ライフサイエンスコーパス: passenger

1 ing of the N-terminal virulence region (the 'passenger').

2 e-exome sequencing projects as 'drivers' or 'passengers'.

3 t proportion of mutations are drivers versus passengers.

4 e is a third group of medium-impact putative passengers.

5 n the metastases were much more likely to be passengers.

6 previously designated as drivers are likely passengers.

7 of two different subdomains within the Ag43 passengers.

8 re hard to distinguish from large numbers of passengers.

9 sponsible for cancer progression and neutral passengers.

10 rs, the CPQ-PRKDC fusion transcript may be a passenger aberration related to gene amplification.

11 omic studies suggest that mildly deleterious passengers accumulate and can collectively slow cancer p

12 However, whether lncRNA alterations are passengers acquired during cancer progression or can act

13 brane domain to translocate their N-terminal passenger across the bacterial outer membrane (OM).

14 ctious disease pandemics that spread through passenger air travel.

15 elucidate such requirements, we used a V(D)J passenger allele system to assay, in mouse GC B cells, s

16 bility that any observed candidate gene is a passenger alteration, given the frequency of alterations

17 antly, in this model both somatic driver and passenger alterations contribute to 'perturbation-driven

18 The effects of passenger alterations on cancer fitness were unrelated t

19 al signal peptide, a surface-exposed central passenger and an outer membrane C-terminal translocator,

20 cogenic or tumor suppressive genes, but also passenger and potential codriver genes.

21 quilibrium process coupled to folding of the passenger and propose a model connecting passenger confo

22 s, yet no causal link between the effects of passengers and cancer progression has been established.

23 y of driver mutations was lower than that of passengers and consequently adjusting mutation recurrenc

24 pplying a multi-modal approach to filter out passengers and more robustly identify putative driver ge

25 -sharing that (i) scales to large numbers of passengers and trips and (ii) dynamically generates opti

26 $9 per seat per one-way flight and costs per passenger are often greater than airport charges levied

27 Some passengers are deleterious to cancer cells, yet have bee

28 Our findings refute traditional paradigms of passengers as neutral events, suggesting that passenger

29 ves prefer to ride in AVs that protect their passengers at all costs.

30 gets SHM hotspots within V exon and S region passengers at similar frequencies and that the normal SH

31 These findings suggest that alloreactive passenger B cells/plasma cells within the kidneys of hig

32 uring its somatic evolution; most are termed passengers because they do not confer cancer phenotypes.

33 ms offers a unique opportunity to understand passenger behavior at a massive scale.

34 We describe how these changes in passenger behavior lead to possible overcrowding and mod

35 , possibly due to protection provided to the passengers by the bus.

36 Passengers can also become targets for immunotherapy or

37 Passengers can provide important information about the e

38 ment breakpoint (GRB) regions, as well as 38 passenger candidate genes (PCGs), altered in humans only

39 lters were loaded with exhaust from a modern passenger car diesel engine on a dynamometer sampled bef

40 odern turbocharged gasoline direct injection passenger car equipped with a three-way catalyst and an

41 The analysis of the passenger car fleet development in the city of Copenhage

42 line-exhaust particle toxicity from a Euro-5 passenger car in a uniquely realistic exposure scenario,

43 hat both methodologies confirm that gasoline passenger car NH(3) emissions are underestimated by a fa

44 CO2 emissions and fuel consumption of an HEV passenger car to a CV of the same make and model during

45 iesel blends on the exhaust emissions from a passenger car was examined.

46 o measure NH3, CO, and CO2 from the top of a passenger car.

47 routes for 100 gasoline vehicles, including passenger cars (PCs), passenger trucks (PTs), and hybrid

48 my and greenhouse-gas emission standards for passenger cars and light trucks.

49 material substitution on GHG emissions from passenger cars and the steel and aluminum industries unt

50 otal annual UK NH(3) emissions from gasoline passenger cars are estimated to be 7.8 +/- 0.3 kt from t

51 ry estimates of urban emissions of NH(3) for passenger cars are underestimated by a factor of 17.

52 ed to assess air pollution concentrations in passenger cars from diesel and electric trains.

53 ir pollutants were significantly elevated in passenger cars in diesel trains compared to electric tra

54 Average increases (and fold differences) in passenger cars of diesel trains compared with electric t

55 remote sensing measurements of over 230,000 passenger cars to estimate total UK ammonia (NH(3)) emis

56 laboratory studies with two gasoline-fueled passenger cars, we found that as much as 20-30% of the n

57 larger vehicles and light trucks relative to passenger cars.

58 ve already been observed earlier with diesel passenger cars; they are considered part of an abnormal

59 Passenger CD4 lymphocytes might therefore contribute to

60 w graft-versus-host (GVH) allorecognition by passenger CD4 T cells within MHC class II-mismatched bm1

61 M also selectively decontaminated islets of "passenger" cells (co-isolated with the islets) and resto

62 ver alterations amongst the vast swathes of "passenger" changes still remains a major challenge.

63 l microtubule bundles coated with chromosome passenger complex (CPC) and centralspindlin that instruc

64 row-inducing signaling complexes, chromosome passenger complex (CPC) and Centralspindlin, to a plane

65 hore (KT) proteins and regulatory chromosome passenger complex (CPC) and spindle assembly checkpoint

66 TD-60 has a typical chromosomal passenger complex (CPC) distribution in mitotic cells, b

67 Chromosomal passenger complex (CPC) has been demonstrated to be a po

68 The chromosomal passenger complex (CPC) in animals, consisting of Aurora

69 The Aurora B chromosomal passenger complex (CPC) is a conserved regulator of mito

70 The chromosomal passenger complex (CPC) is a conserved, essential regula

71 The chromosome passenger complex (CPC) is a master regulator of mitosis

72 The chromosomal passenger complex (CPC) is abundantly localized to the i

73 midplane, which is demarcated by chromosomal passenger complex (CPC) localized on microtubule bundles

74 The chromosomal passenger complex (CPC) localizes to and is the key regu

75 The chromosomal passenger complex (CPC) localizes to centromeres in earl

76 The chromosomal passenger complex (CPC) localizes to centromeres where i

77 Meiotic cells contain a second chromosomal passenger complex (CPC) population, with Aurora kinase B

78 During cytokinesis, the chromosomal passenger complex (CPC) promotes midzone organization, s

79 iated pool of Aurora B kinase, a chromosomal passenger complex (CPC) subunit, which is essential for

80 volved in the recruitment of the chromosomal passenger complex (CPC) to kinetochores in mitosis.

81 alin is a major component of the Chromosomal Passenger Complex (CPC) with well-known functions in mit

82 correlated with components of the chromosome passenger complex (CPC), a key regulator of mitosis.

83 hat perturbs localization of the chromosomal passenger complex (CPC), AURKC p.C229Y is a hypomorph th

84 The chromosomal passenger complex (CPC), composed of inner centromere pr

85 The highly conserved chromosomal passenger complex (CPC), containing mitotic kinase Auror

86 is activity is antagonized by the chromosome passenger complex (CPC), resulting in RhoA activation at

87 B, the catalytic subunit of the chromosomal passenger complex (CPC), uncovering a feedback mechanism

88 The chromosomal passenger complex (CPC), which includes the kinase Auror

89 The four-subunit chromosomal passenger complex (CPC), whose enzymatic subunit is Auro

90 association of Shugoshin and the chromosomal passenger complex (CPC), without abolishing global Auror

91 creating a docking site for the Chromosomal Passenger Complex (CPC).

92 inetochore phosphorylation by the Chromosome Passenger Complex (CPC).

93 Chromosome association of the chromosomal passenger complex (CPC; consisting of Borealin, Survivin

94 ategy to disrupt the activity of chromosomal passenger complex and inhibit neuroblastoma progression.

95 t localization of members of the chromosomal passenger complex and mitotic kinesin-like protein 1 and

96 fness, and mislocalization of the chromosome passenger complex proteins Aurora B kinase (AURKB) and S

97 s the catalytic component of the chromosomal passenger complex, an essential regulator of chromosome

98 is the catalytic component of the chromosome passenger complex, which is involved in correct chromoso

99 the passenger and propose a model connecting passenger conformation to secretion kinetics.

100 ' motion combines randomness and regularity (passengers' destinations being random, but the routes to

101 the targeted gene is flanked by ESC-derived passenger DNA potentially containing mutations.

102 - play a role in oncogenesis, and which are passengers - do not play a role.

103 mbrane protease IcsP yields highly pure IcsA passenger domain (residues 53-758).

104 Their mature form contains a passenger domain and a C-terminal beta-domain that ancho

105 model in which both the translocation of the passenger domain and the membrane integration of the bet

106 Blocking pPL translocation by passenger domain folding favored stabilization of an alt

107 Although it was originally proposed that the passenger domain is translocated across the OM through a

108 c and describe the solution structure of the passenger domain obtained by small-angle X-ray scatterin

109 The passenger domain of BafA induces cell proliferation, tub

110 at vaccination with the recombinant secreted passenger domain of EatA (rEatAp) elicits high titers of

111 ng an epitope tag into the N terminus of the passenger domain of the inverse autotransporter intimin,

112 acteria and facilitates the transport of the passenger domain onto the cell surface.

113 experiments show direct binding of the IcsA passenger domain to both the WASP homology 1 (WH1) domai

114 ng step in autotransporter assembly and that passenger domain translocation does not require the inpu

115 sist of an N-terminal extracellular domain ('passenger domain') and a C-terminal beta-barrel domain t

116 cation unit and an extracellular effector or passenger domain.

117 el domain and an extracellular coiled-coil ("passenger") domain.

118 consisting of an N-terminal extracellular ('passenger') domain and a C-terminal beta barrel ('beta')

119 plasm that persists until the termination of passenger-domain translocation.

120 c proteases; and (v) inverse autotransporter passenger domains are translocated by a hairpin mechanis

121 ant Escherichia coli, Y. pestis, or purified passenger domains.

122 In summary, following transplantation, passenger donor-strain nT-regs can inhibit host adaptive

123 We found that passengers dramatically reduced proliferative fitness (

124 s on two major roads to carry at least three passengers during peak hours.

125 rse end-point outcome is probably due to the passenger event of the nearby ERBB2's amplification.

126 known whether deletion of MIR-491 is only a passenger event or has an important role.

127 more refined picture of the major driver and passenger events in the elucidation of cancer progressio

128 mic site across multiple tumors are actually passenger events, recurring at inherently mutable genomi

129 tatistical modeling to distinguish them from passenger events, which accumulate during tumorigenesis

130 reliable distinction between true driver and passenger events.

131 the therapeutically targetable fusions from passenger events.

132 y enhance discrimination between drivers and passenger events.

133 hing such "driver" mutations from innocuous "passenger" events is critical for prioritizing the valid

134 along with many more pathologically neutral "passenger" events.

135 Pathobionts (or bacterial passengers) exploit disrupted host homeostasis to flouri

136 n oxide (NO (x)) emissions, and the European passenger fleet is highly dieselised, which has resulted

137 and inefficiency in the growing industry of passenger flights.

138 adictory reports regarding the importance of passenger folding as a driving force for OM translocatio

139 isolated cells of all lineages, are adherent passengers for engulfment by the ectodermal epithelium.

140 arian AVs (that is, AVs that sacrifice their passengers for the greater good) and would like others t

141 ust synthetic lethal effects associated with passenger gene alterations and validated two new synthet

142 s for a Sec23b gene trap allele, excluding a passenger gene mutation as the cause of the pancreatic l

143 Passenger gene mutations, which do not have known or pre

144 ulnerabilities resulting from co-deletion of passenger genes neighboring TSG.

145 ng mutations are significantly different for passenger genes, OGs and TSGs.

146 Distinguishing passenger genes, oncogenes (OGs) and tumor-suppressor ge

147 enge the simple dichotomy between driver and passenger genes.

148 tiple cancer lineages augmented by a common "passenger" genomic alteration.

149 During short haul flight, aisle passengers have higher fomite exposure.

150 on in cancer and distinguishing drivers from passengers have important implications for development o

151 and biochemical analyses revealed that these passenger hotspot mutations arise from the preference of

152 els of mutagenesis; (ii) use it to show that passenger hotspots arise from all common mutational proc

153 can accurately predict the fitness costs of passengers in cell lines and in human breast cancers.

154 econd, AID mutates targets in diverse non-Ig passengers in GC B cells at levels similar to those of V

155 ically active driver mutations over inactive passengers in high-throughput sequencing cancer data set

156 The dichotomous model of "drivers" and "passengers" in cancer posits that only a few mutations i

157 show that the aggregated effect of putative passengers, including undetected weak drivers, provides

158 a deontological doctrine by sacrificing the passenger instead of the pedestrian.

159 retained the ability to be incorporated as a passenger into F-driven VLPs, provided that the F protei

160 ge occupancy of 1.54, VTOL GHG emissions per passenger-kilometer are 52% lower than ICEVs and 6% lowe

161 The BC mass emissions per passenger-km were similar to gasoline vehicles, but the

162 recipient-type cells showed a high degree of passenger leukocyte chimerism by immunohistochemistry an

163 lized ex vivo lung perfusion (EVLP) to study passenger leukocyte migration from donor lungs into the

164 Passenger leukocyte transfer from the donor lung to the

165 e obtained from chimeric swine, in which the passenger leukocytes (but not the parenchyma) were major

166 lung transplantation, and the role played by passenger leukocytes in the rejection or acceptance of a

167 potential immunological advantage of lacking passenger leukocytes including antigen-presenting cells.

168 The chimeric lungs containing passenger leukocytes matched to the lung recipient (grou

169 Therefore, the depletion of passenger leukocytes may be clinically applicable as a s

170 Our data indicate that recipient-matching of passenger leukocytes significantly prolongs lung allogra

171 r organs depends on the trafficking of donor passenger leukocytes to the secondary lymphoid organs of

172 (group 2), both the donor parenchyma and the passenger leukocytes were major histocompatibility compl

173 ed whether recipient-matching of donor graft passenger leukocytes would impact graft survival in a pr

174 r HLA are indeed cross-dressed cells and not passenger leukocytes.

175 cal data also suggest an association between passenger load and response to therapeutics, yet no caus

176 assengers as neutral events, suggesting that passenger load reduces the fitness of cancer cells and s

177 e developed new genomic measures of damaging passenger load that can accurately predict the fitness c

178 on of adaptive drivers, but incurs a harmful passenger load that can outweigh driver benefit.

179 duction of genomic instability and increased passenger load.

180 To assess this, we introduced increasing passenger loads into human cell lines and immunocompromi

181 A method for in-use measurement of passenger locomotives, using a portable emissions measur

182 ion rates of two-stroke engines used in many passenger locomotives.

183 into the US through smuggling of pork in air passenger luggage.

184 ty is expected to bring about destruction of passenger lymphocytes within heart allografts, this proc

185 Passenger microbiota may play a role in the maintenance

186 This study reveals how commensal and passenger microorganisms could be important in promoting

187 NA reads uncovered 207 unknown minor strand (passenger) microRNAs of known microRNA loci and 495 nove

188 em cells carry a 129-associated inactivating passenger mutation on the caspase-11 locus, essentially

189 t do not confer growth advantage to tumors - passenger mutations - dominate the mutation landscape of

190 from sequence data, due to a large number of passenger mutations and lack of comprehensive sequence i

191 Passenger mutations are enriched in characteristic nucle

192 ict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing

193 Regional expression of passenger mutations dominantly recruits adaptive respons

194 cability, underscore how patterns of somatic passenger mutations encode the state of the cell of orig

195 Due to the overwhelming number of passenger mutations in the human tumor genome, it is dif

196 o estimate the number and possible effect of passenger mutations in transgenic mice of interest.

197 tumorigenesis in each patient from a sea of passenger mutations is necessary for translating the ful

198 probabilities and frequencies of successive passenger mutations ordered by their time of appearance.

199 that nearly all these mice possess multiple passenger mutations potentially influencing the phenotyp

200 iate from the characteristic contexts around passenger mutations provide a signal in favor of driver

201 ent; tumor types that are highly enriched in passenger mutations show a survival benefit in the setti

202 ter-arising subclones, resulting in numerous passenger mutations that are responsible for intratumora

203 We identify passenger mutations that are significantly associated wi

204 are likely to be obscured by the presence of passenger mutations that do not contribute to cancer pro

205 Annotating these passenger mutations to the reported genetically modified

206 l evolution with the emergence of driver and passenger mutations under the infinite-allele assumption

207 this phenotypic interference of 129-derived passenger mutations with several case studies and develo

208 an be used to distinguish between driver and passenger mutations within these genes.

209 ology in the absence of additional driver or passenger mutations, as a result of their monogenic natu

210 Even with respect to these passenger mutations, our analysis suggests that the gene

211 sformation assays differentiated driver from passenger mutations, revealing that PIK3CA variant activ

212 landscape in AML and distinguish driver from passenger mutations, we compared the mutational profiles

213 n of patterns that differentiate driver from passenger mutations.

214 ver mutations from a larger number of random passenger mutations.

215 tistical methods to discriminate driver from passenger mutations.

216 from much more abundant but inconsequential "passenger" mutations is problematic.

217 ic variants, but most of these variants are "passenger" mutations that are phenotypically neutral and

218 fferentiate these mutations from the benign "passenger" mutations which occur in the tumor but do not

219 Driver, but not passenger, mutations tune gene-expression towards specia

220 antageous) mutations and a greater number of passenger (neutral or mildly deleterious) mutations.

221 mulated data allows us to model the complete passenger of intimin and propose functionality to the Bi

222 angstrom resolution, which confirms that the passenger of intimin has five distinct domains.

223 tomato, such as MYMIV, could be spread as a passenger of TYLCV in tomato.

224 conclude that species invasion is not just a passenger of urban development but also a driver of chan

225 any years considered a passive component or "passenger" of cell-fate determination, cell metabolism i

226 Consider a banal scenario: a seated passenger on a crowded bus stands up and someone takes h

227 he main mode of transport for over 5 million passengers on an average weekday.

228 ause this process, with the biota as passive passengers on continental blocks.

229 are insufficient to distinguish driver from passenger or bystander mutations.

230 of links in a transport network that satisfy passengers or cargo transportation demands while minimiz

231 he role of air travel in bringing infectious passengers or vectors to previously non-endemic areas.

232 itor cells generated in the yolk sac and of 'passenger' or 'transitory' myeloid cells that originate

233 ve kelps, with a wide range of "hitchhiking" passenger organisms, on an Antarctic beach inside the fl

234 with rider capacity of up to 10 simultaneous passengers per vehicle.

235 ally, we analyze parking requirements due to passenger pick-ups and show that increasing convenience

236 oduces a substantial increase in parking for passenger pickup/dropoff.

237 opulations will be more genetically diverse, passenger pigeon genetic diversity was surprisingly low.

238 The extinct passenger pigeon was once the most abundant bird in Nort

239 The passenger pigeon was once the most abundant bird in the

240 m most of the genome, we calculated that the passenger pigeon's effective population size throughout

241 41 mitochondrial and 4 nuclear genomes from passenger pigeons and 2 genomes from band-tailed pigeons

242 genomes from band-tailed pigeons, which are passenger pigeons' closest living relatives.

243 Passenger pigeons' large population size appears to have

244 These passengers present a barrier to cancer progression descr

245 zation sequence (MLS) capable of targeting a passenger protein (GFP) to the mitochondria and that del

246 me that when translocation was blocked an AT passenger remained unfolded in the periplasm.

247 nd which mutations are drivers and which are passengers remains to be determined.

248 hylogenetic network analysis focusing on the passenger revealed for the first time that they actually

249 Thus, in contrast to the traditional 'passenger' role of a co-repressor, CBFA2T2 functions syn

250 erra Leone as of Sept 1, 2014 (reductions in passenger seats by 51% for Liberia, 66% for Guinea, and

251 d an in vivo assay to study AID targeting of passenger sequences replacing a V exon.

252 ail yard (RY) and over-the-rail (OTR) during passenger service.

253 erve the lives of that perspective, i.e. the passenger shifts towards sacrificing the pedestrian, and

254 y stochastic events will be inconsequential "passengers," some will confer a fitness advantage to a c

255 floating islands can play host to a range of passenger species from both their original coastal locat

256 One passenger species, the bryozoan Membranipora membranacea

257 and booster seat use for child motor vehicle passengers, speed limit and drunk driving laws, and alco

258 g persistent, stress-enhanced memory and its passenger strand a potential biomarker for responsivity

259 ading into Argonaute, degradation of cleaved passenger strand and degradation of sliced target RNA.

260 nding of duplex siRNA bound to AGO1 requires passenger strand cleavage in vitro.

261 Moreover, passenger strand cleavage is required for assembly of ac

262 inducing the microRNA (miRNA) miR-33 and its passenger strand miR-33*, Mtb inhibited integrated pathw

263 Typically, Argonaute slices and releases the passenger strand of duplex sRNA to generate active silen

264 miR-122*, the passenger strand of miR-122, regulates the activity of p

265 at internal positions of both the guide and passenger strand of siRNAs and may increase the silencin

266 is regulatory circuit, namely, miR-122*, the passenger strand of the abundantly expressed liver-speci

267 exes, each comprising a mature miRNA and its passenger strand, are produced at rates as fast as 110 +

268 The mir-135b passenger strand, mir-135b-3p, was significantly elevate

269 activity when placed near the 5'-end of the passenger strand.

270 rosophila, C3POs cleave the fragmented siRNA passenger strands and facilitate the activation of RNA-i

271 A walk of (S)-GNA along the guide and passenger strands of a GalNAc conjugate duplex targeting

272 ants dramatically overaccumulated microRNA* (passenger) strands, and immunoprecipitated ALG-1(anti) c

273 estrians or sacrificing themselves and their passenger to save the pedestrians.

274 r maybe, just maybe, he intended for another passenger to sit comfortably, to increase the happiness

275 ss may be a causal driver or inconsequential passenger to the overall tumor phenotype.

276 of origin coincides with an increase in air passengers to Brazil from ZIKV-endemic areas, as well as

277 nificantly associated with the volume of air passengers to China (P = 0.006), parasite prevalence in

278 We randomize the intervention, which nudges passengers to complain to their drivers directly, across

279 Disruptions, or shocks, force passengers to make different decisions concerning which

280 Moreover, phagocytes may contain so called "passenger" transcripts that originate from engulfed apop

281 and folding of the beta-barrel but also for passenger translocation.

282 Diesel-powered trains are used worldwide for passenger transport.

283 om freight are projected to grow faster than passenger transportation or other major end-use sectors,

284 f check-ins and checks-out is considered and passengers travel along fastest paths in a network affec

285 ne vehicles, including passenger cars (PCs), passenger trucks (PTs), and hybrid electric vehicles (HE

286 pecially great as the electrification of the passenger vehicle fleet (from HEVs to PHEVs to BEVs) inc

287 del shows that the total GHGs of the Chinese passenger vehicle fleet are expected to peak in 2032 und

288 emissions savings from hybridization of the passenger vehicle fleet.

289 and charging infrastructure for the Chinese passenger vehicle fleet.

290 ly 30% of the average gasoline use in a U.S. passenger vehicle in 2007.

291 performed with the front brake of a midsize passenger vehicle under both static laboratory and more

292 ower steering motor embedded in conventional passenger vehicles and drive motor/generator embedded in

293 d electronic (EE) components of conventional passenger vehicles and in the end-of-life vehicle shredd

294 hicles, many scarce metals (SMs) are used in passenger vehicles because of their unique physical and

295 n-use NOx emissions from small-engine diesel passenger vehicles produced a significant contribution t

296 easingly embedded in other products, notably passenger vehicles.

297 onsumption and GHG emissions from light-duty passenger vehicles.

298 ir total masses in 100 hypothetical midrange passenger vehicles.

299 f mutations in the exome of cancer cells are passengers, which do not affect the reproductive rate of

300 Comparing fully loaded VTOLs (three passengers) with ground-based cars with an average occup