ライフサイエンスコーパス: paramyxovirus

1 ) is a highly pathogenic and deadly zoonotic paramyxovirus.

2 (NiV), a highly pathogenic biosafety level 4 paramyxovirus.

3 Nipah virus (NiV) is the deadliest known paramyxovirus.

4 nger than the corresponding protein of other paramyxoviruses.

5 may be involved in the replication of these paramyxoviruses.

6 of F, which has not been reported for other paramyxoviruses.

7 ng mechanism(s) of the henipaviruses and the paramyxoviruses.

8 se are poorly understood compared with other paramyxoviruses.

9 attenuated vaccines for hMPV and other human paramyxoviruses.

10 bone" appearance of helical nucleocapsids in paramyxoviruses.

11 he most promising vaccine strategy for human paramyxoviruses.

12 be possible to apply these findings to other paramyxoviruses.

13 ds with diameters of 10 to 14 nm, typical of paramyxoviruses.

14 osure model of membrane fusion triggering by paramyxoviruses.

15 tenuated vaccines for aMPV and perhaps other paramyxoviruses.

16 hibitor of both influenza viruses as well as paramyxoviruses.

17 nal receipt mechanism may be conserved among paramyxoviruses.

18 sm for the targeting of the RIG-I pathway by paramyxoviruses.

19 d is understood neither for MV nor for other paramyxoviruses.

20 membrane fusion triggering and cell entry by Paramyxoviruses.

21 ering broad spectrum antivirals for emerging paramyxoviruses.

22 t Sendai virus or human metapneumovirus, two paramyxoviruses.

23 a new structural-biological finding for the paramyxoviruses.

24 design and development of antivirals against paramyxoviruses.

25 This review focuses on paramyxovirus activation of innate immune pathways, the

26 Unlike that for most paramyxoviruses, activation of the henipavirus fusion pr

27 ch in the last decade has uncovered many new paramyxoviruses, airborne agents that cause epidemic dis

28 The V proteins from other paramyxoviruses also bind LGP2 and demonstrate LGP2-depe

29 In fact, the analogous mechanisms in other paramyxoviruses also remain undetermined.

30 matrix protein of Newcastle disease virus, a paramyxovirus and relative of measles virus, forms dimer

31 Nipah virus (NiV) is a pathogenic paramyxovirus and zoononis with very high human fatality

32 that is a highly effective inhibitor of both paramyxoviruses and a set of criteria to be used for eng

33 ld enhance intrinsic cross-immunity to these paramyxoviruses and approaches to controlling recurring

34 f these findings extends beyond NiV to other paramyxoviruses and enveloped viruses.

35 iral entry field extends beyond NiV to other paramyxoviruses and enveloped viruses.

36 Paramyxoviruses and other negative-strand RNA viruses en

37 tly proposed "stalk exposure model" to other paramyxoviruses and propose an "induced fit" hypothesis

38 proposed for parainfluenza virus 5 to other paramyxoviruses and propose an "induced fit" hypothesis

39 shares sequence homology with members of the paramyxoviruses and the filoviruses.

40 For paramyxoviruses, and by analogy for all other negative-s

41 ajor animal populations capable of harboring paramyxoviruses, and host shifting between these animals

42 n the replication and pathogenicity of avian paramyxoviruses (APMVs), we constructed a reverse geneti

43 Paramyxoviruses are a large family of membrane-enveloped

44 Paramyxoviruses are enveloped negative-strand RNA viruse

45 Paramyxoviruses are enveloped, nonsegmented, negative-st

46 Paramyxoviruses are potent activators of extracellular c

47 Paramyxoviruses are responsible for a wide range of dise

48 terplay between glycoprotein trafficking and paramyxovirus assembly.

49 Nipah virus and Hendra virus are two paramyxoviruses associated with high mortality rates in

50 Paramyxovirus attachment and fusion (F) envelope glycopr

51 amental architecture appears conserved among paramyxovirus attachment protein stalk domains, we predi

52 It is unknown how receptor binding by the paramyxovirus attachment proteins (HN, H, or G) triggers

53 The multifunctional HN protein of some paramyxoviruses, besides functioning as the receptor (si

54 able for individual P domains from different paramyxoviruses, but how P interacts with L and how that

55 genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are uncle

56 gglutinin (HA)-neuraminidase protein (HN) of paramyxoviruses carries out three discrete activities, e

57 hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three distinct activities co

58 VI) of the large (L) polymerase proteins of paramyxoviruses catalyzes methyltransferase (MTase) acti

59 VI) of the large (L) polymerase proteins of paramyxoviruses catalyzes methyltransferase (MTase) acti

60 Upon infection, paramyxoviruses cause a second type of membrane fusion,

61 Paramyxoviruses cause a wide variety of diseases, and ye

62 ion that determines the type of disease that paramyxoviruses cause is relatively small.

63 Infection of cultured cells by paramyxoviruses causes cell death, mediated by a newly d

64 Paramyxovirus cell entry is mediated by the fusion prote

65 Here, we have studied paramyxovirus circulation within populations of endemic

66 Hendra virus is a highly pathogenic paramyxovirus classified as a biosafety level four agent

67 iral RNA-dependent RNA polymerase (vRdRp) of paramyxovirus consists of the large (L) protein and the

68 The fusion apparatus of paramyxoviruses consists of a receptor binding tetramer

69 Paramyxoviruses contain glycoprotein fusion machineries

70 Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented R

71 ruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses and flaviviruses.

72 ignificant zoonotic spillover of chiropteran paramyxoviruses could be missed throughout much of Afric

73 ious RNA viruses, including influenza virus, paramyxovirus, dengue virus, and picornavirus.

74 endra virus (HeV) and Nipah virus (NiV), are paramyxoviruses discovered in the mid- to late 1990s tha

75 vated infection levels as well as widespread paramyxovirus dispersal and frequent host exchange of a

76 ntial that addresses major obstacles of anti-paramyxovirus drug development.

77 parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, encodes a V protein that inhibits viral R

78 Most paramyxoviruses enter epithelial cells of the airway usi

79 Paramyxoviruses enter host cells by fusing the viral env

80 fects the design of effective broad-spectrum paramyxovirus entry inhibitors.

81 Membrane fusion is essential for paramyxovirus entry into target cells and for the cell-c

82 te closure of the fusion core does not drive paramyxovirus entry may aid the design of strategies for

83 unctionally varies conserved elements of the paramyxovirus entry pathway, providing a possible explan

84 ship between enhanced fusion activity in the paramyxovirus F protein and increased susceptibility to

85 ermine factors driving this association, 140 paramyxovirus F protein TM domain sequences were analyze

86 brane-proximal external region (MPER) of the paramyxovirus F protein.

87 protein linked to the TM segments from three paramyxovirus F proteins was analyzed by sedimentation e

88 The structure shares a common core with paramyxovirus F proteins, implicating mechanistic simila

89 nding to just the TM region of two different paramyxovirus F proteins.

90 ilarity between postfusion coronavirus S and paramyxovirus F structures demonstrates that a conserved

91 ding of the mechanism(s) of receptor-induced paramyxovirus F triggering during viral entry and cell-c

92 Integrated with previously reported paramyxovirus F-nAb structures, these data support a mod

93 terminal helix is a necessary early step for paramyxovirus F-protein refolding and presents a novel t

94 ct that these motions may act as a universal paramyxovirus F-triggering mechanism.

95 Importance: The paramyxovirus family of negative-strand RNA viruses caus

96 loped viruses such as HIV and members of the paramyxovirus family use metastable, proteinaceous fusio

97 exes may differ among diverse members of the paramyxovirus family, central elements of the triggering

98 sles virus (MeV), a morbillivirus within the paramyxovirus family, expresses two envelope glycoprotei

99 The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric

100 tic distance in the phylogenetic tree of the paramyxovirus family.

101 ed stabilizing structural element within the paramyxovirus family.

102 G interact with NiV F, a new finding for the paramyxovirus family.

103 es PP1 antagonism as a mechanism employed by paramyxoviruses for evading innate immune recognition.

104 can be applicable to other animal and human paramyxoviruses for rationally designing live attenuated

105 Many paramyxoviruses for which bats and rodents serve as majo

106 nsive structure-function relationship of any paramyxovirus FP and demonstrate that the HeV F FP and p

107 rate that the HeV F FP and potentially other paramyxovirus FPs likely require an alpha-helical struct

108 The paramyxovirus fusion (F) glycoprotein is anchored in the

109 Using a paramyxovirus fusion (F) protein, we tested this paradig

110 recently shown that isolated TMDs from three paramyxovirus fusion (F) proteins interact as trimers us

111 Paramyxovirus fusion (F) proteins promote membrane fusio

112 We suggest a general model for paramyxovirus fusion activation in which receptor engage

113 eded to understand the mechanisms underlying paramyxovirus fusion events.

114 Paramyxovirus fusion with the host cell plasma membrane

115 propose a simple model for the activation of paramyxovirus fusion.

116 with the stalk-mediated activation model of paramyxovirus fusion.

117 favor of the HN stalk-mediated activation of paramyxovirus fusion.

118 In common with most paramyxoviruses, fusion mediated by Sendai virus F prote

119 Receptor binding by members of related paramyxovirus genera rearranges the head domains of the

120 e results advance our basic understanding of paramyxovirus genome packaging interactions and also hav

121 Paramyxovirus genomes are ribonucleoprotein (RNP) comple

122 N-glycans on paramyxovirus glycoproteins are generally required for p

123 phosphorylation site within the P protein in paramyxovirus has been identified as playing a positive

124 is is the first time that the P protein of a paramyxovirus has been systematically analyzed for S/T r

125 he small hydrophobic (SH) protein of certain paramyxoviruses has been found to result in attenuation,

126 Most paramyxoviruses have a limited host range.

127 redness, because non-human coronaviruses and paramyxoviruses have been listed as priority concerns in

128 In addition, paramyxoviruses have evolved diverse mechanisms to disru

129 Paramyxoviruses have previously been shown to block prod

130 Most paramyxoviruses have two integral membrane proteins: fus

131 The tetrameric attachment proteins of paramyxoviruses have vastly different binding affinities

132 Negative-strand RNA viruses, including paramyxoviruses, have been shown to alter autophagy, but

133 hens our model for HeV fusion.IMPORTANCE The paramyxovirus Hendra virus (HeV) causes severe respirato

134 N stalk domain, and properties of a chimeric paramyxovirus HN protein, we propose a simple model for

135 By extensive study of properties of multiple paramyxovirus HN proteins, we show that key features of

136 Paramyxovirus HN, H, and G form a dimer-of-dimers consis

137 targeting, and broaden our understanding of paramyxovirus-host interactions.

138 The paramyxoviruses human respiratory syncytial virus (hRSV)

139 ainst a broad range of influenza viruses and paramyxoviruses.IMPORTANCE Influenza viruses are importa

140 he HN protein, which is conserved in several paramyxoviruses.IMPORTANCE Oncolytic Newcastle disease v

141 nd mRNA editing experiments revealed a novel paramyxovirus in the genus Ferlavirus, named anaconda pa

142 Nipah virus (NiV), a paramyxovirus in the genus Henipavirus, has a mortality

143 cent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw

144 in humans and are biosafety level 4 (BSL-4) paramyxoviruses in the growing genus Henipavirus The att

145 Entry of hMPV is unusual among the paramyxoviruses, in that fusion is accomplished by the f

146 Human paramyxoviruses include global causes of lower respirato

147 Paramyxoviruses include many economically and agricultur

148 Paramyxoviruses include many important animal and human

149 Paramyxoviruses include several insidious and ubiquitous

150 sual broad-spectrum activity against diverse paramyxoviruses including respiroviruses (that is, HPIV1

151 Human paramyxoviruses, including hRSV, hMPV, and hPIV3, cause

152 Paramyxoviruses, including human metapneumovirus (HMPV),

153 The paramyxoviruses, including human parainfluenza viruses (

154 aturally occurring cleavage sites of several paramyxoviruses, including neurovirulent and avirulent s

155 Most paramyxoviruses infect host cells via the concerted acti

156 Paramyxoviruses infect the respiratory tract and the cen

157 Phylogenetic analyses revealed that all paramyxoviruses infecting Malagasy bats are UMRVs and sh

158 portance of innate responses in DC following paramyxovirus infection and their consequences for the a

159 ation that H2S also has a protective role in paramyxovirus infection by modulating inflammatory respo

160 t these pathways, and the innate response to paramyxovirus infection of dendritic cells (DC).

161 ally varies conserved motifs of the proposed paramyxovirus infection pathway.

162 pretreated with IFN-alpha were resistant to paramyxovirus infection.

163 ay indicate a new paradigm for understanding Paramyxovirus infection.

164 For nearly all paramyxoviruses, infection is initiated by fusion of the

165 uld represent a novel treatment strategy for paramyxovirus infections.

166 ggesting a broad inhibitory effect of H2S on paramyxovirus infections.

167 otentially be targeted for the inhibition of paramyxovirus infections.

168 etapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world populati

169 Paramyxoviruses initiate entry through the concerted act

170 Here we show that different paramyxoviruses interact in distinct ways with cells in

171 The fusion process for nearly all paramyxoviruses involves the mixing of the host cell pla

172 Human parainfluenza virus type 3 (HPIV3), a paramyxovirus, is a major viral cause of severe lower re

173 Newcastle disease virus (NDV), an avian paramyxovirus, is a promising OV and is inherently tumor

174 MuV, a paramyxovirus, is an important human pathogen.

175 Newcastle disease virus (NDV), an avian paramyxovirus, is inherently tumor selective and is curr

176 ycoprotein G of Hendra virus (HeV), a deadly paramyxovirus, is N-glycosylated at six sites (G2 to G7)

177 Parainfluenza virus 5 (PIV5), a paramyxovirus, is not known to cause any illness in huma

178 J paramyxovirus (JPV) encodes four integral membrane prote

179 J paramyxovirus (JPV) was first isolated from moribund mic

180 s to Newcastle disease virus (NDV), an avian paramyxovirus known to elicit a strong innate immune res

181 ain organization of phylogenetically diverse Paramyxovirus L proteins derived from measles virus (MeV

182 Specific properties of different paramyxoviruses, like neurotoxicity and immunosuppressio

183 Here we describe four approaches by which paramyxoviruses limit IFN induction: by limiting synthes

184 The V proteins of paramyxoviruses limit interferon induction by binding md

185 Other paramyxovirus M proteins have been shown to dimerize, an

186 and Hendra virus (recently emerged zoonotic paramyxoviruses) M (matrix) protein-derived virus-like p

187 For many paramyxoviruses, M proteins drive viral assembly and egr

188 e and sequence conservation imply that other paramyxovirus matrix proteins function similarly.

189 he cytoplasmic tail of the F proteins of the paramyxoviruses measles virus, mumps virus, Newcastle di

190 s, including orthomyxoviruses (influenza A), paramyxoviruses (measles), and hepadnaviruses (hepatitis

191 interactions as conserved core mechanisms of paramyxovirus-mediated membrane fusion.

192 interactions as conserved core mechanisms of paramyxovirus-mediated membrane fusion.

193 V proteins of measles virus and the related paramyxovirus Nipah virus interact with PP1alpha/gamma,

194 g partner for the M proteins of the zoonotic paramyxoviruses Nipah virus and Hendra virus.

195 espiratory syncytial virus, and the zoonotic paramyxoviruses Nipah virus and Hendra virus.

196 defined regions near the C-terminal ends of paramyxovirus nucleocapsid proteins that are important f

197 the F protein of Newcastle disease virus, a paramyxovirus of a different genus, suggesting a conserv

198 uman metapneumovirus (hMPV) is a respiratory paramyxovirus of global clinical relevance.

199 Paramyxoviruses of the morbillivirus genus, such as meas

200 A quantitative approach to paramyxovirus packaging revealed a majority of infectiou

201 odies (sAbs) against multiple domains of the paramyxovirus parainfluenza 5 (PIV5) pre- and postfusion

202 region (MPSR) (HN, residues 37 to 56) of the paramyxovirus parainfluenza virus (PIV5), a region of th

203 The paramyxovirus parainfluenza virus 5 (PIV5) enters cells

204 ure of the F protein (prefusion form) of the paramyxovirus parainfluenza virus 5 (PIV5) WR isolate wa

205 receptor-binding globular head domain of the paramyxovirus parainfluenza virus 5 HN protein is entire

206 For the paramyxoviruses parainfluenza virus 5 (PIV5) and mumps v

207 Interestingly, papaverine also inhibited paramyxoviruses parainfluenza virus 5 (PIV5), human para

208 teractions of the FP of the F protein of the paramyxovirus, parainfluenza virus 5 (PIV5).

209 biquitination of the matrix (M) protein of a paramyxovirus, parainfluenza virus 5 (PIV5).

210 Paramyxovirus particles are formed by a budding process

211 Infectivity of paramyxovirus particles depends on matrix-nucleocapsid p

212 Paramyxovirus pathogens include measles virus, mumps vir

213 us strains of influenza virus as well as the paramyxoviruses PIV5, HPIV3, and RSV.

214 exploited the well-characterized ability of paramyxovirus (PMV) V proteins to counteract both IFN in

215 The paramyxovirus pneumonia virus of mice (PVM) is a model o

216 The paramyxovirus pneumonia virus of mice (PVM) is a rodent

217 Paramyxovirus polymerases are composed of at least two t

218 During transcription, paramyxoviruses produce capped, methylated, and polyaden

219 Paramyxoviruses produce pleiomorphic particles containin

220 xovirus, Sosuga virus (SosV), is one of many paramyxoviruses recently identified and classified withi

221 factor may be involved in the regulation of paramyxovirus replication and could be a target for broa

222 highlights a critical role of 2'-O MTase in paramyxovirus replication and pathogenesis and a new ave

223 Understanding the regulation of paramyxovirus replication will enable the rational desig

224 Paramyxoviruses represent a remarkably diverse family of

225 Most paramyxoviruses require the interaction of two viral pro

226 Paramyxoviruses require two viral membrane glycoproteins

227 The promotion of membrane fusion by most paramyxoviruses requires an interaction between the vira

228 Cell entry by paramyxoviruses requires fusion between viral and cellul

229 annual and biennial pattern of three common paramyxoviruses, Respiratory Syncytial Virus (RSV), Huma

230 magglutinin-neuraminidase protein of another Paramyxovirus revealed a four-helix bundle stalk.

231 gth viral genomes during infections with the paramyxovirus Sendai virus.

232 stle disease virus (NDV), representing avian paramyxovirus serotype 1 (APMV-1), cause respiratory and

233 Avian paramyxovirus serotype 2 (APMV-2) is one of the nine ser

234 Therefore, we thought to evaluate avian paramyxovirus serotype 3 (APMV-3) strain Netherlands as

235 ith the corresponding ectodomains from avian paramyxovirus serotype 3 (APMV-3).

236 structed a reverse genetics system for avian paramyxovirus serotype 7 (APMV-7) to investigate the rol

237 Our data suggest a model in which paramyxoviruses share an overall common strategy for dir

238 The bat-borne paramyxovirus, Sosuga virus (SosV), is one of many param

239 simultaneous identification of IAV-specific, paramyxovirus-specific, and broad-spectrum inhibitors.

240 Paramyxoviruses such as human parainfluenza virus type-3

241 Respiratory paramyxoviruses such as respiratory syncytial virus (RSV

242 tenuated vaccines for hMPV and perhaps other paramyxoviruses, such as hRSV and hPIV3.

243 Medically important paramyxoviruses, such as measles, mumps, parainfluenza,

244 inhibited the synthesis of the RNA of other paramyxoviruses, such as Nipah virus (NiV), human parain

245 ding hemagglutinin-neuraminidases of certain paramyxoviruses suggest that fusion triggering is preced

246 studies of the triggering mechanism of other paramyxoviruses suggest that receptor binding to their h

247 l action of ISG56/IFIT1, while all the other paramyxoviruses tested were resistant.

248 .IMPORTANCE Nipah virus (NiV) is an emerging paramyxovirus that can cause a lethal respiratory and ne

249 Nipah virus (NiV) is a zoonotic emerging paramyxovirus that can cause fatal respiratory illness o

250 Mumps virus (MuV) is a reemerging paramyxovirus that caused large outbreaks in the United

251 s (hMPV) is a relatively recently identified paramyxovirus that causes acute upper and lower respirat

252 Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respir

253 Hendra virus (HeV) is a zoonotic paramyxovirus that causes deadly illness in horses and h

254 virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fatal encephalitis and respira

255 Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes frequent outbreaks of severe n

256 Nipah virus (NiV) is a zoonotic paramyxovirus that causes high mortality rates in humans

257 Human metapneumovirus (HMPV) is a paramyxovirus that causes respiratory disease worldwide.

258 Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and a

259 uman metapneumovirus (hMPV) is a respiratory paramyxovirus that is distributed worldwide and induces

260 Nipah is an emerging paramyxovirus that is of serious concern to human health

261 h virus (NiV) is a deadly emerging enveloped paramyxovirus that primarily targets human endothelial c

262 Nipah virus (NiV) is a highly lethal paramyxovirus that recently emerged as a causative agent

263 Hendra virus (HeV) is a zoonotic paramyxovirus that utilizes a trimeric fusion (F) protei

264 (HeV) are closely related, recently emerged paramyxoviruses that are capable of causing considerable

265 CE Hendra virus and Nipah virus are zoonotic paramyxoviruses that cause lethal infections in humans.

266 us (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses that cause severe disease in both animal

267 (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capa

268 Bats carry a variety of paramyxoviruses that impact human and domestic animal he

269 This is in contrast to other paramyxoviruses that require attachment protein function

270 and fusion could differ mechanistically from paramyxoviruses that use glycan-based receptors.

271 Unlike the case for most paramyxoviruses, the fusion proteins (F) of a number of

272 Across the paramyxoviruses, these domains share little sequence ide

273 In other paramyxoviruses, these residues were shown to affect fus

274 sequencing (HTS) workflow for investigating paramyxovirus transcription and replication.

275 We conclude that paramyxoviruses trigger the DNA damage response, a pathw

276 As with other paramyxoviruses, two major RSV surface viral glycoprotei

277 ed by Newcastle disease virus (NDV) or avian paramyxovirus type 1 (APMV-1), a negative-sense single-s

278 Avian paramyxovirus type 1, NDV, has been an attractive oncoly

279 referred to as Unclassified Morbilli-related paramyxoviruses (UMRVs).

280 c approaches against NiV and other important paramyxoviruses underscores the need to understand viral

281 These findings indicate that paramyxoviruses use a single amino acid to distinguish M

282 Paramyxoviruses use a specialized fusion protein to merg

283 within infected hosts, the vast majority of paramyxoviruses utilize two viral envelope glycoproteins

284 onsequences of MDA5 and LGP2 interference by paramyxovirus V proteins and help resolve the distinct r

285 Paramyxovirus V proteins are interferon antagonists that

286 Paramyxovirus V proteins bind to MDA5 (melanoma differen

287 Importance: Paramyxovirus V proteins interact with two innate immune

288 Paramyxovirus vaccine vectors based on human parainfluen

289 the crystal structures of HN from different paramyxoviruses, varying energy requirements for fusion

290 ut not of wild-type VSV) and Sendai virus (a paramyxovirus) via inhibition of antiviral gene expressi

291 Paramyxovirus viral fusion proteins (F) insert into the

292 scription (RT)-PCR results were positive for paramyxovirus (viral loads of 2.33 x 10(4) to 1.05 x 10(

293 In paramyxoviruses, viral attachment and membrane fusion ar

294 omain of PIV5 F with the C terminus of other paramyxoviruses were unable to cause cell fusion.

295 bserved with parainfluenza virus 5 (PIV5), a paramyxovirus, when neutralizing antibody was used to bl

296 ribed models, including the one proposed for paramyxovirus, where following random movement efficienc

297 enhanced the replication of Sendai virus (a paramyxovirus), which is also highly sensitive to the ty

298 otypical members of the Henipavirus genus of paramyxoviruses, which are designated biosafety level 4

299 ncing of JPV (JPV-LW) confirms that JPV is a paramyxovirus with several unique features.

300 irus in the genus Ferlavirus, named anaconda paramyxovirus, with a typical Ferlavirus genomic organiz