ライフサイエンスコーパス: pathological

1 lomatous response can be both protective and pathological.

2 l dysfunction, ranging from normal to highly pathological.

3 y) after anodal-tDCS, indicating reversal of pathological abnormalities.

4 The pathological actions of phosphorylated tau are mediated

5 of mHTT, providing novel insights into such pathological activities.

6 epilepsy, in which we successfully suppress pathological activity in a distinct sub-network prior to

7 mechanistic involvement in the generation of pathological activity.

8 system and polycomb repressive complex 2 in pathological AD.

9 Because HDAC6 can transport ubiquitinated pathological aggregates to the MTOC for aggresome format

10 e the functional assembly of FUS and prevent pathological aggregation in cells.

11 Normal versus pathological aggregation may be distinguished by the cap

12 However, modeling healthy and pathological aging of the human vasculature represents a

13 s could be an important mechanism related to pathological alpha-syn aggregation in oligodendrocytes,

14 the mechanistic link between transmission of pathological alpha-Syn and the cardinal features of auto

15 is a convergent area for the propagation of pathological alpha-synuclein from the periphery to the b

16 increase in these mice's serum which led to pathological alterations to the irradiated cells and tis

17 hese results suggest that the combination of pathological amyloid and tau is detrimental to cognitive

18 alpha-Synuclein (alpha-syn), the hallmark pathological amyloid observed in PD, is also elevated in

19 Pathological analysis of olfactory epithelium obtained f

20 individuals with PSP, diagnosed according to pathological and clinical criteria, from two separate co

21 ty, and possibly the correlation between the pathological and clinical heterogeneity of amyloid disea

22 out to investigate the relationship between pathological and clinical presentation at single symptom

23 In such cases, clinical, biochemical, pathological and functional imaging assessments can all

24 ve now been made in the understanding of the pathological and genetic underpinnings of the disease.

25 oRNAs are regulating this complex process in pathological and healthy conditions.

26 Pathological and histological exam of a foot amputated f

27 ic fatty liver disease, which shares similar pathological and metabolic changes with GSD Ia.

28 d from altered proteins over time related to pathological and physiological processes.

29 iate risk stratification utilizing clinical, pathological and potentially also genomic risk data is i

30 Dedicated pathological and radiological reviews were performed to

31 Progress in understanding the emergence of pathological anxiety depends on the availability of para

32 adaptive response to unpredictable threats, pathological anxiety disorders occur when symptoms adver

33 Rather than impaired threat learning, pathological anxiety involves heightened skin conductanc

34 Whether or not adaptive and pathological anxiety share mechanisms remains unknown, b

35 ed as an intermediate translational model of pathological anxiety to improve drug development pipelin

36 odevelopmental changes in threat learning to pathological anxiety, findings from studies in patients

37 ent pattern of activation across induced and pathological anxiety, supporting the proposition that so

38 EMB was performed in pathological areas identified at EVM and CMR.

39 Pathological atrial fibrosis is a major contributor to s

40 cco's area, RA) in eyes with and without non-pathological, axial myopia.

41 and it responds to treatments that decrease pathological basal ganglia (BG) beta oscillations (10-17

42 k factor for cardiovascular disease, but the pathological basis for this association is unclear.

43 ted as a critical regulator of motivated and pathological behavioral states via its output to midbrai

44 Pathological behaviors associated with various neuromusc

45 Boldine has been reported to protect from pathological bone loss during rheumatoid arthritis and o

46 the cells responsible for physiological and pathological bone resorption.

47 and brain structure under physiological and pathological brain conditions.

48 Depletion of CD4(+) T cells showed unique pathological bulbar vacuolation in the brain parenchyma

49 lity of the ECAS in accurately assessing the pathological burden of disease.

50 ular mechanisms that are responsible for the pathological calcium release, regarding the tissue origi

51 and circadian pathways in the regulation of pathological calorie consumption.

52 ic potential of TRPC6 inhibition in treating pathological cardiac and renal conditions, mechanistic u

53 Finally, in vitro experiments clarified pathological cardiac ECM prevents cell homing, thus prov

54 of the HBP under hemodynamic stress induces pathological cardiac hypertrophy and heart failure throu

55 amically changing cell type crosstalk during pathological cardiac hypertrophy but also shed light on

56 hosphatase calcineurin is a key regulator of pathological cardiac hypertrophy whose therapeutic targe

57 protection against pressure overload-induced pathological cardiac hypertrophy.

58 cally, deletion of the Mcub gene exacerbated pathological cardiac remodeling and infarct expansion af

59 letion of Gfat1 in cardiomyocytes attenuates pathological cardiac remodeling in response to pressure

60 t mediate cellular and extracellular injury, pathological cardiac remodelling, and diastolic and syst

61 n response to cell stress to protect against pathological cell death in multiple diseases.

62 We consider the implications of prenatal pathological changes for the onset and progression of HD

63 x 10(6)), which has not lead to irreversible pathological changes in blood flow and kidney tissue, an

64 he pivotal role of cell-cell junction in the pathological changes of asthma.

65 Compared to the OA group, the pathological changes of OA in the OPOA group were consid

66 However, ketamine use can cause extensive pathological changes, including ketamine cystitis.

67 scriptomic data, the cause of biological and pathological changes, is hampered by structural complexi

68 tissue mechanical properties associated with pathological changes.

69 ctimization interventions could prevent such pathological changes.

70 h a compensatory/scarring scenario for brain pathological changes.

71 hrenia and bipolar disorder may have similar pathological characteristics, the biological characteris

72 investigation for other conditions linked to pathological circuitry, including major depressive disor

73 els of HLA-F and -G were correlated with the pathological complete response (pCR).

74 ne-based chemotherapy significantly improved pathological complete response rates with an acceptable

75 he neoadjuvant setting with comparable total pathological complete response rates, supporting the FDA

76 Importantly, the classifier genes predicted pathological complete responses to neoadjuvant chemother

77 uclear alterations are often associated with pathological conditions as in Hutchinson-Gilford progeri

78 s, which has been implicated in diseases and pathological conditions associated with delayed OP toxic

79 s involved as a radical scavenger in several pathological conditions associated with oxidative stress

80 cell release may have applications in other pathological conditions beyond organ transplantation.

81 In different pathological conditions cardiac lymphatics undergo signi

82 ation pathway that protects cells exposed to pathological conditions from stress-induced tissue damag

83 that anti-MPER specificity arises only under pathological conditions in autoantibodies endowed with s

84 ng evidence has demonstrated that peripheral pathological conditions induce physiological regulation

85 r dysfunction and are associated with severe pathological conditions such as acute respiratory distre

86 flammation and is prominent in most vascular pathological conditions such as atherosclerosis and rest

87 e neuronal volume regulation often occurs in pathological conditions such as glutamate excitotoxicity

88 diate succinate and is implicated in various pathological conditions such as rheumatoid arthritis, li

89 aberrant activation of TRPC4 may occur under pathological conditions to cause cell damage.

90 n this mechanism are responsible for several pathological conditions, including acute pancreatitis.

91 erous physiological processes and in various pathological conditions, including cardiovascular diseas

92 e of various selenoproteins under normal and pathological conditions, including in pancreatic beta-ce

93 elp advance therapeutic avenues for managing pathological conditions, such as diseases arising from i

94 of the human brain, under physiological and pathological conditions.

95 s are often early indicators of the onset of pathological conditions.

96 resulting in considerable tissue damage and pathological conditions.

97 ecular role of these antibodies in different pathological conditions.

98 nd emerges as an important regulator of many pathological conditions.

99 tein secretion and autophagy under stress or pathological conditions.

100 onses to a wide variety of physiological and pathological conditions.

101 P dynamics under different physiological and pathological conditions.

102 in but is also secreted in physiological and pathological conditions.

103 n of these processes (ie, the good); (2) the pathological consequence of circadian governance impairm

104 This importance is highlighted by the pathological consequences and impaired performance resul

105 Our results in rats suggest pathological consequences from chronic TRAP exposure, in

106 ic vaccine or treat severe EBV infection and pathological consequences in immunodeficient hosts.

107 well-established, but the physiological and pathological consequences of decreased cMyBP-C phosphory

108 to be ignored, chronic stress has important pathological consequences, including cardiovascular dise

109 functions that may have both protective and pathological consequences.

110 A modifications frequently results in severe pathological consequences.

111 ion of specialized functions tailored to the pathological context.

112 tions contributes to synapse loss, the major pathological correlate to cognitive decline in AD.

113 sphorylation of Cx43 serine-triplet triggers pathological Cx43 redistribution to the lateral sides of

114 These proteomic and pathological data from this largely unexplored region of

115 radation of lubricin, which could affect the pathological decrease of the lubrication in degenerative

116 3 mutant mouse lines, this novel model shows pathological deficits throughout the CNS including accum

117 term developmental anoikis distinguishes the pathological detachment of progenitor cells from the nor

118 closed state of the channel, resulting in a pathological diastolic Ca(2+) leak from the SR that both

119 The clinical and pathological differences between synucleinopathies such

120 rtant peptide-specific mechanisms of dynamic pathological disequilibrium of cellular and circuit acti

121 ocally advanced rectal cancer could increase pathological downstaging and act on occult micrometastat

122 urvival, intracellular localization, and the pathological effects, as dysfunction of RPEs leads to AM

123 ring pregnancy, and its potential downstream pathological effects, including tissue damage and fetal

124 defines both its physiological function and pathological effects.

125 ture suggests molecular mechanisms for their pathological effects.

126 s organize into disjoint, cell-type specific pathological ensembles in which abGCs play an outsized r

127 on of the infundibulum, which is the primary pathological event in acne.

128 Synapse dysfunction is emerging as an early pathological event in frontotemporal dementia (FTD), how

129 insulin-producing beta-cells is the central pathological event in type 1 and 2 diabetes, which has l

130 All of these pathological events were rescued in acinar cells treated

131 mbination of machine learning algorithms and pathological examination reports, we developed a classif

132 sacrificed, and the esophagus submitted for pathological examination, including 10 discrete histolog

133 lternative to the qualitative and subjective pathological examination.

134 Pathological expansion of the TNR within the FRAXA locus

135 ed seeding by IL15-induced tau oligomers and pathological extracts from donors with AD and chronic tr

136 llographic studies) can be correlated to the pathological fate of the native fold; the low fold stabi

137 , and TDP-43 mislocalization in MNs is a key pathological feature of >95% of ALS cases.

138 Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease.

139 ews were performed to correlate clinical and pathological features (including detailed pathological f

140 lin were compared with RS alone and clinical-pathological features alone using likelihood ratio tests

141 igenesis and metastasis, which resembles the pathological features in human patients.

142 These H(2)O(2)(-)-induced pathological features of AD in GiDs are consistently rec

143 to demyelination and axonal loss, which are pathological features of multiple sclerosis (MS), the mo

144 This model demonstrates pathological features of the human disease, including in

145 nd pathological features (including detailed pathological features of the parenchymal margin) with re

146 sess graft function, it does not reflect the pathological features or progressive nature of the disea

147 ich oligodendrocyte cell-death is one of the pathological features.

148 and cardiovascular involvement were dominant pathological features.

149 rs shared a similar constellation of adverse pathological features.

150 ctly model the human disease, it shares many pathological features.

151 tween BMI and risk of CRC by major molecular pathological features: microsatellite instability (MSI),

152 ostatic and hedonic brain nuclei can lead to pathological feeding behaviors, namely overconsumption o

153 rcoma (FUS) forms physiological granules and pathological fibrils, which facilitate RNA functions and

154 isualized any type of clinically significant pathological finding.

155 uses a practical approach to review the main pathological findings and their interpretation, and the

156 ant ATXN1 is expressed throughout the brain, pathological findings reveal severe atrophy of cerebella

157 No pathological findings were reported in 43.2% of the stud

158 lepsy is a dynamic disorder characterized by pathological fluctuations in brain state, surprisingly l

159 uted to account for the added energy cost of pathological gait.

160 ression of c-Myc, which in turn stimulated a pathological gene program.

161 osphorylated and misfolded tau protein are a pathological hallmark of Alzheimer's disease and other t

162 resence and evolution of focal lesions - the pathological hallmark of MS.

163 ion into insoluble filaments is the defining pathological hallmark of tauopathies.

164 de hormone amylin into amyloid deposits is a pathological hallmark of type-2 diabetes (T2D).

165 e presence or absence of Alzheimer's disease pathological hallmarks: amyloid plaques (A), phosphoryla

166 mal brain function overlap in frequency with pathological HFOs.

167 Gross pathological, histological, and ultrastructural examinat

168 Pathological hotspots were identified within the A-band

169 Pathological hotspots within the A-band of TTN may be in

170 alterations in GABAergic networks and dampen pathological hyperexcitability in adults with XLID.

171 inhibitor TP-10, attenuated cardiac myocyte pathological hypertrophy induced by Angiotensin II, phen

172 The pathological impact of UNC-45B in muscle disease remaine

173 nctions of these cytokines in protective and pathological inflammation.

174 ng whether this EEG slowing is linked to the pathological intrusion of sleep-like cortical dynamics w

175 ng deformations should also be considered in pathological irreversible swelling.

176 stiffness on the biomechanics of healthy and pathological joints.

177 atabase, and this was further confirmed with pathological LGG patient samples, including malignantly

178 In this study, we characterized pathological linkage of OP to OA, and evaluated the effe

179 Our results demonstrate a link between pathological localisation of ANKH mutants with different

180 mputational modeling, we find that the early pathological loci of NFTs in CTE brains are regions of h

181 To assess pathological lung lipid composition, previous knowledge

182 Pathological malfunction of GPR52 signalling occurs prim

183 Correlation of HDI data to serological and pathological measurements was performed.

184 roperties will increase the understanding of pathological mechanical mechanisms underlying aortic dis

185 evidence implicates redox dysregulation as a pathological mechanism driving the emergence of psychosi

186 esis, and trabecular bone loss, uncovering a pathological mechanism underlying the link between muscl

187 es across diseases as well as into potential pathological mechanisms and the effects of different tre

188 However, the pathological mechanisms governing TMJ OA are poorly unde

189 ic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the imp

190 Altogether, these data shed light on new pathological mechanisms involving platelet activation an

191 misfolding, traumatic brain injury or other pathological mechanisms may explain the increased risk f

192 The underlying pathological mechanisms of glaucomatous trabecular meshw

193 treatments help to elucidate therapeutic or pathological mechanisms, and to assist clinicians in opt

194 Following intra-striatal delivery, pathological mHTT-positive protein aggregates were distr

195 to roles of nucleus accumbens mechanisms in pathological motivations, including addiction and parano

196 Pathological mutations of Cx26 abolish the CO(2) -depend

197 d retinal diseases and for the correction of pathological mutations with non-canonical protospacer-ad

198 unit (CaNAbeta) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aa

199 d to define a regulatory pathway controlling pathological myocyte hypertrophy.

200 preoperative chemoradiotherapy would improve pathological near complete response rate compared with c

201 h biological changes are linked to relevant, pathological neurochemistry, and brain function.

202 The cellular consequences of these pathological NOTCH3 fragments are an important area for

203 enetic and osteogenic response in hMSCs with pathological nuclear mechanosensing.

204 isease (PID) has not been directly linked to pathological organ changes.

205 odulation of other distinct physiological or pathological oscillatory activities could also play an i

206 ion and discuss how these interactions shape pathological outcomes.

207 el insights into RD aetiology and underlying pathological pathways.

208 core fucosylation can be seen in the complex pathological phenotypes of FUT8 null mice, which display

209 Our results suggest that AN may arise from pathological positive feedback loops: voluntary food res

210 The clinico-pathological predictors, AJCC version 7 (AJCC 7), AJCC 8

211 It is now known that the pathological process in Parkinson disease may begin deca

212 ks the disease in the exocrine pancreas to a pathological process in the endocrine pancreas, suggesti

213 Cardiac fibrosis is a pathological process that contributes to the development

214 ate that such structures are involved in the pathological process.

215 lites are involved in many physiological and pathological processes in human cells; thus, our results

216 nt will help elucidate the physiological and pathological processes including those of cancer.

217 help elucidate fundamental physiological and pathological processes related to the mycomembrane and m

218 essential roles in various physiological and pathological processes such as blood coagulation, skelet

219 and repair, in wound healing and in numerous pathological processes such as cancer progression or dia

220 hed a steady state and analyzed to determine pathological processes that were activated, inactivated,

221 some release have been implicated in various pathological processes, including the progression of Alz

222 Abdominal adiposity may trigger causal pathological processes, partially independent from blood

223 widespread implications in physiological and pathological processes, ranging from neurological develo

224 eractions mediate critical physiological and pathological processes, such as neuronal plasticity, dev

225 at plays a pivotal role in physiological and pathological processes.

226 ed to important cellular, physiological, and pathological processes.

227 e of FXIIa and thrombin in physiological and pathological processes.

228 gration is central to many developmental and pathological processes.

229 ntral role in a variety of physiological and pathological processes.

230 trocytes appear to mediate or exacerbate the pathological processes.

231 s a route to a plausible mechanistic link to pathological processes.

232 defense while switching on an Nrf2-operated pathological program toward ferroptosis in cardiomyocyte

233 Many of apo(a)'s potential pathological properties, such as inhibition of plasmin g

234 nowledge of the cell-to-cell transmission of pathological proteins and to identify key questions for

235 ing these concepts with a focus on two major pathological proteins: tau and alpha-synuclein.

236 = 8%) but was associated with a significant pathological regression (TRG1-2 = 44% vs 8%, P < 0.001)

237 However, perioperative FOLFOX induces pathological regression and downstaging.

238 roblasts that might underlie distinctions in pathological remodeling of the RV in biventricular HF.

239 2 prevented HFD-induced cardiac dysfunction, pathological remodeling, and mitochondria dysfunction, a

240 In addition, Nrf2KO inhibited cardiac pathological remodeling, apoptosis, and oxidative stress

241 ning after ischemic injury to reduce ongoing pathological remodeling.

242 up difference in the number of 90% or higher pathological response of 36.1% (83.8% CI 16.5-55.8).

243 rol group, the number of patients with a 90% pathological response or higher was 14 (58%) of 24 patie

244 ificantly accurate predictions of PDXGEM for pathological response or survival outcomes were observed

245 ve FOLFOX chemotherapy did not improve major pathological response rate (TRG1 = 8%) but was associate

246 ut is not associated with an increased major pathological response rate as expected.

247 The improvement in pathological response rate with the addition of pazopani

248 The primary endpoint was major pathological response, defined as the presence of 10% or

249 l analysis reveals that the Miller&Payne 4/5 pathological response, indicating 90-100% tumor-cell los

250 ndrome in individuals who develop persistent pathological responses to parenchymal injury or stress.

251 ications for understanding physiological and pathological responses to ROS and highlight the importan

252 abdominal radiologist who was blinded to the pathological results.

253 identify and characterise physiological and pathological RNA targets of FUS.

254 bout whether autophagy has a protective or a pathological role in kidney fibrosis, and about the prec

255 vels than the healthy controls, supporting a pathological role of this pathway.

256 s physiological processes, evidence of their pathological roles have also been obtained in the last d

257 We discuss possible physiological and pathological roles of these interactions in regulation o

258 been difficult to quantitatively detect such pathological seeding activities in patient biosamples, e

259 ransferred between cells are referred to as 'pathological seeds'.

260 information of the structural properties of pathological seeds.

261 t cell on the conformation and properties of pathological seeds.

262 d that altered ensembles are associated with pathological sensory cortical processing phenotypes resu

263 plays an integral role in physiology, and in pathological settings, may contribute to either enhance

264 t preserving FA oxidation (FAO) prevents the pathological shift of substrate preference, preserves ca

265 Pathological signaling of the VGLUT3-mGluR5 axis is link

266 s bear substantial genetic, evolutional, and pathological significance in genome analyses.

267 r to be differentially recruited to specific pathological sites when mobilized by distinct inactivate

268 al roles in various biological processes and pathological situations.

269 nvironment in a variety of physiological and pathological situations.

270 ions, mimicking a range of physiological and pathological situations.

271 metastasis with/without NAT and clinical and pathological stage to evaluate rates of downstaging.

272 Here we addressed the sequence of pathological staging in Alzheimer's disease using two in

273 r results are in accordance with established pathological staging systems and may have implications f

274 the process, producing a complex, multilevel pathological state.

275 erobic species and is a prominent feature of pathological states encountered in bacterial infection,

276 ve both for imaging and treatment of various pathological states including stroke.

277 The cytokine, GDF15, is produced in pathological states which cause cellular stress, includi

278 his question is critical especially for some pathological states, in which mitochondrial deficits are

279 mportantly, this transfer occurs not only in pathological stimulation but also by neuronal activation

280 enous CITED4 in response to physiological or pathological stress is unknown.

281 This finding suggests that M204-scFv targets pathological structures that are formed by tau in neurod

282 specificity for identification of myocardial pathological substrates.

283 rget the 2 main proteins associated with FTD pathological subtypes: TDP-43 (FTLD-TDP) and tau (FTLD-t

284 Our findings suggest that pathological superior colliculus visual responses in de

285 other pathologies observed via an extensive pathological survey of a human skeletal collection, as w

286 nerate data that relate more directly to the pathological symptoms and clinical parameters observed i

287 novel approaches to modulate protective and pathological T cell responses in human diseases.

288 generation by showing that LSD1 localizes to pathological tau aggregates in Alzheimer's disease cases

289 1S tauopathy mouse model to demonstrate that pathological tau can exclude LSD1 from the nucleus in ne

290 The deposition of pathological tau is a common feature in several neurodeg

291 ggravates EC-Tau aggregation and accelerates pathological tau spread into the hippocampus.

292 In conclusion, pathological TDP-43 modifications can be mediated via mu

293 All cases had a pathological test to ascertain a breast cancer diagnosis

294 s are chief effector cells of hemostasis and pathological thrombosis.

295 explant model in which we have characterized pathological tissue integrity, barrier function and meta

296 The pathological traits include reduced axonal transport, sy

297 Ubiquitous pathological triggers cannot be responsible for the sele

298 in experimental models, but also during the pathological vagaries in neurons, will thus have far-rea

299 The ADC values of normal and pathological vertebrae were estimated, and the threshold

300 progenitor (AHNP) cells, that we found to be pathological when isolated from postmortem PD patients'