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1 Yet Abeta formation itself may not be pathogenic.
2 iant from variant of unknown significance to pathogenic.
3 ithms suggested that this mutation is likely pathogenic.
4 -of-function (LoF) alleles and classified as pathogenic.
5 eted HCM disease variants (pathogenic/likely pathogenic: 18%, P<0.0001) but an excess of variants of
6 1), as compared to Whites (pathogenic/likely pathogenic: 31%, excess of variants of uncertain signifi
7 demonstrates that therapeutically targetable pathogenic Abeta seeds already exist during the lag phas
8 e effect of TTR against cellular toxicity of pathogenic Abeta, a protein associated with Alzheimer's
11 To determine if B. anthracis PGA confers a pathogenic advantage over other PGAs, we compared the re
12 hesise that the parallel emergence of highly-pathogenic AIV may be facilitated by permissive or compe
22 host interacts with all microbes-beneficial, pathogenic, and commensal-and an opportunity to discover
25 ers of autoantigens to T cells, producers of pathogenic antibodies, and reservoirs for viruses that t
26 ntial host innate immune responses to highly pathogenic arenavirus infections.IMPORTANCE Arenavirus N
28 have shown previously that ATXN3-depleted or pathogenic ATXN3-expressing cells abrogate polynucleotid
32 ses of distinct phenotypes.IMPORTANCE Highly pathogenic avian influenza A(H5N1) viruses have circulat
33 ly this new method to the analysis of highly pathogenic avian influenza H5N1 clade data in the Mekong
34 ntly been shown to be associated with highly pathogenic avian influenza virus (HPAIV) H5N1 outbreaks
35 rticular concern in Bangladesh, where highly pathogenic avian influenza viruses of the A(H5N1) subtyp
37 cterial activity against multiple strains of pathogenic bacteria and promoted the clearance of intrac
39 Dy-I-PhiAB6TSP also cross-reacted with other pathogenic bacteria containing Pse on their surface poly
42 The rapid increase in antibiotic resistant pathogenic bacteria has become a global threat, which be
43 used antibiotics experienced by potentially pathogenic bacteria that are asymptomatically colonizing
45 ctors, whereas when they are produced by non-pathogenic bacteria, they become food ingredients or bio
56 a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs and suggest that th
59 se data show a unique interaction of between pathogenic C difficile and F nucleatum in the intestinal
60 nt with ovarian cancer with a known germline pathogenic cancer susceptibility gene variant should be
61 enced a prior marked intestinal expansion of pathogenic Candida species; this expansion consisted of
67 g non-neuronal function of Cdkl5, identify a pathogenic Cdkl5-Sox9 axis in epithelial cell-death, and
69 e purpose of this study was to determine the pathogenic changes that occur in myoepithelial cells (ME
71 s human mucosal tissues and skin, can become pathogenic, clinically manifesting most commonly as orop
72 yndrome coronavirus 2 (SARS-CoV-2), causes a pathogenic condition that has been termed coronavirus di
73 ntly implicated in a vast array of paramount pathogenic conditions in humans, including multiple scle
74 suggests that vascular pathology is a likely pathogenic contributor to age-related dementia, includin
81 en widely used for the diagnosis of virus or pathogenic disease by gold standard (PCR, qPCR, RT-qPCR)
85 tic data were collected on 107 patients with pathogenic DSP mutations and 81 patients with pathogenic
87 umoral and cellular immune responses against pathogenic Ebola viruses and support further evaluation
91 D25(+) regulatory T (iTreg) cells can become pathogenic effector cells, enhancing lung allergic respo
92 y and provide new insight into the potential pathogenic effects of Abeta-IAPP hetero-oligomerization
95 Abeta species, which are considered the main pathogenic entity in AD, as compared to rodent Abeta, th
97 ular coupling have been proposed to be a key pathogenic factor in the onset and progression of Alzhei
98 on in FDD and FBD knock-in mice, which carry pathogenic FDD and FBD mutations into the mouse endogeno
99 findings suggest that the R101Q mutation is pathogenic for NLGN4 and can lead to synaptic dysfunctio
101 in Tregs resulted in their acquisition of a pathogenic FOXP3(+)T-bet(+)IFNgamma(+) phenotype at CHS
103 firstly, in the biocontrol of beneficial and pathogenic fungi in increasingly arid crop soils and, se
105 e-scale screening for PSD inhibitors against pathogenic fungi, antibiotic-resistant bacteria, and neo
109 identification of several clinical subtypes, pathogenic genes and putative causative environmental ag
112 nted independent tumors in two children with pathogenic germline mutations by genotyping somatic muta
113 Lynch syndrome (LS) arises in patients with pathogenic germline variants in DNA mismatch repair gene
114 s sequenced, varying observed frequencies of pathogenic germline variants in patients with cancer, di
115 egulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
121 (FS) is a blistering skin disease caused by pathogenic IgG4 autoantibodies to desmoglein 1 (DSG1).
122 hma, potentially through the accumulation of pathogenic IL5(+) IL17A(+) CD4(+) effector T-cells.
123 tribution of CD4(+) T cells to protective or pathogenic immune responses to SARS-CoV-2 infection rema
129 which is otherwise present in the wild-type pathogenic JUNV, causes GPC retention in the endoplasmic
131 ation of two diverse species and serovars of pathogenic leptospires directly from host kidney tissue.
132 supports the primary isolation of fastidious pathogenic leptospires directly from infected host tissu
134 th CD4(+) T cells and myeloid cells produced pathogenic levels of VEGF-A within HSV-1-infected cornea
138 te outcome included the presence of multiple pathogenic/likely pathogenic sarcomeric variants (hazard
139 t onset of Parkinson's disease patients with pathogenic/likely pathogenic variants in ATP13A2, PLA2G6
140 the age at onset of carriers with other gene pathogenic/likely pathogenic variants was similar to tha
141 onfidently interpreted HCM disease variants (pathogenic/likely pathogenic: 18%, P<0.0001) but an exce
142 ance (24%, P<0.0001), as compared to Whites (pathogenic/likely pathogenic: 31%, excess of variants of
144 e of LOAD and VAD, thus underlying a further pathogenic link between these two forms of dementia.
146 a to identify rare, pathogenic (P) or likely pathogenic (LP) variants in 102 individuals with PNES an
148 onic phospholipids to plasma, is a plausible pathogenic mechanism explaining adverse obstetrical outc
153 s field regarding the molecular genetics and pathogenic mechanisms of CDAs, through an analysis of th
157 trix and joint lubricants, FLS in RA produce pathogenic mediators such as cytokines and proteases tha
161 s included symptomatic carriers (n=185) of a pathogenic mutation in chromosome 9 open reading frame 7
162 a 14- angstrom structure of LRRK2 bearing a pathogenic mutation that oligomerizes as a right-handed
166 iation and progression but also on screening pathogenic mutations in meiosis-associated diseases.
169 nocytes from healthy skin commonly contained pathogenic mutations, although these mutations tended to
174 proaches cannot directly identify individual pathogenic noncoding mutations from personal cancer geno
175 present a deep learning framework to capture pathogenic noncoding mutations in personal cancer genome
180 s/pandemics and/or terrorist/criminal use of pathogenic organisms warrants continued exploration and
181 of single representative pathogenic and non-pathogenic ovine isolates over ten time-points by enumer
182 ole-genome genotyping data to identify rare, pathogenic (P) or likely pathogenic (LP) variants in 102
186 athogenic DSP mutations and 81 patients with pathogenic plakophilin 2 (PKP2) mutations as a compariso
189 nces and binding characteristics, plus their pathogenic potential using transfected HEK293T cells, ro
190 signal from the inflammatory liver for this pathogenic process in the hepatic conditional beta-caten
191 ies have different targets within the immune pathogenic process, and the four trials have similaritie
199 40 monogenic disorders, and undoubtedly more pathogenic repeat expansions remain to be discovered.
200 an identify large expansions of 41 out of 44 pathogenic repeats, including nine recently reported non
202 uppresses the development of exacerbated and pathogenic responses and contributes to lesions stabilit
203 wild-type (WT) mice with various doses of a pathogenic retrovirus (Friend virus) and assessed immune
207 hermore, whether NLRP3 plays a protective or pathogenic role during Leishmania spp. infection is far
208 s Review weighs the evidence that supports a pathogenic role for PAD enzymes in RA as both promoters
216 s, the interrelationships, and the potential pathogenic roles of these reactive proliferative and sen
219 d the presence of multiple pathogenic/likely pathogenic sarcomeric variants (hazard ratio [HR], 5.6 [
221 nt human and animal pathogens as well as non-pathogenic species such as ecologically critical symbion
222 genomes from 73 saprotrophic, endophytic and pathogenic species, and 62 mycorrhizal species, includin
223 ervation of the genes encoding ETT2 in human pathogenic ST69 strains strongly suggests it has importa
226 howed antibacterial activity against several pathogenic strains at submicromolar concentrations.
228 tentially contribute to the emergence of new pathogenic strains including strains with epidemic poten
229 both within the intestinal tract (intestinal pathogenic strains) and outside (extraintestinal pathoge
231 tiate a sequence variant as either benign or pathogenic, such that the appropriate therapeutic interv
232 mmune response triggered upon the binding of pathogenic superantigens to T cell receptors (TCRs) and/
233 sB(9-23) by both limiting the development of pathogenic T cells and supporting the selection of Tregs
234 ertoire by increasing levels of autoreactive pathogenic T cells while suppressing development and/or
237 ents, resulting in enrichment of potentially pathogenic taxa and antimicrobial resistance genes.
241 that is circumstantially reputed to be less pathogenic than the epidemic strains from Europe 1 linea
245 particularly attractive because while it is pathogenic to avians (e.g., chickens), it does not cause
246 he factors and mutations responsible for the pathogenic transformation of a patient-derived lambda LC
247 ca because they conferred protection against pathogenic trypanosomes that cause African sleeping sick
248 d ARRs by telephone to disclose the familial pathogenic variant and offer telephone counseling and ma
250 ng NCCN criteria were more likely to carry a pathogenic variant in 9 predisposition genes compared wi
251 /or ovarian cancer in two children, a likely pathogenic variant in the gene associated with Lowe synd
256 model to identify carriers of LS and non-LS pathogenic variants (PVs) among patients with CRC and EC
257 ually exclusive, chromosomal instability and pathogenic variants affecting the long arm of chromosome
258 ompared with those with known high-penetrant pathogenic variants and are more likely to remain unilat
259 h the identification of candidate non-coding pathogenic variants and their functional validation may
263 of myosins in the SRX conformation, whereas pathogenic variants destabilized these and increased the
268 on's disease patients with pathogenic/likely pathogenic variants in ATP13A2, PLA2G6, PRKN, or PINK1 w
269 earning method identified more patients with pathogenic variants in cancer-predisposition genes than
270 neurodegeneration but also demonstrate that pathogenic variants in GBF1 are associated with HMN/CMT2
274 ity of PXE are PXE-like phenotypes caused by pathogenic variants in other ectopic mineralization-asso
280 We identified 39 patients, in whom biallelic pathogenic variants in the CUBN gene were associated wit
283 e uveal melanoma patients with BAP1 germline pathogenic variants obtained from previous publications
284 f carriers with other gene pathogenic/likely pathogenic variants was similar to that of non-carriers.
286 bands with newly diagnosed cancer-associated pathogenic variants were offered facilitated cascade tes
288 r, receptor-level IR (e.g., insulin receptor pathogenic variants, INSR) causes hyperglycemia without
294 extends to the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-
297 rly-onset forms of deafness, predicted to be pathogenic, were detected in 25.7% of mARHL and 22.7% of
299 mes for fast determination and monitoring of pathogenic (Zika, Dengue, SARS-Cov-2 (inducer of COVID-1