ライフサイエンスコーパス: pathologically

1 dence suggest that alpha-Syn and tau overlap pathologically.

2 henotypic heterogeneity, both clinically and pathologically.

3 ther biopsy results are negative or positive pathologically.

4 were evenly matched both demographically and pathologically.

5 ine expansion diseases differ clinically and pathologically.

6 n 167 women (75%), 56 of which were verified pathologically, 111 by cytology and/or during follow-up

7 re it stabilizes active GTP-rab5, leading to pathologically accelerated endocytosis, endosome swellin

8 uishing them from their normal counterparts: pathologically activated Akt signaling axis, increased c

9 better understand how these pathways become pathologically activated and to potentially identify new

10 Dynamic encounters with pathologically activated enhancers responsive to a range

11 Accumulation of pathologically activated immature myeloid cells with pot

12 regulation in extracellular matrix that are pathologically activated in MFS.

13 (hypoxia-inducible factor)-1alpha, which was pathologically activated in normoxic MCT-RVfib.

14 efinition of the molecular pathways that are pathologically activated in the disease.

15 oid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial fo

16 shown be play critical role in clearance of pathologically activated trypsin protecting against panc

17 s cause microcephaly by delaying mitosis and pathologically activating the mitotic surveillance pathw

18 -fixed thin sections of clinically acute and pathologically active cases of MS.

19 451, a radioligand with increased binding to pathologically affected regions in tauopathies and TDP-4

20 -specific fragmentation of NOTCH3 protein in pathologically affected vessels of human CADASIL-affecte

21 mals was significantly decreased, it did not pathologically alter kidney structure and functions unde

22 Myodural bridges may be pathologically altered in connective tissue disease as e

23 study was to focus on the interaction of the pathologically altered right heart with the anatomically

24 In ALS, pathologically altered TDP-43 is believed to lead to dis

25 of implantation >30 days and </=3 years were pathologically analyzed, and comparison of vascular resp

26 Dual-tracer PET/CT was performed on 35 pathologically and clinically confirmed and untreated pa

27 ral sclerosis (ALS) can overlap genetically, pathologically and clinically with FTD indicating the tw

28 Finally, DGCR8 was downregulated in pathologically and naturally aged hMSCs, whereas DGCR8 o

29 ible explanations is that FTD is clinically, pathologically, and genetically heterogeneous.

30 Relative to healthy control subjects, pathologically anxious participants exhibited enhanced r

31 tion with TXA enema prevented clinically and pathologically apparent pathogen-mediated AL in mice.

32 ent subsolid nodules (SSN) <==3 cm diagnosed pathologically as adenocarcinoma spectrum to investigate

33 physiologically as the second messenger and pathologically as an inducer of oxidative stress in inju

34 Such cases are generally referred to pathologically as encephalitis, not otherwise specified

35 Over half of all FTD cases are classified pathologically as frontotemporal lobar degeneration (FTL

36 dogenic proteins is that the majority of the pathologically associated proteins are involved in lipid

37 dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DN

38 ot previously known to be physiologically or pathologically associated with tau (e.g. RNA binding pro

39 s were extinguished in 50% of patients, were pathologically attenuated without a documented rod or co

40 Pathologically, Batten disease is characterized by lysos

41 Pathologically, BET proteins are frequently overexpresse

42 age and more severe airflow obstruction and pathologically by a second T2 network derived from T2-sk

43 se and Parkinson's disease are characterized pathologically by aberrant protein accumulation, such as

44 Alzheimer's disease, which is defined pathologically by abundant amyloid plaques and neurofibr

45 neurodegenerative diseases are characterized pathologically by accumulation of misfolded proteins as

46 etitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau

47 g autoimmune myopathy (NAM) is characterized pathologically by necrotic muscle fibers with absent or

48 ve neurodegenerative condition characterised pathologically by neuronal cell loss due to abnormal tau

49 the huntingtin gene (HTT) and characterized pathologically by the loss of pyramidal neurons in sever

50 are neurodegenerative disorder characterized pathologically by the presence of eosinophilic inclusion

51 Parkinson's disease (PD) is characterized pathologically by the selective loss of substantia nigra

52 y by symptoms of esophageal dysfunction and, pathologically, by an eosinophil-predominant tissue infi

53 ers, including Alzheimer's disease, that are pathologically characterized by aggregates of phosphoryl

54 disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine n

55 Microsatellite expansion disorders are pathologically characterized by RNA foci formation and r

56 Alzheimer's disease (AD) is pathologically characterized by the deposition of extrac

57 Alzheimer's disease (AD) is pathologically characterized by the deposition of the be

58 ted in ALS-FTD spectrum disorders, which are pathologically characterized by transactive response DNA

59 f ventricular MF have never been extensively pathologically characterized.

60 Pathologically classified resected lung adenocarcinomas

61 hird of patients with esophageal cancer show pathologically complete response after nCRT according to

62 After nCRT, one-third of patients have a pathologically complete response in the resection specim

63 We identified all cases with pathologically confirmed AD (NIA-Reagan intermediate-hig

64 brains of six cases with severe dementia and pathologically confirmed AD.

65 wing the initial FL diagnosis, including 147 pathologically confirmed and 232 clinically suspected ca

66 gional Veterans Affairs Medical Center and a pathologically confirmed Barrett's esophagus registry.

67 We identified 52 women with pathologically confirmed breast implant ALCL.

68 This study included 277 pathologically confirmed breast lesions.

69 1, participants included 17 individuals with pathologically confirmed CAA-ri and 37 control group mem

70 Studies of pathologically confirmed cancer patients were included i

71 In patients with pathologically confirmed CBD, accuracy of diagnosis was

72 al tissue samples derived from patients with pathologically confirmed central nervous system inflamma

73 Patients aged 18 years or older with pathologically confirmed diffuse large B-cell lymphoma,

74 in RAB39B cause intellectual disability and pathologically confirmed early-onset Parkinson disease.

75 We sought to determine the incidence of pathologically confirmed EGLs, by lesion type, among men

76 an HPV line-probe assay was performed on all pathologically confirmed EGLs.

77 nd a significant linear dose response for 38 pathologically confirmed follicular adenoma cases.

78 , we used GWAS metadata, tissue samples from pathologically confirmed frontotemporal lobar degenerati

79 mean age, 55 years; range, 19-94 years) with pathologically confirmed GIST who were identified with a

80 tients newly diagnosed as having cT1-2 N1-2b pathologically confirmed HPV-negative OPSCC in 2010 to 2

81 EGLs (n = 377) were pathologically confirmed in 228 men, 198 of whom had inc

82 dentified with the HR-OCT coincided with the pathologically confirmed margin mark in all eyes.

83 A postmortem cohort of pathologically confirmed MS (n = 47) and control (n = 10

84 8%) were correctly diagnosed in life and had pathologically confirmed multiple system atrophy.

85 We prospectively enrolled 112 patients with pathologically confirmed NETs of gastroenteropancreatic

86 y axillary burden after NST in patients with pathologically confirmed node-positive breast cancer (cN

87 med CAA-ri and 37 control group members with pathologically confirmed noninflammatory CAA.

88 Thirty patients with pathologically confirmed NSCLC were included.

89 demonstrated that loss of RAB39B resulted in pathologically confirmed Parkinson disease.

90 ition and analysis, were used to distinguish pathologically confirmed PCa patients from prostate beni

91 5 at 4 tertiary referral centers to identify pathologically confirmed PDAC patients.

92 and were at least 10 years post-diagnosis of pathologically confirmed primary Hodgkin's lymphoma.

93 Two of the patients had pathologically confirmed RCC in further evaluation.

94 ), 80 healthy controls, and 19 patients with pathologically confirmed RCC.

95 482 pathologically confirmed renal cell carcinoma lesions fr

96 o identify patients 66 years or older with a pathologically confirmed small kidney cancer (<4 cm) dia

97 d 18 years or older and had treatment-naive, pathologically confirmed stage IIIB or stage IV lung ade

98 er undertaken on brain samples from patients pathologically confirmed to have suffered from AD, and t

99 ars) were eligible for the study if they had pathologically confirmed, advanced (unresectable or meta

100 noglobulin G, and all sarcoidosis cases were pathologically confirmed.

101 NAs in pre-operative plasma from a cohort of pathologically-confirmed IPMN cases of various grades of

102 ibrillar Abeta deposits, hyperphosphorylated/pathologically conformed Tau, and premature neuronal los

103 be evaluated with a skin biopsy to visualize pathologically decreased densities of the small nerve fi

104 Thus, pathologically deficient Ca(2+) homeostasis during HF is

105 einaceous aggregates termed Lewy bodies that pathologically define synucleinopathies including Parkin

106 n in Alzheimer's disease (AD) differs across pathologically defined AD subtypes (hippocampal sparing

107 It is pathologically defined as intimal fibromuscular dysplasi

108 s including tauopathies, a group of diseases pathologically defined by accumulation of tau protein in

109 In total, 105 patients with pathologically defined CAA were included: 52 with autops

110 ose To evaluate MRI features associated with pathologically defined extraprostatic extension (EPE) of

111 The neostriatal atrophy that pathologically defines Huntington's disease was absent i

112 nic progenitor cell preferentially generates pathologically deleterious myofibroblasts after injury.

113 an essential mediator for the elimination of pathologically detached cells.

114 rison with a library of DESI mass spectra of pathologically determined tissue types.

115 Pathologically diagnosed human cases ranging from no lik

116 rom ageing controls and similar age subjects pathologically diagnosed with Alzheimer's disease, mixed

117 Thirty-three patients who were pathologically diagnosed with the presence of peritoneal

118 g function and the auditory tubes can become pathologically dilated.

119 Each of these risk factors pathologically disrupts the lipidome, including immunomo

120 idiopathic pulmonary fibrosis (IPF) are two pathologically distinct chronic lung diseases that are a

121 Pathologically distinct dementias exhibit characteristic

122 synuclein aggregates produces clinically and pathologically distinct diseases.

123 were previously associated with modifying a pathologically distinct form of muscular dystrophy and i

124 In pathologically distinct neuromuscular disorders, we aime

125 significant reduction in portal pressure in pathologically distinct PHT models, through augmentation

126 s of an individual with a neurologically and pathologically distinct repeat expansion disorder, spino

127 lymphoma (PMBL) represents a clinically and pathologically distinct subtype of large B-cell lymphoma

128 ally compartmentalized rifampin exposures in pathologically distinct TB lesions within the same patie

129 larly challenging to tackle because they are pathologically diverse and are often asymptomatic.

130 s, after injury to clear damaged neurons, or pathologically during disease.

131 loss occurs normally during development and pathologically during neurodegenerative disease.

132 Complete removal of gravity does not pathologically elevate ICP but does prevent the normal l

133 Pathologically elevated 1-deoxySL concentrations cause h

134 ore, we found that obese humans and mice had pathologically elevated concentrations of circulating as

135 However, the radiological markers of pathologically elevated ICP have not been specifically v

136 Our results show that the features of pathologically elevated ICP in children may differ consi

137 ring ICP and improving CPP for patients with pathologically elevated ICP on Earth.

138 activity of the amygdala and, consequently, pathologically elevated levels of negative affect.

139 The pathologically elevated mutant dynorphin A levels in the

140 Humans and mice with insulin resistance show pathologically elevated plasma asprosin, and its loss of

141 Electrophysiological analysis revealed a pathologically elevated synaptic activity in ChAc MSNs.

142 The disruption of pathologically enhanced beta oscillations is considered

143 scillations over the damaged hemisphere were pathologically enhanced both during the baseline-fixatio

144 has been hypothesized to act by reducing the pathologically enhanced semantic, anxiety-related associ

145 patch-clamp electrophysiology, we detected a pathologically enhanced synaptic activity in ChAc neuron

146 requency (15-30 Hz) oscillations that become pathologically exaggerated throughout basal ganglia circ

147 The median total inguinal lymph nodes pathologically examined (SLN + MILND) was 12.0 (interqua

148 9)Zr-trastuzumab by PET/CT were biopsied and pathologically examined to define HER2 status.

149 Pathologically, FXTAS is characterized by ubiquitin-posi

150 Pathologically, genetic alterations, including SETDB1 am

151 NSCLC is a genetically and pathologically heterogeneous disease, giving rise to lun

152 Frontotemporal dementia (FTD) is a pathologically heterogeneous neurodegenerative disorder

153 rmally small (6%) and physiological (25%) to pathologically high (50%) variability mimicking hyperten

154 croglial P2X7Rs being the primary targets of pathologically high extracellular ATP concentrations, al

155 In Parkinson's disease (PD), pathologically high levels of beta activity (12-30 Hz) r

156 Stimulation with pathologically high levels of Vegf, or overexpression of

157 de ((18)F-NaF) has the potential to identify pathologically high-risk nascent microcalcification.

158 eart development, exercise and pregnancy) or pathologically (high blood pressure and heart-valve regu

159 Pathologically, high levels of aldosterone are associate

160 Pathologically, human breast cancers with Snail1(+) CAF

161 y in cardiomyocytes from physiologically and pathologically hypertrophied rat hearts, and correlated

162 s of liver cysts that are radiologically and pathologically identical to those seen in autosomal domi

163 son's disease (PD), alpha-synuclein (alphaS) pathologically impacts the brain, a highly lipid-rich or

164 physiological malfunction are believed to be pathologically implicated in considerable neurological d

165 ses, when immune responses are dysregulated, pathologically important cells might represent only a sm

166 ions for a diverse range of functionally and pathologically important intrinsically disordered protei

167 (ADP)-ribosylation is a physiologically and pathologically important post-translational modification

168 s have been identified and these mutants are pathologically important, few theoretical studies have i

169 pha), induced physiologically by fasting and pathologically in diabetes, resulted in dramatic downreg

170 complications to be recognized and explained pathologically in patients with CKD.

171 sembly and may also perform other functions; pathologically, in contrast, alpha-synuclein misfolds in

172 al cardiac slow-twitch myofiber proteins and pathologically increased expression of genes encoding sk

173 ifferences between cases with clinically and pathologically indistinguishable characteristics, sugges

174 ell responses and antibody production within pathologically inflamed non-lymphoid tissues.

175 muscle biopsies, displaying efficacy only on pathologically inflamed samples.

176 berrant function of these systems, including pathologically inhibited superior colliculus activity, d

177 2-high" (T2-hi) phenotypic signature, which pathologically is driven by the type 2 cytokines Interle

178 ease feature that, while strongly associated pathologically, is poorly understood functionally.

179 ce of the disease is chicken line dependent; pathologically, it appeared to mimic avian leukosis but

180 Pathologically, JEV infection causes an acute encephalop

181 re of ENaC is yet undetermined, the bases of pathologically linked mutations in ENaC subunits alpha,

182 eover, we demonstrate that TDP-43, a protein pathologically linked to amyotrophic lateral sclerosis a

183 Furthermore, cells with pathologically low levels of cytoplasmic RNA are detecte

184 ive neurodegenerative disease resulting from pathologically low levels of survival motor neuron (SMN)

185 Furthermore, pathologically low or high variability moved mitochondri

186 Pathologically, LYG is graded by the number and density

187 Clinically and pathologically, MAS bears strong similarity to hemophago

188 howed a significantly lower discrepancy with pathologically measured necrosis (residual standard erro

189 Orthodontic treatment can successfully align pathologically migrated teeth and lead to improvement of

190 ly potentiates the propensity of alphasyn to pathologically misfold into uniquely toxic fibrils with

191 n may modulate the propensity of alphasyn to pathologically misfold; 3) compare experiments evaluatin

192 es are caused by PrP(Sc), a self-replicating pathologically misfolded protein that exerts toxicity pr

193 es SNARE-complex assembly at the synapse but pathologically misfolds into neurotoxic aggregates that

194 and human DMD tissues, Cx43 was found to be pathologically mislocalized to lateral sides of cardiomy

195 Pathologically, multiple system atrophy is characterized

196 overexpression of fluorescently tagged WT or pathologically mutant aSyn constructs.

197 volumes were reduced by omitting PORT to the pathologically negative (PN0) neck in patients with prim

198 LN status in VC, allowing the prediction of pathologically negative groins and thus the selection of

199 omote tumor progression along with many more pathologically neutral "passenger" events.

200 o identify cases of incident, nonmetastatic, pathologically node-negative breast cancer in women aged

201 with a survival benefit in high risk T2-4a, pathologically node-negative distal esophageal adenocarc

202 ant survival benefit in completely resected, pathologically node-negative distal esophageal adenocarc

203 rocess that uses averaging to regularize the pathologically noisy representation of letter feature po

204 f events that lead to cell transformation in pathologically normal epidermal cells that have been exp

205 proteoglycan, dcn Clinically, compared with pathologically normal human subjects, patients with IPF

206 arie-Tooth disease 1A, and classification as pathologically or clinically definite by MRC criteria wa

207 therapeutics effective for newly identified pathologically or molecularly defined subgroups.

208 tage-sensing domains (VSDs) are perturbed to pathologically or therapeutically modulate Na(+) current

209 at because the left hemisphere in neglect is pathologically over-excited it ought to be suppressed.

210 In those with T1R, the host immune response pathologically overcompensates for the actual infectious

211 cted individuals but also in individuals who pathologically overeat.

212 ent) asymmetric dimerization, as well as how pathologically overexpressed EGFR or constitutively acti

213 trophic lateral sclerosis are clinically and pathologically overlapping disorders with shared genetic

214 t cell activation occurs when mast cells are pathologically overproduced or if their activation is ou

215 The atrophic tubules display pathologically persistent signaling increases that trigg

216 Pathologically, persistent rims corresponded to an iron-

217 Pathologically, PHF5A K29 hyperacetylation and KDM3A upr

218 ory symptoms are hypothesized to arise when 'pathologically precise prior beliefs' mediated by attent

219 The observed changes tracked back to a pathologically primed stage in neural stem cells (NSCs),

220 ion and extracellular matrix deposition, and pathologically promoting fibrosis and cancer cell dissem

221 Pathologically, prostate cancer-associated SPOP mutants

222 Thirty (37%) patients had pathologically proved acute appendicitis.

223 e 4D CT and parathyroid surgery resulting in pathologically proved removal of adenoma from July 2010

224 of the 53 patients who were operated on had pathologically proven acute appendicitis.

225 Eleven cases of pathologically proven acute gangrenous cholecystitis and

226 nsent included 186 consecutive patients with pathologically proven advanced HGSC after primary cytore

227 Of 21 patients with pathologically proven axillary nodal metastases, (18)F-f

228 hip of antiphospholipid antibodies (aPLs) to pathologically proven brain infarcts.

229 We present a very unusual, pathologically proven case of clear cell variety of pedi

230 Adults (aged >=18 years) with a pathologically proven diagnosis of SCLC, Eastern Coopera

231 s retrospectively reviewed for patients with pathologically proven ECD.

232 (18)F-fluciclovine detected pathologically proven extraaxillary nodal metastases in

233 lyse CHCHD10 in a cohort of 21 families with pathologically proven frontotemporal dementia-amyotrophi

234 Patients with pathologically proven HER2-positive metastases subsequen

235 Retrospective study of 2840 patients with pathologically proven HNSCC undergoing curative RT at a

236 n1, according to the absence or presence of pathologically proven lymph node metastasis.

237 Forty-four patients (with pathologically proven lymphoma disease) underwent stagin

238 The prevalence of pathologically proven malignancy was 0.1% (3 of 1,597).

239 One hundred and twenty-eight patients with pathologically proven mCRC (512 liver metastases) underw

240 ognitive impairment in the largest number of pathologically proven multiple system atrophy cases desc

241 ein pathology, 148 consecutive patients with pathologically proven multiple system atrophy were revie

242 A benign IMLN was pathologically proven or defined as showing 1 year of im

243 vember 2012 to June 2014 in 94 patients with pathologically proven parathyroid adenomas or hyperplasi

244 informed consent, included 244 patients with pathologically proven serous ovarian cancer (mean age +/

245 retrospective study, patients diagnosed with pathologically proven solitary or multiple HCAs between

246 109 pathologically proven subsolid nodules (SSN) were segmen

247 The two LST lesions with BRAF mutation were pathologically proven to be serrated adenoma.

248 nalysis focused on patients with HCC who had pathologically proven vascular invasion (VI) because of

249 tified 10 patients with metastatic cancer (7 pathologically proven) who developed severe venous limb

250 Malignant IMLNs were pathologically proven.

251 Telomerase is pathologically reactivated in most human cancers, where

252 DR is pathologically recognized as bile duct hyperplasia and i

253 signaling in pyramidal neurons that in turn pathologically recruits l-type Ca(2+) channels to facili

254 e signaling in pyramidal neurons, which then pathologically recruits voltage-gated l-type Ca(2+) chan

255 This revealed pathologically reduced drift rate in the patient group,

256 Intracellular sensing of pathologically relevant biomolecules could provide essen

257 of premature senescence, a functionally and pathologically relevant cellular state.

258 s is involved in tissue injury induced under pathologically relevant conditions is poorly understood.

259 f infarction, nonischemic cryoinjury and the pathologically relevant coronary artery ligation, we con

260 tivation mediates EC permeability induced by pathologically relevant cyclic stretch.

261 ssion of SNAI1, a key modulator of EMT, is a pathologically relevant event in human acute myeloid leu

262 of active fibrogenesis, thus representing a pathologically relevant fibroblast subpopulation.

263 We show that the formation of pathologically relevant inclusions is driven by aberrant

264 rophin serves as a powerful co-stimulator of pathologically relevant pathways within the 'unhealthy'

265 We observed that formation of pathologically relevant protein inclusions was driven by

266 e inclusion of exon 17b in the SORT1 mRNA, a pathologically relevant splicing event known to be regul

267 Induction of this ligand/receptor system is pathologically relevant, as a decrease in apoptosis, aft

268 a pressing need to identify the few that are pathologically relevant.

269 yer at which FLG deficiency is thought to be pathologically relevant.

270 intact human prostate surface obtained with pathologically-relevant contrast and subcellular detail,

271 model in which fibroblasts are activated to pathologically remodel the ECM in IPF via a positive fee

272 oietin-like protein 2 (ANGPTL2) increases in pathologically-remodeled hearts of mice and humans, whil

273 or overwhelming threats can become activated pathologically, resulting in symptoms that resemble thos

274 ast cancer surgery were impedimetrically and pathologically scanned, analyzed, and probable electro-p

275 ropathological findings between FTLD-TDP and pathologically severe LATE-NC.

276 QAT scores were continuously distributed and pathologically shifted; 13.2% (95% CI, 10.3%-16.1%) of i

277 small-for-gestational-age (SGA) infants from pathologically small infants in a human cohort.

278 en those that are healthy and those that are pathologically small.

279 on of multiple sclerosis (MS) and may mark a pathologically specific proinflammatory component of the

280 hase-sensitive inversion recovery are highly pathologically specific when using existing scoring crit

281 o 2014 in the National Cancer Data Base were pathologically staged according to the 7th and 8th editi

282 hepcidin suppression in physiologically and pathologically stimulated erythropoiesis.

283 thin cardiac (coronary) endothelial cells of pathologically stressed hearts to trigger the Ace2-to-Ac

284 itial fibrosis and mechanical dysfunction of pathologically stressed hearts.

285 Pathologically swollen lymph nodes (LNs), or buboes, cha

286 Pathologically, the aberrant accumulation of senescent c

287 Pathologically, the amplification or activation of AURKA

288 Pathologically, the expression of EphA4 was detected in

289 of patients with AFP-producing tumors, but, pathologically, they had fewer lesions (25% vs 35% with

290 ion event during development and contributes pathologically to carcinoma and fibrosis progression.

291 as foot lesions similar both clinically and pathologically to those seen in digital dermatitis (DD)

292 Compared with pathologically typical cases, svPPA-tau showed significa

293 Ultimately, we found that optic-nerve crush pathologically upregulated activity in amacrine cells, w

294 his, the largest study of APOE e2 effects on pathologically verified CVD, e2 was not protective again

295 entified VZV antigen in 11 of 11 aortas with pathologically verified granulomatous arteritis, in 1 of

296 S: The study included 19 adult patients with pathologically verified renal tumors: 9 patients with cl

297 tified as a promising therapy for stiffening pathologically weakened corneas.

298 ,708 injection also restored the strength of pathologically weakened excitatory synaptic transmission

299 fts (VCA) can undergo rejection, manifesting pathologically with skin changes that form the basis of

300 y, with mice showing early onset ataxia, and pathologically, with progressive histologic evidence of