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1  enzymes cellular glutathione peroxidase and paraoxonase).
2 hiolactonase is identical with that of human paraoxonase.
3 herence, without increases in HDL-associated paraoxonase.
4 c properties, and physiological roles of the paraoxonases.
5 ON1 suggest an anti-atherogenic function for paraoxonases.
6 d covered by this review have indicated that paraoxonase 1 'status' (i.e. activity and/or concentrati
7  colony-stimulating factor receptor (MCSFR), paraoxonase 1 (normalized to prothrombin protein), and l
8                                              Paraoxonase 1 (PON 1) is a serum glycoprotein associated
9 ed increased activation and stabilization of paraoxonase 1 (PON1) activity (mumol/min/mg) when compar
10                                    Low serum paraoxonase 1 (PON1) activity determined with paraoxon a
11 terol (HDL-C), apolipoprotein A-I (Apo A-I), paraoxonase 1 (PON1) activity, hepatic gene expression,
12 s may be related to decreased HDL-associated paraoxonase 1 (PON1) activity.
13  proficient organophosphatases such as serum paraoxonase 1 (PON1) and the organophosphate-hydrolyzing
14                    Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein-associ
15  documented that apoA-I, myeloperoxidase and paraoxonase 1 (PON1) form a complex in HDL that is criti
16 e high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) hydrolyzes lactones, aromatic ester
17                                              Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)
18                                              Paraoxonase 1 (PON1) is a high-density lipoprotein-assoc
19                                        Serum paraoxonase 1 (PON1) is a native lactonase capable of pr
20                                              Paraoxonase 1 (PON1) is reported to have antioxidant and
21                          Reduced activity of paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-a
22 cysteine ligase catalytic subunit (Gclc) and paraoxonase 1 (PON1).
23                                        HDL's paraoxonase 1 activity was unaffected by calcium treatme
24 n only a small component of the variation in paraoxonase 1 activity.
25 h both coronary heart disease and diminished paraoxonase 1 activity.
26         Two antiinflammatory HDL components, paraoxonase 1 and apolipoprotein A-I, were also measured
27 protein, cholesterol ester transfer protein, paraoxonase 1 and platelet activating factor acetylhydro
28 erstanding the basic biochemical function of paraoxonase 1 and the discovery of possible modulators o
29  mechanisms underlying the mode of action of paraoxonase 1 and the factors which modulate its activit
30 r regional cord blood DNA methylation at the Paraoxonase 1 gene (PON1) that persisted in early childh
31  coronary heart disease risk factor than the paraoxonase 1 genetic polymorphisms.
32                  New findings on the role of paraoxonase 1 in homocysteine metabolism are reviewed, a
33                                              Paraoxonase 1 is much the most extensively researched an
34                  Experiments with transgenic paraoxonase 1 knock-out mice indicate the potential for
35 gh-density lipoprotein is largely due to the paraoxonase 1 located on it.
36                                Studies using paraoxonase 1 null mice by gene targeting and transgenic
37          The recent controversy over whether paraoxonase 1 or platelet-activating factor acetylhydrol
38  that genetic epidemiological studies of the paraoxonase 1 polymorphisms in relation to coronary hear
39 disease (MND) is supported by association of paraoxonase 1 polymorphisms with amyotrophic lateral scl
40 sgenic mice corroborated the hypothesis that paraoxonase 1 protects against atherosclerosis.
41                                              Paraoxonase 1 protects against protein N-homocysteinylat
42 an underestimate of the true contribution of paraoxonase 1 to coronary heart disease because these po
43                                              Paraoxonase 1(PON1) is an HDL-associated protein, which
44 r interaction = 0.004) and weakly for rs662 (paraoxonase 1) (beta = -3.6, 95% confidence interval: -1
45 cleotide polymorphisms (SNPs) from the PON1 (paraoxonase 1) gene influence the ability to metabolize
46 ncluding apoAI (apolipoprotein AI) and PON1 (paraoxonase 1) prevent cellular oxidative stress and LDL
47                      During the past decade, paraoxonase 1, a HDL-associated protein, has been demons
48             We conclude that, in addition to paraoxonase 1, both paraoxonase 2 and paraoxonase 3 prot
49                               In contrast to paraoxonase 1, the other two members of the paraoxonase
50 ein 8, lysosome C, prenylcysteine oxidase 1, paraoxonase 1, transthyretin, serum amyloid A4, and fibr
51 isease risk associated with polymorphisms of paraoxonase 1, which are most active in lipid peroxide h
52 utritional and pharmacological regulation of paraoxonase 1.
53 ar biology of the antiatherosclerotic enzyme paraoxonase 1.
54                                  Human serum paraoxonase-1 (HuPON1) has the capacity to hydrolyze ary
55 cluding apolipoprotein (apo) A-II, apoE, and paraoxonase-1 (P < 0.05).
56 nducted to determine the effects of tannase, paraoxonase-1 (PON-1) and/or cysteine protease (CP) on t
57 lated hepatic CAT (activity and expression), paraoxonase-1 (PON-1) expression and down-regulated heme
58                                              Paraoxonase-1 (PON-1) is involved in the prevention of a
59                                              Paraoxonase-1 (PON1) is an HDL-associated protein of 354
60                                              Paraoxonase-1 (PON1) is associated with high-density lip
61 ty of high density lipoprotein (HDL)-derived paraoxonase-1 (PON1) was investigated, using peroxidized
62                                              Paraoxonase-1 (PON1), an high density lipoprotein (HDL)-
63 ffer cell expression of a transgene encoding paraoxonase-1 (PON1), whose plasma activity correlates w
64        Using LE-PCR, we determined the human paraoxonase-1 [PON1] molecular haplotypes at three loci
65 y antioxidant/anti-inflammatory capacity and paraoxonase-1 activity were not significant.
66 ioxidant/anti-inflammatory capacity, and (3) paraoxonase-1 activity.
67  haptoglobin, and hemopexin) and depleted of paraoxonase-1 after SFA-HFD in comparison with MUFA-HFD.
68 otein activity), HDL antioxidant properties (paraoxonase-1 arylesterase activity and total HDL antiox
69 creased HDL ability to esterify cholesterol, paraoxonase-1 arylesterase activity, and HDL vasodilator
70 y, we show that PPARgamma induces macrophage paraoxonase 2 (PON-2), an enzyme that degrades QS molecu
71                  The intracellular lactonase paraoxonase 2 (PON2) hydrolyzes and inactivates 3OC12 an
72 cells damaged by C12-HSL exposure, while the paraoxonase 2 (PON2) inhibitor (Triazolo[4,3-a]quinolone
73 ssed genes associated with cancer, including paraoxonase 2 (PON2), whereas DKONR MEF expressed little
74 e found that p53 transcriptionally represses paraoxonase 2 (PON2), which regulates GLUT1-mediated glu
75  up-regulated, whereas antioxidant proteins, paraoxonase 2 and glutathione peroxidase 3, were down-re
76 ast 2 years suggesting a protective role for paraoxonase 2 and paraoxonase 3 in the development of at
77 ude that, in addition to paraoxonase 1, both paraoxonase 2 and paraoxonase 3 proteins are protective
78 mbers of the paraoxonase gene family, namely paraoxonase 2 and paraoxonase 3, are either undetectable
79      Adenovirus-mediated expression of human paraoxonase 2 or paraoxonase 3 proteins protects against
80  and paraoxonase 3, are either undetectable (paraoxonase 2) or detected at very low levels (paraoxona
81                                              Paraoxonase 2-deficient mice develop significantly large
82                                              Paraoxonase-2 (PON-2) is a membrane-bound lactonase with
83 se effects are dependent on the induction of paraoxonase-2, a QS hydrolyzing enzyme, that mitigates t
84 al cells by a mechanism that is mediated via paraoxonase-2.
85                                              Paraoxonase 3 (PON3) is a member of the PON family, whic
86                                              Paraoxonase 3 (PON3) is expressed in the aldosterone-sen
87                                              Paraoxonase 3 (PON3) is expressed in the distal nephron
88 ting a protective role for paraoxonase 2 and paraoxonase 3 in the development of atherosclerosis in m
89 ion to paraoxonase 1, both paraoxonase 2 and paraoxonase 3 proteins are protective against the develo
90 ediated expression of human paraoxonase 2 or paraoxonase 3 proteins protects against the development
91 raoxonase 2) or detected at very low levels (paraoxonase 3) on HDL, and are considered to participate
92 xonase gene family, namely paraoxonase 2 and paraoxonase 3, are either undetectable (paraoxonase 2) o
93 associations were observed with cathepsin D, paraoxonase 3, renin andfollistatin, neither of which wa
94 and lowest PON1 activity quartiles were, for paraoxonase, 3.4 (95% CI, 2.1-5.5; P < .001) and for ary
95 port the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO).
96 otect is a decrease in the activity of serum paraoxonase, a serum esterase carried on HDL that has pr
97 1, PON3 has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones s
98  protein, phospholipid transfer protein, and paraoxonase activities) were measured at the end of each
99    Turkey and chicken, like most birds, lack paraoxonase activity and are very susceptible to organop
100  HDL with purified paraoxonase restored both paraoxonase activity and the ability to protect against
101 eatment increased plasma HDL cholesterol and paraoxonase activity compared with PBS and inhibited inc
102 ctivity is minimal, whereas the kcat for the paraoxonase activity is negatively perturbed by up to 10
103 ructurally and functionally critical for the paraoxonase activity of PON1 prevent it from being able
104                The H115W variant of G2E6 has paraoxonase activity similar to that of wild-type G2E6,
105 ed in patients on HD, whereas HDL-associated paraoxonase activity was lowest in patients on PD.
106 pre-beta mobility and enriched in apoA-I and paraoxonase activity were found in plasma.
107 hosphates (OPs) by OPH and determining serum paraoxonase activity which appears to be important for p
108 rrelated less strongly (r=-0.36, P=0.025 for paraoxonase activity) or did not correlate at all (pheny
109 otein lipid hydroperoxides (LOOH), increased paraoxonase activity, increased plasma HDL-cholesterol l
110 rmation of pre-beta HDL containing increased paraoxonase activity, resulting in significant improveme
111 ect associated with a 5-fold increase in HDL paraoxonase activity.
112 ith pre-beta mobility enriched in apoA-I and paraoxonase activity.
113 zed phospholipids or PAF, yet displayed full paraoxonase activity.
114 ability to hydrolyze oxidized lipids in LDL, paraoxonase also alters the oxidative state of macrophag
115 t was associated with a decreased content of paraoxonase, an enzyme that protects against LDL oxidati
116           These and other data indicate that paraoxonase, an organophosphate-detoxifying enzyme whose
117 dicates that both the serum concentration of paraoxonase and an individual's genotype are related to
118  in the genes for glutathione S-transferase, paraoxonase and apolipoprotein E on the risk of coronary
119                                        Serum paraoxonase and aryl esterase activity did not differ be
120 rtile (23/315 [7.3%]) and 235/324 [7.7%] for paraoxonase and arylesterase, respectively) compared wit
121 311 [25.1%] and 75/319 [23.5%]; P < .001 for paraoxonase and arylesterase, respectively).
122  specifically by the OPases, mammalian serum paraoxonase and bacterial organophosphorus hydrolase (OP
123 nalyses showed that 2 Delta variables, Delta paraoxonase and Delta HDL(2), were significantly heritab
124 s with respect to the mechanism of action of paraoxonase and differences between the family members t
125                            The activities of paraoxonase and platelet-activating factor acetylhydrola
126 ptoglobin-related protein (Hpr), hemoglobin, paraoxonase, and apoA-II, whereas TLF2 is a larger, poor
127 protein associated with the plasma esterase, paraoxonase, and clusterin.
128 eins: apolipoprotein AI, apolipoprotein AII, paraoxonase, and the primate-specific haptoglobin-relate
129 ains mainly apoA-I and Hpr, trace amounts of paraoxonase, apoA-II, and haptoglobin, but no detectable
130 oteins associated with HDL metabolism (e.g., paraoxonase, apolipoprotein A-I, lecithin:cholesterol ac
131       Common polymorphisms in genes encoding paraoxonase are established risk factors in a variety of
132 ess index (OSI), lipid hydroperoxide levels, paraoxonase, arylesterase, and ceruloplasmin activity, p
133  lipid hydroperoxides, and the activities of paraoxonase, arylesterase, and ceruloplasmin.
134                                        Serum paraoxonase/arylesterase (PON) is an "A" esterase found
135               Until recently, only the serum paraoxonase/arylesterase (PON1) had been purified and ch
136 TRX2 [anthrax toxin receptor 2], PON1 [serum paraoxonase/arylesterase], SERPINA1 [alpha-1-antitrypsin
137 erol acyltransferase and apolipoprotein E is paraoxonase associated with non-HDL lipoproteins.
138                          The displacement of paraoxonase by serum amyloid A may explain in part the p
139 ted with HDL such as PAF acetylhydrolase and paraoxonase can participate in the elimination of biolog
140 h free ghrelin and paraoxon, a substrate for paraoxonase, can inhibit this interaction.
141 is detoxified by the serum Hcy-thiolactonase/paraoxonase carried on high density lipoprotein.
142 0 times more sensitive for OPH and mammalian paraoxonase detection than existing methods.
143 eered variant of the reconstructed ancestral paraoxonase enzyme N9, catalysed the dynamic kinetic res
144 lexes, as was total dimethylphosphates after paraoxonase expression was considered.
145 advances have been made in research into the paraoxonase family and atherosclerosis, much more needs
146                                          The paraoxonase family consists of three members (PON1, PON2
147 otein-associated antioxidant enzymes such as paraoxonase from inhibition and protect apoA-I from oxid
148 underscore the utility of all members of the paraoxonase gene family as therapeutic targets for the t
149                                          The paraoxonase gene family contains at least three members:
150  paraoxonase 1, the other two members of the paraoxonase gene family, namely paraoxonase 2 and paraox
151  the discovery that two other members of the paraoxonase gene family, PON2 and PON3, may also have im
152                  Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in p
153                                              Paraoxonase has a genetic polymorphism that results in a
154  of studies of genetic determinants of serum paraoxonase have reported apparently conflicting results
155 ic lesion development, supporting a role for paraoxonase in atherogenesis.
156  also to coronary heart disease, implicating paraoxonase in the development of atherosclerosis.
157                                              Paraoxonase is an arylesterase enzyme that is expressed
158                 The exact mechanism by which paraoxonase is cardioprotective is not clear, although i
159 hough there have been suggestions that serum paraoxonase is important in protecting against coronary
160                                  Human serum paraoxonase is located on an HDL.
161 malian hepatocytes, here we characterize the paraoxonase-like C20orf3/adipocyte plasma-membrane-assoc
162 s suggested these proteins interact with the paraoxonase-like MEC-6 and the cholesterol-binding stoma
163                   An additional protein, the paraoxonase-like protein MEC-6, is essential for transdu
164                                The levels of paraoxonase mRNA decreased in B6 mice upon challenge wit
165 ed from the B6 and C3H parental strains, low paraoxonase mRNA levels segregated with aortic lesion de
166 rties, along with the HDL-associated enzymes paraoxonase, platelet activating factor acetylhydrolase
167 e that alterations in the relative levels of paraoxonase, platelet-activating factor acetylhydrolase,
168 anti- to a proinflammatory particle and that paraoxonase plays a role in this transformation.
169 ommon polymorphism at codon 192 in the human paraoxonase (PON) 1 gene has been shown to be associated
170           Since 3OC12-HSL can be degraded by paraoxonase (PON) family members, we hypothesized that P
171 hown to be hydrolytically inactivated by the paraoxonase (PON) family of calcium-dependent esterases,
172                                          The paraoxonase (PON) gene family includes three members, PO
173                                              Paraoxonase (PON) is transported primarily on apolipopro
174 eased apolipoprotein J (apoJ), and decreased paraoxonase (PON) mRNA levels.
175                                              Paraoxonase (PON), a high-density lipoprotein-associated
176 sly shown that two antioxidant-like enzymes, paraoxonase (PON)-1 and PON3, are high density lipoprote
177 iated with HDL; apolipoprotein J (apoJ), and paraoxonase (PON).
178       There was significantly reduced plasma paraoxonase (PON-1) activity, impaired HDL vascular anti
179 92R, L55M, and T(-107)C polymorphisms in the paraoxonase PON1 gene and the S311C polymorphism in the
180  density lipoprotein (HDL)-associated enzyme paraoxonase (PON1) contributes significantly to the deto
181                          The hypothesis that paraoxonase (PON1) has a role in preventing atherosclero
182                                              Paraoxonase (PON1) hydrolyses organophosphate insecticid
183                         Human HDL-associated paraoxonase (PON1) hydrolyzes a number of toxic organoph
184                                        Serum paraoxonase (PON1) is an enzyme associated exclusively w
185                                        Serum paraoxonase (PON1) is an esterase that is associated wit
186                     A physiological role for paraoxonase (PON1) is still uncertain, but it catalyzes
187 uses on the functional genomics of the human paraoxonase (PON1) polymorphisms.
188                                        Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits L
189                                              Paraoxonase (PON1), carried on high-density lipoproteins
190  Pseudomonas diminuta, and a mammalian serum paraoxonase (PON1), confirmed that the analogues mimic t
191                                        Serum paraoxonase (PON1), present on high density lipoprotein,
192                                              Paraoxonases (PONs) are a family of lactonases with prom
193                                              Paraoxonases (PONs) are a family of proteins that may pl
194                                        Serum paraoxonases (PONs) are detoxifying lactonases that were
195 c diet but increased in C3H, indicating that paraoxonase production is under genetic control.
196                The structural portion of the paraoxonase protein is encoded by nine exons that form t
197 loning and characterization of human PON2, a paraoxonase-related gene-2 that is physically linked wit
198   Several important advances in the field of paraoxonase research have occurred during this review pe
199 (192) and PON1 L(55)Q(192) isoforms of human paraoxonase, respectively.
200 n of the apoAII transgenic HDL with purified paraoxonase restored both paraoxonase activity and the a
201 increased periodontitis risk nor an impaired paraoxonase status.
202  accelerated in the presence of rabbit serum paraoxonase, suggesting that organophosphorus hydrolase
203 ere hydrolyzed in human plasma by the enzyme paraoxonase to the respective hydroxy acids, which were
204 tes and 3 proteins (Cathepsin D, Galectin-4, Paraoxonase type 3) with a novel association with incide
205 n-4, with an increased risk of diabetes, and Paraoxonase type 3, with a decreased risk of diabetes, r
206 els of leptin, heparin cofactor 2, and serum paraoxonase were associated with mortality after adjusti
207 -spanning protein with limited similarity to paraoxonases, which are implicated in human coronary hea
208  homocysteine thiolactone, the thiolactonase/paraoxonase would protect proteins against homocysteinyl
209 vance our earlier QM/MM maturation of A17 Ig-paraoxonase (WTIgP) as a reactibody for organophosphorus

 
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