ライフサイエンスコーパス: paraquat

1 rent oxidizing agents (hydrogen peroxide and paraquat).

2 ts and mitochondria following treatment with paraquat.

3 the superoxide-generating redox-cycling drug paraquat.

4 cold and reactive oxygen species-generating paraquat.

5 )O(2) production by the redox cycling agent, paraquat.

6 e susceptible to oxidative stress induced by paraquat.

7 ced tolerance to oxidative stress induced by paraquat.

8 sed resistance to the free-radical generator paraquat.

9 ion has been reported between a cryptand and paraquat.

10 e and Delta sodA1 cells after treatment with paraquat.

11 etected at lower levels after treatment with paraquat.

12 in brain regions of normal mice treated with paraquat.

13 ction exhibit variation in susceptibility to paraquat.

14 iotics such as berberine, rhodamine 123, and paraquat.

15 factors, we treated DJ-1-deficient mice with paraquat.

16 eroxide generated by the redox-cycling agent paraquat.

17 ent with the superoxide-generating compound, paraquat.

18 ecrotic lesions, and increased resistance to paraquat.

19 of nickel, copper, alkaline pH, menadione or paraquat.

20 in; however, the mutant was less tolerant to paraquat.

21 der aerobic conditions or in the presence of paraquat.

22 roxides, and the superoxide-generating agent paraquat.

23 Y) were protected from damage to cadmium and paraquat.

24 he knockdown of TcSOD2 by exposing larvae to paraquat.

25 ty of the transgenic plants to polyamine and paraquat.

26 ath following exposure to subtoxic levels of paraquat.

27 but not by tert-butylhydroquinone (tBHQ) or paraquat.

28 enhanced by the superoxide-producing agent, paraquat.

29 of c-FLIP(L) protein induced by menadione or paraquat.

30 HeLa cancer cells treated with menadione or paraquat.

31 one of the most powerful hosts reported for paraquats.

32 tri(1,4,7,10,13-pentaoxatridecyl) (3b), with paraquat (1) have 2:1 stoichiometry.

33 Paraquat (10-100 microm) was found to cause a 2-4-fold i

34 f a tetracationic molecular square, cyclobis(paraquat-4,4'-biphenylene), as the pi-electron deficient

35 ger, square-shaped diradical host, [cyclobis(paraquat-4,4'-biphenylene)](2(+*)) (MS(2(+*))).

36 ant K(a) = 5.0 x 10(6) M(-1) in acetone with paraquat, 9000 times greater than the crown ether system

37 epletion in the presence of methyl viologen (paraquat), a known agent of oxidative stress and source

38 to dopamine cells, suspicion has focused on paraquat, a common herbicide with chemical structure sim

39 atenin signaling manipulation in vitro using paraquat, a known oxidative stress inducer.

40 S1 gene render sos1 mutants more tolerant to paraquat, a non-selective herbicide causing oxidative st

41 Paraquat, a prooxidant widely used in stress tests, had

42 Paraquat, a reactive oxygen species generator, alone was

43 a producer of reactive oxygen species (ROS), paraquat, all rescued wild-type worms from hemiasterlin

44 higher risk when exposed to either maneb or paraquat alone (odds ratio = 2.27, 95% CI: 0.91, 5.70) o

45 the most severe consequences of exposure to paraquat, an herbicide that causes rapid alveolar inflam

46 t was combined with a sensor for analysis of paraquat, an herbicide widely used over the world.

47 Exposure to paraquat, an herbicide with structure similar to the dop

48 ed by low levels of the superoxide-generator paraquat and by a mutation that inhibits respiration.

49 utant are killed to a greater extent only by paraquat and diamide, whereas they are less susceptible

50 etermination of two bipyridylium herbicides, paraquat and diquat, in cowpeas by UPLC-MS/MS in a total

51 dietary supplementation with two compounds, paraquat and ethanol, on food ingestion and preference.

52 hypersensitivity of SelH shRNA HeLa cells to paraquat and H2O2, but not to hydroxyurea, neocarzinosta

53 tenuated neuronal death mediated by combined paraquat and iron treatment.

54 opathology, were treated with the pesticides paraquat and maneb (either singly or together), and thei

55 ergic neurotoxicity produced by the combined paraquat and maneb model of the Parkinson disease phenot

56 Environmental paraquat and neonatal iron exposure have both been separ

57 HL knockout animals with the potent oxidizer paraquat and observed a robust induction of cellular sen

58 ity to those environmental agents, including paraquat and rotenone, linked to PD in humans.

59 nsitivity to the superoxide-generating agent paraquat and to organic hydroperoxides.

60 nd 4, possessed diminished binding with both paraquats and diquat relative to the 30-crown-based anal

61 ease (PD)-linked toxins (rotenone, maneb, or paraquat) and documented significant protection in neuro

62 pyocyanin (and the closely related molecule paraquat) and the acyl-homoserine lactone 3-OC12-HSL sig

63 erbicides (2,4,5-T, atrazine, cyanazine, and paraquat) and two insecticides (chlorpyrifos and chlorda

64 ed by their respective inducers: salicylate, paraquat, and decanoate.

65 to killing by hydrogen peroxide, menadione, paraquat, and diamide.

66 stimuli such as staurosporine, thapsigargin, paraquat, and H(2)O(2) showed significantly enhanced sur

67 rodegeneration, including hyperoxia, dietary paraquat, and heat stress.

68 yl), anesthetics, neurotoxins, the pesticide paraquat, and heparin anti-coagulants by the PK approach

69 ve stresses induced by hydrogen peroxide and paraquat, and it reduced transformation efficiency about

70 P1 to P28 and was also sensitive to hypoxia, paraquat, and myocardial infarction.

71 Environmental toxins, such as the herbicide paraquat, appear to be risk factors, and it has been pro

72 sponse to oxidative stress (i.e. H(2)O(2) or paraquat application), heat shock, or wounding.

73 , Zat7, or WRKY25 in response to H(2)O(2) or paraquat application.

74 l tested compounds, not even of the cationic paraquat at pH 7, 9, and 11.

75 or that can situate alongside a pi-accepting paraquat-based macrocycle by folding of a flexible linke

76 be an aromatic edge-to-face interaction of a paraquat beta-proton with the hydroquinone moiety; this

77 The complex based on dibenzo-24-crown-8 and paraquat bis(hexafluorophosphate) is not ion paired in s

78 oTEMPO reversed many proteomic signatures of paraquat but this reversal was incomplete.

79 However, exposure to 38 degrees C, paraquat, cadmium, or deletion of SOD1 enhanced two- to

80 We find that paraquat can replicate a broad spectrum of parkinsonian

81 Ingestion of paraquat causes multi-organ failure.

82 nds the KPF6 and allows the colored cryptand-paraquat complex to reform.

83 red in the presence of paraquat, there was a paraquat concentration-dependent increase in the formati

84 best estimated through measurement of blood paraquat concentrations but this facility is not availab

85 0 nm was linearly proportional to thiram and paraquat concentrations in the ranges from 0.5 to 1000 m

86 Formation of the paraquat/cryptand-based pseudorotaxanes can be switched

87 ement of ROS from NADPH oxidase in mediating paraquat cytotoxicity in BV-2 microglial cells and this

88 Isotopically labeled internal standards, Paraquat-D6 and Diquat-D4, were used and added to the te

89 We found four independent factors for paraquat death prediction: amylase, PaCO2, leukocyte num

90 new cryptands form pseudorotaxanes with the paraquat derivative N,N'-bis(beta-hydroxyethyl)-4,4'-bip

91 atives and bis(p-phenylene)-34-crown-10 with paraquat derivatives are all ion paired in solution and

92 It was found that these cryptands bind paraquat derivatives very strongly.

93 The first cylindrical host for paraquat derivatives was prepared and characterized by X

94 Their complexes with paraquat derivatives were studied by proton NMR spectros

95 s a luminescent crown ether based host 1 and paraquat derivatives, 2(PF(6))(2) and 3(PF(6))(2), as gu

96 MOF-1001 is capable of docking paraquat dication (PQT2+) guests within the macrocycles

97 e included as controls (simazine, maneb, and paraquat dichloride).

98 The same dose of paraquat did not interfere with implantation in WT mice.

99 K+ displaces paraquat diol from the cryptands, converting yellow-oran

100 4,4'-bipyridinium bis(hexafluorophosphate) ("paraquat diol", 6): Ka=1.0x10(4) and 1.4x10(4) M-1, resp

101 ctures are reported for both cryptands, both paraquat diol-based pseudorotaxanes, both NH4PF6 complex

102 widespread protein expression changes in the paraquat-exposed heart especially in organelle-containin

103 aminergic neuron death, and morbidity during paraquat exposure but confer sensitivity to hydrogen per

104 test the hypothesis that chronic, low-level paraquat exposure causes restrictive lung function with

105 es not readily support the causative role of paraquat exposure in idiopathic Parkinson's disease.

106 ence interval = 0.9-3.0) with the cumulative paraquat exposure index in models adjusted for age, weig

107 In linear regression models, cumulative paraquat exposure was not an independent predictor of VA

108 The association of paraquat exposure with ventilatory equivalent and oxygen

109 gnificantly higher with increased cumulative paraquat exposure.

110 They generated estimates for maneb and paraquat exposures incurred between 1974 and 1999.

111 ding to the beta-pyridinium hydrogens of the paraquat guests.

112 Most (66.6%) were paraquat handlers; 24.8% of handlers and 27.3% of nonhan

113 Its complex with paraquat has 1:2 stoichiometry.

114 Exposure of mice to the herbicide paraquat has been demonstrated to result in the selectiv

115 exposure to the oxidant-producing herbicide paraquat has been implicated as a risk factor in Parkins

116 fection, or treatment with salicylate or the paraquat herbicide that generates activated oxygen speci

117 Nrf2 activity, increases their resistance to paraquat, hydrogen peroxide, cadmium, and UV light, rend

118 s study assessed the brain uptake of [(11)C]-paraquat in adult male rhesus macaques using quantitativ

119 poptotic gene BAX, and superoxide-generating paraquat in Arabidopsis or Nicotiana benthamiana.

120 Results showed minimal uptake of [(11)C]-paraquat in the macaque brain.

121 be for the sensitive detection of thiram and paraquat in water and food samples.

122 models of Parkinson's disease (PD), MPTP and paraquat, in young animals, its prolonged elevation resu

123 that exposure to a combination of maneb and paraquat increases PD risk, particularly in younger subj

124 Examples include enhanced methyl viologen (Paraquat)-induced oxidative stress tolerance in Mn-super

125 The protocol was set up using Paraquat-induced carbonylation, a model that induces pro

126 ROS and the underlying signaling pathway for paraquat-induced cytotoxicity to BV-2 microglial cells.

127 (EUK-134 and EUK-189) in protecting against paraquat-induced dopaminergic cell death in both the rat

128 thway inhibitor CEP-11004 effectively blocks paraquat-induced dopaminergic neuronal death in vivo.

129 rray analyses were conducted to evaluate the paraquat-induced global transcriptional response of Baci

130 pherol and N-acetylcysteine (NAC) attenuated paraquat-induced implantation failure in P(4)-treated Fk

131 from this enzyme are likely to contribute to paraquat-induced lung toxicity.

132 In the paraquat-induced model of Parkinsonism, this nigro-vagal

133 dings support a role for oxidative stress in paraquat-induced neurotoxicity and suggest novel therape

134 EUK-134 or EUK-189 significantly attenuates paraquat-induced neurotoxicity in vitro in a concentrati

135 amine synthesis, can alter susceptibility to paraquat-induced oxidative damage.

136 uced uterine PRDX6 levels are susceptible to paraquat-induced oxidative stress (OS), leading to impla

137 2-treated UOK262 renal carcinoma cells and a paraquat-induced oxidative stress cell model, demonstrat

138 FOXO transcription factor and protected from paraquat-induced oxidative stress.

139 Paraquat-induced ROS production (including superoxide an

140 d kinases (ERK1/2) could partially attenuate paraquat-induced ROS production and cell death.

141 Paraquat-induced ROS production was inhibited by NADPH o

142 f superoxide dismutase (SOD) enzymes against paraquat-induced toxicity, as well as the therapeutic po

143 Apocynin and DPI also rescued cells from paraquat-induced toxicity.

144 selective PKCdelta inhibitor, also inhibited paraquat-induced translocation of p67phox.

145 Our data show that paraquat induces the sequential phosphorylation of c-Jun

146 Although intraperitoneal paraquat injections in mice cause a selective loss of do

147 s is sufficient to confer protection against paraquat insult.

148 gly, protection against the neurotoxicity of paraquat is conferred by mutations that elevate dopamine

149 in vivo effects have been ambiguous because paraquat is di-cationic in plasma, which raises question

150 This acute exposure study found that paraquat is excluded from the brain by the blood brain b

151 duced by treatment with rotenone, MPP(+), or paraquat is independent of complex I inhibition.

152 Paraquat is known to induce toxicity in cells by stimula

153 Paraquat is thus frequently used in the fruit fly Drosop

154 -1)) and very high association constants for paraquats (Ka > 10(5) M(-1)) in acetone at 22 degrees C.

155 rotenone or induction of oxidative stress by paraquat led to an increase in the phosphorylation of v-

156 Non-transgenic mice chronically exposed to paraquat + maneb exhibited significant reductions in loc

157 Even a single injection of paraquat + maneb in the non-transgenic treated group mod

158 To begin to determine critical pathways of paraquat + maneb neurotoxicity, the functions of cell de

159 d to saline, paraquat, or the combination of paraquat + maneb twice a week for 9 weeks.

160 assertion that protective mechanisms against paraquat + maneb-induced neurodegeneration could involve

161 droperoxides in the midbrain and striatum of paraquat + maneb-treated non-transgenic mice was not det

162 l toxins, including environmental pesticides paraquat, maneb, and rotenone.

163 sociated with the disorder and that iron and paraquat may act via common oxidative stress-mediated me

164 valent and oxygen desaturation suggests that paraquat may be associated with subclinical gas exchange

165 gnaling cascade is a direct activator of the paraquat-mediated nigral dopaminergic neuronal apoptotic

166 antimycin A prevented mitochondrial- but not paraquat-mediated oxygen flux into cells.

167 systemic administration of EUK-189 decreases paraquat-mediated SNpc dopaminergic neuronal cell death

168 the CL mutants do not display sensitivity to paraquat, menadione or hydrogen peroxide (H2O2).

169 hibit excessive elevations of ROS induced by paraquat, menadione, and light stress and prevent cell d

170 ance was observed for fibroblasts exposed to paraquat, methyl methanesulfonate, and rotenone (P<0.05

171 Although in vitro evidence for paraquat neurotoxicity to dopamine cells is well establi

172 Paraquat neurotoxicity was compared in control animals v

173 ing microsensors, we measured the effects of paraquat on oxygen flux into murine lung epithelial cell

174 ute exposure of the oxidative stress inducer paraquat on protein expression in mouse hearts.

175 Rats were given injections of paraquat once weekly for 3 weeks to induce features of P

176 osure to reactive oxygen species generators (paraquat or cadmium), or lack of superoxide dismutases.

177 stance of MCF7 breast cancer cells to either paraquat or doxorubicin.

178 ative stress induced by agents such as H2O2, paraquat or oxygen.

179 und its axis and lies with its smaller side (paraquat or phenyl ring) parallel to the surface to acco

180 eir tolerance to oxidative stress imposed by paraquat or t-butyl hydroperoxide, or were subjected to

181 = 2.2 (95% CI: 1.5, 3.3), and the herbicide paraquat (OR(adj) = 1.8 (95% CI: 1.1, 2.8) was significa

182 y (i.e. treatment of mice with the herbicide paraquat) or transgenic protein overexpression, the intr

183 ound that exposure of RPE cells to H(2)O(2), paraquat, or A2E-mediated photooxidation resulted in inc

184 ls with the superoxide generators menadione, paraquat, or buthionine sulfoximine down-regulates c-FLI

185 s treated with brefeldin A, rotenone, maneb, paraquat, or preformed fibrils of alpha-synuclein.

186 non-transgenic mice were exposed to saline, paraquat, or the combination of paraquat + maneb twice a

187 RGC5 cells against TNFalpha cytotoxicity and paraquat oxidative stress.

188 lasmic diphenyleneiodonium-sensitive NAD(P)H:paraquat oxidoreductase.

189 eceptor, inspired by the ubiquitous cyclobis(paraquat- p-phenylene)cyclophane ("blue box").

190 quat-p-phenylene) (CTPQT(6+) ) and cyclotris(paraquat-p-1,4-dimethoxyphenylene) (MCTPQT(6+) ) were pr

191 bstituted tetracationic cyclophane, cyclobis(paraquat-p-1,4-dimethoxyphenylene), which associates in

192 ution of the well-known cyclophane, cyclobis(paraquat-p-phenylene) (BB(4+) ), and two cucurbit[7]uril

193 ability of the diradical dicationic cyclobis(paraquat-p-phenylene) (CBPQT(2(*+))) ring to form inclus

194 rings of the bipyridinium units in cyclobis(paraquat-p-phenylene) (CBPQT(4+) or "blue box") and desc

195 otion of the ring-shaped component, cyclobis(paraquat-p-phenylene) (CBPQT(4+)) (denoted as the ring),

196 g interactions taking place between cyclobis(paraquat-p-phenylene) (CBPQT(4+)) and five different mon

197 )) generated by the complexation of cyclobis(paraquat-p-phenylene) (CBPQT(4+)) and the guest molecule

198 dox-active rotaxanes, which drove a cyclobis(paraquat-p-phenylene) (CBPQT(4+)) mobile ring between a

199 pyridinium (P-BIPY(2+)) unit and a cyclobis (paraquat-p-phenylene) (CBPQT(4+)) ring component.

200 istable [2]rotaxane consisting of a cyclobis(paraquat-p-phenylene) (CBPQT(4+)) ring encircling a dumb

201 s mechanically interlocked with the cyclobis(paraquat-p-phenylene) (CBPQT(4+)) ring has also been pre

202 The location of the two cyclobis(paraquat-p-phenylene) (CBPQT(4+)) rings can be controlle

203 nes formed between these stalks and cyclobis(paraquat-p-phenylene) (CBPQT(4+)) rings, and (c) bistabl

204 us series of [2]rotaxanes, in which cyclobis(paraquat-p-phenylene) (CBPQT(4+)) serves as the ring com

205 aphthalene (DNP) units encircled by cyclobis(paraquat-p-phenylene) (CBPQT(4+)), a pi electron-accepti

206 on a tetracationic cyclophane host, cyclobis(paraquat-p-phenylene) (CBPQT(4+)), and a 1,5-dioxynaphth

207 otion of the ring-shaped component, cyclobis(paraquat-p-phenylene) (CBPQT(4+)), between a monopyrrolo

208 ous hosts-cucurbit[7]uril (CB7) and cyclobis(paraquat-p-phenylene) (CBPQT(4+)), respectively-using th

209 with the tetracationic cyclophane, cyclobis(paraquat-p-phenylene) (CBPQT(4+)), was synthesized by do

210 y with the tetracationic cyclophane cyclobis(paraquat-p-phenylene) (CBPQT(4+)), were obtained by dono

211 We find that the orientation of the cyclobis(paraquat-p-phenylene) (CBPQT) ring depends dramatically

212 ur donor-acceptor [2]catenanes with cyclobis(paraquat-p-phenylene) (CBPQT4+) as the pi-electron-accep

213 station, and (iii) a tetracationic cyclobis(paraquat-p-phenylene) (CBPQT4+) pi-electron-acceptor cyc

214 cled by a tetracationic cyclophane, cyclobis(paraquat-p-phenylene) (CBPQT4+), contrary to what is obs

215 Cyclotris(paraquat-p-phenylene) (CTPQT(6+) ) and cyclotris(paraqua

216 s observed for the reduced state of cyclobis(paraquat-p-phenylene) and that of its trisradical tricat

217 e unit, interlocked mechanically by cyclobis(paraquat-p-phenylene) as its tetrachloride, exists as a

218 onor-acceptor [2]catenanes based on cyclobis(paraquat-p-phenylene) as the pi-acceptor ring have been

219 ely strong inclusion complexes with cyclobis(paraquat-p-phenylene) in its diradical dicationic redox

220 The 'blue box' (cyclobis(paraquat-p-phenylene) or CBPQT(4+)), developed by Stodda

221 tristable [2]rotaxane composed of a cyclobis(paraquat-p-phenylene) ring and a dumbbell with tetrathia

222 d bistable [2]rotaxane containing a cyclobis(paraquat-p-phenylene) ring and tetrathiafulvalene/1,5-di

223 rown ether occupies the cavity of a cyclobis(paraquat-p-phenylene) ring and the other in which a 1,5-

224 The cyclobis(paraquat-p-phenylene) ring in the [2]rotaxane can be swi

225 Altering the redox state of a cyclobis(paraquat-p-phenylene) ring simultaneously (i) inverts th

226 sed of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings has been obtained from the o

227 eptor [3]catenane incorporating two cyclobis(paraquat-p-phenylene) rings linked together by a dinapht

228 sed of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings-with "zero", one, and two mo

229 ane composed of two rigid and fixed cyclobis(paraquat-p-phenylene) rings.

230 is [2]rotaxane, which consists of a cyclobis(paraquat-p-phenylene) shuttle (CBPQT(4+))(PF(6)(-))(4) (

231 on of the tetracationic cyclophane, cyclobis(paraquat-p-phenylene), and the radical cation generated

232 xtensively studied macrocyclic host cyclobis(paraquat-p-phenylene)--the so-called "blue-box"--it is s

233 ' (BB(4+)) tetracationic cyclophane cyclobis(paraquat-p-phenylene).

234 with the discovery that MV(+*) and [cyclobis(paraquat-p-phenylene)](2(+*)) (CBPQT(2(+*))) form a stro

235 Patients with acute paraquat poisoning were recruited.

236 seful prognostic marker of death after acute paraquat poisoning.

237 Paraquat (PQ(2+)) is a prototypic toxin known to exert i

238 Paraquat (PQ) causes selective degeneration of dopaminer

239 The herbicide paraquat (PQ) has increasingly been reported in epidemio

240 ttent (biweekly) exposure to intraperitoneal Paraquat (PQ) plus Maneb (MB).

241 function sigma(M) protein, was sensitive to paraquat (PQ), a superoxide-generating reagent, but not

242 ree different isolates of P. aeruginosa with paraquat (PQ), a superoxide-producing agent.

243 ntal oxidative stressors, like the herbicide paraquat (PQ), has been linked to the development of Par

244 Exposure to paraquat (PQ), hydrogen peroxide, or organic peroxides s

245 Here, using paraquat (PQ)-based in vitro and in vivo PD models, we s

246 as a model organism, we report the effect of paraquat (PQ)-induced OS on wild type worms on the funct

247 ling in a Drosophila PD model in response to paraquat (PQ)-induced oxidative stress to identify pre-s

248 AT1 and paraspeckles in cultured cells under paraquat (PQ)-induced oxidative stress.

249 H2O2 induced intramitochondrial O2-, whereas paraquat produced O2- outside of the mitochondria, and t

250 or NADPH, and readily generates the reduced paraquat radical.

251 in reductase or recombinant enzyme possessed paraquat reductase activity.

252 Purified paraquat reductase from the cells contained thioredoxin

253 complemented the SNO-dependent phenotypes of paraquat resistant 2-1 (par2-1) plants but not the NO-re

254 od LOQ was 10 and 20mugkg(-1) for diquat and paraquat, respectively.

255 The administration of paraquat resulted in significantly higher 24-h mortality

256 tochondrial homeostasis by the model oxidant paraquat results in decreased angiogenesis, showing a di

257 rythroid progenitor cells by the pro-oxidant Paraquat reversed the effect of UCP2 deficiency on cell

258 confers tolerance against stress induced by Paraquat, Rose Bengal, heavy metal, and the synthetic au

259 61 (95% CI: 1.03, 2.50; ptrend = 0.02)], and paraquat [RRIWD>Median = 1.95 (95% CI: 1.03, 3.70; ptren

260 with the oxidative stress-producing reagent paraquat showed a breakdown of sleep:wake cycles similar

261 On the other hand, paraquat showed average recoveries between 68 and 103% w

262 DJ-1-deficient mice treated with paraquat showed decreased proteasome activities and incr

263 In aerated solutions, paraquat signal was not distinguished due to the strong

264 elta sodA1) had transcriptional responses to paraquat similar to, but notably larger than, those of t

265 anipulations did not increase sensitivity to paraquat, sodium azide, divalent metal ions (Fe(II) or C

266 onionic pollutants were highly linear, while paraquat sorption was strongly concentration dependent.

267 Binding of two different 4,4'-bipyridinium (paraquat) species (3) and 2,2'-bipyridinium (diquat) 4 b

268 al of dopaminergic neurons and resistance to paraquat stress, but showed acute sensitivity to hydroge

269 he ROS-generating herbicide methyl viologen (paraquat), suggesting a common protective role for proli

270 own function in the heart to be triggered by paraquat, suggesting they may have functions in oxidativ

271 ss adaptation and produces the male-specific paraquat (superoxide) stress adaptation.

272 ress, whereas males but not females adapt to paraquat (superoxide) stress.

273 's disease in males, male Drosophila exhibit paraquat symptoms earlier than females.

274 nding constant (Ka = 2.4 x 10(5) M(-1)) with paraquats than the analogous dibenzo-30-crown-10-based c

275 owth traits under heat stress, arsenite, and paraquat, the majority of which were best explained by a

276 ase protein were cultured in the presence of paraquat, there was a paraquat concentration-dependent i

277 n to the redox-cycling agents, menadione and paraquat; this reduced survival was accompanied by an ac

278 e.g. H(2)O(2), peroxynitrite, menadione, and paraquat) through transient alterations in gene expressi

279 ne, and 2-naphthol), and of the organocation paraquat to unreduced and electrochemically reduced Leon

280 subsequent pro-apoptotic insults and reduces paraquat toxicity in Drosophila.

281 dopaminergic neurons protects flies against paraquat toxicity in vivo, ameliorating defects in dopam

282 uclein within nigral dopaminergic neurons of paraquat-treated and alpha-synuclein-overexpressing anim

283 ting against the oxidative damage induced by paraquat treatment, our data demonstrated that in Drosop

284 levels was examined by using heat stress and paraquat treatment.

285 yperresponsive to oxidative damage caused by paraquat treatment.

286 are sensitive to oxidative stress induced by paraquat treatment.

287 o cell death induced by rotenone, MPP(+), or paraquat treatments, the absence of complex I activity d

288 in wild-type worms using ethidium bromide or paraquat triggered statin resistance, and similar observ

289 pts a folded conformation, where each of two paraquat units remain sandwiched between the two aromati

290 Detailed (1)H NMR studies revealed that two paraquat units were bound cooperatively by the two crown

291 When using the oxygen filter, paraquat was clearly detected with a better-defined resp

292 Tolerance to Cu, Zn and paraquat was unaffected by MT deficiency but these plant

293 The highest concentrations of paraquat were seen in the pineal gland and the lateral v

294 asts are more sensitive to streptonigrin and paraquat when deleted for Ku80 as compared with Ku70.

295 nematode survival in response to rotenone or paraquat, which are agents that cause mitochondrial dysf

296 Rearing mutants on paraquat, which generates toxic free radicals in vivo, c

297 nitrogen species (RNS) generator, and 0.5 mM paraquat, which produces reactive oxygen species (ROS),

298 ence links chronic exposure to the pesticide paraquat with the incidence of the disease, most probabl

299 d the heart from oxidative stress induced by paraquat, with increased expression of antioxidants, suc

300 PH oxidase inhibitor, blocked the effects of paraquat without altering mitochondrial respiration.