therefore paramount to understanding their roles in homeostasis an

294 lderness defenders and Indigenous peoples is paramount, to avoid environmental degradation.

295 The unveiling of their tuning principles is paramount towards a comprehension of not only their opti

296 The development of quantum networks will be paramount towards practical and secure telecommunication

297 inexpensive, and necessary reagent for this paramount transformation.

298 rt Failure With Preserved Ejection Fraction (PARAMOUNT) trial at baseline, 12 and 36 weeks after rand

299 amed reactions of fundamental importance and paramount utility in organic synthesis have been reinves

300 ency on the likelihood of mutation events is paramount when following this approach.