ライフサイエンスコーパス: pathological mechanism

1 was activated in mutant mice, identifying a pathological mechanism.

2 determination, and our understanding of its pathological mechanism.

3 e results provide insight into its potential pathological mechanism.

4 ymptoms are difficult to ascribe to a single pathological mechanism.

5 peat expansions in affected tissues as a key pathological mechanism.

6 mation and provides new insights for the nGD pathological mechanism.

7 e and pseudo-hypoxia has been suggested as a pathological mechanism.

8 nstrumental for the further understanding of pathological mechanisms.

9 t understanding of HTT function and the main pathological mechanisms.

10 iated MG may be different in etiological and pathological mechanisms.

11 NA level have all been suggested as possible pathological mechanisms.

12 are ends of a spectrum and may share common pathological mechanisms.

13 ultifactorial, caused by multiple underlying pathological mechanisms.

14 disease progression and identify underlying pathological mechanisms.

15 ut MacTel to screen for novel cell-intrinsic pathological mechanisms.

16 tion-mediated sodium and fluid imbalance are pathological mechanisms.

17 ntia (FTD), exhibit distinct yet overlapping pathological mechanisms.

18 re is a clear need to investigate additional pathological mechanisms.

19 lay of loss-of-function and gain-of-function pathological mechanisms.

20 on of AD and a useful tool in exploring AD's pathological mechanisms.

21 able to the understanding of AD genetics and pathological mechanisms.

22 erties, and their roles in physiological and pathological mechanisms.

23 n annotated gene functions in the search for pathological mechanisms.

24 sarcoidosis, would identify disease-specific pathological mechanisms.

25 ing Barrett's progression and the underlying pathological mechanisms.

26 of stress, not simply involve a reversal of pathological mechanisms.

27 ons calling for novel interventions based on pathological mechanisms.

28 rden of subclinical infections and elucidate pathological mechanisms.

29 ential hypertension results from a mosaic of pathological mechanisms.

30 s reflecting the heterogeneity of underlying pathological mechanisms.

31 nd dementia, and to both shared and distinct pathological mechanisms.

32 ttle is known about its involvement in other pathological mechanisms.

33 al signs and is likely caused by an array of pathological mechanisms.

34 hich could provide improved understanding of pathological mechanisms across a host of enteric neuropa

35 nical p38 pathway regulated SMC apoptosis, a pathological mechanism also governed by Kruppel-like fac

36 ) is associated with multiple etiologies and pathological mechanisms, among which oxidative stress (O

37 a significant clinical problem; however, its pathological mechanism and effective treatments remain e

38 It also revealed an opposite pathological mechanism and inverse therapeutic concepts

39 To uncover the pathological mechanism and provide comprehensive genotyp

40 of the mitogen IGF-1, suggesting a possible pathological mechanism and therapeutic target.

41 cause dental malformations through different pathological mechanisms and can be regarded as distinct

42 ture, providing a platform for understanding pathological mechanisms and designing treatment strategi

43 ding to seizures is important for disclosing pathological mechanisms and developing therapeutic appro

44 may influence each other by several complex pathological mechanisms and have a mutual promoting effe

45 atterns do not align well with their diverse pathological mechanisms and hence do not inform optimal

46 ients with heart failure, but the underlying pathological mechanisms and implications are largely unk

47 netic causes of AD could identify underlying pathological mechanisms and lead to potential treatments

48 Pathological mechanisms and potential treatments for ON

49 condary tauopathy, neither the cause nor the pathological mechanisms and repercussions are understood

50 nt of CRC will provide new insights into the pathological mechanisms and reveal novel prognostic biom

51 arting from immunosenescence, ageing-related pathological mechanisms and specific features like enlar

52 loped to gain insight into the molecular and pathological mechanisms and test new therapeutics, focus

53 may advance our understanding of underlying pathological mechanisms and the complex relationship bet

54 es across diseases as well as into potential pathological mechanisms and the effects of different tre

55 The pathological mechanisms and the related immunological pa

56 ersus microscopy in PSP may reflect distinct pathological mechanisms, and elucidation of these proces

57 hole exome sequencing results, insights into pathological mechanisms, and possible therapies will hin

58 treatments help to elucidate therapeutic or pathological mechanisms, and to assist clinicians in opt

59 diverging function of each isoform and what pathological mechanisms are activated upon their loss re

60 Multiple pathological mechanisms are involved in the development

61 of neonatal morbidity and mortality, but its pathological mechanisms are largely unknown.

62 The pathological mechanisms are likely heterogeneous, but we

63 pothesis continues to accrue, the underlying pathological mechanisms are not well understood.

64 cult to detect in human muscle biopsies, and pathological mechanisms are obscure.

65 s and its position in the gene, two possible pathological mechanisms are proposed: (1) the protein ma

66 n described in association with ALS, but the pathological mechanisms are still poorly understood.

67 wn as hydrocephalus; however, the underlying pathological mechanisms are unclear.

68 ve impairment but the responsible underlying pathological mechanisms are unknown.

69 he role of spreading depolarization as a key pathological mechanism associated with microvascular dys

70 ry of Abeta will allow speedy delineation of pathological mechanisms associated with specific neurode

71 To accumulate knowledge of the pathological mechanisms behind the condition at the meth

72 mmunity, not only yielding insights into the pathological mechanisms but also providing potential bio

73 This study describes a new molecular pathological mechanism by which a silent mutation inhibi

74 The pathological mechanism by which Abeta causes neuronal dy

75 These findings demonstrate a pathological mechanism by which altered membrane lipid c

76 cases, have been described recently, but the pathological mechanism by which causal mutations result

77 microscopy holds potential for understanding pathological mechanisms by mapping molecular signatures

78 ce has allowed investigators to evaluate the pathological mechanisms by which different genes influen

79 ed in paraneoplastic syndromes; however, the pathological mechanisms by which tumors influence host o

80 ived stem cells, different developmental and pathological mechanisms can be modeled and investigated

81 sights into the structure of usherin and the pathological mechanisms caused by small pathogenic in-fr

82 tophagy is disturbed through largely unknown pathological mechanisms, causing mitochondrial damage an

83 As yet, the pathological mechanisms connecting mutant Rab7 protein e

84 ement of resurgent currents may constitute a pathological mechanism contributing to sensory neuron hy

85 Better understanding of the pathological mechanisms contributing to epileptogenesis

86 Connecting diseases with similar pathological mechanisms could inspire novel strategies o

87 The exact pathological mechanisms determining disease onset and pr

88 evidence implicates redox dysregulation as a pathological mechanism driving the emergence of psychosi

89 d peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on re

90 evaluated for their potential in determining pathological mechanisms, elucidating therapeutic health

91 current understanding of CAC into three main pathological mechanisms: first, vascular endothelial cel

92 re and function of the AIS, thus revealing a pathological mechanism for ARHGEF9-associated DEE.

93 conclusion, we identified a common molecular pathological mechanism for both executive dysfunction an

94 ed Nup homeostasis as a prominent initiating pathological mechanism for familial and sporadic ALS and

95 r cells, these observations suggest a likely pathological mechanism for IMPDH1-mediated hereditary bl

96 eceptor target for GRK2 and represents a new pathological mechanism for this kinase in the failing he

97 eptides has been considered one of the major pathological mechanisms for Alzheimer disease.

98 interest in using EM in understanding novel pathological mechanisms for different subtypes of asthma

99 Aging and oxidative stress are two prominent pathological mechanisms for Parkinson's disease (PD) tha

100 However, the pathological mechanisms governing TMJ OA are poorly unde

101 he infectious triggers and immunological and pathological mechanisms has advanced substantially in th

102 Although the pathological mechanisms have not been definitively eluci

103 lity to EBV infection, though the underlying pathological mechanisms have not yet been identified.

104 omplication of cranial radiotherapy, and its pathological mechanisms have yet to be elucidated.

105 riants and indicated at least three distinct pathological mechanisms: (i) defective cell membrane exp

106 c Ca(2+)-permeable membrane pores is a major pathological mechanism in AD and introduce TIRF imaging

107 cytotoxic, potentially representing a novel pathological mechanism in AD which may be further exacer

108 ndrial DNA (mtDNA) deletions is an important pathological mechanism in adults with mtDNA maintenance

109 e neuromuscular junction implicated as a key pathological mechanism in ALS, and each lower motor unit

110 mation has been increasingly implicated as a pathological mechanism in dementia and demonstration tha

111 nded polyglutamine is thought to be a common pathological mechanism in HD and other glutamine repeat

112 SR Ca(2+) leak as a shared Ca(2+)-dependent pathological mechanism in HF and AF, a new class of drug

113 ecies production has emerged as an important pathological mechanism in myocardial ischemia/reperfusio

114 our results implicate mutant RAB32 in a key pathological mechanism in PD-LRRK2 kinase activity(5-7)-

115 indicating that intravascular hemolysis is a pathological mechanism in several human diseases, includ

116 regulation as a potential contributor to the pathological mechanism in SMA.

117 d with dilated cardiomyopathy (DCM), but the pathological mechanism in the heart is unknown.

118 propose that chromosome missegregation is a pathological mechanism in this disorder.

119 ng will optimize our approach to control all pathological mechanisms in AD, inflammation, barrier dys

120 tations give rise to unique gain-of-function pathological mechanisms in CH.

121 These diseases have many pathological mechanisms in common, and there may be rela

122 ic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the imp

123 implicate dysregulation in these pathways as pathological mechanisms in HD.

124 ve been particularly valuable for clarifying pathological mechanisms in heart failure, an etiological

125 The authors then discuss several common pathological mechanisms in HFpEF and DM, including sodiu

126 ered SC lipid metabolism are thus underlying pathological mechanisms in mitochondria-related peripher

127 This work delineates pathological mechanisms in neural cells harboring TCF4 m

128 To study novel pathological mechanisms in neuronopathic Gaucher disease

129 argue that these findings shed light on the pathological mechanisms in the ALS/FTD spectrum and conc

130 lvements in both physiological functions and pathological mechanisms in the CNS.

131 use infection model presents new findings on pathological mechanisms in the colon.

132 the regulation of LD turnover and potential pathological mechanisms in Troyer syndrome.

133 stem may be compensatory, rather than purely pathological, mechanisms in certain contexts.

134 Interestingly, many pathological mechanisms, including iron accumulation and

135 t expansion diseases and consider the likely pathological mechanisms, including RNA toxicity, CGG rep

136 n incomplete understanding of the underlying pathological mechanisms, including the effects of hyperg

137 These pathological mechanisms interfere with vessel patency th

138 including HSP70 and HSP90, key regulators of pathological mechanisms involved in diabetes complicatio

139 Here, we review the cell types and pathological mechanisms involved in disease development

140 The pathological mechanisms involved in ocular VACV infectio

141 ese results open avenues for deciphering the pathological mechanisms involved in pigmentation disease

142 These pigments are implicated in pathological mechanisms involved in several vision-threa

143 These pigments are implicated in pathological mechanisms involved in some vision-threaten

144 s (after expression of myogenin) or that the pathological mechanisms involved in these neoplasms also

145 ing developed in an effort to understand the pathological mechanisms involved.

146 llectively, these findings delineate a novel pathological mechanism involving aberrant APP processing

147 tures and data presented here suggest that a pathological mechanism involving abnormal cholesterol tr

148 These results suggest a pathological mechanism involving opportunistic behavior.

149 s information might shed light on underlying pathological mechanisms involving inflammation and could

150 liable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and

151 Altogether, these data shed light on new pathological mechanisms involving platelet activation an

152 y that arises and despite many theories, the pathological mechanism is not fully understood.

153 ata, we propose oxidative stress as a common pathological mechanism leading to PVI impairment in schi

154 in DS/AD and sporadic AD brains, converging pathological mechanisms leading to chronic oxidative str

155 Mitotic perturbations can contribute to pathological mechanisms leading to cortical malformation

156 ngs provide evidence for a novel MDD-related pathological mechanism linking local neurotrophic suppor

157 misfolding, traumatic brain injury or other pathological mechanisms may explain the increased risk f

158 Several distinct pathological mechanisms, not active in every patient, de

159 Pathological mechanisms occurring in this disease have n

160 ation approved agent to treat the underlying pathological mechanism of chronic dry eye, has demonstra

161 ergic interneurons, the opposite of the main pathological mechanism of DS.

162 on may therefore provide a model for a novel pathological mechanism of Duchenne muscular dystrophy an

163 suggesting the possible activity-stimulated pathological mechanism of FSHD.

164 The physiological function and pathological mechanism of FUS are not well understood, p

165 The pathological mechanism of IBMPFD is not clear and there

166 spectrum of disorders unified by the common pathological mechanism of length-dependent axonal degene

167 eakpoint has prognostic utility and that the pathological mechanism of mapping to an R-band cannot be

168 ating cortical spreading depression (CSD), a pathological mechanism of migraine.

169 afish model of what is potentially the novel pathological mechanism of muscle attachment failure in D

170 sm of CSD initiation, which is relevant as a pathological mechanism of Nav1.1 FHM3 mutations, and pos

171 rophic lateral sclerosis (ALS); however, the pathological mechanism of PFN1 in this fatal disease is

172 his study provided critical insight into the pathological mechanism of psychological suboptimal healt

173 and aged animals and shed light on potential pathological mechanisms of abnormal muscle proprioceptio

174 ACE1, treatments that address the underlying pathological mechanisms of AD are still lacking.

175 To better understand the pathological mechanisms of alphaSyn, we generated induce

176 the lung, which is not only relevant to the pathological mechanisms of ARDS, but might also represen

177 primate disease models for understanding the pathological mechanisms of brain disorders and for devel

178 in the past few decades in illuminating the pathological mechanisms of cancer and in developing new

179 COVID-19 in Bergamo, Italy, to determine the pathological mechanisms of cardiac injury.

180 Our results also provide insight into pathological mechanisms of CMS.

181 and DCs may collaborate with T cells in the pathological mechanisms of coronary arteritis.

182 uch regulatory systems may contribute to the pathological mechanisms of degenerative motor neuron dis

183 atment of symptoms but also on targeting the pathological mechanisms of disease, ideally before sympt

184 dicating their potential significance in the pathological mechanisms of epilepsy.

185 r future investigations of physiological and pathological mechanisms of exosome biogenesis, protein t

186 Understanding the pathological mechanisms of fibrosis in the kidney and ot

187 The underlying pathological mechanisms of glaucomatous trabecular meshw

188 This work suggests the complexity of the pathological mechanisms of GRIN2D-mediated developmental

189 s, however, an in-depth understanding of the pathological mechanisms of HCM has led to the developmen

190 l identifies a novel strategy to explore the pathological mechanisms of HSAN1.

191 individual patient and provide insight into pathological mechanisms of human disease.

192 muscle could provide a valuable clue to the pathological mechanisms of IBM.

193 In this review we survey molecular and pathological mechanisms of inflammaging in vascular and

194 which to test competing hypotheses regarding pathological mechanisms of inflammation in NEC, suggest

195 t of the cilium and provide insight into the pathological mechanisms of LCA and related ciliopathies.

196 damental insights into the physiological and pathological mechanisms of life.

197 The pathological mechanisms of LST were as follows: (1) sten

198 entions is a valuable tool for research into pathological mechanisms of mania.

199 The classification and pathological mechanisms of many central nervous system i

200 contrast the underlying disease networks and pathological mechanisms of monogenic as opposed to compl

201 Hepatic metabolomic studies yielded multiple pathological mechanisms of NAFLD.

202 olysensitized; and to investigate the physio-pathological mechanisms of nasal diseases.

203 to our understanding of synapse assembly and pathological mechanisms of neuromuscular disorders.

204 ts ErbB receptors has been implicated in the pathological mechanisms of schizophrenia, loss of Nrg1 m

205 vide a resource to explore physiological and pathological mechanisms of splicing regulation.

206 AD) improves distorted cardiac geometry, the pathological mechanisms of the "reverse remodeling" of t

207 eptibility/resistance to MD and defining the pathological mechanisms of the disease gives us a much g

208 fers many new avenues for investigation into pathological mechanisms of the disease, with implication

209 macrophages were also used to elucidate the pathological mechanisms of the generation of IL-31.

210 Given the overlapping pathological mechanisms of the highlighted products, we

211 These studies may shed light on the pathological mechanisms of these diseases, with implicat

212 ients with DNO, which supports the different pathological mechanisms of these diseases.

213 Recent advances in our understanding of the pathological mechanisms of thrombotic thrombocytopenic p

214 However, the underlying pathological mechanisms of TM dysfunction in POAG remain

215 itions, generally of genetic origin, but the pathological mechanisms often remain obscure.

216 odulators simultaneously addressing multiple pathological mechanisms or overcoming pathway robustness

217 multimorbidity) can either exacerbate these pathological mechanisms or reduce the patient's toleranc

218 Regardless of the underlying pathological mechanisms oxidative stress seems to be pre

219 ular disease, most causes share an important pathological mechanism: oxidative stress.

220 he biochemical, cellular, physiological, and pathological mechanisms regulated by PREPL.

221 ted methodology to explore physiological and pathological mechanisms related to brain function and dy

222 , and the underlying genetic, molecular, and pathological mechanisms related to NPSs in AD.

223 subsequent renal failure, but the underlying pathological mechanisms remain elusive.

224 Its underlying pathological mechanisms remain elusive.

225 henne muscular dystrophy (DMD); however, the pathological mechanisms remain largely unknown.

226 sease, remodeling, and heart failure but the pathological mechanisms remain obscure.

227 The underlying pathological mechanisms remain poorly understood.

228 However, the key pathological mechanisms remain unclear and human DYRK1A

229 However, the underlying pathological mechanisms remain unclear because of a lack

230 including toxic shock syndrome, the specific pathological mechanisms remain unclear.

231 us fat distribution; however, the underlying pathological mechanisms remain unknown.

232 nge is related to cell swelling, the precise pathological mechanism remains elusive.

233 However, the underlying pathological mechanism remains elusive.

234 endosomal/lysosomal pathways, but the exact pathological mechanism remains poorly understood.

235 risk factor for dementia, but the associated pathological mechanisms remains unclear.

236 r in Huntington's disease (HD), one putative pathological mechanism reported to play a prominent role

237 However, the complexity of AD pathological mechanisms requires an in-depth understandi

238 ver, the roles of LEMD2 in the heart and the pathological mechanisms responsible for its association

239 Prior attempts to assess the pathological mechanisms responsible for psychiatric diso

240 an cerebral cortex development, and that the pathological mechanism resulting from the mutations we d

241 sis (ALS) is a complex disease with numerous pathological mechanisms resulting in a heterogeneous pat

242 I, there is an urgent need to understand the pathological mechanism(s) involved on a neurobiological,

243 cause dilated cardiomyopathy through unknown pathological mechanism(s).

244 Addressing an upstream pathological mechanism shared between these disorders, t

245 In addition, the precise pathological mechanisms still need to be established.

246 a significant role, leading to activation of pathological mechanisms such as increased oxidative stre

247 F) and cardiac arrhythmias share overlapping pathological mechanisms that act cooperatively to accele

248 Very little is known about the pathological mechanisms that are involved, and the infor

249 in translating the human genetic findings to pathological mechanisms that are translatable back to th

250 h DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurova

251 rns and paves the way to pinpoint underlying pathological mechanisms that contribute to the progressi

252 blasts, which provides new insights into the pathological mechanisms that drive lymphoma biology.

253 A better understanding of the pathological mechanisms that drive neurodegeneration in

254 obust cellular models are key in determining pathological mechanisms that lead to neurotoxicity in Hu

255 h stable IHD does not address the underlying pathological mechanisms that lead to the progression of

256 These findings bring physiological and pathological mechanisms that mediate OHT into mechanobio

257 ing may be attributable to a reversal of the pathological mechanisms that occur in remodeling or the

258 fatty acids (PUFAs) could target some of the pathological mechanisms that underlie damage after SCI.

259 The pathological mechanisms that underlie T helper type 2 ce

260 prompts further experiments into underlying pathological mechanisms to identify new therapeutic appr

261 e results further demonstrate that different pathological mechanisms underlie PCP-induced neuronal da

262 We hypothesized that the pathological mechanism underlying SAP-IFN-gamma cardiomy

263 regulation of key neuropeptides, providing a pathological mechanism underlying TBX3-associated pubert

264 esis, and trabecular bone loss, uncovering a pathological mechanism underlying the link between muscl

265 Vascular response is an essential pathological mechanism underlying various inflammatory d

266 A better understanding of specific pathological mechanisms underlying ACS due to plaque ero

267 in the esophagus, as well as in elucidating pathological mechanisms underlying BA and CA.

268 diate link between overnutrition and certain pathological mechanisms underlying cardiovascular diseas

269 The pathological mechanisms underlying COVID-19 respiratory

270 n measurements can be used to understand the pathological mechanisms underlying disease processes.

271 Pathological mechanisms underlying Down syndrome (DS)/Tr

272 Identification of the pathological mechanisms underlying GBA-associated parkin

273 he Hcn1M294L mouse provides insight into the pathological mechanisms underlying hyperexcitability in

274 The challenge of dissecting pathological mechanisms underlying IBD has led to the de

275 four decades, evolving understanding of the pathological mechanisms underlying incident heart failur

276 tter understand the genetic architecture and pathological mechanisms underlying neurodegeneration in

277 The pathological mechanisms underlying neurological deficits

278 In order to identify pathological mechanisms underlying NPC and uncover poten

279 networks to give a novel perspective on the pathological mechanisms underlying Parkinson's disease d

280 ing of social memory in vCA1, as well as the pathological mechanisms underlying social memory impairm

281 To understand the pathological mechanisms underlying such relationships, h

282 Specific pathological mechanisms underlying symptoms have not yet

283 The pathological mechanisms underlying these toxicities are

284 The pathological mechanisms underlying this novel axonal neu

285 ntrolled cell proliferation, but the precise pathological mechanisms underlying tumorigenesis often r

286 Pathological mechanisms underlying ventricular enlargeme

287 well as a more detailed understanding of the pathological mechanisms underpinning Parkinson's dementi

288 ll types needed to mimic disease and dissect pathological mechanisms, we have constructed, characteri

289 Collectively, this work identified a pathological mechanism whereby elevated phytosterols res

290 hus, tau mutations cause FTDP-17 by multiple pathological mechanisms, which may explain the phenotypi

291 anding the complexity of complement-mediated pathological mechanisms will aid in the development of a

292 tifying genes and pathways that may underlie pathological mechanisms with the neural models.