ライフサイエンスコーパス: pathogenicity

1 d increased migratory capability, suggesting pathogenicity.

2 t immune mechanism for regulating chlamydial pathogenicity.

3 n LASV growth, cell tropism, host range, and pathogenicity.

4 terbinafine without significantly affecting pathogenicity.

5 hyphal tip expansion and to be required for pathogenicity.

6 ot reduce in vitro viral fitness and in vivo pathogenicity.

7 tically alter their subcellular behavior and pathogenicity.

8 metabolic enzyme in bacterial physiology and pathogenicity.

9 ce conservation does not necessarily predict pathogenicity.

10 that loss of PTEN function was indicative of pathogenicity.

11 Bacillus anthracis that is required for its pathogenicity.

12 as HBV coinfection did not alter schistosome pathogenicity.

13 as causing persistent infection and lacking pathogenicity.

14 over intestinal luminal colonization but not pathogenicity.

15 c cation channel that is important for virus pathogenicity.

16 variants of unknown significance with likely pathogenicity.

17 resistance without concomitant reductions in pathogenicity.

18 cruits fl-mHTT to aggregates and rescues its pathogenicity.

19 l roles in metabolic processes and bacterial pathogenicity.

20 hat OT1 mice can actively inhibit chlamydial pathogenicity.

21 assay to assist prediction of TNNT2 variant pathogenicity.

22 ying the core mechanisms that underpin their pathogenicity.

23 T cells are necessary to inhibit chlamydial pathogenicity.

24 efinitive connection between aggregation and pathogenicity.

25 d, but did not cause, Notch-dependent T cell pathogenicity.

26 ted to antibiotic resistance, virulence, and pathogenicity.

27 hancers linked to a gene reflect its disease pathogenicity.

28 encing by the HUSH complex, supporting their pathogenicity.

29 ning its infection structure development and pathogenicity.

30 nutrient acquisition, biofilm formation, and pathogenicity.

31 a key step in niche or host colonization and pathogenicity.

32 ella's virulence factor VirF, hence reducing pathogenicity.

33 t of T-helper (Th) 17-cells, where it limits pathogenicity.

34 risks of reversion to virulence or residual pathogenicity.

35 e of temperature on disease transmission and pathogenicity.

36 s by which CD4(+) T cells promote chlamydial pathogenicity.

37 missense variants showed strong evidence of pathogenicity.

38 ad no previously described role in S. aureus pathogenicity.

39 ion and can be used to predict TNNT2 variant pathogenicity.

40 -titer viral replication, immune escape, and pathogenicity.

41 of Chlamydia-specific T cells in chlamydial pathogenicity.

42 chotomous role for NaCl in shaping Th17 cell pathogenicity.

43 on (syncytium formation), which is linked to pathogenicity.

44 red for apical secretion-mediated growth and pathogenicity.

45 l15kDa copies mutated almost completely lost pathogenicity.

46 s crucial in maintaining T cell function and pathogenicity.

47 fferent approaches to predict each variants' pathogenicity.

48 S. aureus and instead promoted DeltahemB SCV pathogenicity.

49 increase Dicer binding affinity and enhance pathogenicity.

50 , which has shown a correlation with isolate pathogenicity.

51 is a factor contributing to variation in its pathogenicity.

52 t into their community ecology and potential pathogenicity.

53 52 variants were classified by likelihood of pathogenicity.

54 ne the structural properties involved in its pathogenicity.

55 and epileptic seizures for further proof of pathogenicity.

56 ogenicity can be uncoupled from inflammatory pathogenicity.

57 sing SIR2 in the Deltaupl3 mutant remediated pathogenicity.

58 2SigHunter identified 25 Pathogenicity, 1 tRNA, 2 Virulence and 2 Repeats from 27

59 y, 1 tRNA, 2 Virulence and 2 Repeats from 27 Pathogenicity, 1 tRNA, 2 Virulence and 2 Repeats, and de

60 ent of the periodontal pocket may impact its pathogenicity, an understanding of its oxidative stress

61 ) and the selection of variants with altered pathogenicity and ability to spread in populations.

62 thod of determining subtypes associated with pathogenicity and antibiotic resistance patterns.

63 To understand the pathogenicity and antigenic potential of SARS-CoV-2 and

64 ution of clinically relevant determinants of pathogenicity and antimicrobial resistance.

65 plant production, and reduced potential for pathogenicity and belowground biological warfare.

66 host-damaging virulence factors that mediate pathogenicity and blunt immune defenses.

67 oplasma lipoproteins play a relevant role in pathogenicity and directly interact with the host immune

68 ions elicit cross-immunity that can modulate pathogenicity and disease burden at the population level

69 on, undermining fundamental understanding of pathogenicity and drug susceptibility.

70 The pathogenicity and establishment of S. aureus infections

71 gens that use numerous virulence factors for pathogenicity and fitness in plant hosts.

72 g the molecular mechanisms that drive fungal pathogenicity and host responses to fungal infections.

73 -enhanced innate disease response to reduced pathogenicity and increased growth.

74 topathogenic Th17 cells did not reduce their pathogenicity and instead elevated their expression of t

75 ays using CRISPR/Cas9 to study TNNT2 variant pathogenicity and pathophysiology.

76 ticipants of European ancestry to assess the pathogenicity and penetrance of putatively clinically im

77 llar pocket plays a crucial role in parasite pathogenicity and persistence in the host and has a grea

78 could be crucial contributors to coronavirus pathogenicity and possible targets for diagnostics, prog

79 ncover molecular mechanisms of host seeking, pathogenicity and practical applications to improve the

80 ions, highlighting the complexity of disease pathogenicity and providing insights into TBK1 activatio

81 ), an anionic glycopolymer that is linked to pathogenicity and regulation of cell division and PG syn

82 focusing on the analysis of genes related to pathogenicity and response to stress, we analyzed our pr

83 a CTV effector that negatively affects virus pathogenicity and suggest that N. benthamiana recognizes

84 a biofilm community contributes to both its pathogenicity and survival in aquatic environmental nich

85 Thus, the quenching of QS to prevent pathogenicity and to increase bacterial susceptibility t

86 including genetics, molecular/cell biology, pathogenicity and transcriptomic profiling.

87 ced heat persistence in vitro, and increased pathogenicity and transmissibility in chickens.

88 spiratory tract cells, and in vivo mammalian pathogenicity and transmissibility were investigated.

89 is believed to play an important role in the pathogenicity and transmission of SARS-CoV-2.

90 tested genes decrease the level of nematodes pathogenicity and/or the average female size, thereby re

91 Bacterial polymers have important roles in pathogenicity, and their varied chemical and material pr

92 n MDCK cells and enhanced viral replication, pathogenicity, and transmission in dogs.

93 ilippines raised concerns about food safety, pathogenicity, and zoonotic potential, questions that ar

94 e bacteria is critical for surface adhesion, pathogenicity, antibiotic resistance and survival.

95 Mechanisms of M. hominis pathogenicity are still largely obscure, and only a limi

96 viviral RNAs (sfRNAs) is important for viral pathogenicity as a common feature of flaviviruses.

97 t PrP posttranslational modifications direct pathogenicity as well as the rate of disease progression

98 d component in evaluation of influenza virus pathogenicity, as necropsy findings can provide importan

99 etion, expression analysis, biochemistry and pathogenicity assays to demonstrate that VdAtf1 governs

100 ed discrete changes in the expression of key pathogenicity-associated genes.

101 Pathogenicity at these locations included expression of

102 Low-pathogenicity avian influenza A(H9N2) viruses, enzootic

103 mensional structural analysis.IMPORTANCE Low-pathogenicity avian influenza virus (LPAIV) subtypes can

104 is known about HA head glycosylation of low-pathogenicity avian influenza virus (LPAIV) subtypes.

105 ion in urodeles and determine differences in pathogenicity between strains, 45 adult smooth newts (Li

106 ent methods to assess protein misfolding and pathogenicity both in vitro and in vivo.

107 or tropism is thought to have determined the pathogenicity-but also aided in the control-of severe ac

108 est that bacterial polyphosphate potentiates pathogenicity by acting as an extracellular signal that

109 monstrate that K. pneumoniae can enhance its pathogenicity by adopting two opposing infection program

110 Antibody V(D)J mutations conferred pathogenicity by causing the antigen-bound autoantibodie

111 HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibilit

112 tudies reveal that HA stability may regulate pathogenicity by modulating IFN responses.IMPORTANCE Div

113 bacterium significantly increased bacterial pathogenicity by suppressing host immune defense.

114 Thus, chlamydial pathogenicity can be mediated by distinct host mechanism

115 Harmonization of variant pathogenicity classification across laboratories is impo

116 DNA methylation in strains with differential pathogenicity demonstrating that N6-methyladenine (6mA),

117 Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing

118 To limit microbial pathogenicity during infection, host organisms attempt t

119 To provide evidence for pathogenicity, each variant was assessed in silico; in a

120 ely regulates the DSF synthase regulation of pathogenicity factor F (RpfF).

121 ce understanding of the impacts from a major pathogenicity factor of SARS-CoV-2.

122 hain of mycolic acids (MAs), important lipid pathogenicity factors of Mycobacterium tuberculosis (Mtb

123 In the absence of these typical pathogenicity factors, P. ananatis induces necrotic symp

124 Given the importance of siderophores as pathogenicity factors, we used transporters specific for

125 y in function from beneficial antibiotics to pathogenicity factors.

126 ng insect and mouse models indicate roles in pathogenicity for 31 phosphatases involved in various pr

127 tural domains, and predict the likelihood of pathogenicity for 98% of all BRCA1 missense variants in

128 Selected pathogenicity, growth, and morphological characteristics

129 To achieve this, we propagated low-pathogenicity H7N9 virus in the presence of polyclonal a

130 oopted to promote murine and human Th17 cell pathogenicity, if T cell stimulation occurred in a proin

131 replication in cell lines and reduced viral pathogenicity in a mouse model.

132 ctively drives Th17 cell differentiation and pathogenicity in autoimmunity.

133 eCanPIE has been applied to classify variant pathogenicity in cancer predisposition genes in two larg

134 We report the global evolution of pathogenicity in carbapenem-resistant K. pneumoniae, res

135 ls are sufficient for attenuating chlamydial pathogenicity in CD8 knockout mice.

136 recombinant NDV (rNDV) that has much reduced pathogenicity in chickens but is highly oncolytic.

137 n pH, 6.0), attenuates virus replication and pathogenicity in DBA/2 mice compared to wild-type (WT) v

138 rthermore, truncation of PA-X enhanced viral pathogenicity in dogs, as shown by aggravated clinical s

139 Its pathogenicity in humans is largely due to its propensity

140 the HA properties needed for replication and pathogenicity in mammals may guide response efforts to c

141 for pigs has remained elusive, with unclear pathogenicity in naturally infected animals and only one

142 cs technology, we evaluated its role in PEDV pathogenicity in neonatal piglets.

143 ein structure to rationalizing the variants' pathogenicity in terms of the perturbed molecular mechan

144 evaluated the effect of FTY720 on chlamydial pathogenicity in the current study.

145 e gastrointestinal tract correlated with its pathogenicity in the upper genital tract, we evaluated t

146 an FTY720-resistant pathway and maintain its pathogenicity in the upper genital tract.

147 ion greatly diminishes viral replication and pathogenicity in vivo by modulating type I IFN responses

148 t G. vaginalis clades have varying levels of pathogenicity in WSW, with acquisition occurring through

149 ) that enables fully automated assessment of pathogenicity, incorporating both sequence coevolution d

150 ere, we present the Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE), a web- an

151 ar genetic and genomic knowledge of oomycete pathogenicity is essential to gain the full context of h

152 Building up functional databases for pathogenicity is key to implementing these approaches.

153 se status, accurate determination of variant pathogenicity is of utmost importance in the diagnosis o

154 How polyphosphate potentiates pathogenicity is poorly understood.

155 pneumoniae ecology, population structure or pathogenicity is relatively limited.

156 We found that ataxin-3 pathogenicity is saliently controlled by polyglutamine-a

157 henotypes in rT1, demonstrating that NM hTau pathogenicity is specific to postnatal development.

158 nsidered an exclusion criterion, whereas its pathogenicity is still under debate.

159 ugh understanding of Acinetobacter baumannii pathogenicity is the key to identifying novel drug targe

160 gene amplification, a major driver of cancer pathogenicity, is often mediated through focal amplifica

161 H. pylori strains containing the cag pathogenicity island (cag PAI) are associated with a hig

162 However, 17 other cag pathogenicity island (cagPAI) genes, as well as some non

163 rboring the cag (cytotoxin-associated genes) pathogenicity island (cagPAI).

164 These factors activate Francisella pathogenicity island (FPI) gene expression, which is req

165 sociated with lower expression of Salmonella pathogenicity island (SPI) 1 genes in S.

166 codes the master-regulator of the Salmonella Pathogenicity Island 1 (SPI-1), was present in the adapt

167 both a repressor and activator of Salmonella Pathogenicity Island 1 gene expression, and both regulat

168 acidifies to pH 5.6; acidification activates pathogenicity island 2 (SPI-2).

169 The cag pathogenicity island contains genes encoding a secreted

170 Analysis of the T3SS2 pathogenicity island encoding the T3SS2 appeared to lack

171 c class of lipoproteins (Lpls), encoded on a pathogenicity island in S. aureus, dampens the H2AX phos

172 licobacter pylori strains containing the cag pathogenicity island is a risk factor for development of

173 with unchanged cagY, we sequenced the entire pathogenicity island of 60 such isolates using single-mo

174 on the bi-functional RfaE enzyme and the Cag pathogenicity island of H. pylori, is accompanied by rep

175 p2, is similar to the Pseudomonas aeruginosa pathogenicity island PAPI.

176 Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes

177 cteria carrying the colibactin-producing pks pathogenicity island.

178 tory cross-talk between two major Salmonella pathogenicity islands, SPI-1 and SPI-2, was responsible

179 sing AraC-type transcriptional regulators in pathogenicity islands.

180 tal acquisition of diverse papGII-containing pathogenicity islands.

181 ive correlation between basal leaf angle and pathogenicity level in Johnsongrass.

182 rrelations between leaf midrib thickness and pathogenicity level in sorghum and Johnsongrass but not

183 ints were inoculated with C. sublineola, and pathogenicity level was recorded 4-days-post-inoculation

184 dy glycan motifs involved in immunogenicity, pathogenicity, molecular mimicry, and immune evasion, ex

185 ed guidelines to collect and interrogate the pathogenicity of 44 USP9X variants associated with neuro

186 yses were also undertaken to investigate the pathogenicity of a candidate variant MYBPC3 c.1224-52G>A

187 computational methods predict the potential pathogenicity of a missense variant but fail to differen

188 or the first time the role of the GGT in the pathogenicity of A. baumannii.

189 The pathogenicity of all reported mosaic/germline mutations

190 These data supporting the pathogenicity of anti-Caspr2 antibodies are consistent w

191 n glycating environments could alleviate the pathogenicity of aSyn.

192 zed to predict glycan immunogenicity and the pathogenicity of bacterial strains, as well as investiga

193 tic disease, data related to the ecology and pathogenicity of bovine tuberculosis is scarce, especial

194 length transcripts, helping to determine the pathogenicity of BRCA2 leaky splicing variants, some of

195 rovide new biological tools for studying the pathogenicity of C. difficile.

196 disease pathology and assays to evaluate the pathogenicity of candidate mutations in the SETX gene.

197 riants (TTNtvs), have been implicated in the pathogenicity of cardiomyopathy.

198 also provides tools to better understand the pathogenicity of CDG-associated TMEM165 mutations.

199 We also determined that the pathogenicity of certain variants may have arisen from r

200 ntributes to host-temperature adaptation and pathogenicity of cryptococci.

201 Pathogenicity of detected sputum ANCA was assessed using

202 f FANCD2 monoubiquitination to determine the pathogenicity of each variant.

203 uous polarized growth and contributes to the pathogenicity of F. graminearum.

204 and we critically review the evidence on the pathogenicity of GAD antibodies.

205 To assess the pathogenicity of GAS and S. aureus for muscles in compar

206 of anti-PF4/H IgG by IdeS could suppress the pathogenicity of HIT antibodies.

207 ion and function play a critical role in the pathogenicity of human neurodevelopmental disorder.

208 ll infiltration and altered polarization and pathogenicity of infiltrating T cells.

209 crease in antigen reactivity, clonality, and pathogenicity of insulin-specific T cells that develop i

210 We then examined the pathogenicity of key metabolic mutants in mice and confi

211 response in lung tissues contribute to high pathogenicity of MERS-CoV.

212 dered mutant Huntingtin (mHtt) vis-a-vis the pathogenicity of mHtt on transcription factor function a

213 cance of protein dynamics in determining the pathogenicity of missense variants.

214 The pathogenicity of mutations was significantly higher in t

215 The pathogenicity of Mycobacterium tuberculosis depends upon

216 highlights the importance of considering the pathogenicity of non-rare variants in relatively prevale

217 iation or cell programming, or interpret the pathogenicity of noncoding variation.

218 ERCA1 western blot can assist in proving the pathogenicity of novel ATP2A1 mutations.

219 bserved HPO phenotype, and (3) the predicted pathogenicity of observed genotypes.

220 Hsc70-4 also enhances pathogenicity of other polyglutamine proteins.

221 Although no evidence of pathogenicity of P. homopolare in Condors was found, thi

222 novel component involved in development and pathogenicity of P. palmivora and possibly other Phytoph

223 ory responses, which might contribute to the pathogenicity of PA-X-truncated CIVs.

224 liminate cellular contributions to potential pathogenicity of pemphigus antibodies, bead assays coate

225 stand in contrast to the lack of identified pathogenicity of previously reported pegiviruses, which

226 udy, we investigated the role of TLR7 in the pathogenicity of RABV in a mouse model.

227 es will help refine our understanding of the pathogenicity of rare genetic variants.

228 o and in vivo studies support the functional pathogenicity of rare UQCRC1 variants in familial parkin

229 d during the H5N2 outbreak, and studying the pathogenicity of reassortant viruses generated with the

230 Here, we investigated the pathogenicity of S. maltophilia alone and during polymic

231 ydrates that are critical to persistence and pathogenicity of S. mutans.

232 importance of gene expression control on the pathogenicity of S. pneumoniae.

233 However, the pathogenicity of S1RE102Q and the beneficial impact of S

234 uct the evolutionary origins of the enhanced pathogenicity of SARS-CoV-2 and other coronaviruses that

235 However, the pathogenicity of SCN5A variants is often unknown or disp

236 tted us to make consensus predictions on the pathogenicity of single amino acid variants in ROMK.

237 Thus, IL-17A limits pathogenicity of Th17 cells by inducing IL-24.

238 lytic FGIN-1-27 inhibits differentiation and pathogenicity of Th17 cells in vitro and in vivo using t

239 tant part of this comparison was identifying pathogenicity of the bacteria isolated from the samples.

240 her characterization of the epidemiology and pathogenicity of the four morphologically identical Enta

241 AD and this affects the polarized growth and pathogenicity of the fungus.

242 specific effects and might contribute to the pathogenicity of the haplotype.

243 To understand the pathogenicity of the human CFL2 mutation, p.A35T, that f

244 We then assayed the pathogenicity of the identified rare variants using CRIS

245 using morpholinos was created to assess the pathogenicity of the identified variant.

246 cause iron is essential for the survival and pathogenicity of the microorganism, this protein constit

247 nd functional studies will help validate the pathogenicity of the mutations identified.

248 thy and provides functional evidence for the pathogenicity of the newly identified missense mutation.

249 The pathogenicity of the other four containing at least one

250 To confirm pathogenicity of the previously identified causative mut

251 antigen yield, potentially by decreasing the pathogenicity of the virus in embryonated eggs.

252 ion, thereby increasing the transmission and pathogenicity of the virus.

253 We assessed the penetrance and pathogenicity of these high-quality variants by testing

254 ruginosa is believed to be important for the pathogenicity of this bacterium in individuals with cyst

255 at likely contribute to the transmission and pathogenicity of this pandemic agent.IMPORTANCE The deve

256 has been available for studying in vivo the pathogenicity of this protein.

257 In summary we provide strong evidence for pathogenicity of this variant in a member of the core TR

258 s and biochemical assays, we demonstrate the pathogenicity of this variant, showing that the change r

259 The pathogenicity of this virus has been studied in the calf

260 0.93 [95% CI, 0.83-0.97]) support the likely pathogenicity of TNNT2:p.R286H.

261 se supports the growing body of evidence for pathogenicity of Turicella otitidis and demonstrates the

262 owledge is valuable for assessing the likely pathogenicity of variant ZIC proteins associated with hu

263 d-derived fibroblasts to further confirm the pathogenicity of variants in these genes and found reduc

264 y virulence determinants associated with the pathogenicity of wild-type strains.

265 mino acid 159 of the E protein modulates the pathogenicity of WNV by affecting viral replication and

266 rred significantly increased replication and pathogenicity on H9N2 virus in mice and ferrets.

267 t cells to subvert host immunity and promote pathogenicity on their host plants by manipulating speci

268 role in infection structure development and pathogenicity, Ppal15kDa was found to be highly induced

269 Although its pathogenicity precluded in vivo studies, the M. tubercul

270 ction over previous tools, and that splicing pathogenicity prediction is distinct from predicting mol

271 e of variants in presbycusis was provided by pathogenicity prediction programs, documented haploinsuf

272 We present here the Variant Combinations Pathogenicity Predictor (VarCoPP), a machine-learning ap

273 on and blind tests, respectively), while our pathogenicity predictor achieved a Matthew's Correlation

274 ferrets compared to the H5N2 virus; however, pathogenicity profiles varied among the H5N6 viruses tes

275 Our findings of differing pathogenicity-related characteristics among the three sp

276 ue to potential species-level differences in pathogenicity-related characteristics.

277 Still, the factors that control Th17 pathogenicity remain incompletely defined.

278 precise molecular mechanisms underlying its pathogenicity remain unclear.

279 istance and consequences of these changes on pathogenicity remain unknown.

280 sative of disease, and returns interpretable pathogenicity score distributions on individual genomes.

281 (LD) score regression to evaluate published pathogenicity scores across 41 common diseases and compl

282 We then improve upon published pathogenicity scores by developing AnnotBoost, a machine

283 informativeness of Mendelian disease-derived pathogenicity scores for common disease and improve upon

284 Despite considerable progress on pathogenicity scores prioritizing variants for Mendelian

285 rning-based workflow, called SVFX, to assign pathogenicity scores to somatic and germline SVs.

286 ine learning framework to impute and denoise pathogenicity scores using a broad set of functional ann

287 sly uninformative and previously informative pathogenicity scores, implying that Mendelian and common

288 t corresponded to the levels of reduction in pathogenicity, suggesting that Ppal15kDa plays an import

289 angle distribution data were correlated with pathogenicity test data from excised-leaf assays for thr

290 ivin-A as a critical controller of Th17 cell pathogenicity that can be targeted for the suppression o

291 This finding contrasts with the lack of pathogenicity that is characteristic of previously repor

292 t information regarding disease severity and pathogenicity that is not otherwise available from the l

293 se variants showed replicative abilities and pathogenicity that is similar to those of wild-type isol

294 pite the critical role of SrrAB in S. aureus pathogenicity, the mechanism by which the SrrAB TCS sens

295 able resource for evaluating influenza virus pathogenicity; thus, understanding the most effective te

296 n, has been associated with the replication, pathogenicity, transmissibility, and interspecies adapta

297 We integrated bioinformatics pathogenicity triage, mean serum Ca concentrations, and

298 man neutrophil killing, but this increase in pathogenicity was not due to resistance to neutrophil ex

299 Reclassification of pathogenicity was performed according to the modified 20

300 TN may be informative in determining variant pathogenicity when incorporated into current American Co