ライフサイエンスコーパス: pathfind

1 ance molecule receptor in regulation of axon pathfinding.

2 r axons and play important roles during axon pathfinding.

3 her to regulate synapse development and axon pathfinding.

4 activity of pioneer axons and regulate axon pathfinding.

5 ance information to orchestrate ocular motor pathfinding.

6 involved in cell cycle regulation and axonal pathfinding.

7 Robo class proteins and participates in axon pathfinding.

8 f its function disrupts axonal extension and pathfinding.

9 wn effect on neuron survival, regulates axon pathfinding.

10 ation, transducing signals required for axon pathfinding.

11 lar retention resulting in aberrant neuronal pathfinding.

12 nd in parallel to ced-10/Rac, to control DTC pathfinding.

13 such as LTP, LTD, spine motility, and axonal pathfinding.

14 in wiring events that follow successful axon pathfinding.

15 direct olfactory sensory neuron (OSN) axonal pathfinding.

16 ncies may differentially modulate motoneuron pathfinding.

17 s defects in commissural axon projection and pathfinding.

18 ty of Slit function during intraretinal axon pathfinding.

19 guidance cues provide the basis for neuronal pathfinding.

20 n, promoting its outgrowth, and guiding axon pathfinding.

21 active oxygen species that also affects axon pathfinding.

22 ements that steer directional changes during pathfinding.

23 developmental function in ocular motor axon pathfinding.

24 ncreased VAB-1 levels elicited aberrant axon pathfinding.

25 norhabditis elegans L1CAM, functions in axon pathfinding.

26 al axons and proper anterior-posterior (A-P) pathfinding.

27 t this antagonism is important during axonal pathfinding.

28 generally Mmp2 plays the predominant role in pathfinding.

29 molecule in neural morphogenesis and axonal pathfinding.

30 g CNS and is required for motor and CNS axon pathfinding.

31 including germ cell development and neuronal pathfinding.

32 on in all of these processes except neuronal pathfinding.

33 branching morphogenesis, as well as neuronal pathfinding.

34 w players utilized by the growth cone during pathfinding.

35 ion in synapse formation rather than in axon pathfinding.

36 in the lateral CNS and also, later, in axon pathfinding.

37 her to specify cell fate or to direct axonal pathfinding.

38 ons, possibly in the growth cone during axon pathfinding.

39 in parallel to Rac/MIG-15 signaling in axon pathfinding.

40 oliferation, neuronal positioning and axonal pathfinding.

41 and may play a role in axonal elongation or pathfinding.

42 ion channel in guiding vascular tip cells in pathfinding.

43 elopment include neuronal migration and axon pathfinding.

44 red for the nonautonomous regulation of axon pathfinding.

45 e growth cone (GC) during axon outgrowth and pathfinding.

46 ghting the important role pseudopods play in pathfinding.

47 ical signals as important regulators of axon pathfinding.

48 tracellular matrix collagen XV in motor axon pathfinding.

49 ns rely on guidance molecules to direct axon pathfinding.

50 oning of the cell bodies and peripheral axon pathfinding.

51 re locally translated and have roles in axon pathfinding.

52 europilin-2 is required for precrossing axon pathfinding.

53 vo, but, unexpectedly, does not disrupt axon pathfinding.

54 iple guidance cues is integrated during axon pathfinding.

55 collaboratively regulate SAX-3-mediated axon pathfinding.

56 spinal cord commissural axon projection and pathfinding.

57 nd that NMD acts locally to influence axonal pathfinding.

58 influencing neuronal growth, inhibition, and pathfinding.

59 s a navigation system to instruct filopodial pathfinding, a process that is crucial for continuous ce

60 utaneous pathways, conversely, would enhance pathfinding abilities.

61 e Bax and type III Nrg1 double mutants, axon pathfinding abnormalities were seen for TrkA(+) neurons

62 ing at their targets, developing axons cease pathfinding and begin instead to arborize and form synap

63 verse developmental processes such as axonal pathfinding and cell adhesion.

64 Many genes that affect axon pathfinding and cell migration have been identified.

65 ED-10 Rac, RAC-2 Rac, and UNC-34 Ena in axon pathfinding and cell migration, also acts with MIG-15 in

66 have all been implicated in regulating axon pathfinding and cell migration.

67 t that APP overexpression may perturb axonal pathfinding and circuit formation in developing DS brain

68 t prenatally displayed major defects in axon pathfinding and cortical interneuron migration.

69 a precomputed subpath network into metabolic pathfinding and demonstrates how this leads to a concise

70 llular cues thereby ensuring correct neurite pathfinding and development of the nervous system.

71 In addition, we find that axonal pathfinding and fasciculation are abnormal in corticospi

72 is required during DTC migration for proper pathfinding and for cessation of DTC migration at the en

73 fate proteoglycans (HSPGs and CSPGs) in axon pathfinding and have linked HSPGs to specific signaling

74 sential role for lactosamine in sensory axon pathfinding and in the formation of OB synaptic connecti

75 ction similarly altered zebrafish motor axon pathfinding and increased dynein-based transport velocit

76 (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically wit

77 t5a (-/-) phenotype, perturbing post-mitotic pathfinding and leading to apoptosis.

78 n of molecular mechanisms that underlie axon pathfinding and map formation.

79 cogenic transformation and perhaps even axon pathfinding and memory consolidation.

80 Thus, extensive pathfinding and morphological rearrangement of central a

81 Moreover, by linking axon pathfinding and neural progenitor behaviors, our results

82 and novel role for collagen XV in motor axon pathfinding and neuromuscular development.

83 We found that hypoxia caused specific axon pathfinding and neuronal migration defects in C. elegans

84 ted guidance factors are known to guide axon pathfinding and neuronal migration.

85 uding C&E, cochlear cell orientation, axonal pathfinding and neuronal migration.

86 at regulate axon branching, commissural axon pathfinding and neuronal migration.

87 factors released from myelin may impair axon pathfinding and neuroregeneration after injury.

88 ng the dorso-ventral axis but also in axonal pathfinding and organisation of the axonal scaffold.

89 orrelates with early defects in neural crest pathfinding and peripheral ganglion formation.

90 edgehog (Hh) signaling for intraretinal axon pathfinding and show that Shh acts to pattern the optic

91 plays an important role in neurite extension/pathfinding and survival providing a causal link between

92 Axon pathfinding and synapse formation are essential processe

93 control neuronal fate determination, axonal pathfinding and synaptic communication and plasticity.

94 ow known to participate in axon development, pathfinding and synaptic formation and function.

95 culate from other axons is critical for axon pathfinding and target innervation.

96 elles of developing neurons that enable axon pathfinding and target recognition for precise wiring of

97 lating larval and adult locomotion, and axon pathfinding and targeting of embryonic motoneurons.

98 ap neurons can be subdivided based upon axon pathfinding and their expression of neuropeptidergic mar

99 that ANG plays an important role in neurite pathfinding and this has implications for ALS.

100 ronal migration, neurite outgrowth, neuronal pathfinding, and axonal fasciculation.

101 neurite outgrowth and differentiation, axon pathfinding, and dendritic spine formation and maintenan

102 trophic support to neurons, modulating axon pathfinding, and driving nerve fasciculation.

103 Rs, with subsequent effects on axon sorting, pathfinding, and extension, and glomerulus development.

104 c shRNA impedes axon initiation, elongation, pathfinding, and fasciculation.

105 motor neuron specification, axon growth and pathfinding, and mRNA expression, are unaffected in Munc

106 vertebrate tissue boundary formation, axonal pathfinding, and stem cell regeneration by steering cell

107 ranched dynamically and profusely throughout pathfinding, and successive branches oriented growth con

108 ee redundant pathways that each control axon pathfinding, and that the NIK kinase MIG-15 acts in each

109 r, the RNA-binding proteins involved in axon pathfinding, and their corresponding mRNA targets, are s

110 processes, including embryogenesis, neuronal pathfinding, and tumor formation.

111 ed by these transcription factors to control pathfinding are poorly defined.

112 aling pathways employed in axonal growth and pathfinding are similar to those in mammals.

113 ys important roles in neuronal migration and pathfinding as well as in angiogenesis in zebrafish.

114 s of these results, we investigated neuronal pathfinding at P5.

115 l substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila embryonic CNS midline.

116 optic nerve astrocytes, and anomalous axonal pathfinding at the optic chiasm.

117 Hypoxia exerted its effect on axon pathfinding, at least in part, through HIF-1-dependent r

118 Pathfinding axons change responses to guidance cues at i

119 Wnt3 expression in the cingulate callosal pathfinding axons is developmentally regulated by anothe

120 st to show that ADCY8 is required for axonal pathfinding before axons reach their targets.

121 guidance cue to orchestrate this epithelial pathfinding behavior, but how this signal is received by

122 re-crossing CI growth cones exhibit distinct pathfinding behaviors compared to post-crossing axons an

123 ons are not precisely ordered during initial pathfinding but become corrected later, with missorted a

124 wn here not to affect these molecules or D-V pathfinding but to strongly perturb the anteroposterior

125 abundantly in most fiber tracts during axon pathfinding but were downregulated beginning in synaptog

126 hogenic proteins (BMPs) are involved in axon pathfinding, but how they guide growth cones remains elu

127 stream of Rac in Caenorhabditis elegans axon pathfinding, but the cellular role of UNC-115 in this pr

128 owing axon, and indeed, many proteins direct pathfinding by both structures.

129 yonic day 11.5, and that Fz3 is required for pathfinding by dopaminergic and serotonergic axons in th

130 e ribonucleolytic activity of hANG, affected pathfinding by P19-derived neurons but not neuronal diff

131 e receptor-like roles in the control of axon pathfinding by repulsion, although it is largely unknown

132 syndrome (agenesis of corpus callosum, axon pathfinding, cardiac, ocular, and genital defects).

133 al developmental processes, such as neuronal pathfinding, cell adhesion and synaptogenesis.

134 es previously shown to be necessary for this pathfinding choice.

135 olution the detailed behaviors of individual pathfinding CI growth cones on the ipsilateral and contr

136 suggesting that their identity and neuronal pathfinding cues are both intact.

137 ein complexes that receive and transmit axon pathfinding cues during development are essential to cir

138 correctly executed the binary dorsal-ventral pathfinding decision but failed to make the subsequent p

139 ctivity differentially affects the two major pathfinding decisions made by chick lumbosacral motoneur

140 cords differentially perturbed the two main pathfinding decisions made by motoneurons, dorsal-ventra

141 execution of several stereotyped motor axon pathfinding decisions.

142 ment of neural projections but not for early pathfinding decisions.

143 ilopodial PY levels may underlie growth cone pathfinding decisions.

144 uency differentially disrupt these two major pathfinding decisions.

145 racellular signaling cascades to direct axon pathfinding decisions.

146 rs, has been implicated in mediating midline pathfinding decisions; however, the complexity of these

147 nd/or intellectual disability, variable axon pathfinding defects (corpus callosum agenesis or hypopla

148 nus toxin expression results in pioneer axon pathfinding defects and altered spinal entry.

149 very low, and this was correlated with axon pathfinding defects and cell death.

150 epithelium results in unexpectedly localized pathfinding defects at the caudal turn in the mid-optic

151 Bicd1/Fignl1 interaction induced motor axon pathfinding defects characteristic of Fignl1 gain or los

152 te appropriately, the HSNs also display axon pathfinding defects in ham-3 mutants.

153 Axon pathfinding defects included dysgenesis of the corpus ca

154 f dynein activity partially rescued the axon pathfinding defects of Fignl1-depleted larvae.

155 ted ablation of Ext1 causes commissural axon pathfinding defects that share similarities with those o

156 Corresponding axonal pathfinding defects were specific to NOVA2 deficiency: N

157 ic ablation of adaxial cells causes profound pathfinding defects, suggesting the existence of adaxial

158 les for PlexB in central and peripheral axon pathfinding, define a functional ligand for PlexB, and i

159 hRNA techniques resulted in perturbed axonal pathfinding, delay in midline crossing, excess branching

160 Accurate retinotectal axon pathfinding depends upon the correct establishment of do

161 s study was to determine changes in neuronal pathfinding during early postnatal brain development of

162 ng pathway in motoneurons necessary for axon pathfinding during embryogenesis.

163 use PlexB and PlexA, respectively, for axon pathfinding during neural development.

164 l for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brai

165 Brn3b(KO) RGC axons show correct but delayed pathfinding during the early stages of embryonic develop

166 d reveal that it is required for normal axon pathfinding during vertebrate development.

167 t promotes axon outgrowth and regulates axon pathfinding, elevates cyclic AMP (cAMP) levels in growth

168 Apart from their role in axon pathfinding, emerging lines of evidence suggest that a w

169 cantly, the drugs used previously to produce pathfinding errors altered transient frequency but not d

170 cause motoneurons to make dorsoventral (D-V) pathfinding errors and to alter the expression of molecu

171 l frequency allowed axons to correct the A-P pathfinding errors by altering their trajectories distal

172 These pathfinding errors can be corrected by the reexpression

173 r arising trkA(+) afferents make significant pathfinding errors in animals with reduced Shh function,

174 Loss and gain of col15a1b function provoke pathfinding errors in primary and secondary motoneuron a

175 d in motoneurons making dorsal-ventral (D-V) pathfinding errors in the limb and in the altered expres

176 the presence of picrotoxin prevented the D-V pathfinding errors in the limb and maintained the normal

177 SDF1 signaling in vivo rescues retinal axon pathfinding errors in zebrafish mutants that have a part

178 These pathfinding errors of spinal secondary motoneuron axons

179 ly and quantitatively identical intraretinal pathfinding errors to those reported previously in Slit

180 To distinguish whether the pathfinding errors were caused by perturbation of the no

181 ments resulted in aberrant axonal growth and pathfinding errors, suggesting that local tissue stiffne

182 ceptor expression and caused cell-autonomous pathfinding errors.

183 nal cord, whereas those farther away display pathfinding errors.

184 enopus retinotectal system results in axonal pathfinding errors.

185 hypoplasia and a wide repertoire of RGC axon pathfinding errors.

186 d a synergistic increase in the incidence of pathfinding errors.

187 ption factor Nerfin-1, required for CNS axon pathfinding events, is subject to post-transcriptional s

188 east and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR

189 on migration and thalamo-cortical axon (TCA) pathfinding follow similar trajectories and timing, sugg

190 No changes in corneal neurotrophin or nerve pathfinding gene expressions accompany corneal transitio

191 ds to determine molecular diffusion rates in pathfinding growth cones in vivo.

192 During axon pathfinding, growth cones commonly show changes in sensi

193 Following axon pathfinding, growth cones transition from stochastic fil

194 oordinated mechanism underlying the cellular pathfinding guided by signal gradients and the mechanist

195 ole of L1-CAMs in neurite extension and axon pathfinding has been extensively studied, much less is k

196 cification of motoneuron morphology and axon pathfinding has been studied extensively, implicating th

197 ile guidance cues contributing to motor axon pathfinding have been identified, the intracellular path

198 ated in guiding various steps of optic nerve pathfinding, however much less is known about transcript

199 ic space, a new meta-algorithm for metabolic pathfinding, Hub Pathway search with Atom Tracking (HPAT

200 plicated in retinal ganglion cell (RGC) axon pathfinding in a number of species.

201 for normal sensory neuron survival and axon pathfinding in both central and peripheral targets.

202 soderm, is required for embryonic motoneuron pathfinding in Drosophila.

203 tigated the role of Wnt signaling in central pathfinding in Fzd3 mutant mice and Fzd3 morpholino trea

204 for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU.

205 ctive neuronal proliferation, migration, and pathfinding in response to Scn1b deletion may contribute

206 filopodial protrusions are non-essential for pathfinding in retinal axons.

207 ons, including neuronal migration and axonal pathfinding in the brain.

208 embrane receptors in regulating dorsolateral pathfinding in the chick trunk.

209 haperone BiP/GRP78 during axon outgrowth and pathfinding in the developing mammalian brain.

210 ication during development, including axonal pathfinding in the nervous system and cell-cell interact

211 ion of polarized Akt activity disrupted axon pathfinding in vitro and in vivo.

212 aminin, and that it is likely to affect axon pathfinding in vivo.

213 axon guidance in vitro and commissural axon pathfinding in vivo.

214 ctions are necessary for proper sensory axon pathfinding in vivo.

215 vitro, suggesting that FAK may control axon pathfinding in vivo.

216 fish primary motor neurons (PMN) during axon pathfinding in vivo.

217 ticularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Dros

218 l as mutants with specific defects in axonal pathfinding, including exit from the spinal cord and pat

219 upport a model in which Shh acts in RGC axon pathfinding indirectly by regulating axon guidance cues

220 to rescue alterations of retinotectal axonal pathfinding induced by loss of NOVA2 ortholog in zebrafi

221 ial step of retinal ganglion cell (RGC) axon pathfinding involves directed growth of RGC axons toward

222 ish a previously unknown mechanism of axonal pathfinding involving vascular-derived endothelins, and

223 The current understanding of axon pathfinding is based mainly on chemical signaling.

224 Axon pathfinding is critical for nervous system development,

225 Precise axon pathfinding is crucial for establishment of the initial

226 Strikingly, in hda-1(cw2) mutants, axon pathfinding is defective; specific axons often appear to

227 ion or by raphe neuron ablation, commissural pathfinding is disrupted.

228 Axon pathfinding is essential for the establishment of proper

229 Axon pathfinding is orchestrated by numerous guidance cues, i

230 An important model for axon pathfinding is provided by guidance of embryonic commiss

231 ance of this scaffold, and consequently axon pathfinding, is dependent on the expression of an atypic

232 diates neurite outgrowth, fasciculation, and pathfinding, is expressed on tumor vasculature.

233 e same way as IgCAM-mediated axon growth and pathfinding; it relies not only on extracellular adhesio

234 as repellants in vertebrate embryonic axonal pathfinding may also inhibit regeneration.

235 sent the first demonstration of eye-specific pathfinding mediated by axon guidance cues and, taken wi

236 r cancer cells, and by inactivating the axon pathfinding molecule L1CAM, which metastatic cells expre

237 Axon pathfinding, neurite outgrowth, synaptogenesis, neurotra

238 euronal development such as embryonic axonal pathfinding, neuroblast proliferation in the larval brai

239 uction of expression of Wnt3 by the callosal pathfinding neurons, which antagonize the inhibitory eff

240 ues, not only in nonneural cells but also in pathfinding neurons.

241 required for trunk neural crest migration or pathfinding, nor for the formation of dorsal root or sym

242 Dscam (Dscam(del17) ; Dscam(2J)), RGC axons pathfind normally, but growth from the chiasm toward the

243 ocyanine perchlorate) labeling to assess the pathfinding of commissural axons in the spinal cords of

244 us and its serotonergic projections regulate pathfinding of commissural axons in zebrafish.

245 gnaling protein previously implicated in the pathfinding of corticospinal axons in mice.

246 rgic projections from raphe neurons regulate pathfinding of crossing axons.

247 ellipsoid body (EB), where it influences the pathfinding of EB axons.

248 The pathfinding of motor axons is an important model system

249 acts (except for the corpus callosum) during pathfinding of pioneer axons.

250 certain proteins is required for the correct pathfinding of R-neurons.

251 Other developmental processes, such as pathfinding of RGCs at the optic chiasm and hippocampal

252 nt role in the specification, patterning and pathfinding of sensory neurons.

253 embryonic exposure to nicotine alters axonal pathfinding of spinal secondary motoneurons in zebrafish

254 optic nerve and retina, and abnormal axonal pathfinding of the ganglion cell axons at the optic chia

255 unicolumnar neurons, indicating that axonal pathfinding of the two systems may be controlled indepen

256 Focussing on the pathfinding of TrkA+ NGF-dependent axons, we demonstrate

257 sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolysis of

258 affect neuronal identity specification, axon pathfinding, or EphA/ephrinA signaling during the develo

259 d membrane-bound proteins involved in neural pathfinding, organogenesis, and tumor progression, throu

260 during axonal development, including axonal pathfinding, orientation of axons in chemotactic gradien

261 icotine-induced changes in motoneuron axonal pathfinding persisted into adulthood.

262 In addition, Mmp2 overexpression pathfinding phenotypes depend on frac activity, indicati

263 ated protein, a crucial molecule involved in pathfinding, plasticity, and regeneration.

264 ests itself in axonal branching, turning and pathfinding, presynaptic differentiation, and growth con

265 ms in RNA nanotechnology can be reduced to a pathfinding problem and automatically solved through an

266 o strongly perturb the anteroposterior (A-P) pathfinding process by which motoneurons fasciculate int

267 The fmi-1 mutants exhibit defective axon pathfinding, reduced synapse number, aberrant synapse si

268 his activity may play a major role in axonal pathfinding, refinement of topographic maps, dendritic m

269 Thus ray axon pathfinding relies on a variety of general and more ray

270 It is clear that axon pathfinding requires a growth cone to sample and integra

271 Successful axon pathfinding requires both correct patterning of tissues,

272 of many extracellular guidance cues on axon pathfinding requires Ca2+ influx at the growth cone, but

273 Axon pathfinding requires directional responses of growth con

274 Thus, efficacious pathfinding requires Phr1 activity for coordinating the

275 Proper axon pathfinding requires that growth cones execute appropria

276 f precomputed subpaths, whereas a comparable pathfinding search algorithm that does not use precomput

277 rm prior to the sensory afferents, and their pathfinding show no dependence on sensory axons, as abla

278 rturbed dorsal-ventral but not pool-specific pathfinding, shows that modest changes in frequency diff

279 l streams join the segmental trajectories of pathfinding spinal motor axons, suggesting that interact

280 ntal processes, such as axonal outgrowth and pathfinding, synaptogenesis, and the maturation of ion c

281 -laser sources(6), few-body physics(7,8) and pathfinding techniques for atom-wave interferometry(9-12

282 lish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion

283 membrane-bound proteins important for neural pathfinding, the class of proteins called Semaphorins ar

284 ules and receptors that regulate growth cone pathfinding, the signaling cascades underlying distinct

285 CNS is an indispensable phase of motor axon pathfinding, the underlying molecular mechanisms remain

286 Abl also regulates motor axon pathfinding through a non-overlapping set of functional

287 undamental cellular processes, from neuronal pathfinding to cell division.

288 olarization and migration to axon growth and pathfinding to dendrite growth and branching to synaptog

289 ging from neurotrophic modulation of neurite pathfinding to stimulation of cellular networks.

290 Axonal pathfinding toward the dorsal striatum was determined by

291 CaP motoneurons stalling along their ventral pathfinding trajectory.

292 Comparative profiling of "young" (pathfinding) versus "old" (target-arriving) Xenopus grow

293 No effect on neuronal pathfinding was detected.

294 layer structures were disrupted, and axonal pathfinding was impaired.

295 An in vivo correlate of altered TCA pathfinding was obtained by transient manipulation of 5-

296 to adopt serotonergic phenotype and correct pathfinding, whereas ADF are unaffected in unc-86-null m

297 Netrin-1 is critical for axonal pathfinding which shares similarities with formation of

298 n after injury depends on accuracy of axonal pathfinding, which is primarily believed to be influence

299 nes of cells to study their effects on nerve pathfinding within the peripheral nervous system.

300 cules and diffusible cues both regulate axon pathfinding, yet how these two modes of signaling intera