ライフサイエンスコーパス: pathological change

1 mouse models has been identified as an early pathological change.

2 ring ASO administered after the detection of pathological change.

3 ns in cytoplasm has been observed as a major pathological change.

4 ng a requirement for the T4SS to elicit this pathological change.

5 h a compensatory/scarring scenario for brain pathological changes.

6 sting a potential mechanism for the observed pathological changes.

7 elium (RPE), reportedly display the earliest pathological changes.

8 nd evaluating behavioral, physiological, and pathological changes.

9 y barrier function, thereby exacerbating the pathological changes.

10 adiponectin treatment corrected HFD-induced pathological changes.

11 susceptibility or resilience to Alzheimer's pathological changes.

12 ging system for Lewy body disease-associated pathological changes.

13 tissue mechanical properties associated with pathological changes.

14 ion has not been dissociated from coexisting pathological changes.

15 t of nidogen-1 in the mouse showed only mild pathological changes.

16 SHHF rats were also assessed at 6 months for pathological changes.

17 normal synaptic transmission, plasticity and pathological changes.

18 ing has been implicated as a basis for these pathological changes.

19 tion or with densities of common age-related pathological changes.

20 erapeutic strategies to slow down or prevent pathological changes.

21 after transfer, mediating more long-lasting pathological changes.

22 argeted replacement (TR) mice, which lack AD pathological changes.

23 h less progression and earlier resolution of pathological changes.

24 ctimization interventions could prevent such pathological changes.

25 reported in lab animals and associated with pathological changes.

26 ty is necessary for the progression of these pathological changes.

27 t them are limited and insensitive to subtle pathological changes.

28 man proteins can sensitively reflect various pathological changes.

29 ocalization in response to physiological and pathological changes.

30 acrophages of the CNS and act as sensors for pathological changes.

31 eimer's disease is characterized by multiple pathological changes, a biomarker panel reflecting co-oc

32 luenced by environmental factors that induce pathological changes affecting the network of epigenetic

33 Similar pathological changes also occur at every level of the sp

34 chiatric symptom of Alzheimer's disease (AD) pathological changes and a possible marker of anatomical

35 perhomocysteinemia results in liver or brain pathological changes and accelerates atherosclerosis.

36 ction is widely implicated in cardiovascular pathological changes and development of vascular disease

37 ance imaging readily captures presymptomatic pathological changes and disease propagation in c9orf72-

38 Geniposide caused liver injury evidenced by pathological changes and increases in serum alanine amin

39 beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell fun

40 r UV-stimulated signal transduction inducing pathological changes and skin damage.

41 at have been postulated to set the stage for pathological changes and symptoms that are observed at l

42 f this study was to compare radiological and pathological changes and test the adjunct efficacy of So

43 In this scenario, some pathological changes and their clinical correlates could

44 affect siRNA delivery, the disease-dependent pathological changes and their role in pulmonary disease

45 nst lethal MA15 or IAV challenge and reduced pathological changes and virus loads in the lungs at ear

46 ice displayed a similar onset of disease and pathological changes, and none of the analyses to assess

47 ampus causes cognitive deficiency, NFTs-like pathological changes, and oxidative stress as seen in AD

48 ent (EE) on disease modification in terms of pathological change are inconclusive.

49 , and microbial dysbiosis and that these gut pathological changes are linked to hypertension.

50 ions and bursting, suggesting that all three pathological changes are mechanistically linked.

51 ous FUS has no effect, confirming that these pathological changes are mutant FUS dependent.

52 Pathological changes associated with acute rejection, in

53 better understand the increasingly important pathological changes associated with aging.

54 et isolates resulted in death accompanied by pathological changes associated with ARDS.

55 the basic biology of CLN3 and the underlying pathological changes associated with CLN3 disease.

56 imited resolving power for discerning subtle pathological changes associated with early diseases.

57 The spectrum of pathological changes associated with known gene defects

58 We recognized and quantified the pathological changes associated with nerve degeneration

59 ineage, are thought to contribute to various pathological changes associated with poor patient outcom

60 PGD(2) and/or activation of DP1 may prevent pathological changes associated with TED.

61 rogression depending on the stage and on the pathological changes associated with the stage.

62 roviding direct evidence of undefined unique pathological changes at different bone hierarchical leve

63 e have developed, tend to detect microscopic pathological changes based on features derived from gene

64 However, over time the pathological changes become dominated by widespread micr

65 ction via multiple mechanisms and that these pathological changes can be reversed, in part, with aero

66 These pathological changes cause abrupt development of a sever

67 To identify pathological changes caused by beta-catenin loss in the

68 individuals who are older than 40 years have pathological changes characteristic of Alzheimer's disea

69 zation while its loss-of-function results in pathological changes characteristic of ASDs.

70 Overdistension of hollow organs evokes pathological changes characterized by smooth muscle remo

71 Likewise, in mice IMQ triggers pathological changes closely resembling psoriatic plaque

72 major disease condition, in turn leading to pathological changes collectively recognized as metaboli

73 epleted infected wild-type mice displayed no pathological changes, compared to untreated infected con

74 1 and how it might contribute to some of the pathological changes detected in infected mice.

75 A specific anatomical pattern of pathological changes developing in the brain suggests th

76 Histological analysis of tissues showed no pathological changes due to predatory bacteria.

77 s that lead to granuloma formation and other pathological changes during infection.

78 HIV replication and associated virus-induced pathological changes during the acute and asymptomatic s

79 oE isoforms contribute to various AD-related pathological changes (e.g., amyloid plaques and synaptic

80 e metabolic fuels and oxygen, contributes to pathological changes following traumatic spinal cord or

81 We consider the implications of prenatal pathological changes for the onset and progression of HD

82 We suggest that some of these pathological changes (for example, focal PC axonal swell

83 A common pathological change found in AD-affected brains is the a

84 of naPPA are associated with the spectrum of pathological changes found in frontotemporal lobar degen

85 allenged with WT bacteria compared to severe pathological changes found in the infected and nonimmuni

86 on signaling network are integrated to yield pathological changes has not been defined.

87 Cardiac function and pathological changes (hypertrophy, fibrosis, inflammatio

88 Pathological changes identified include plaque and tangl

89 Fibrosis is recognized as the major pathological change in adipose tissue during the develop

90 Synaptic loss is the earliest pathological change in Alzheimer disease (AD) and is the

91 Endocytic dysfunction is an early pathological change in Alzheimer's disease (AD) and Down

92 A chronic proinflammatory state precedes pathological change in arterial endothelial cells locate

93 gnificant, sub-acute (four hours post-blast) pathological change in bTBI.

94 ocular blood flow deficit could be an early pathological change in diabetic retinopathy.

95 d early recognition and intervention of this pathological change in future trials will help to optimi

96 e Sod1 gene; this mutation is identical to a pathological change in human familial ALS (fALS) which r

97 The most obvious pathological change in multiple sclerosis is multifocal

98 Our results suggest that any pathological change in plasma composition, RBC cytosol v

99 nerally viewed as a gradually developing and pathological change in T cell function.

100 Thus, our results identify pathological change in the nonlinear interaction between

101 mal cells is associated with amelioration of pathological changes in a human model of graft-vs-host d

102 we investigated neurodegeneration-associated pathological changes in a mouse model of chronic Toxopla

103 rocesses also lead to similar behavioral and pathological changes in a neuropathic pain model of peri

104 Increased titers were associated with marked pathological changes in all organs examined, especially

105 ework for investigating how OPTN may trigger pathological changes in ALS and other OPTN-linked neurod

106 f primary importance in developing models of pathological changes in Alzheimer's disease (AD).

107 junction are the earliest sites to manifest pathological changes in amyotrophic lateral sclerosis (A

108 anti-Abeta antibodies on the behavioral and pathological changes in an aged Tg2576 mouse model of AD

109 a prominent theory supported by genetic and pathological changes in an array of neurodegenerative di

110 may underlie vessel-specific differences and pathological changes in arterial wall size and structure

111 RI is a sensitive modality for assessment of pathological changes in articular cartilage.

112 Although pathological changes in axonal morphology have emerged a

113 Pathological changes in axons undergoing radial expansio

114 extreme, may be a factor that contributes to pathological changes in behavior or physiological respon

115 e practitioners and even patients to monitor pathological changes in biomarker levels.

116 x 10(6)), which has not lead to irreversible pathological changes in blood flow and kidney tissue, an

117 For example, pathological changes in blood flow-induced shear stress

118 derived from affected individuals displayed pathological changes in both the enteric nervous system

119 that chronic use of e-cigarettes will induce pathological changes in both the heart and lungs.

120 ufficiency in chronic stroke might be due to pathological changes in brain areas remote from the init

121 of dendritic spines with consequential major pathological changes in brain function.

122 l when attempting to distinguish normal from pathological changes in cardiac function during exercise

123 py to noninvasively assess physiological and pathological changes in cardiac metabolism in the human

124 emerged as key sites of vulnerability during pathological changes in cell excitability in disease sta

125 s a sensitive indicator of physiological and pathological changes in cells, with many potential appli

126 thy controls, subjects with TLE demonstrated pathological changes in circumscribed regions of the FF,

127 defined as biomarker evidence of Alzheimer's pathological changes in cognitively healthy individuals.

128 l tissue birefringence properties to monitor pathological changes in collagen and elastin.

129 Major BBB pathological changes in contralateral remote striatum an

130 aques, alpha-synuclein inclusions, and other pathological changes in cortical regions.

131 The results suggest that physiological or pathological changes in Derlin-1 expression levels may a

132 Pathological changes in diabetes include mesangial expan

133 These data demonstrate that pathological changes in DNA methylation homeostasis may

134 Pathological changes in excitability of cortical tissue

135 's disease (AD), but the molecular basis for pathological changes in FAT were undetermined.

136 Dysregulated MET signaling may lead to pathological changes in forebrain maturation and connect

137 ical for gamma oscillations, indicating that pathological changes in gamma activity may depend on sub

138 on, improves lymphatic function and reverses pathological changes in gene expression in lymphatic end

139 notype of different mouse strains as well as pathological changes in glaucoma and optic nerve disease

140 Our findings demonstrate that it is the pathological changes in IF organization that cause the l

141 ERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy pr

142 sal route with type A F. tularensis, and the pathological changes in infected tissues were characteri

143 to be strongly efficient in the detection of pathological changes in injured wrists.

144 en in heart failure, and can directly induce pathological changes in ion channels, Ca(2+) handling an

145 zed by inflammatory processes that result in pathological changes in joint tissues, including cartila

146 fects of 30 rmTBIs, examining structural and pathological changes in mice up to 365 days after injury

147 Electron microscopy revealed pathological changes in mitochondria, myofibrils, and mi

148 ading to actions that reflect or precipitate pathological changes in mood.

149 linically important site that is affected by pathological changes in most patients with multiple scle

150 sought to determine if lung hemodynamics and pathological changes in Mtb infected cells can be used f

151 e the progression of feline SMA, we assessed pathological changes in muscle and spinal cord from 3 da

152 Pathological changes in network function can be directly

153 owever, mechanisms by which physiological or pathological changes in osmolality impact chondrocyte fu

154 However, recent studies have revealed pathological changes in other cells and tissues of the n

155 contrast, post-mortem studies indicate that pathological changes in Parkinson's disease (Lewy neurit

156 ctroscopy, can detect non-focal, spinal cord pathological changes in patients with multiple sclerosis

157 The importance of the pathological changes in proteoglycans has driven the nee

158 emain in our understanding of the underlying pathological changes in pulmonary arteries and veins in

159 The pathological changes in remote brain areas likely indica

160 Together, these findings suggest that pathological changes in renal iron homeostasis occurs in

161 In stark contrast, we did not observe any pathological changes in S129D-treated animals.

162 tantial component of the etiology stems from pathological changes in sensory and non-sensory cells in

163 cess glutamate signaling also contributes to pathological changes in sensory hair cells.

164 Pathological changes in specific catabolic pathways, whi

165 ese networks may contribute to expression of pathological changes in stress-related disorders.

166 Pathological changes in striatal shape were evaluated us

167 echanism may contribute to developmental and pathological changes in synapse numbers.

168 itochondrial distribution occur secondary to pathological changes in tau.

169 Second, CD40 promoted pathological changes in the airways, including intralumi

170 ed cortical excitability, thought to reflect pathological changes in the balance of local excitatory

171 TLR5 stimulation significantly improves pathological changes in the cecum and colon of C. diffic

172 cimens revealed differential ultrastructural pathological changes in the cellular elements of the mic

173 odel of temporal lobe epilepsy to test which pathological changes in the dentate gyrus correlate with

174 sitive to detect more subtle and progressive pathological changes in the dermis, such as those seen i

175 Pathological changes in the dorsal fornix were beyond th

176 novel explanation for the development of the pathological changes in the early stages of globoid cell

177 may be candidates for enhancement to correct pathological changes in the FX brain.

178 bolic control is associated with significant pathological changes in the gastric wall that affect all

179 anding of the regulatory networks that drive pathological changes in the heart, this approach has bee

180 may be beneficial against the metabolic and pathological changes in the heart.

181 Therefore, the pathological changes in the inner ear of the mice with S

182 pment of novel chemotherapeutics that target pathological changes in the lipid composition of cancero

183 ted contrast agents or agents that can sense pathological changes in the local environment.

184 clearance, more weight loss, and more severe pathological changes in the lung than did WT and Egr1 KO

185 Our understanding of whether pathological changes in the microcirculation can be reve

186 ly, we performed comparative analyses on the pathological changes in the models and the HIV-1 patient

187 ircadian rhythms plus HFD potentiate OA-like pathological changes in the mouse joints.

188 overexpressed beta-synuclein does not cause pathological changes in the nervous system of transgenic

189 s, a phantom auditory percept, is encoded by pathological changes in the neural synchrony code of per

190 ges in visual evoked cortical potentials and pathological changes in the optic nerve and CNS, whereas

191 A major cause of inaccurate examinations of pathological changes in the paranasal sinuses may be due

192 a, and other retinal diseases that can cause pathological changes in the photoreceptors.

193 Here, we investigated postmortem pathological changes in the PPN of PD cases.

194 expansion of germinal center B cells led to pathological changes in the spleens of chronically infec

195 , chronic gammaherpesvirus infection induced pathological changes in the spleens of infected animals.

196 acterial numbers in vagina and prevention of pathological changes in the upper genital tract.

197 However, pathological changes in the vasculature may be present t

198 Further, the pathological changes in tumors following treatment with

199 Pathological changes in vascular permeability are driven

200 alone can induce WT MN death and associated pathological changes in vivo.

201 -rex1(-/-) mice showed significantly reduced pathological changes including the expression of alpha-s

202 cy and multiple sclerosis (MS) share certain pathological changes, including conduction disturbances.

203 e were challenged with type A F. tularensis, pathological changes, including extensive cell death, we

204 animals from the majority of asthma-specific pathological changes, including inhibition of eosinophil

205 However, ketamine use can cause extensive pathological changes, including ketamine cystitis.

206 vealed by the absence of Brucella associated pathological changes, including splenomegaly, hepatomega

207 r accumulation coincided with behavioral and pathological changes, indicating that these oligomers ma

208 the immunological mechanisms involved in the pathological changes induced by chronic exposure to mult

209 ter PH was also effective at alleviating the pathological changes induced by the MCD diet.

210 ly used and non-invasive method of detecting pathological changes inside the human body.

211 focusing on the possibility that the initial pathological changes involve oxidative-induced inflammat

212 ly on the idea that the temporal sequence of pathological changes is as critical as the changes per s

213 scriptomic data, the cause of biological and pathological changes, is hampered by structural complexi

214 of stress fibers and increased lamellipodia, pathological changes leading to proteinuria in HIV-assoc

215 change in Alzheimer disease (AD) and is the pathological change most directly correlated with the de

216 The first pathological change observed in the PPT1(-/-) brain is r

217 mutant protein in heterozygotes prevents the pathological changes observed in homozygotes.

218 uboptimal T cell response contributes to the pathological changes observed in SARS.

219 paradigm has been challenged because not all pathological changes observed in the asthmatic airways a

220 Pathological changes observed within 5 days of Ang II in

221 Diverse pathological changes occur in the white matter (WM) of p

222 These pathological changes occur very early in the course of t

223 This study identified pathological changes occurring before the development of

224 M (decellularized ECM) and then analyzed the pathological changes occurring in decellularized ECM dur

225 ivo characterization of dynamic inflammatory pathological changes occurring in newly forming lesions

226 ritical role in the induction and subsequent pathological changes of acute liver injury.

227 he pivotal role of cell-cell junction in the pathological changes of asthma.

228 d hence could be promising for understanding pathological changes of brain connectome.

229 n fecal water content, without producing the pathological changes of colitis, and it did not cause we

230 s inflammatory response is necessary for the pathological changes of lymphedema, including fibrosis,

231 Compared to the OA group, the pathological changes of OA in the OPOA group were consid

232 ta1 in subchondral bone seem to initiate the pathological changes of osteoarthritis, and inhibition o

233 ase progression is characterized by numerous pathological changes of the cellular immune system.

234 , CD4/CD8) are most strongly associated with pathological changes of the immune system.

235 (H & E) staining was performed to detect the pathological changes of the lung and liver tissues.

236 ermidis colonising the gut can cause serious pathological changes on certain organs such as kidney, l

237 rotein isoforms can be indicative of initial pathological changes or pathology development.

238 loid plaques and followed the progression of pathological changes over time.

239 ities are static traits of BD or result from pathological changes over time.

240 was performed to evaluate the individualized pathological changes over time.

241 ction alters the CNS compartment and induces pathological changes, paving the way for discovery of bi

242 ese relate to physiological, biochemical and pathological changes remains a critical problem.

243 ibe a novel model of tauopathy that develops pathological changes reminiscent of early stage Alzheime

244 Modeling of these pathological changes requires both spatially resolved cl

245 medieval times, show atypical and extensive pathological changes resembling contemporary PDB affecti

246 NA-Seq data from young mice prior to retinal pathological changes revealed that increased vulnerabili

247 nificantly greater rescue and prevented both pathological changes, revealing a non-cell-autonomous ba

248 the mature ~44kDa protein, identical to the pathological changes seen in AD.

249 pression of intracellular Abeta(1-42) led to pathological changes seen in human Alzheimer disease bra

250 ould underlie some of the motor deficits and pathological changes seen in JNCL patients.

251 This includes specific microvascular pathological changes seen in patient biopsies and is dep

252 Pathological changes seen in the endometrial biopsies in

253 s complemented mutant developed clinical and pathological changes similar to those observed in WT-inf

254 So far unknown, these pathological changes somehow divert growing axons away f

255 are affected by ALS-causing mutations, with pathological changes starting at their peripheral nerve

256 Existing techniques measure gross pathological changes, such as fibrosis, but are not suff

257 These pathological changes suggest that Parkinson's disease is

258 arkinson's disease, before the appearance of pathological changes, supports the view that disturbed c

259 ples for better understanding of the complex pathological changes taking place in mitochondrial disea

260 Moreover, little is known about the subtle pathological changes that can characterize the brain of

261 ity to successfully adapt to stress produces pathological changes that can lead to depression.

262 , repetitive injuries produce behavioral and pathological changes that continue to evolve many months

263 ach provides a novel model to understand the pathological changes that follow from localized apoptosi

264 e results are relevant for interpretation of pathological changes that have been reported in response

265 unctional hepatocytes to a broad spectrum of pathological changes that impose both cellular and metab

266 This remodeling involves pathological changes that include chamber dilation, card

267 ssection is complicated by the wide range of pathological changes that occur after dissection.

268 Here, we examine the pathological changes that occur in LTs during HIV and si

269 silica into the lungs of rodents results in pathological changes that strongly mimic human silicosis

270 nt contributions to our understanding of the pathological changes that take place in ET.

271 diabetes, by ameliorating the glucolipotoxic pathological changes that underlie the development of pe

272 eficiency in myofiber triggers the disease's pathological changes, the degree of satellite cell (SC)

273 creased ACh activity in AD may contribute to pathological changes through global alterations in alter

274 Our findings implicate pathological changes to biophysical characteristics of S

275 of neurobiological events that may result in pathological changes to brain structure and function tha

276 Neurological disease drives symptoms through pathological changes to circuit functions.

277 mice, which have impaired contractility and pathological changes to fibres and their extracellular m

278 Status epilepticus (SE) triggers pathological changes to hippocampal dendrites that may p

279 HIV infection results in profound pathological changes to LTs induced by persistent chroni

280 unlikely to be a prerequisite for subsequent pathological changes to occur in vivo.

281 Pathological changes to the tau protein, including confo

282 Physiological or pathological changes to titin stiffness therefore affect

283 o predict locations to monitor for potential pathological changes, to detect early signs of disease,

284 37H/+) or Sod2(+/-) exhibited no significant pathological changes until 12 months of age.

285 analysis may be more sensitive for detecting pathological changes using PET-MRI in AD compared to glo

286 critical role of the A2AR signaling in these pathological changes was confirmed by alleviation of the

287 To trace the pathological changes, we performed a comprehensive analy

288 These pathological changes were accompanied by impaired diasto

289 Importantly, the observed pathological changes were associated with severe loss of

290 Most of these pathological changes were attenuated by PARP inhibitors.

291 No pathological changes were detected in noninfected d3Tx m

292 on, and secretion of cytokines and all these pathological changes were effectively inhibited by DCPIB

293 rvations, viral loads, immune responses, and pathological changes were examined on days 2, 4, 6, 8, 1

294 iseased wild birds found and the severity of pathological changes were higher during the 2016-17 outb

295 ross lesions was identified, but microscopic pathological changes were seen in the liver of infected

296 The degrees of pathological changes were significantly more severe in s

297 ppocampal arteries are small and affected by pathological changes when cerebral small vessel disease

298 ent force was insufficient to activate these pathological changes, whereas higher and prolonged appli

299 (MCI) and glucose hypometabolism is an early pathological change within AD brain.

300 We explore how obesity can actually cause pathological changes within the hypothalamus of the brai