ライフサイエンスコーパス: pathogenetic

1 ross GWAS datasets, to explore their "shared pathogenetics".

2 genesis, linking intrinsic immunity to tumor pathogenetics.

3 s of mutations is an important goal of human pathogenetics.

4 It is highly likely that these changes are pathogenetic, accounting for loss of glucose responsiven

5 roporation and to assess their antiviral and pathogenetic activity in vitro and in HBV-infected human

6 te PTLD often resembles tumors with distinct pathogenetic alterations and nodal appearance.

7 ome and observed conservation of the central pathogenetic alterations.

8 in the JAK-STAT pathway is important from a pathogenetic and diagnostic perspective, important quest

9 These data reveal a pathogenetic and molecular basis for glaucoma and demons

10 arkinson's disease (PD), both of which share pathogenetic and neurologic similarities with human immu

11 atency nor lytic replication, with important pathogenetic and therapeutic consequences.

12 ants were classified as "pathogenetic/likely pathogenetic" and two as "of uncertain significance." Co

13 This tool can be of great value in clinical, pathogenetic, and epidemiological research studies on ce

14 ns, is to provide an overview of diagnostic, pathogenetic, and treatment considerations in bipolar di

15 trial cultures, public-private partnerships, pathogenetic- and structure-led drug design, efficient d

16 biliary epithelial cells; this mechanism is pathogenetic, as shown by the protective effects of Src

17 e main unsolved problems, mostly focusing on pathogenetic aspects and host immunity to the virus.

18 nces have been made in understanding the key pathogenetic aspects of scleroderma, and these have led

19 is a disease with genetic and environmental pathogenetic background.

20 des, where novel insights into the molecular pathogenetic basis for sarcomas has dramatically (re)sha

21 A pathogenetic basis for the differing roles of skin and s

22 rfecta, but suggests SMPD3 deficiency as the pathogenetic basis of a novel form of chondrodysplasia.

23 17, has transformed our understanding of the pathogenetic basis of an increasing number of chronic im

24 heme among myeloproliferative neoplasms, the pathogenetic basis of chronic neutrophilic leukemia (CNL

25 emains unclear but this new insight into the pathogenetic basis of L-ORD has implications for future

26 Understanding of the genetic and pathogenetic basis of LN has improved substantially over

27 ss has been made in our understanding of the pathogenetic basis of myeloproliferative neoplasms.

28 rable advances in our understanding of their pathogenetic basis.

29 s and across GWASs, thereby revealing shared pathogenetics between diseases in an unsupervised fashio

30 In the absence of diagnostic and pathogenetic biomarkers, diagnosis and treatment may be

31 of the peripheral nervous system in the ALS pathogenetic cascade.

32 We conclude that there may be a pathogenetic change in aged human brain arterioles that

33 accumulation of Abeta peptide and associated pathogenetic changes (eg, inflammation, oxidative stress

34 rall reduction in amyloidosis and associated pathogenetic changes in the brain resulted in decreased

35 atic diseases and periodontitis share common pathogenetic characteristics, such as proinflammatory tr

36 The goal of this review was to propose a pathogenetic classification of acute coronary syndromes

37 l organism." In parallel, however, we need a pathogenetic classification to describe the pathways and

38 unction of Htt is thought to be an important pathogenetic component of HD.

39 Thus, ER stress is a targetable pathogenetic component of the phenotypes caused by Droso

40 new clinical features in a more appropriate pathogenetic context.

41 The individual pathogenetic contribution of each gene variant is diffic

42 , IDH, IKZF1, or EZH2 mutations; the precise pathogenetic contribution of these mutations is under in

43 The latter seem to represent a pivotal pathogenetic, diagnostic, and prognostic factor in this

44 en HFpEF and HFrEF, supporting the notion of pathogenetic differences among HF subtypes.

45 fected in GCK-diabetes, reflecting important pathogenetic differences between the two MODY forms.

46 h basophils, mast cells constitute a central pathogenetic element of anaphylactic (IgE-dependent) and

47 nosomes into the brain parenchyma is a major pathogenetic event in African trypanosomiasis.

48 erization-a process postulated to be the key pathogenetic event in Alzheimer's disease.

49 the BCR-ABL tyrosine kinase is the critical pathogenetic event in CML and an ideal target for therap

50 HIF signaling pathway could be an important pathogenetic event in the development and progression of

51 infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobact

52 ic program of the tumour cell of origin or a pathogenetic event.

53 hereas chromosomal translocations are common pathogenetic events in cancer, mechanisms that promote t

54 mutation (EGFRvIII/DeltaEGFR) are signature pathogenetic events that are invariably expressed in a h

55 l allow this paradigm of targeting molecular pathogenetic events to be applied to many additional hem

56 s and is internalized, leading to a range of pathogenetic events.

57 orces that RTL is a marker and potentially a pathogenetic factor for CKD progression.

58 ature but also a novel prognostic marker and pathogenetic factor for this malignancy.

59 ANCE STATEMENT Amyloid-beta (Abeta) is a key pathogenetic factor in Alzheimer's disease.

60 Oxidative stress, a pathogenetic factor in many conditions, including chroni

61 predisposition is recognized as an important pathogenetic factor in otitis media (OM) and associated

62 lucidated that oxidative stress is a pivotal pathogenetic factor of age-related bone loss and strengt

63 stence has been suspected to be an important pathogenetic factor.

64 Herein, relevant pathogenetic factors and underlying mechanisms as well a

65 ctive oxygen species in sickled AS RBCs is a pathogenetic feature shared by parasitized thalassemic a

66 The common pathogenetic features in STEC-HUS, aHUS, and secondary H

67 eir potential to alter the immunological and pathogenetic features of HLA-B27 as a function of the ER

68 esis and, as a result, its epidemiologic and pathogenetic features remain poorly understood.

69 ese data suggest that iMCD-TAFRO might share pathogenetic features with clonal inflammatory disorders

70 isease lead to large kidney cysts that share pathogenetic features.

71 way are important for disease, informing the pathogenetic function of additional cytokines (such as t

72 (GRN+), compared with FTLD patients without pathogenetic GRN mutations (GRN-) and healthy controls (

73 Neuronal degeneration represents a pathogenetic hallmark after different brain insults, suc

74 her criterion emphasizes the etiology or the pathogenetic heterogeneity of acute decreases in kidney

75 peutic strategies are needed to address this pathogenetic heterogeneity.

76 The pathogenetic immune mechanisms involved (cell-mediated v

77 acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood.

78 In this study, we examine the pathogenetic impact of somatic hemizygous 13q12.2 microd

79 agnostic and possible prognostic utility and pathogenetic implications of serologic abnormalities in

80 cted to HLA-B27 positive cases, has profound pathogenetic implications.

81 be detected using MC but may have important pathogenetic implications.

82 and primary myelofibrosis has diagnostic and pathogenetic implications.

83 rophilic inflammation is understood to be of pathogenetic importance in chronic obstructive pulmonary

84 To identify the pathogenetic importance of telomerase in lung fibrosis,

85 anges in gene expression in PBMCs, providing pathogenetic insights and a core subset of genes that, i

86 Our results provide new pathogenetic insights and identify possible therapeutic

87 Third, the pathogenetic insights have delivered new treatment optio

88 diagnostics of MD/CCRDs and may offer novel pathogenetic insights that may be of particular value fo

89 esent in GBA (mut/wt) carriers may offer new pathogenetic insights to and potential therapeutic targe

90 in IgG-deficient mice implicated IgG as the pathogenetic ligand for endothelial FcgammaRIIB in obesi

91 guidelines, six variants were classified as "pathogenetic/likely pathogenetic" and two as "of uncerta

92 A common pathogenetic link between LGL leukemia and RA is propose

93 Hashimoto's thyroiditis strongly suggests a pathogenetic link between this autoimmune disorder and m

94 netic basis of PH and cellular and molecular pathogenetic links should further expand our understandi

95 Pathogenetic markers of diabetic kidney disease (DKD) pr

96 Important pathogenetic MC contributions to other inflammatory and

97 ints to cell-mediated immunity as a relevant pathogenetic mechanism and potential therapeutic target

98 ed gene cluster and malignancy, reveal a new pathogenetic mechanism associated with acquired regions

99 me that AVS, COA and HLHS can share a common pathogenetic mechanism at the molecular level, explainin

100 The pathogenetic mechanism by which a poly-A tract results i

101 The findings suggest a common pathogenetic mechanism connecting certain iDCMs and othe

102 voltage-dependent gating represent a common pathogenetic mechanism for genetically inherited channel

103 ostatic control by PRDM1 may be an important pathogenetic mechanism for NKCL.

104 tic variation is now being investigated as a pathogenetic mechanism for other diseases.

105 possibly leading to central apnea, may be a pathogenetic mechanism for SUDEP.

106 oblastic bone formation is impaired, a clear pathogenetic mechanism has not been depicted yet.

107 blish chronic active BCR signalling as a new pathogenetic mechanism in ABC DLBCL, suggesting several

108 cogenic transcripts may represent a critical pathogenetic mechanism in MLL-rearranged B-ALL and suppo

109 lammatory cell responsiveness to PGE(2) as a pathogenetic mechanism in patients with aspirin-sensitiv

110 sociated cellular stressors may be a seminal pathogenetic mechanism in the development of involutiona

111 and Creutzfeldt-Jakob disease share a common pathogenetic mechanism involving aggregation and deposit

112 ptic encephalopathy (EE), yet the underlying pathogenetic mechanism is unclear.

113 uption of the barrier element as a potential pathogenetic mechanism of human disease.

114 rt a role for impaired ubiquitination in the pathogenetic mechanism of RCBTB1 mutations.

115 lutamatergic terminals can constitute a main pathogenetic mechanism of RLS symptoms.

116 In conclusion, we report new insight in the pathogenetic mechanism of viitligo and indicate that the

117 re considered in the context of the presumed pathogenetic mechanism related to the neurotropic proper

118 in human autoimmune diseases, but a unifying pathogenetic mechanism remains elusive.

119 s identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell

120 These molecular changes define a pathogenetic mechanism that leads to preaxial polydactyl

121 s suggest that downregulation of mGluR5 is a pathogenetic mechanism underlying nicotine dependence an

122 ld be personalized to address the underlying pathogenetic mechanism.

123 ritical for dermatitis, revealing a separate pathogenetic mechanism.

124 with normal skeletal muscle through a novel pathogenetic mechanism.

125 plement dysregulation (CD) is the underlying pathogenetic mechanism.

126 ied into different types on the basis of the pathogenetic mechanism: primary PAP is characterized by

127 ion and oxidative stress, which are the main pathogenetic mechanisms actually recognized in the perio

128 of different inflammatory diseases, yet the pathogenetic mechanisms and cell types involved vary sig

129 models will be critical to understanding the pathogenetic mechanisms and developing more specific ant

130 tools for the elucidation of the underlying pathogenetic mechanisms and for preclinical studies.

131 Growing understanding of ebolavirus pathogenetic mechanisms and important new clinical obser

132 a basis for further studies to elucidate the pathogenetic mechanisms and phenotypic spectrum of assoc

133 genes will facilitate better elucidation of pathogenetic mechanisms and possible corrective therapie

134 nd pathways provide insights into underlying pathogenetic mechanisms and possible triggers of GV, est

135 tely, liver cancer, despite the fact that no pathogenetic mechanisms are known which are shared by th

136 rder to understand their contribution to the pathogenetic mechanisms associated with cortical patholo

137 There appear to be common pathogenetic mechanisms between poor oral health and car

138 hese antibodies are directly involved in the pathogenetic mechanisms by binding to the regions where

139 These pathogenetic mechanisms can include functional alteratio

140 r this disease course results from different pathogenetic mechanisms compared with secondary progress

141 recent years, a general understanding of the pathogenetic mechanisms driving HUS has increased.

142 We will take a journey from basic pathogenetic mechanisms elicited by viral infections tha

143 dings support the hypothesis of two separate pathogenetic mechanisms for M. pneumoniae-associated neu

144 The pathogenetic mechanisms for these changes had not been i

145 hypomyelinating leukodystrophies (HLD7) with pathogenetic mechanisms hypothesised to involve impaired

146 to greatly enhance our understanding of the pathogenetic mechanisms in lymphoma.

147 The cascade of inflammatory pathogenetic mechanisms in multiple sclerosis (MS) has n

148 Pathogenetic mechanisms in PV, ET, and PMF include stem

149 We attempted to elucidate possible pathogenetic mechanisms in scleroderma by analysis of ge

150 f Notch has provided important insights into pathogenetic mechanisms in the CNS and many other tissue

151 Our findings demonstrate the different pathogenetic mechanisms in wild-type and humanized mice

152 Because of the inherent complexity of the pathogenetic mechanisms involved in CF, which include im

153 Insights into the pathogenetic mechanisms involved in lymphoma impact the

154 hemostatic complications, the already known pathogenetic mechanisms involved, and the effect of vary

155 ggesting that exploration of other causes or pathogenetic mechanisms is warranted.

156 Different pathogenetic mechanisms might cause similar asthma sympt

157 s of natural history, biology, and molecular pathogenetic mechanisms of CDA.

158 The pathogenetic mechanisms of CR need to be better understo

159 kappaB functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7.

160 d provide new insight into the pathology and pathogenetic mechanisms of HACD1 CNM.

161 Pathogenetic mechanisms of HE deduced from cell culture

162 eve our data provide novel insights into the pathogenetic mechanisms of HHT and potential therapeutic

163 , we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis.

164 To investigate the pathogenetic mechanisms of mitochondrial presequence pro

165 Pathogenetic mechanisms of narcolepsy have so far mainly

166 hogenesis of AILD, definition of the precise pathogenetic mechanisms of recurrent AILD, and developme

167 finition, and in identifying possible immuno-pathogenetic mechanisms of severe infection.

168 esearch is needed to better characterize the pathogenetic mechanisms of SLE, identify additional ther

169 The pathogenetic mechanisms of these diseases and the causes

170 we summarize current knowledge regarding the pathogenetic mechanisms of viral HCC.

171 We here focused on the pathogenetic mechanisms potentially linking immune cell

172 4, -19q13.32, +16p11.2), suggesting distinct pathogenetic mechanisms relative to age.

173 upregulated at the growth plate, the precise pathogenetic mechanisms remain to be elucidated.

174 ls; however, the common underlying molecular pathogenetic mechanisms remain unclear.

175 ed syncytial muscle-for which the underlying pathogenetic mechanisms remain unclear.

176 no effective therapies for this illness, and pathogenetic mechanisms remain undefined.

177 In contrast, the pathogenetic mechanisms responsible for type 1 VWD remai

178 of SSc-ILD have not been validated, and the pathogenetic mechanisms that engender this pulmonary res

179 ncoprotein PAX-FOXO1, but the underlying RMS pathogenetic mechanisms that impede differentiation and

180 Understanding the pathogenetic mechanisms that shape such relationships, a

181 39 Suppl 1, 59-74] but rather to outline the pathogenetic mechanisms that these analyses are revealin

182 RASopathies can be caused by several pathogenetic mechanisms that ultimately impact or alter

183 important in leukemogenesis, the underlying pathogenetic mechanisms they trigger remain largely unkn

184 These findings suggest that complex pathogenetic mechanisms underlie human deafness DFNB59.

185 These results indicate that different pathogenetic mechanisms underlie transformation to JAK2

186 Major gaps remain regarding pathogenetic mechanisms underlying clinical heterogeneit

187 F-beta signaling contributes to knowledge of pathogenetic mechanisms underlying common craniofacial b

188 Thus, studying pathogenetic mechanisms underlying SCZ requires studying

189 The pathogenetic mechanisms underlying the liver disease are

190 The precise pathogenetic mechanisms underlying these inferior outcom

191 Further insight into GCH1-associated pathogenetic mechanisms will shed light on the role of d

192 etic risk variants indicate that LATE shares pathogenetic mechanisms with both frontotemporal lobar d

193 Microscopic colitis shares pathogenetic mechanisms with inflammatory bowel disease

194 The pathogenetic mechanisms, clinical symptoms and severity

195 ether these DLBCL subtypes arise by distinct pathogenetic mechanisms, we analyzed 203 DLBCL biopsy sa

196 ly unexplored level of complexity in disease pathogenetic mechanisms.

197 tis and be of help to better understand some pathogenetic mechanisms.

198 f B-cell differentiation stage and potential pathogenetic mechanisms.

199 s a deeper understanding of the underpinning pathogenetic mechanisms.

200 iac transplants, likely indicating divergent pathogenetic mechanisms.

201 cation of the different forms and insight on pathogenetic mechanisms.

202 pe-phenotype associations suggest additional pathogenetic mechanisms.

203 aises the possibility that they share common pathogenetic mechanisms.

204 nct genetic pathways linked to DCM and their pathogenetic mechanisms.

205 ink between a modifiable risk factor and the pathogenetic mechanisms.

206 This mechanism provides a novel pathogenetic model for the association of 13q deletions

207 Recently, a new pathogenetic model involving miRNAs and protein coding g

208 e rodent with brain iron deficiency (BID), a pathogenetic model of restless legs syndrome (RLS).

209 To further investigate this pathogenetic model, we ascertained and collected 108 Chi

210 Current pathogenetic models suggest that postprandial hyperlipid

211 ttenuated muscle fat infiltration as well as pathogenetic molecular pathways related to muscle mass r

212 ardiographic septal shape and the underlying pathogenetic mutation, time has come to subdivide the on

213 The presence of additional likely pathogenetic mutations beyond RB1 inactivation was assoc

214 To date, pathogenetic mutations in 16 distinct genes have been im

215 alysis is now uncovering a remarkable set of pathogenetic mutations that alter the Hh pathway, thus c

216 To elucidate the pathogenetics of human lung development, we studied a un

217 idence comes from human studies, pointing to pathogenetic or protective MC functions in patients with

218 tients with systemic mastocytosis, but their pathogenetic or treatment relevance is unknown.

219 eries provides the clinical correlate to the pathogenetic parallels between CRDD and Crohn disease.

220 Here, we investigated whether this pathogenetic pathway could affect podocyte phenotype in

221 BCR signaling is a central pathogenetic pathway in chronic lymphocytic leukemia (CL

222 Further studies supported a pathogenetic pathway whereby the CD8+ T cell product, IF

223 of various protein fragments into a rational pathogenetic pathway(s).

224 novo lipogenesis [DNL]) may be a modifiable pathogenetic pathway.

225 uggesting that they are involved in a common pathogenetic pathway; however, the molecular mechanism t

226 Deeper insight into pathogenetic pathways and into the biological effects of

227 sis of DR through the modulation of multiple pathogenetic pathways and may be novel therapeutic targe

228 These genes delineated the pathogenetic pathways and rendered significant insight i

229 nterrupt neointimal hyperplasia and relevant pathogenetic pathways are essential.

230 The pathogenetic pathways include oxidative stress, advanced

231 of asthma is likely due in part to distinct pathogenetic pathways that depend on preceding/comorbid

232 with non-TNBC, likely arises from different pathogenetic pathways, and benign breast disease (BBD) p

233 al/retinal pathologies, suggesting different pathogenetic pathways.

234 ciated with inherent susceptibility for TNBC pathogenetic pathways.

235 , indicating the existence of four different pathogenetic patterns.

236 hether these indicators represent a distinct pathogenetic phenotype of DKD will require a large study

237 Numerous cytokine activities with pathogenetic potential have now been demonstrated in rhe

238 pancreatic beta-cells is a well established pathogenetic process in type 2 diabetes.

239 The pathogenetic process involving hyperglycemia, BMDCs, and

240 s in schizophrenia, suggesting that a shared pathogenetic process might underlie diverse cortical pat

241 Lipotoxicity is a presumed pathogenetic process whereby elevated circulating and st

242 helial-mesenchymal transition (EMT) as a key pathogenetic process.

243 The key pathogenetic processes and causes of death are unknown,

244 These pathogenetic processes are interdependent and also indiv

245 To investigate pathogenetic processes relevant to cutaneous lupus as co

246 t ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset

247 lood, Wang et al describe the occurrence and pathogenetic relevance of IDH2R172 mutations in angioimm

248 Thus, these data highlight the pathogenetic relevance of the macrophage polarization st

249 Investing in primary prevention and pathogenetic research is essential to reduce this burden

250 re, this child-rearing style may also play a pathogenetic role by transmitting trauma- and stressor-r

251 A pathogenetic role for autoantibodies is suspected, but t

252 nted genes L3MBTL1 and SGK2, indicative of a pathogenetic role for loss of the active paternally inhe

253 Our results demonstrate a pathogenetic role for VWF-platelet interaction in flow d

254 rosis factor-alpha and interleukin-6, play a pathogenetic role in chronic heart failure, and anti-inf

255 y and antiangiogenic Tregs play an essential pathogenetic role in chronic ischemic HF to promote immu

256 EMENT Neuroinflammation is thought to have a pathogenetic role in epilepsy, a disorder characterized

257 hat autoimmune CD8 T cells play an important pathogenetic role in gastrointestinal dysmotility and ma

258 tioxidant defenses have been shown to play a pathogenetic role in human and animal models of inflamma

259 th, survival, and motility and plays a major pathogenetic role in human prostate cancer (PCa).

260 the bone marrow of MDS patients and played a pathogenetic role in the development of ineffective hema

261 oxygen/nitrogen species-PARP pathway plays a pathogenetic role in the development of liver inflammati

262 r, these results suggest that CLU may play a pathogenetic role in TTR and Ig light chain amyloidoses

263 ter studies in human primary GBM, validate a pathogenetic role of a common tumour suppressor mutation

264 vations provided novel information about the pathogenetic role of a TESC-NHE1-pHi axis in mediating s

265 th diseased Bruch membrane in PXE suggests a pathogenetic role of Bruch membrane alterations for the

266 oral neomycin and polymyxin B, indicating a pathogenetic role of gut-derived bacterial products.

267 In order to assess the pathogenetic role of lesions in the grey and white matte

268 y have clinical utility given the widespread pathogenetic role of MYC in cancer.

269 Our findings are consistent with a pathogenetic role of TGF-beta1/3, demonstrating the effi

270 cal and clinical findings supporting the key pathogenetic role of the NLRP3 inflammasome and IL-1 cyt

271 of aPLA(2)R antibody titer and highlight the pathogenetic role of these antibodies, especially the Ig

272 To gain insight into and test the possible pathogenetic role of this pathway, we designed a conditi

273 It is unclear whether it has a pathogenetic role or simply reveals the presence of unde

274 se (IBD), and in various carcinomas, yet its pathogenetic role remains unknown.

275 ative vasculopathies in which EndoMT plays a pathogenetic role.

276 chemokine expression, we attempted to reveal pathogenetic roles for this pathway of MC activation.

277 regulated ion channel module have well-known pathogenetic roles in cardiac dysrhythmias.

278 vels of specific antibodies assigned salient pathogenetic roles in IgA nephropathy.

279 IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases

280 es of autoantibody, but their most important pathogenetic roles may be to present autoantigens to T c

281 These findings support the pathogenetic segregation of these entities and define no

282 is intimately linked with the unraveling of pathogenetic sequelae.

283 a subset of patients negative for AQP4-IgG, pathogenetic serum IgG antibodies to myelin oligodendroc

284 In most patients, NMO is caused by pathogenetic serum IgG autoantibodies to aquaporin 4 (AQ

285 erine 129 phosphorylation of alpha-Syn is of pathogenetic significance and that promoting PP2A activi

286 Ang-2 has recently been shown to have pathogenetic significance in sepsis and acute lung injur

287 st this bacterium in ReA patients, but their pathogenetic significance, autoimmune potential, and rel

288 ies to SERCA2a suggesting that they may have pathogenetic significance.

289 These results provide insights into the pathogenetic similarities and differences between PsC an

290 ghput experimental model of epilepsy-related pathogenetic states.

291 Cortical spreading depression (CSD) is a key pathogenetic step in migraine with aura.

292 , inclusion of noncoding genomic elements in pathogenetic studies and their consideration as therapeu

293 ue to limited access to human neural tissue, pathogenetic studies have, so far, mostly focused on the

294 tform using BAGS-assigned subtypes may allow pathogenetic studies to improve disease management.

295 mission of HIV in multiple epidemiologic and pathogenetic studies.

296 mong at least 10 sarcomeric genes confer the pathogenetic substrate for this 'disease of the sarcomer

297 Pathogenetic theories of dacryops that implicate a failu

298 ally improved clinical outcomes and informed pathogenetic understanding, but no cure as yet exists.

299 ders are at a crossroads of rapidly evolving pathogenetic understanding, leading to changes in diagno

300 the endoplasmic reticulum (ER) and elicits a pathogenetic unfolded protein response (UPR).