ライフサイエンスコーパス: pathologic

1 These areas of pathologic abnormalities can serve as imaging biomarkers

2 valuated for technical success, depiction of pathologic abnormalities of the CLS, and access site for

3 acular tissue in mFS are similar to iERM-FS, pathologic abnormalities of the ILM were exclusively pre

4 Anatomic variations, a lymphatic pathologic abnormality, and interventional access routes

5 ed by presence of the KIT D816V mutation and pathologic accumulation of neoplastic mast cells (MCs) i

6 roach for selectively protecting against the pathologic actions of Abeta in AD.SIGNIFICANCE STATEMENT

7 positive AD, clinical syndrome of AD, and/or pathologic AD brain, finding features that are highly se

8 t to mechanisms of disorders associated with pathologic adaptation, such as tinnitus.

9 are particularly susceptible to THC-induced pathologic alterations, including dysregulation of DAerg

10 To date, pathologic analyses have been limited to patient reports

11 Pathologic analysis revealed Pten/Kdm5b mice displayed m

12 tastases were tissue sampled and examined by pathologic analysis to document HER2 status.

13 re were 3 (15%) node-positive cases on final pathologic analysis, and all of these LNs (including 1 w

14 PHL) is a rare lymphoma entity with distinct pathologic and clinical characteristics.

15 e chain reaction assay), with correlation of pathologic and clinical features, including comorbiditie

16 cognitive loss mainly reflects non-normative pathologic and mortality-related processes rather than n

17 sma NT1 levels capture very early cognitive, pathologic and neurodegenerative changes along the AD tr

18 ds, providing new opportunities to probe the pathologic and potentially therapeutic implications of U

19 ver, these same variants likely catalyze the pathologic and progressive features of COPD when expande

20 Clinical, pathologic, and surgical information; sRT; timing and du

21 c stimuli to anti-VEGF agents, which inhibit pathologic angiogenesis but also extend normal intrareti

22 lation has proven to be effective in curbing pathologic angiogenesis in experimental oxygen-induced r

23 55%) than HbS variant eyes (n = 9, 26%) had pathologic areas of retinal thinning associated with SCP

24 Pathologic assessment showed nonspecific interstitial pn

25 esponse of the primary tumor with associated pathologic axillary outcome.

26 ularities (70%), confluent B lines (60%) and pathologic B lines (50%).

27 ciated with different clinical, genetic, and pathologic backgrounds, the pathomechanisms underlying n

28 Fgfr2KO mice had evidence of pathologic basal cell endoreplication associated with ab

29 repair after cyclophosphamide exposure from pathologic basal cell endoreplication.

30 or the pharmacological modulation of related pathologic behaviors.

31 show that Siglec-15 is directly involved in pathologic bone erosion in the K/BxN serum-transfer arth

32 s show a role of Siglec-15 as a regulator of pathologic bone resorption in arthritis and highlight it

33 ardiac stress, an event that is required for pathologic cardiomyocyte remodeling.

34 ta (Abeta) provides an in vivo biomarker for pathologic changes associated with Alzheimer disease (AD

35 Although postmortem pathologic changes consistent with chronic traumatic enc

36 c and peptidergic neurons are susceptible to pathologic changes from SIV infection, and intervention

37 se findings reveal a deeper structure to the pathologic changes identified in the neurophysiology of

38 HIV infection drives pathologic changes in the dorsal root ganglia (DRG) thro

39 Vs as a therapeutic to reduce injury-related pathologic changes in the physiology and structure of pr

40 paB super-repressor mitigated behavioral and pathologic changes in transgenic mouse models of amyotro

41 Pathologic changes to the gut microbiome have recently b

42 l necrosis, inflammation, fibrosis, or other pathologic changes, suggesting biocompatibility of NETs.

43 reatment approaches, stratified according to pathologic characteristics.

44 N DBS at 130 pulses per second (pps) reduced pathologic circling and ameliorated deficits in forelimb

45 resent study we investigated whether certain pathologic circumstances exacerbate fentanyl-induced blo

46 rimary objective was to estimate the rate of pathologic complete response (pCR) at the time of surger

47 llowed by surgery establishes a considerable pathologic complete response (pCR) in EC.

48 The aim was to investigate whether pathologic complete response (pCR) in the breast is corr

49 investigate the association between MSI and pathologic complete response (pCR) in this patient popul

50 mized, multicenter, phase II trial comparing pathologic complete response (pCR) rates (ypT0/is, N0) a

51 The primary end point is pathologic complete response (pCR).

52 added to neoadjuvant chemotherapy increased pathologic complete response (pCR).

53 Achieving a pathologic complete response confers a significant survi

54 ved in all patients undergoing surgery, with pathologic complete response in 13 patients (34%).

55 assisted biopsy (VAB) to reliably diagnose a pathologic complete response in the breast (pCR-B).

56 oadjuvant systemic treatment (NST) elicits a pathologic complete response in up to 80% of women with

57 Pathologic complete response rates have improved on acco

58 R0 and pathologic complete response rates were 96% and 62%, res

59 The median survival of patients achieving a pathologic complete response was 83.8 months compared wi

60 RCB-0 (pathologic complete response) rate was 53% and RCB-0/I w

61 nse to NAC are independently associated with pathologic complete response.

62 ical impairments caused by acute exposure to pathologic concentrations of Abeta without impairing nor

63 s review, we provide an overview of the main pathologic concepts in osteomyelitis, with a focus on th

64 We examined 4 pathologic conditions of IR in humans to examine pathway

65 ) findings of the normal anatomy and various pathologic conditions of the ankle and foot commonly enc

66 eristic MRI features of common traumatic and pathologic conditions of the hip.

67 s, and MRI findings of various traumatic and pathologic conditions of the wrist and hand including oc

68 y in the assessment of various traumatic and pathologic conditions of this region, and it is frequent

69 etwork connectivity characteristic for these pathologic conditions remains unclear.

70 ty liver disease can progress to more severe pathologic conditions such as cirrhosis and liver cancer

71 red while interpreting the OCT parameters in pathologic conditions such as glaucoma.

72 features and they may represent 2 different pathologic conditions with equally different clinical im

73 In rare pathologic conditions, connective tissue phenotype mast

74 ation about changes in nociceptive output in pathologic conditions, leading to pain hypersensitivity.

75 ous stimuli and how this encoding changes in pathologic conditions, leading to pain.

76 helial cell integrity and its involvement in pathologic conditions, several promising therapeutic str

77 jury, inflammatory conditions, or many other pathologic conditions, the endothelial glycocalyx is dam

78 inery have been associated with inflammatory pathologic conditions, we now appreciate that autophagic

79 , and revascularization of ischemic areas in pathologic conditions.

80 es, mental dysfunction, and many other brain pathologic conditions.

81 ignaling pathways under both physiologic and pathologic conditions.

82 nsequently, the neuronal output change under pathologic conditions.

83 ine-tune specific signals in physiologic and pathologic conditions.

84 te on end-of-treatment (EOT) imaging or with pathologic confirmation at 100 days postradiotherapy com

85 Pathologic confirmation was available for 143 nodules (1

86 ENE-positive or ENE-negative on the basis of pathologic confirmation.

87 ging diagnosis of HCC, without necessity for pathologic confirmation.

88 ain these physiologic rhythms invariably has pathologic consequences.

89 ication of subjects in the Alzheimer Disease pathologic continuum, as well as a finer-grained assessm

90 s an effective method to destroy and regress pathologic corneal blood and lymphatic vessels.

91 ntrapulmonary lymph nodes (IPLNs) at CT with pathologic correlation.

92 le in severe asthma: on the one hand driving pathologic corticosteroid-refractory mixed granulocytic

93 Additional family history and pathologic criteria garnered moderate consensus.

94 Using a multiparametric MRI-pathologic cross-correlative approach and computational

95 is study contributes to the understanding of pathologic Cx43 remodeling and encourages further resear

96 L1-mediated epigenetic regulation of TLR4 in pathologic diabetic wound repair and suggest a target fo

97 pirin/NSAIDs/anti-coagulants/anti-platelets, pathologic diagnoses (including different types of colon

98 Pathologic diagnoses were low-grade conjunctival melanoc

99 Pathologic diagnosis requires labor-intensive reading of

100 1, 15.7 vs 20.0 rectal P< 0.001) and have N0 pathologic disease (43.6% vs 26.7% gastric P< 0.001, 51.

101 g to destabilize the microvasculature during pathologic disorders like inflammation and cancer.

102 function are the strongest correlate to the pathologic disturbance of cognitive ability observed in

103 Pathologic downstaging (pDS) to neoadjuvant chemotherapy

104 This paradox intimates Tfh cells as key pathologic effectors, consistent with an observed Tfh si

105 Therefore, the pathologic effects of whole CS on the differentiation of

106 appearances of the most commonly encountered pathologic entities.

107 s that specifically target chronic itch as a pathologic entity are currently still not available.

108 ed ligand-receptor crosstalk, with potential pathologic epithelial-to-stromal interactions.

109 nd global cellular physiology in response to pathologic ER stress.

110 ly undocumented roles for TRPA1 in promoting pathologic ERS and cytotoxicity elicited by pneumotoxic

111 Pathologic evaluation of the removed endotracheal tube c

112 however, SLN mapping requires LN biopsy for pathologic evaluation, since there are no clinical imagi

113 wo forms of cell death may be crucial during pathologic evaluations.

114 ulability state has been reported as a major pathologic event in COVID-19, and thromboembolic complic

115 standing to IPM physiology and describes the pathologic events following deficits in proteoglycans, p

116 Dissection of the pathologic events in lesional skin has led to knowledge

117 with distal esophageal adenocarcinoma and no pathologic evidence of nodal disease.

118 , humoral and cellular immune responses, and pathologic evidence of viral pneumonia.

119 r Stage III CRC, if combined with imaging or pathologic evidence, these markers promise more precise

120 e 3 lesions, whereas the fourth was shown on pathologic examination to represent chronic prostatitis.

121 al and 17 HCM hearts) underwent micro-CT and pathologic examination.

122 and discordance rates between radiologic and pathologic examinations were compared between the two bi

123 d more discordance existed in radiologic and pathologic examinations, with a similar percentage of ca

124 lar structures occur in both physiologic and pathologic extracellular spaces and often involve intera

125 saic, vascular flow, and various features of pathologic eyes could be visualized.

126 ts, and a unique role for TRPV3 in fettering pathologic facets of the integrated ERS response.

127 In the presence of at least 1 high-risk pathologic feature (nodal or margin involvement or LVI)

128 This pathologic feature is driven by amyloid-beta oligomers (

129 h binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other n

130 Chronic inflammation is a pathologic feature of neurodegeneration and aging; howev

131 overall survival in those with no high-risk pathologic features (median survivals: 54.6 vs 42.7 mo f

132 In the presence of any high-risk pathologic features (nodal or margin involvement or LVI)

133 Correlation between these pathologic features and dementia has been challenged by

134 useful model for C3G because they share many pathologic features consistent with the human disease.

135 istinct from Coats disease in that exudative pathologic features occur exclusively in the setting of

136 duals, cognitively intact despite displaying pathologic features of AD.

137 n this review, we highlight the clinical and pathologic features of HSTCL.

138 e cells (PASMCs) represents one of the major pathologic features of pulmonary hypertension (PH).

139 clinic for 52 of 151 patients who showed no pathologic features on initial examination.

140 plantation, but the severity of preoperative pathologic features was not controlled for.

141 In most eyes, regardless of whether retinal pathologic features were present, it was challenging to

142 ting domestic cats, shares many clinical and pathologic features with type 2 diabetes in humans.

143 to enabling identification of central vessel pathologic features, ferumoxytol-enhanced MR angiography

144 SIK or who have radial keratotomy and ocular pathologic features, including glaucoma, age-related mac

145 For peripheral pathologic features, Optos P200DTx captured unique findi

146 To discern the spectrum of pathologic features, we performed a detailed clinical ge

147 ts with DR without severe concurrent macular pathologic features.

148 thy that resembles the human skeletal muscle pathologic features.

149 wn about the causes of death and the virus's pathologic features.

150 eventive FICS for consolidation of impending pathologic femoral neck fracture with a mean follow-up o

151 rther alphasyn misfolding and propagation of pathologic fibrils in a prion-like process.

152 ng PKC with pharmacological tools to inhibit pathologic fibrosis has not been fully evaluated.

153 these unique populations in homeostasis and pathologic fibrosis.

154 The gross and microscopic pathologic findings as well as the alterations in the cy

155 ociated AKI, our current knowledge of kidney pathologic findings in COVID-19 is limited.

156 current state of the art for the imaging and pathologic findings of this disorder and outline a few o

157 In total, 211 patients (81%) showed pathologic findings on (18)F-rhPSMA-7 PET/CT.

158 ion, a primary SeV infection led to worsened pathologic findings on secondary heterologous viral chal

159 Pathologic findings revealed ischemic enteritis with pat

160 psy-proven HER2-positive metastases, two had pathologic findings that demonstrated HER2-negative dise

161 We documented clinical features, pathologic findings, and outcomes.

162 usion In participants with diverse pulmonary pathologic findings, deep convolutional neural networks

163 primate genital tract and cause uterine wall pathologic findings.

164 disease entity, with different clinical and pathologic findings.

165 f any screw dislodgement or development of a pathologic fracture at completion of the study.

166 o investigate potential correlations between pathologic fractures (PFs) and prognosis of patients wit

167 by interventional radiologists for impending pathologic fractures are becoming more pertinent, as pat

168 nternal cemented screws (FICS) for impending pathologic fractures of the femoral neck.

169 tive consolidation of impending femoral neck pathologic fractures.

170 ve changes, infection, and insufficiency and pathologic fractures.

171 ize the physiological role and highlight the pathologic function for each protein of the oxygen-sensi

172 Amyloid-beta deposition into plaques is a pathologic hallmark of Alzheimer disease appearing years

173 lts to the brain and represents an important pathologic hallmark of neurodegenerative diseases includ

174 Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, how

175 Heart failure is characterized by pathologic hemodynamic derangements, including elevated

176 and inflammatory components that results in pathologic heterogeneity complicates the development of

177 Such pathologic hyperinflammation, fulfilling criteria for ha

178 hat adapts neural cells to physiological and pathologic hypoxic cues.

179 e convolutional neural networks, to classify pathologic images by using smaller datasets.

180 large B-cell lymphoma (DLBCL) and non-DLBCL pathologic images from three hospitals separately using

181 , ATF6, or PERK signaling to both ameliorate pathologic imbalances in UPR signaling implicated in the

182 w being tested as a cytokine for suppressing pathologic immune responses in autoimmune diseases and g

183 e an effective preventative strategy against pathologic inclusion formation.

184 merize to form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases, inc

185 results across a wide range of clinical and pathologic indications and is fast enough to enhance and

186 erogeneous family of immune cells regulating pathologic inflammation and beneficial tissue repair.

187 PF is not completely understood but involves pathologic inflammation and subsequent failure to resolv

188 but is also the basis for the development of pathologic inflammatory conditions within the CNS, such

189 ory phenotype and improves resolution during pathologic inflammatory responses.

190 cases would benefit most from more in-depth pathologic inspection.

191 The rates of R0 resection and pathologic invasion of venous and arterial walls were 52

192 tients with HER2-positive breast cancer with pathologic invasive residual disease at surgery after st

193 Whether microglia are protective or pathologic is context dependent; the outcome varies as a

194 Results: In total, 142 pathologic lesions along with normal tissues were analyz

195 njecture, the accumulation of fibroblasts in pathologic lesions offers insight into biologic mechanis

196 the environmental factors and characteristic pathologic lesions, are necessary components of the case

197 ciated dedifferentiation programs, potential pathologic ligand-receptor crosstalk, novel genes, and t

198 A values after RARP (P = 0.004) and positive pathologic lymph node status (P = 0.006) were independen

199 Higher PSA levels after RARP and positive pathologic lymph node status were significantly associat

200 as well as with significantly lower rates of pathologic lymph nodes, perineural invasion, and venous

201 Normal and pathologic maculae were imaged in vivo using still and v

202 orescein angiography for comparison with the pathologic maculae.

203 extrapancreatic invasion, and lower rate of pathologic major response.

204 and the underlying processes that drive the pathologic manifestations of the disease remain largely

205 arently, a broad range of neurodevelopmental pathologic mechanisms also target oropharyngeal and cran

206 proteoglycans in retinal physiology and the pathologic mechanisms that lead to vision loss, we gener

207 We further show that pathologic microvascular leakage in CD31-deficient mice

208 Moreover, we show that pathologic MMD mutations cluster in the composite E3 dom

209 l single-cell variation in heteroplasmy of a pathologic mtDNA variant, which we associate with intra-

210 In a clinical-pathologic multivariable model, the parameters most pred

211 ease from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively o

212 Severe forms of myopia (pathologic myopia) are associated with a risk of other a

213 Of 156 patients, 30 (19%) had pathologic N1, 122 (78%) had pathologic N2 (pN2), and 4

214 s, 30 (19%) had pathologic N1, 122 (78%) had pathologic N2 (pN2), and 4 (3%) had pathologic N3 (pN3)

215 78%) had pathologic N2 (pN2), and 4 (3%) had pathologic N3 (pN3) disease.

216 point (1.00-1.04), p = 0.003; and any acute pathologic neurologic sign/event, 5.04 (2.15-12.01), p <

217 iopulmonary resuscitation, and appearance of pathologic neurologic signs were associated with adverse

218 y percentage TR in the primary tumor bed and pathologic nodal stage (ypN0) using Kaplan-Meier plots.

219 treatments for the management of diseases of pathologic ocular angiogenesis.

220 ateral stromal depigmentation, without other pathologic ocular findings.

221 rveillance largely consist of tumors without pathologic or genetic data.

222 During a 2-year follow-up, radiologic and pathologic outcome data for all recalled women were obta

223 on between the genetic modifications and the pathologic outcome is emerging: CFHR1, CFHR3, and Factor

224 alcifications from all radiology reports and pathologic outcome of recalled women with 2-year follow-

225 types in mammals, which has made attributing pathologic outcomes to replication at specific sites dif

226 Given the clinical and pathologic overlap, the molecular overlap between CADASI

227 nal processing of nociception in a number of pathologic pain disorders.

228 ule growth and clinical, CT morphologic, and pathologic parameters were studied.

229 The pathologic pattern found depends on when in the evolutio

230 d mice, an age before the development of tau pathologic phenotype.

231 ized term that describes a scope of distinct pathologic phenotypes of variable severity, which share

232 Detection of the pathologic placental blood vessel lesion decidual vascul

233 prompting immediate search for the causative pathologic process.

234 ti-inflammatory activity and inhibit various pathologic processes in preclinical disease models, incl

235 is associated with important homeostatic and pathologic processes in skin.

236 ficant proportion of GGO correlated with the pathologic processes of diffuse alveolar damage, capilla

237 epetitive elements and their connection with pathologic processes remains elusive.

238 being informative for common physiologic and pathologic processes.

239 how changes in neuroinflammation and amyloid pathologic processes.

240 lood is likely linked to specific cell-level pathologic processes.

241 a heterogeneous clinical syndrome without a pathologic reference standard, allowing for subjectivity

242 s performed on 100 consecutive patients with pathologic reflux.

243 Chronic hypoxia leads to pathologic remodeling of the pulmonary vasculature and p

244 A post hoc analysis of all pathologic reports from patients with stage III CC inclu

245 Patient demographics, biopsy target type, pathologic reports, surgical excision specimens when ava

246 the rate, predictors, and impact of complete pathologic response (cPR) to pretransplant locoregional

247 The primary endpoints were complete pathologic response (pCR), disease-free survival, and ov

248 gical mechanisms, clinical trial design, and pathologic response assessments.

249 This study evaluated the pathologic response of talazoparib alone for 6 months in

250 Patients were compared according to the pathologic response of the primary tumor with associated

251 perioperative format is difficult; (4) Major pathologic response rate of 33% is encouraging.

252 e findings may allow the definition of major pathologic response to be expanded, from pCR to >=90% TR

253 argins, and 24 (33%) had a complete or major pathologic response to therapy.

254 0 status is the strongest indicator of major pathologic response to trimodality therapy, in addition

255 Independent predictors of major pathologic response were bevacizumab use (odds ratio [OR

256 included resection rate, margin positivity, pathologic response, and toxicity.

257 ne microenvironment that vary by subtype and pathologic response.

258 ch was subsequently confirmed via a complete pathologic response.

259 phy scans did not correlate with survival or pathologic response.

260 Pathologic responses were confirmed by central review.

261 points to central role of NF-kappaB in such pathologic responses, yet the precise mechanisms underpi

262 Purpose To compare biopsy target types, pathologic results, and discordance rates for 2 years pr

263 to know expected changes in biopsy targets, pathologic results, and discordance rates.

264 logic retinas), 12 of 16 normal and 11 of 16 pathologic retinas demonstrated at least average image q

265 From 32 eyes imaged (16 normal and 16 pathologic retinas), 12 of 16 normal and 11 of 16 pathol

266 were visualized (12 of 16 normal and 2 of 16 pathologic retinas), parafoveal mosaic patterns appeared

267 photoreceptors could not be resolved in most pathologic retinas.

268 c intra- and inter-neuronal networks through pathologic rewiring of the chaperome system into epichap

269 ron is an essential biometal that may have a pathologic role in this process.

270 In this study, we investigated the pathologic role of 5'-cap translation, which is regulate

271 In this study, we investigated the pathologic role of IL-1alpha, one of the two proinflamma

272 Together, these results suggest a pathologic role of monocytes in the two-hit (immune plus

273 Recent findings suggest a pathologic role of skeletal muscle in amyotrophic latera

274 e complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis.

275 nged from 0.025 mg/kg to 2.5 mg/kg, improved pathologic scores in experimental allergic encephalitis

276 ce (AI) helps to reduce the labor of reading pathologic slides, diagnostic accuracy has not reached a

277 e 2 radiotracers and with reference-standard pathologic specimens obtained from radical prostatectomy

278 Disruption of APC results in pathologic stabilization of beta-catenin and oncogenesis

279 ph node dissection (RPLND) for patients with pathologic stage (PS) IIA nonseminomatous germ cell tumo

280 While tumor diagnosis and pathologic staging (gross and microscopic examination of

281 rts the view that glycocalyx damage is a key pathologic step in a diverse array of clinical condition

282 its selective activation under conditions of pathologic stress.

283 association between cerebral MH load and tau pathologic structure measured in healthy older individua

284 nosis of adenoma and early adenocarcinoma, a pathologic subtype of non-small cell lung cancer.

285 fear responses related to stress coping and pathologic systems states.

286 Pathologic T-category was the greatest predictor of CRM+

287 closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary

288 dditionally, intracerebral microinjection of pathologic tau led to increased tau aggregates in mice i

289 -amyloid deposition), phosphorylated tau (T, pathologic tau), and total tau (N, neurodegeneration) to

290 The controls were ascertained using pathologic testing, clinical examinations, and/or other

291 d is required for both normal hemostasis and pathologic thrombogenesis, it also participates in its o

292 Progressive disease leads to pathologic tissue remodeling, with ensuing esophageal ri

293 l to patients with smaller tumors, even when pathologic tumor burden is considered.

294 included alpha-fetoprotein response to LRT, pathologic tumor number and size, and wait time >12 mont

295 l was equivalent at 1, 3, or 5 years despite pathologic tumor size.

296 n happens in unique phases that have diverse pathologic underpinnings in the initiation and maintenan

297 Despite advances in the pathologic understanding of eosinophilic esophagitis (Eo

298 dictors of postresection survival, including pathologic variables and CA19-9, not only provides bette

299 The relationship of pain scores with pathologic variables was also investigated in a cohort o

300 c stratification, outperforming clinical and pathologic variables.