ライフサイエンスコーパス: pathogenic mechanism

1 bitory balance in specific circuits is a key pathogenic mechanism.

2 was also reproduced in vitro, confirming the pathogenic mechanism.

3 LRRK2 G2019S carriers may reflect a distinct pathogenic mechanism.

4 impairment of the immune cytotoxic arm as a pathogenic mechanism.

5 istics that leave them susceptible to common pathogenic mechanisms.

6 inase module, indicating probable overlap in pathogenic mechanisms.

7 particular molecular properties and distinct pathogenic mechanisms.

8 actors cause or are results of IBD and their pathogenic mechanisms.

9 in the same individuals, suggesting similar pathogenic mechanisms.

10 n and human disease, and delineate potential pathogenic mechanisms.

11 milar in Ig-MPGN and C3G, suggesting similar pathogenic mechanisms.

12 ty of the infection and provide insight into pathogenic mechanisms.

13 verse etiologies are likely due to different pathogenic mechanisms.

14 gments, suggesting a chirality of underlying pathogenic mechanisms.

15 ses with distinct clinical presentations and pathogenic mechanisms.

16 t may promote our understanding of Chlamydia pathogenic mechanisms.

17 taneous NVP HSR and advance insight into its pathogenic mechanisms.

18 tion of misfolded proteins, they share other pathogenic mechanisms.

19 ia is a heritable brain illness with unknown pathogenic mechanisms.

20 suggesting that the 2 syndromes share common pathogenic mechanisms.

21 model for investigating plasmid-independent pathogenic mechanisms.

22 r concomitant symptoms, suggesting different pathogenic mechanisms.

23 hese disorders and little is known about the pathogenic mechanisms.

24 th for clinical management and to understand pathogenic mechanisms.

25 mension for further investigating chlamydial pathogenic mechanisms.

26 ea worldwide, yet we know little about their pathogenic mechanisms.

27 ry disorders) are the most widely recognized pathogenic mechanisms.

28 sms with in vivo behavior and help to reveal pathogenic mechanisms.

29 tin gene (HTT) and involves a complex web of pathogenic mechanisms.

30 t the advent of T2DM and give insight to its pathogenic mechanisms.

31 lammatory processes are governed by distinct pathogenic mechanisms.

32 estricted due to a poor understanding of the pathogenic mechanisms.

33 irst evidence that oxytocin-pathway-specific pathogenic mechanisms account for social impairments acr

34 Collectively, this study reveals novel pathogenic mechanisms adopted by F. tularensis to modula

35 ansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approac

36 tu during AH, providing a previously unknown pathogenic mechanism and new avenues for treatment.

37 This review aims to describe the pathogenic mechanism and route of spread of the causativ

38 However, the primary pathogenic mechanism and subcellular site of action for

39 The pathogenic mechanism and the neuromuscular reflex-relate

40 man variants, enable the characterization of pathogenic mechanisms and are amenable to drug tests.

41 untargeted metabolomic profiling to identify pathogenic mechanisms and candidate disease biomarkers i

42 viral infection, generate new hypotheses of pathogenic mechanisms and confirm mechanisms of disease.

43 iewed as an enigmatic disease with uncertain pathogenic mechanisms and confusion around diagnosis, cl

44 ad nature of this damage makes understanding pathogenic mechanisms and devising new treatments diffic

45 el to identify new disease-causing variants, pathogenic mechanisms and drugs that will impact medicin

46 The underlying pathogenic mechanisms and effective disease-modifying th

47 -mutant can be used for studying the disease pathogenic mechanisms and for testing novel therapies fo

48 sensitive asthma and to use them to identify pathogenic mechanisms and investigate new treatment appr

49 de an up-to-date discussion on the potential pathogenic mechanisms and management of IIH.

50 early multiple sclerosis lesion and identify pathogenic mechanisms and opportunities for therapy.

51 iatric diseases, little is known about their pathogenic mechanisms and potential therapeutic interven

52 cribe the animal models available to uncover pathogenic mechanisms and related host immune responses.

53 to our understanding of genetic principles, pathogenic mechanisms and therapeutic modalities.

54 rons are a promising model in which to study pathogenic mechanisms and therapeutic targets.

55 Collectively, these data can delineate pathogenic mechanisms and thereby help maximize benefici

56 remains unclear whether these factors share pathogenic mechanisms and whether links exist with islet

57 d to reveal the complexity of the underlying pathogenic mechanisms and will lead to novel treatments

58 A focused review of gene fusions, their pathogenic mechanism, and gene fusion detection methods

59 , Fishbein et al. report novel driver genes, pathogenic mechanisms, and markers of malignancy.

60 orroborating clinical assessments, informing pathogenic mechanisms, and revealing new therapeutic tar

61 Well-defined pathogenic mechanisms, and the basis for phenotypic hete

62 In summary, this study revealed a novel pathogenic mechanism applicable to various forms of blin

63 The underlying pathogenic mechanisms are largely unknown.

64 f human neurobrucellosis, but the underlying pathogenic mechanisms are largely unknown.

65 DL2 have similar clinical profiles, distinct pathogenic mechanisms are likely to drive toxicity in Dr

66 However, ASD pathogenic mechanisms are poorly understood.

67 e human deaths each year than influenza, its pathogenic mechanisms are poorly understood.

68 ut our understanding of its target genes and pathogenic mechanisms are still limited.

69 progresses to end-stage kidney failure, but pathogenic mechanisms are still poorly understood.

70 dementia share many risk factors, and their pathogenic mechanisms are suggested to be related.

71 However, the pathogenic mechanisms are unknown, and previous studies

72 have not been examined functionally and the pathogenic mechanisms are unknown.

73 forms of Parkinson's disease but the precise pathogenic mechanisms are unknown.

74 eukodystrophy 10 (HLD10), but the associated pathogenic mechanisms are unknown.

75 The pathogenic mechanism, associated clinical features, and

76 Our findings identify a potential pathogenic mechanism attributable to MATR3 mutations and

77 how that high c-Jun elevation is a potential pathogenic mechanism because it inhibits myelination.

78 The need for individualized definitions of pathogenic mechanisms before initiating therapy extends

79 omics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD

80 rved, providing novel insight into potential pathogenic mechanisms behind OME.

81 Our findings also uncover a new pathogenic mechanism by which beta-catenin promotes podo

82 owever, in the absence of LEE, the molecular pathogenic mechanisms by STEC strains are unknown.

83 In this review we discuss the pathogenic mechanisms by which cohesin mutations contrib

84 rmore, in R6/2 mice, LNA-CTG blocked several pathogenic mechanisms caused by expanded CAG RNA, includ

85 rs underlying the formation of CPB and their pathogenic mechanism closely resemble those responsible

86 hese findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria a

87 These may have different pathogenic mechanisms: Congenital cataracts induce the u

88 Elucidation of pathogenic mechanisms could lead to new targets for trea

89 ts worldwide distribution and multifactorial pathogenic mechanisms, COVID-19 poses a global threat to

90 agile X syndrome patients, suggesting common pathogenic mechanisms derived from disruptions of cytopl

91 Our findings reveal novel pathogenic mechanisms driven by ATRX deficiency in gliom

92 ective treatment for HD, in part because the pathogenic mechanism driving the disease is not fully un

93 causes a spectrum of liver diseases, but the pathogenic mechanisms driving the onset and progression

94 ctive immunity and a CD8(+) T cell-dependent pathogenic mechanism during chlamydial infection in C57B

95 , facilitating research toward understanding pathogenic mechanisms, evaluation of therapeutic outcome

96 onic phospholipids to plasma, is a plausible pathogenic mechanism explaining adverse obstetrical outc

97 t perturbation of ALP function is a relevant pathogenic mechanism for AD-ANCL and supports the use of

98 role of the SEC61 complex, as a contributory pathogenic mechanism for ADTKD.

99 Together, these results suggest a pathogenic mechanism for FHHNC involving transcellular C

100 , our data thus unveil a clinically relevant pathogenic mechanism for HSCR that involves cell-autonom

101 Altogether, our data reveal a potential pathogenic mechanism for male bias in NLGN4X-associated

102 umulatively, our results highlight a complex pathogenic mechanism for PD where short- and long-term o

103 These findings identify an in vivo molecular pathogenic mechanism for R91W mutation and provide a fea

104 ngiotensin system (RAS) has emerged as a key pathogenic mechanism for these disorders; angiotensin (A

105 berrant target recognition as the underlying pathogenic mechanism for this novel KS-associated varian

106 by mst depletion in the visceral muscle as a pathogenic mechanism for VM.

107 activated epithelial cells, pointing to new pathogenic mechanisms for future clinical intervention.

108 features increasingly realized as important pathogenic mechanisms for neurodegenerative diseases.

109 The pathogenic mechanisms for rabies are not well understood

110 en together, our findings have shed light on pathogenic mechanisms for VEGF antagonism-associated adv

111 marrow transplantation to target the primary pathogenic mechanism (GALC deficiency) and two secondary

112 ease heterogeneity and poor understanding of pathogenic mechanisms hampers the identification of ther

113 stroesophageal reflux disease, although this pathogenic mechanism has not been proven.

114 2L and Miyoshi myopathy type 3, although the pathogenic mechanism has remained elusive.

115 nantly muscle-specific phenotype a number of pathogenic mechanisms have been proposed, including a di

116 veral therapeutic approaches targeting these pathogenic mechanisms have failed in clinical or preclin

117 To explore an alternative pathogenic mechanism, I propose that the triggering even

118 al tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney inj

119 ric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.

120 des, which is widely considered an essential pathogenic mechanism in Alzheimer's disease (AD).

121 The importance of IgE as a central pathogenic mechanism in autoimmunity has now been clinic

122 creasing oxidative stress, revealing another pathogenic mechanism in C9ORF72-related ALS and FTD.

123 uclear factor kappaB pathway seems to be key pathogenic mechanism in chronic pancreatitis.

124 mpromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other

125 mosomal compartmentation are not the primary pathogenic mechanism in heart failure due to lamin A/C h

126 aberrant neovascularization is an essential pathogenic mechanism in many human diseases, including d

127 AR-gamma and GLUT-1 by E. coli K1 is a novel pathogenic mechanism in meningitis, and pharmacological

128 r nuclear envelope, while its loss reveals a pathogenic mechanism in microcephaly.

129 by autoantibodies (Abs) is considered a rare pathogenic mechanism in myasthenia gravis (MG), but is u

130 pporting the role for mitophagy failure as a pathogenic mechanism in PD.

131 uggest abnormal cell cycle reactivation as a pathogenic mechanism in SBMA.

132 and provide a framework for elucidating the pathogenic mechanism in the subset of obese patients wit

133 Here, we describe a pathogenic mechanism in which follicular translocation o

134 y, we revisited these controversies over key pathogenic mechanisms in a lethal model of secondary bac

135 secretase, contributing to the age-dependent pathogenic mechanisms in AD.

136 tween the ageing process itself and emerging pathogenic mechanisms in ALS/FTD.

137 s direct interaction might contribute to the pathogenic mechanisms in complement-mediated, inflammato

138 Pathogenic mechanisms in CSU due to PI may include speci

139 Pathogenic mechanisms in CSU patients with thyroid autoi

140 o changes in extracellular cues and mediates pathogenic mechanisms in disease states.

141 onal control in fibrosis and highlight novel pathogenic mechanisms in heart failure.

142 sive disease, possibly implying CSF-mediated pathogenic mechanisms in lesion development that may dif

143 This effect might exacerbate underlying pathogenic mechanisms in lupus nephritis.

144 ) inflammation and permeability are critical pathogenic mechanisms in many inflammatory conditions in

145 t fully understood, which makes the study of pathogenic mechanisms in these diseases a challenge for

146 cies in wounds yet little is known about its pathogenic mechanisms in this setting.

147 roperties of bacterial infection to specific pathogenic mechanisms in wound healing.

148 ugh incurable, prion disease follows a clear pathogenic mechanism, in which a single gene gives rise

149 tual disability, prompts us to hypothesize a pathogenic mechanism, in which APP acts as a modulator o

150 The key molecular pathogenic mechanisms include alpha-synuclein misfolding

151 neurotransmission, and also suggest that the pathogenic mechanisms include direct antagonistic action

152 nflammatory cells that are implicated in the pathogenic mechanism, including mast cells, basophils, a

153 contribution to furthering understanding of pathogenic mechanisms initiated by polyQ tract proteins.

154 To date, the pathogenic mechanism involved remains poorly understood.

155 However, pathogenic mechanisms involved in CKD such as renal hypo

156 pairment and postural stability, and discuss pathogenic mechanisms involved in the association of the

157 es will be important to fully comprehend the pathogenic mechanisms involved in this disease and for t

158 nd mouse models of MS and go on to suggest a pathogenic mechanism involving lack of IL-22-mediated in

159 ith Alzheimer's disease, suggesting a common pathogenic mechanism involving macrophage phagocytosis a

160 This association could be due to shared pathogenic mechanisms involving elevated matrix metallop

161 However, the underlying pathogenic mechanism is largely unclear.

162 One pathogenic mechanism is the aberrant accumulation of dip

163 ) causes severe fetal defects, but the exact pathogenic mechanism is unclear.

164 ucial role of HSP47 in the KDELR2-associated pathogenic mechanism leading to OI.

165 myloid beta protein (Abeta) is a fundamental pathogenic mechanism leading to the neuronal damage pres

166 nimals have shed light on previously unknown pathogenic mechanisms leading to the identification of p

167 Despite its clinical importance, the pathogenic mechanism linking the variant to liver diseas

168 The pathogenic mechanisms linking them remain poorly underst

169 These suggest that these proposed pathogenic mechanisms may not be the underlying causes f

170 health have raised questions about potential pathogenic mechanism mediated by autoantibodies.

171 and cell-based approaches to uncover a dual pathogenic mechanism mediated by tau acetylation.

172 on; improved understanding of the underlying pathogenic mechanisms might lead to better clinical outc

173 coli (EIEC) is a unique pathovar that has a pathogenic mechanism nearly indistinguishable from that

174 ion in larger prospective studies, and their pathogenic mechanisms need to be better understood.

175 to patients, allowing to dissect the subtle pathogenic mechanisms occurring in otherwise very compro

176 ling in 22q11DS mice, and it may mediate the pathogenic mechanism of 22q11DS-related psychosis and co

177 ible role of neurodevelopmental genes in the pathogenic mechanism of ADHD.

178 The poorly understood pathogenic mechanism of amyloid diseases makes early sta

179 role for nucleocytoplasmic transport in the pathogenic mechanism of c9ALS/FTD.

180 itochondrial calcium deregulation is a novel pathogenic mechanism of cognitive deficiencies in schizo

181 ole induces sFlt-1, which might underlie the pathogenic mechanism of early-onset preeclampsia develop

182 The pathogenic mechanism of EKV-associated Cx31 mutants rema

183 The pathogenic mechanism of HIV-1-associated cardiomyopathy

184 ion, our study provides new insight into the pathogenic mechanism of intracellular bacteria to modula

185 ase, with implications for understanding the pathogenic mechanism of Parkinson's disease and for deve

186 for a prominent role of inflammation in the pathogenic mechanism of PHH and PIH and highlight promis

187 hese PDI modifications may contribute to the pathogenic mechanism of several diseases associated with

188 to be hallmarks of H5N1 virus infection, the pathogenic mechanism of the A(H7N9) virus in humans is l

189 phage infiltration into the aortic wall is a pathogenic mechanism of the condition.

190 Elucidation of the molecular pathogenic mechanism of the disease and discovery of eff

191 However, the cellular basis and pathogenic mechanism of the SLC25A46-related neuropathie

192 These findings provide insight into the pathogenic mechanism of this gain-of-function mutation o

193 ndings identify a developmentally restricted pathogenic mechanism of VPA and establish the use of rep

194 production of this cytokine is implicated in pathogenic mechanisms of a number of inflammatory diseas

195 and disease onset provides insight into the pathogenic mechanisms of a T cell-mediated autoimmune co

196 database also includes information about 13 pathogenic mechanisms of action for B. mallei and B. pse

197 ins for B. mallei and B. pseudomallei, their pathogenic mechanisms of action, and host factors are no

198 One of the proposed pathogenic mechanisms of alpha-syn mutations is mitochon

199 is study may deepen our understanding of the pathogenic mechanisms of ALS and other devastating disea

200 provides novel mechanistic insights into the pathogenic mechanisms of apoE4 and insulin resistance in

201 isease, advances in our understanding of the pathogenic mechanisms of arrhythmogenic cardiomyopathy o

202 -cell activation have important roles in the pathogenic mechanisms of both diseases.

203 s field regarding the molecular genetics and pathogenic mechanisms of CDAs, through an analysis of th

204 The immuno-pathogenic mechanisms of chronic hepatitis C virus (HCV)

205 Little is known about the pathogenic mechanisms of chronic pancreatitis.

206 issense mutation of LRSAM1 gene and explores pathogenic mechanisms of CMT2P.

207 Pathogenic mechanisms of CRS have recently become the fo

208 The pathogenic mechanisms of disease development include Ag-

209 ethodology for drug therapies and studies on pathogenic mechanisms of disease.

210 y A potential agent of bioterrorism, but the pathogenic mechanisms of F. tularensis are largely unkno

211 citing advances reveal the complexity of the pathogenic mechanisms of FTD and ALS and suggest promisi

212 However, the pathogenic mechanisms of fungal GH12 proteins have not b

213 r findings may help understand the potential pathogenic mechanisms of HAART-associated NeuroAIDS and

214 These results provide insight into pathogenic mechanisms of human biotin deficiency, the re

215 This mouse model will help delineate the pathogenic mechanisms of human corneal dystrophy.

216 Our findings expand the known pathogenic mechanisms of IgE-mediated inflammation beyon

217 However, the pathogenic mechanisms of most of these SNPs remain elusi

218 We review the pathogenic mechanisms of NASH and therapeutic options, a

219 The pathogenic mechanisms of NPC, particularly those involvi

220 However, the pathogenic mechanisms of psoriasis are not fully underst

221 Delineation of shared and disease-specific pathogenic mechanisms of remodelling between the sinonas

222 ntly tasked with overcoming newly developing pathogenic mechanisms of resistance to host immunity.

223 n immune system but also shed light onto the pathogenic mechanisms of T1D and the genetic variants th

224 them is crucial to our understanding of the pathogenic mechanisms of T3SSs.

225 The pathogenic mechanisms of the 2 forms of dry eye give an

226 However, the pathogenic mechanisms of the disease remain unclear.

227 9) use Ngn2-induced neurons to elucidate the pathogenic mechanisms of the teratogenic compound valpro

228 The pathogenic mechanisms of these viruses are largely unkno

229 A thorough understanding of the pathogenic mechanisms of these viruses will help us to d

230 PF3B mutations, permitting us to interrogate pathogenic mechanisms of UPF3B-associated NDDs.

231 ial to improving our understanding about the pathogenic mechanisms of various diseases.

232 e and zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling.

233 RRT2 at the synapse and the understanding of pathogenic mechanisms on the basis of PRRT2-related neur

234 se amino acid perturbations reflect isolated pathogenic mechanisms or if they are part of overall cha

235 ortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true in

236 ivitis (VKC) is a severe ocular allergy with pathogenic mechanism poorly understood and no efficaciou

237 The pathogenic mechanism probably corresponds to an alterati

238 ad to neurodegeneration and are amplified by pathogenic mechanisms related to brain ageing and accumu

239 in Eda and Edar mutant mice and explore the pathogenic mechanisms related to glandular function, mic

240 research focused on establishing convergent pathogenic mechanisms relevant to the potential treatmen

241 common human inflammatory skin disease, its pathogenic mechanisms remain incompletely understood.

242 in various human diseases, but miRNA-related pathogenic mechanisms remain incompletely understood.

243 Pathogenic mechanisms remain insufficiently understood;

244 ), a rare congenital muscle disease, but the pathogenic mechanisms remain largely unknown.

245 ly associated with scoliosis [10, 11], other pathogenic mechanisms remain to be determined.

246 The precise pathogenic mechanisms remain undetermined.

247 t prevalent psychiatric disorders, but their pathogenic mechanism remains poorly understood.

248 us (SLE) yet understanding of the underlying pathogenic mechanisms remains incomplete.

249 implicate these autoantibodies as a possible pathogenic mechanism responsible for the reduction in ci

250 Our data demonstrate that the pathogenic mechanisms responsible for chronic inflammato

251 the course of MS is driven by the very same pathogenic mechanisms responsible for the disease, the a

252 The pathogenic mechanism resulting in cell dysfunction and d

253 associated neuroinflammation is a potential pathogenic mechanism resulting in neuronal damage and de

254 humans, and used this system to explore the pathogenic mechanisms resulting from the sporadic Alzhei

255 ic pathways in lupus nephritis, the emerging pathogenic mechanism(s) may be encountered with new indi

256 m and that this may be linked to other known pathogenic mechanisms such as mitochondrial dysfunction.

257 rearrangements and provides insight into new pathogenic mechanisms, such as altered regulation due to

258 Multiple pathogenic mechanisms, such as lung epithelial damage an

259 These findings reveal a potential pathogenic mechanism that acts as a feedback loop contri

260 lting from UPR over-activation is a distinct pathogenic mechanism that can by itself be effectively t

261 ation made in C57BL/6J mice and suggesting a pathogenic mechanism that is independent of CD8(+) T cel

262 st time, therefore providing novel potential pathogenic mechanisms that can be explored in future stu

263 ns provides an important insight into common pathogenic mechanisms that cause both seizures and abnor

264 provide a framework for understanding basic pathogenic mechanisms that drive severe clinical hypertr

265 nced considerably in recent years, revealing pathogenic mechanisms that potentially underlie ciliopat

266 The pathogenic mechanisms that underlie these associations c

267 odegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disea

268 diverse pathologies with distinct underlying pathogenic mechanisms; the final disease outcome is then

269 this cholesterol trafficking defect, but the pathogenic mechanisms through which NPC1 deficiency caus

270 Our findings provide pathogenic mechanisms to explain the association between

271 2(R47H) KI rats may prove valuable to define pathogenic mechanisms triggered by the Trem2 R47H varian

272 efine human-Abeta-dependent and -independent pathogenic mechanisms triggered by this variant.

273 means of testing the hypothesis that common pathogenic mechanisms underlie ADHD and these other neur

274 al loop model of HIV/AIDS, we identified the pathogenic mechanism underlying sustained disruption of

275 In this report, we investigated the pathogenic mechanism underlying the deafness-associated

276 ovide a cellular phenotype for investigating pathogenic mechanisms underlying AS and identifying nove

277 the immune system can help us to uncover the pathogenic mechanisms underlying CRS.

278 which is a key to uncovering mutational and pathogenic mechanisms underlying genomic disorders.

279 lso facilitate progress toward understanding pathogenic mechanisms underlying psychosis onset, which

280 However, the pathogenic mechanisms underlying renal ischemia/reperfus

281 Insights into the pathogenic mechanisms underlying SARS-CoV-2 infection an

282 To date, the pathogenic mechanisms underlying Schnitzler syndrome rem

283 stantial gaps remain in our understanding of pathogenic mechanisms underlying the development of type

284 The pathogenic mechanisms underlying these abnormalities hav

285 However, the pathogenic mechanisms underlying these associations are

286 llmark of the disease, however the molecular pathogenic mechanisms underlying this phenomenon are not

287 a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis

288 Together, our results reveal pathogenic mechanisms underlying ZIKV infection in the d

289 thus providing a unique opportunity to study pathogenic mechanisms unrelated to alpha-synuclein toxic

290 racterization of such genes may reveal novel pathogenic mechanisms used by particularly virulent isol

291 To uncover underlying pathogenic mechanisms, we found that DNA damage was grea

292 To study APP protective/pathogenic mechanisms, we generated knock-in rats carryi

293 These studies identify a pathogenic mechanism where loss of ERG causes endothelia

294 Our study uncovers the pathogenic mechanism whereby absence of RPGR(ORF15) glut

295 at onset in HD and SCAs, suggesting a common pathogenic mechanism, which could operate through the ob

296 Two pathogenic mechanisms, which may not be mutually exclusi

297 Enhancing our understanding of critical pathogenic mechanisms will enable the development of nov

298 nalling reconciles the existence of a shared pathogenic mechanism with the biological and clinical he

299 ental syndrome that may share phenotypic and pathogenic mechanisms with CACH/VWM.

300 rain slice model of CWD enables the study of pathogenic mechanisms with translational implications fo