ライフサイエンスコーパス: partial

1 rough clodronate-mediated depletion showed a partial abrogation of toxicity.

2 Overall, these results show that short-term partial ACAT inhibition, coupled to increased cholestero

3 upled, and whether mutant proteins retaining partial activity can complement one another, is unclear

4 n (E(max)-type fitting), and epsilon = 1: no partial agonism (Clark equation).

5 bleeding, establishing a causal link between partial agonism and impaired hemostasis.

6 ut not corepressor associations, implicating partial agonism as the main driver of its dissociative p

7 a) the presence of "receptor reserve" and/or partial agonism, (b) multiple responses assessed at diff

8 2/alpha3beta4 selectivity to the alpha4beta2 partial agonism.

9 alpha4beta2 nicotinic acetylcholine receptor partial agonist and alpha7 receptor full agonist varenic

10 e of the full agonist cAMP, but not with the partial agonist cGMP.

11 0 and modified tirofiban are as effective as partial agonist drugs in inhibiting vascular thrombosis

12 ist to treat BC is potentially superior to a partial agonist given BPTPE's delayed induction of UPR a

13 A novel partial agonist of the EPAC isoform 1 (EPAC1), I942, was

14 eu-Arg-Tyr-NH(2) (1), reported to be a Y(4)R partial agonist with high affinity (pK(i) Y(4)R: 8.43).

15 (3)AR-selective nucleosides are low efficacy partial agonists and novel, nuanced modulators of the A(

16 tetrol and Selective Human Estrogen-Receptor Partial Agonists are being evaluated in endocrine-resist

17 s side effects, guiding the future design of partial agonists as selective GR modulators with an impr

18 tuents affected intrinsic activity to afford partial agonists with a range of efficacies.

19 estingly, both l-glucose-derived ligands are partial agonists: they are among the least efficacious a

20 ell proportion estimations when markers from partial/all cell types are available.

21 Partial amorphization of the ZIF-backbone by ball-millin

22 ) was 41% (95% CI, 26% to 58%), including 13 partial and 3 complete responses.

23 oxic water and N(2) O and N(2) production by partial and complete denitrification in anoxic zones in

24 undergo a TACE-treatment are categorised in partial and complete responders one day after the treatm

25 There we distinguish between partial and complete responders, where parts of the vasc

26 h brachial plexopathy, six of eight making a partial and ongoing recovery; and (v) five patients with

27 intact OR genes, and found a large ratio of partial and pseudogenes to intact OR genes (2:1), sugges

28 icity of 97.4% (95% CI, 95.2%-98.6%), with a partial area under the summary receiver-operating charac

29 rons limit fear to threats with a history of partial association with an aversive stimulus, with pote

30 for the probability of GON by human graders (partial AUC = 0.529 vs 0.411, respectively; P = .016).

31 The partial AUC for the M2M DL algorithm was significantly h

32 er operating characteristic curves (AUC) and partial AUC for the region of clinically meaningful spec

33 s promising therapeutic strategies, but with partial benefits.

34 tive configurations in which Oct4 recognizes partial binding sites display stable TF-DNA interactions

35 of a B41-specific nAb, but we recovered only partial binding.

36 e kinase receptors (RTKs), consistent with a partial block of their trafficking from the ER to the Go

37 PulseCam can also detect venous or partial blood flow occlusion that is difficult to identi

38 f 23dd demonstrated good plasma exposure and partial blood-brain barrier penetration.

39 ltiple micronuclei/binucleated cell, whereas partial-body exposures produce fewer such lymphocytes.

40 Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose u

41 e relatively low polarity solvents result in partial charge transfer in the host donor-guest acceptor

42 r, these findings suggest the existence of a partial chemical map underlying glomerular arrangement i

43 Mediation analysis suggested a role for partial cis-epigenetic control of protein expression wit

44 We show that correctly accounting for the partial coherence of the electron beam is a prerequisite

45 uctural reconstructions due to the intrinsic partial coherence of the electron beam.

46 language processing approach in addition to partial cohort preprocessing with a LASSO-based model, w

47 that upholds the oxyanion loop, leading to a partial collapse of the conserved S1 pocket, consistent

48 ration affecting the anterior temporal lobe, partial compensation appears to be possible by over-recr

49 y studying viable mutant plants generated by partial complementation of homozygous lethal OXA2a trans

50 0.007) and higher stable disease >=6 months/partial/complete remission rate (52.1% versus 30.4% P <

51 rotected from SIV acquisition but manifested partial control of viremia.

52 We argue that partial cooption is made possible because 1) the anterio

53 ot procedure was illustrated by synthesizing partial core oligosaccharide structure present in the li

54 Ex vivo measurements revealed a partial correlation between (177)Lu-DOTATATE uptake and

55 Partial correlation networks demonstrated fluctuations i

56 ph analysis of the adjacency matrix based on partial correlations between time series in the differen

57 biotics on AMA discharge, and (3) received a partial course of IV antibiotics and were prescribed ora

58 intravenous (IV) antibiotics, (2) received a partial course of IV antibiotics but were not prescribed

59 of the MH by the ILM flap in 14 eyes (82%), partial coverage in 1 eye (6%), and no coverage in 2 eye

60 s for known complexes with ligands that have partial coverage of the target ligand, performs conforma

61 We describe the partial cranium and skeleton of a new diprotodontian mar

62 radaic efficiency (FE) of (48 +/- 2)% with a partial current density of (108 +/- 5) mA cm(-2) and a m

63 oxide electrolyte (pH ~ 15) with an ethylene partial current density of 1.3 amperes per square centim

64 th a Faradaic efficiency of 72 per cent at a partial current density of 230 milliamperes per square c

65 still low in neutral media (60 per cent at a partial current density of 7 milliamperes per square cen

66 age response is essential for Mtb to survive partial DarG(Mtb) -depletion and leads to a hypermutable

67 During daytime, only partial dark-adaptation was achieved and rhabdoms remain

68 , 1.36) in SNP363) was observed, while using partial datasets that contain shared and unique SNPs sho

69 Astringency was enhanced following partial dealcoholization of one wine, but diminished in

70 conditions, FTIR spectroscopy indicates the partial deconfinement of the monatomic metal centers dri

71 The low free energy barrier to partial dehydration in the absence of conformational cha

72 ith 49.3% feed moisture prompting favourable partial denaturation to produce TMBP with desirable qual

73 By pairing multivariate partial dependence and accumulated local effect plots wi

74 Partial depolymerization in vitro of nonphosphorylated s

75 nt step achieved an almost 100% recovery and partial depolymerization of chitin from shrimp shell was

76 film fabrication process proceeds through a partial depolymerization/repolymerization mechanism, pro

77 temic restriction of serum l-Met, either via partial dietary restriction or with bacterial l-Met-degr

78 zed form of the governing reaction-diffusion partial differential equation (PDE).

79 hat tracks the position of individuals and a partial differential equation model that describes locus

80 Nested Laplace Approximation with Stochastic Partial Differential Equation, INLA-SPDE) is used to pre

81 The partial differential equations (PDEs) are derived using

82 d valley networks is produced by a system of partial differential equations coupling landscape evolut

83 inflammatory mediators is described through partial differential equations, and immune cells (neutro

84 sified in mathematics as a linear, parabolic partial-differential equation.

85 d the long-sought first melt produced during partial differentiation of a carbonaceous chondritic pla

86 erned by the conservative motion of Shockley partial dislocation pairs, which fundamentally suppress

87 lying dynamic coactivation patterns, and its partial dissociation from respiration effects during tas

88 ide polymorphism effects as either additive, partial dominant, dominant or over-dominant.

89 In a Phase I, randomized, partial double-blind, placebo-controlled study of 36 mal

90 We induced severe acute pancreatitis by partial duct ligation with caerulein stimulation or intr

91 lication of the pcbAB-pcbC-penDE complex and partial duplication of fragments of regulatory genes.

92 The draft assemblies contain several partial duplications of penicillin-pathway genes in all

93 es is a viable strategy for improving on the partial efficacy of gB/MF59 vaccination and should be fu

94 , (57)Fe, and (95)Mo ENDOR to illuminate the partial electron-density redistribution upon E(4)(H(2),2

95 EPN3-induced partial EMT is instrumental for the transition from in s

96 on in anhedonia (F(1,103) = 10.32, p = .002, partial eta(2) = .09).

97 -electron correlations have been observed at partial fillings of the flat electronic bands in recent

98 Partial flow recovery with forest age cannot be commonly

99 PAT, the human ortholog of ADE4, showed only partial function whereas all other genes complemented fu

100 coding gene, followed by diversification and partial functional specialization.

101 lled trial of Nissen vs. anterior 180-degree partial fundoplication at up to 10 years follow-up showe

102 To address this, partial fundoplications have been proposed.

103 emerged nidufexor (LMB763), a compound with partial FXR agonistic activity in vitro and FXR-dependen

104 This cuprate 'pseudogap' manifests as a partial gap in the electronic density of states at the F

105 inorganic substrates, which we attribute to partial graphitization and covalent coupling between PDA

106 who responded to the survey reported full or partial Guidelines implementation.

107 The primary objective was the rate of partial hematologic response (PR) or better.

108 Different surgical procedures, including partial hepatectomy (PH), intraoperative portal vein lig

109 L-2Rgamma(-/-) (NSG) mice that had undergone partial hepatectomy (PHx) represented the best combinati

110 encouraging results have been reported with partial hepatectomy for solitary metastases, with percut

111 Liver regrowth following partial hepatectomy is enabled by proliferation of hepat

112 d by two intermediate complexes, one being a partial high-spin form and the second another intermedia

113 as judged by a spectral shift with at least partial high-spin iron character, followed by a slower c

114 ae were evaluated: True K [History], True K [Partial History], True K [No History], Double-K Holladay

115 ome amplification (SGA) was used to generate partial HIV-1 polymerase genomes in paired CSF and plasm

116 trate model value, we assess the benefits of partial (i.e., at 2013 levels) and optimal (i.e., fully

117 Aniridia was total in 52 eyes and partial in 14 eyes.

118 Using partial information decomposition, we next compute the i

119 ome conformation capture experiments provide partial information on the chromatin organization in a c

120 aily, the public is confronted with a mix of partial information, conflicting information and sometim

121 Here, we determined whether short-term partial inhibition of ACAT, in combination with an enhan

122 y process but instead proceeds with multiple partial intermediate states.

123 ge 36 (12-69) years] underwent 61 SSIS's for partial intestinal obstruction.

124 r in Larrea was highly dynamic, ranging from partial isohydry to extreme anisohydry.

125 ly affected both the efficacy and potency of partial kappa agonists, such as the benzomorphans, and t

126 Among all BRCA2 VUS, those causing partial/leaky splicing defects are the most challenging

127 endent modeling of class analogy (SIMCA) and partial least square discriminant analysis (PLS-DA).

128 ng the multivariate statistical technique of partial least square discriminant analysis.

129 Seed partial least squares (PLS) analysis showed that this SE

130 A Partial Least Squares (PLS) model was constructed, givin

131 re bacterial strains, a fluorescent dye, and partial least squares (PLS) modeling was developed to as

132 year of 'Tempranillo' grape clones and with Partial Least Squares (PLS) regressions to predict its c

133 rmative adult brain gene expression data and partial least squares analysis to find the weighted gene

134 Using partial least squares analysis, we identified latent var

135 Both sparse partial least squares and kernel canonical correlation a

136 ized multivariate techniques, such as sparse partial least squares and kernel canonical correlation a

137 classified correctly all samples, while the partial least squares coupled with SPA for interval sele

138 incipal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), a

139 nfrared (ATR-MIR) spectroscopy combined with Partial Least Squares Discriminant Analysis (PLS-DA) to

140 ted by regression coefficients (RC) from the partial least squares regression (PLSR) model based on t

141 Partial least squares regression (PLSR) models based on

142 Finally, partial least squares regression (PLSR) was used to esti

143 Also, partial least squares regression and principal component

144 A Sparse Partial Least Squares regression model was able to expla

145 ivariate calibration models were built using Partial Least Squares regression to determine dry matter

146 ver, we use the multivariate analysis method partial least squares that combines multiple features of

147 Partial Least Squares was used to identify brain regions

148 Partial Least Squares-Discriminant Analysis (PLS-DA) ide

149 Partial Least Squares-Discriminant Analysis (PLS-DA) of

150 Partial least squares-discriminant analysis of the MS/MS

151 ive spectral models were constructed using a partial least-squares regression approach.

152 atory multigroup analysis using multivariate partial least-squares structural equation models, to gen

153 al lower at the basal plasma membrane due to partial limited accessibility for antibodies.

154 donation and are appropriate candidates for partial liver donation.

155 We found that partial loss function of Ik2, the fly homologue of TBK1

156 Although a partial loss of BCCIP function is sufficient to trigger

157 A partial loss of BCCIP function was sufficient to trigger

158 , this study also demonstrates that combined partial loss of c-Cbl and inactivation of APC significan

159 rations included cytoplasm vacuolization and partial loss of epidermal stratification.

160 normalized peak current) and 22 variants had partial loss of function (10%-50% normalized peak curren

161 Partial loss of function of Spn-F, a downstream phosphor

162 thology can arise from absence of FKBP22, or partial loss of its function.

163 with DREPP-dependent MT fragmentation and a partial loss of the ability to reorganize the MT cytoske

164 Partial loss-of-function Fech(m1Pas) mutant mice showed

165 ooperating with MDMX and inhibiting p53, and partial loss-of-function in suppressing Wnt signaling.

166 We chart a partial map of brain regions that may be relevant for br

167 gan studying this factor, which we call the "partial masking factor," by measuring detection threshol

168 However, thanks to the prognostic value of partial metabolic response assessed by both PERCIST and

169 omplementary pattern of a linear increase of partial molar volume change with a pressure rise was est

170 The attendant changes in partial molar volumes varied substantially, but not in s

171 d gokushoviruses; however, we show that even partial motifs enable phages to persist cytoplasmically

172 Partial nephrectomy induced cardiomyopathy and anemia in

173 and 10 years was longer than for radical or partial nephrectomy, especially for patients at higher r

174 f uremic cardiomyopathy in mice subjected to partial nephrectomy.

175 hough the coupling of ANAMMOX processes with partial nitrification is already widespread, especially

176 Partial nitritation (i.e., conversion of ammonium to nit

177 eam anaerobic fluidized-bed bioreactor and a partial nitritation-anammox fluidized-bed membrane biore

178 trophy and dysfunction during the genesis of partial obstruction in vivo, we tested whether rapamycin

179 obamate in patients with uncontrolled focal (partial)-onset epilepsy.

180 Partial or complete crystal structures of all MSC consti

181 of context fear memories in rats with prior partial or complete HPC damage.

182 tinctive brain malformation characterized by partial or complete loss of the cerebellar vermis with f

183 Partial or complete resolution of subretinal fluid was a

184 Higher rates of very good partial or complete response rates (64% v 39%; hazard ra

185 All participants had an imaging-confirmed partial or complete response to NST and underwent study-

186 is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostat

187 lso be used with chirp contours that perform partial or multiple revolutions on the unit circle.

188 ow that transparency results from structural partial order inhibiting light scattering, while preserv

189 We also observed partial ordering of the core histone H2A C-terminal and

190 Partial organ resection is not only a common clinical ap

191 ygen present in the methanol produced in the partial oxidation of methane to methanol over Cu-SSZ-13

192 Selective partial oxidation of methane to methanol suffers from lo

193 uld lead to new approaches for improving the partial oxidation properties of copper zeolites.

194 We observed previously that partial oxidation was responsible for increased TK(high)

195 There were 183 total pancreatectomies, 113 partial pancreatoduodenectomies, 79 distal pancreatectom

196 The partial PKC agonist isophthalate derivative bis(1-ethylp

197 A total of 209 partial pol gene sequences of HIV-1 CRF55_01B were sampl

198 We use partial pooling of information between countries, with b

199 concerted transition state in which there is partial positive charge developing on the C-O carbon ato

200 c1 to disrupt its H3K27me3 engagement causes partial postnatal lethality, supporting a role in develo

201 ncy of CO formation is affected by the CO(2) partial pressure (0.1-0.5 bar) and the proton concentrat

202 silicate weathering cycle, atmospheric CO(2) partial pressure (pCO(2)) responds to changes in surface

203 pressure (pO(2)), and a lower carbon dioxide partial pressure (pCO(2)).

204 re bioreactors will result in elevated CO(2) partial pressure (pCO(2)).

205 they show a more stable pH, a higher oxygen partial pressure (pO(2)), and a lower carbon dioxide par

206 Since varying the oxygen partial pressure during growth is likely to change the s

207 with a lowest achievable first-day arterial partial pressure of CO2 of >=60 mm Hg.

208 normobaric hypoxia chamber by decreasing the partial pressure of oxygen in inhaled air stepwisely (pO

209 The radiological and partial pressure of oxygen, arterial (Pao2)/fraction of

210 the case of absorbing R-134a at a high F-gas partial pressure.

211 tion, the algorithm controlled O(2):H(2) gas partial pressures to approach a target average Cu oxidat

212 t] are primarily regulated by their relative partial pressures, [Formula: see text]/[Formula: see tex

213 s (~30 nm) but synthesized at various oxygen partial pressures: 10, 30, 50, 100, 150, 200 and 250 mTo

214 sequestration of mRNAs in ribonucleoprotein partials prior to drying, or the lower tolerance of M. i

215 HIV-1 and SIV vaccine candidates have shown partial protection against viral challenges in rhesus ma

216 nd T cell immune responses but provided only partial protection against ZIKV viremia in BALB/c mice.

217 hondrial Ca(2+) uptake in cardiomyocytes and partial protection from ischemia-reperfusion injury by r

218 no PVD on 6-mm scans and were classified as partial PVD on 16.5-mm scans because vitreoretinal separ

219 On 6-mm scans, we classified eyes as stage 3 partial PVD when the posterior vitreous cortex was visua

220 millimeter scans distinguished complete from partial PVD with good sensitivity and specificity but mi

221 Partial recording of the diastolic pathway of the clinic

222 llowed by full skeletal recovery in NN dams, partial recovery in LN and poor bone recovery in LL dams

223 ensity decreased in the first 6 months, with partial recovery later.

224 n; one made a full recovery, 10 of 12 made a partial recovery, and one patient died; (iii) ischaemic

225 The partial reduction of ECm during RNA synthesis was circum

226 tion, dendrite regeneration was sensitive to partial reduction of gammaTubulin.

227 n through G4-forming sequences, and exhibits partial redundancy with an adjacent PARP-binding domain.

228 tegy towards overcoming this challenge, with partial relief aggregation.

229 a first diagnosis of AHA remains high until partial remission is achieved, and weekly measured FVIII

230 above salivary gland uptake translated into partial remission, with an odds ratio (OR) of 60.265 (95

231 Elevated LDH implied a reduced chance for partial remission, with an OR of 0.094 (95% CI, 0.017-0.

232 ore specifically, bamboo is densified by the partial removal of its lignin and hemicellulose, followe

233 situation, but recovered rapidly during the partial reopening phase.

234 due to vaccine serotypes (VT) has declined, partial replacement by non-vaccine serotypes (NVT) was o

235 loid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on

236 was found between patients with complete or partial response (210 Gy; 95% CI, 161-274 Gy; n = 13) an

237 , and 19 patients (47.5%) achieved very good partial response (dFLC <40 mg/L) or better.

238 failure was defined as failure to achieve a partial response (PR) by the end of the 4-week induction

239 Patients with a confirmed partial response (PR) or complete response (CR) within 6

240 ving a complete response (CR) or a very good partial response (VGPR) by independent review.

241 A radiologically complete or partial response occurs more often in patients using the

242 nd yielded an overall response rate (ORR) of partial response or better of 95.8% (95% confidence inte

243 survival (PFS) of patients with complete and partial response were statistically comparable.

244 The overall response rate, including partial response with lymphocytosis, with acalabrutinib

245 ents with an objective response (complete or partial response) as assessed by an independent radiolog

246 tients with an overall response (complete or partial response) as assessed by the investigators accor

247 n (n = 12) was 100% (complete response, 92%; partial response, 8%).

248 with a complete response and 24 (31%) with a partial response.

249 complete response and 14 (18%; 10-28) had a partial response.

250 e, there was one complete response and seven partial responses (objective response rate 19%, 95% CI 9

251 phase-I clinical trials and early data show partial responses in nearly half of patients with lung c

252 Objective partial responses were observed in 66 (48%; 95% CI 39-56

253 Confirmed partial responses were seen in 8% (90% CI, 3% to 18%) an

254 f 42 patients had an objective response (all partial responses) and 14 (33%; 20-50) had 6-month non-p

255 f 39 patients had an objective response (all partial responses) by 6 months; in patients with osteosa

256 nts (5%) achieved an objective response (all partial responses).

257 e response (CR), 2 CRs in target lesions, 25 partial responses, 18 responses of stable disease, 2 une

258 t cancers, 1 had a complete response, 11 had partial responses, and 66 had stable disease.

259 as 38% with two complete responses and seven partial responses.

260 nfirmed complete response and five confirmed partial responses.

261 ects receiving CFTR modulator therapy showed partial restoration of CFTR function in platelets, which

262 played reduced levels of AGO1-loaded miRNAs, partial retention of miRNA in the nucleus, and reduced l

263 Partial river flow recovery (towards non-forested condit

264 g Tbet-deficient (Tbet KO) mice, we showed a partial role for Th1 subset CD4(+) T cells in vaccine pr

265 studies showed that dysbiosis played only a partial role in maintaining tight junction protein expre

266 Our generator networks are trained on partial scans created from a new dataset of 16227 scanni

267 hs from spiral, jittered gridlike, and other partial scans.

268 ve Lpar1 null mutant mice are protected from partial sciatic nerve ligation (PSNL)-induced neuropathi

269 inociceptive properties in the capsaicin and partial sciatic nerve ligation models in mice.

270 Using this tool, we uncovered partial segregation of inhibitory spontaneous and evoked

271 st recently presented with continuous simple partial seizures and occasional breakthrough complex par

272 seizures and occasional breakthrough complex partial seizures with postictal migraines.

273 ologically extended the neural mass model of partial seizures, the Epileptor, by including two neuron

274 After partial sialoadenectomy, we performed whole-gland measur

275 Where Clar's static drawings capture only a partial sketch of the electronic properties of a molecul

276 Participants underwent partial sleep deprivation (3 h sleep opportunity at the

277 Partial sleep deprivation caused decreased activation in

278 lication to TP_SFE_CO(2) data confirmed that partial solubilization mainly depended on oil availabili

279 Previous studies provided partial structures(10-14), but the structure of the cent

280 ated food models (cake and beef burger) with partial substitution CW2%/AA4% oleogel as the optimized

281 polymer with a large bandgap of 2.9 eV; the partial substitution of PBDB-T by PTAA reduces the absor

282 Breads were produced with partial substitution of wheat flour by corn (CF), green

283 narios, including full suppression (0.001%), partial suppression (1%), mitigation (10%), and do nothi

284 In recall, a partial synchronization among the same subset of Primed

285 icial (SNFL) and deep (DNFL) slabs through a partial thickness plane set at the modal thickness (mode

286 Here, we establish that partial time reversal transforms the beam splitter linea

287 Measurements from the partial 'toothed' dentary point to a giant body size for

288 nts, because their impact can be buffered by partial tracking of the optimum by the mean phenotype.

289 iate treatment, 8 (1.8%) of 443 who received partial treatment, and 1 (0.2%) of 517 who completed tre

290 oxidation of conserved cysteine residues and partial unfolding of its structure convert the heat shoc

291 Adopting the partial use of dried specimens will help achieve improve

292 These results highlight that even partial vaccination with a leaky vaccine can have unfore

293 ated the utility of our method by amplifying partial viral genomes from 6 HeV-infected tissue samples

294 Nevertheless, recall responses and partial virus control in chronic infection appear little

295 One patient displayed a partial VL response (2-log of VL reduction) but a good c

296 yes was determined from changes in posterior partial volume (PPV).

297 There was no group-wise difference in partial volume corrected glutamate concentration between

298 ses was calculated after applying PETPVC for partial-volume correction of the SPECT reconstructions.

299 he MRI navigator sequence as well as a novel partial-volume correction that accounts for background h

300 ps exhibit no morbidity or mortality despite partial X reactivation.