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1 P3) shows high specificity towards export of parthenolide.
2 xel or nocodazole compromised the effects of parthenolide.
3  in the presence of the NF-kappaB inhibitor, parthenolide.
4 s effectively blocked by NF-kappaB inhibitor parthenolide.
5 ancer cells treated with the cytotoxic agent parthenolide.
6 e NF-kappaB inhibition was assessed by using parthenolide.
7 t on NF-kappaB, as indicated by studies with parthenolide.
8 ich was inhibited by the NF-kappaB inhibitor parthenolide.
9 t inhibitor and bound to the natural product parthenolide.
10 l alcohol, lanolin, tixocortol pivalate, and parthenolide.
11 gets of the antiinflammatory natural product parthenolide.
12                Three groups of rats received parthenolide (0.25, 0.5, or 1 mg/kg) 15 min before endot
13 min before endotoxin; another group received parthenolide (1 mg/kg) 3 h after endotoxin.
14                     A group of rats received parthenolide (1 mg/kg) intraperitoneally.
15                      We demonstrate that the parthenolide, 2-deoxyglucose, temsirolimus (termed PDT)
16 tion, and iNOS expression were attenuated by parthenolide (3mg/kg), the active constituent of feverfe
17 stration (FDA)-approved IL-1R antagonist; or parthenolide, a caspase-1 and nuclear factor kappa-light
18 stration (FDA)-approved IL-1R antagonist; or parthenolide, a caspase-1 and nuclear factor kappa-light
19                      Hence, cotreatment with parthenolide, a compound blocking microtubule detyrosina
20                            We also show that parthenolide, a NF-kappaB inhibitor, sensitizes breast c
21                                              Parthenolide, a potent and specific inhibitor of NFkappa
22                           Here, we show that parthenolide, a sesquiterpene lactone, selectively exhib
23 phenol found in the plant Curcuma longa, and parthenolide, a sesquiterpene lactone, suppress both lig
24 ned to investigate the biological effects of parthenolide, a specific inhibitor of NF-kappaB activati
25 eatment of C. pneumoniae-infected HUVEC with parthenolide, a specific inhibitor of NF-kappaB activati
26 nyl containing compounds ethacrynic acid and parthenolide activated Nrf2 in normal peripheral blood m
27                 In this report, we show that parthenolide activates c-Jun N-terminal kinase (JNK), wh
28                   In PC3 but not PrEC cells, parthenolide activates NADPH oxidase, leading to a decre
29  from the mitochondria in cells treated with parthenolide alone.
30                               Treatment with parthenolide also abolished formation of nitrotyrosine a
31                               Treatment with parthenolide also abolished nitrotyrosine formation, PAR
32 t on the response to LPS, LY294002 (LY2) and parthenolide (an IkappaB kinase inhibitor) were both pot
33 hibitor), wortmannin (a PI3K inhibitor), and parthenolide (an IkappaB kinase inhibitor), inhibited pa
34                                              Parthenolide, an active ingredient of herbal remedies su
35 itumor activity of the sesquiterpene lactone parthenolide, an active ingredient of medicinal plants,
36                 As a starting point, we used parthenolide, an agent shown to target critical mechanis
37 ies, we used oligonucleotide microarrays and parthenolide, an NF-kappa B-specific inhibitor, to ident
38 s for these lactams were benchmarked against parthenolide and a synthetic alpha-methylene-gamma-lacto
39                           The IKK inhibitors parthenolide and aspirin blocked the activities of infec
40             In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of N
41                                     Although parthenolide and BMS-345541 had no inhibitory effects on
42                 The selective IKK inhibitors parthenolide and BMS-345541 prevented ovariectomy-induce
43 tion in different species and nerves, making parthenolide and DMAPT the first promising drugs for cur
44 he therapeutic anti-inflammatory activity of parthenolide and identify vinyl sulfones as a new class
45 s and strongly suggest that a combination of parthenolide and tamoxifen may offer a novel therapeutic
46 nd complex was successfully detected between parthenolide and thioredoxin (PfTrx) in a five-protein m
47 tors, including dehydrocostus lactone (DHL), parthenolide, and beta-lapachone, all of which are innoc
48 1-7085, caffeic acid phenethyl ester (CAPE), parthenolide, and curcumin; protein kinase (PK)C inhibit
49      Eucalyptol, limonene, linalool, thymol, parthenolide, andrographolide, 18beta-glycyrrhetinic aci
50 ds, we identify 15-deoxy-Delta12,14-PGJ2 and parthenolide as inhibitors of caspase-4-mediated inflamm
51                                  LY2 but not parthenolide blocked the LPS-induced stabilization of FP
52                                              Parthenolide, but not wortmanin or the MAPK inhibitor PD
53 nstrate for the first time that curcumin and parthenolide can directly inhibit Nod2-mediated signalin
54                                              Parthenolide causes oxidative stress in PC3 cells but no
55                                              Parthenolide causes tubulin protein aggregation and prev
56 ion of these proteins increases the required parthenolide concentrations to promote axon regeneration
57 short total synthesis of the novel unnatural parthenolide diastereomer (+/-)-4,5-dia-parthenolide was
58 mic application of the prodrug dimethylamino-parthenolide (DMAPT) facilitates axon regeneration in th
59  parthenolide or its prodrug di-methyl-amino-parthenolide (DMAPT) markedly facilitates the regenerati
60  studies identified an analog, dimethylamino-parthenolide (DMAPT), which induces rapid death of prima
61 oY, an epoxide inhibitor of VASH1/2-SVBP,(9) parthenolide does not block VASH1-SVBP activity in vitro
62 and the administration of the HDAC inhibitor parthenolide during obstructive cholestasis in vivo prom
63 ells (EC50 = 0.57-2.90 muM) when compared to parthenolide (EC50 = 6.0) and showed potent antileukemic
64                    We previously showed that parthenolide enhances ROS production in prostate cancer
65                             We conclude that parthenolide exerts beneficial effects during endotoxic
66 11-13) Using mass spectrometry, we show that parthenolide forms adducts on both cysteine and histidin
67 rmacological inhibition of detyrosination by parthenolide fully mimicked this axon growth promotion i
68   Importantly, when combined with radiation, parthenolide further increases ROS levels in PC3 cells w
69  or a small-molecule inhibitor of NF-kappaB (parthenolide; IC(50)=500 nM in tamoxifen-resistant cells
70 In vivo pretreatment and post-treatment with parthenolide improved the hemodynamic profile and reduce
71                       In vivo treatment with parthenolide improved the hemodynamic profile and surviv
72            This study examines the effect of parthenolide in endotoxic shock in rodents.
73    DNA binding of NF-kappaB was inhibited by parthenolide in the lung, whereas degradation of IkappaB
74 gly, either local or systemic application of parthenolide in wild-type mice dose-dependently accelera
75                                 In contrast, parthenolide increases oxidation of KEAP1 in normal pros
76                                     In vivo, parthenolide increases radiosensitivity of mouse xenogra
77                             Mechanistically, parthenolide increases the level of cellular ROS and cau
78                                              Parthenolide induced phosphorylation of Bid and increase
79 he JNK inhibitor SP600125 reduced TRAIL plus parthenolide-induced apoptosis.
80            JNK activity is necessary for the parthenolide-induced sensitization to TRAIL because a do
81                                              Parthenolide inhibited NF-kappaB activation in response
82 hat the herbal NF-kappaB inhibitory compound parthenolide inhibits the activity of multiple inflammas
83 lectively, our work supports the notion that parthenolide is a promiscuous inhibitor of many cellular
84 ity of the relevant carboxypeptidase(s).(10) Parthenolide is a sesquiterpene lactone that forms coval
85                                              Parthenolide is a sesquiterpene lactone used in folk med
86 c methods, we determined that treatment with parthenolide leads to induction of compensatory mechanis
87 of cells with a specific NFkappaB inhibitor, parthenolide, led to loss of NFkappaB activity and down-
88  MYBPC3 mouse models and its inhibition with parthenolide normalized contraction and relaxation time
89 he IKK inhibitors celastrol, BMS-345541, and parthenolide on bone cell function in vitro and ovariect
90 P1 in controlling the differential effect of parthenolide on tumor and normal cell radiosensitivity.
91 rmacological inhibition of detyrosination by parthenolide or cnicin mimicked this axon growth promoti
92 In vivo, repeated intravenous application of parthenolide or its prodrug di-methyl-amino-parthenolide
93 nce, the IKK inhibitors acetylsalicylate and parthenolide prevented FA-induced reductions in insulin-
94                                     However, parthenolide promotes adult sensory neurons' axon growth
95  with Anakinra or inflammasome activity with parthenolide provides a promising approach for extending
96 iously shown that the plant-derived compound parthenolide (PTL) can impair the survival and leukemoge
97 trated that the naturally occurring compound parthenolide (PTL) can induce death of human LSCs in vit
98                                              Parthenolide (PTL) has been shown to cause apoptosis of
99 his premise, we identified compounds such as parthenolide (PTL) or piperlongumine that induce almost
100         The present studies demonstrate that parthenolide (PTL), a naturally occurring small molecule
101 s have shown that the sesquiterpene lactone, parthenolide (PTL), ablates bulk, progenitor, and stem A
102 unds presented include artemisinin (ART, 1), parthenolide (PTL, 2), thapsigargin (TPG, 3), andrograph
103 emsirolimus as agents that can be added to a parthenolide regimen as a means to inhibit such compensa
104 with inhibition of NF-kappaB by gliotoxin or parthenolide resulting in the abrogation of hypoxic surv
105                                              Parthenolide reversed resistance of breast cancer cells
106  downstream redox target that contributes to parthenolide's radiosensitization effect in prostate can
107              Together, the results show that parthenolide selectively activates NADPH oxidase and med
108 riments, pretreatment or post-treatment with parthenolide significantly improved survival in mice cha
109                            Both Anakinra and parthenolide significantly reduced graft inflammation an
110                               The VASH1-SVBP-parthenolide structure provides a framework for designin
111               We also identified a compound, parthenolide, that suppressed brain metastasis by blocki
112                                              Parthenolide through JNK increased the TRAIL-mediated de
113 ells treated with a combination of TRAIL and parthenolide underwent massive typical apoptosis and aty
114 ural parthenolide diastereomer (+/-)-4,5-dia-parthenolide was accomplished in 13 steps and an overall
115 ) in a five-protein mixture, as well as when parthenolide was mixed in a bacterial cell lysate spiked
116                  These beneficial effects of parthenolide were associated with reduction of NF-kappaB
117 e in blocking influx of both costunolide and parthenolide, when these substrates are infiltrated into
118 results identify a new antitumor activity of parthenolide, which can be exploited to reverse resistan
119  have therefore relied on a natural product, parthenolide, which is widely believed to block detyrosi

 
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