ライフサイエンスコーパス: pathomechanism

1 C-mediated protein degradation, suggesting a pathomechanism.

2 otrophic and can interact with more than one pathomechanism.

3 e of FLUX-reacting T cells in the underlying pathomechanism.

4 neovascular ("wet") AMD, suggesting a common pathomechanism.

5 firm our findings and explore the underlying pathomechanism.

6 and ciliary body edema may play role in the pathomechanism.

7 a mitochondrial encephalomyopathy of unknown pathomechanism.

8 tibodies has been proposed as the underlying pathomechanism.

9 rum of ADPKD phenotypes with a PC1-dependent pathomechanism.

10 nce supports that LOMG has a distinct immune pathomechanism.

11 n correlates may aid clinical translation of pathomechanism.

12 idence for the role of SDR9C7 in the disease pathomechanism.

13 of these transcripts will most likely inform pathomechanism.

14 o psoriasis rather than any knowledge of its pathomechanism.

15 s in these regions that might be relevant to pathomechanism.

16 erosis, which both involve macrophage-driven pathomechanisms.

17 tic uremic syndrome (aHUS) in the underlying pathomechanisms.

18 cellular phenotype and suggesting different pathomechanisms.

19 dentifying its causes, eliciting factors and pathomechanisms.

20 essive forms of OI suggests common molecular pathomechanisms.

21 n in mice through different gain of function pathomechanisms.

22 future treatment strategies targeting these pathomechanisms.

23 health conditions corresponding to distinct pathomechanisms.

24 with varying ages of onset, progression and pathomechanisms.

25 ta are modeled as networks and are mined for pathomechanisms.

26 outcomes and could contribute to delineating pathomechanisms.

27 ient neurons, suggesting different molecular pathomechanisms.

28 immune signatures and, ultimately, distinct pathomechanisms.

29 ult-to-predict adverse reaction with complex pathomechanisms.

30 f hiPSC differentiation to unveil long-range pathomechanisms.

31 ry studies help in deciphering the molecular pathomechanisms.

32 epresent different genetic and environmental pathomechanisms.

33 ferent fibrotic diseases also have different pathomechanisms.

34 eases and how these structures contribute to pathomechanisms.

35 levance of PI in CSU and we discuss possible pathomechanisms.

36 ient treatment modality interfering with GPP pathomechanisms.

37 and postictal arrhythmias suggest different pathomechanisms.

38 or fruitful and rapid investigation of viral pathomechanisms, a collaborative and interdisciplinary a

39 This study reveals a novel pathomechanism affecting muscle regeneration and mainten

40 se in turn have the potential to both inform pathomechanism and assist in the rational molecular clas

41 genesis is an important clue to decipher the pathomechanism and develop efficient therapies.

42 There is a marked heterogeneity of the pathomechanism and development of hereditary angioedema

43 Elucidating pathomechanism and identifying novel therapeutic targets

44 understanding of its clinical presentation, pathomechanism and role of various tick species in the d

45 le, scientists have proposed an immune-based pathomechanism and the condition has been coined vaccine

46 ma oscillation may have implications for the pathomechanism and treatment of cognitive impairment in

47 ul DN by matching to novel or established DN pathomechanisms and also for improved clinical trials st

48 mal model that can be used to define disease pathomechanisms and biologically important domains withi

49 ed by discussions of the anatomy, underlying pathomechanisms and clinical significance of individual

50 monstrate that astrocytes are central in VWM pathomechanisms and constitute potential therapeutic tar

51 Tape strips provide insight into disease pathomechanisms and cutaneous disease activity.

52 To explore pathomechanisms and develop new preclinical treatment ap

53 el 4 (BSL-4) facility, little is known about pathomechanisms and host interactions.

54 to regenerated human tissue can thus dissect pathomechanisms and identify targets that reverse diseas

55 improve the understanding of the underlying pathomechanisms and identify the optimal dosing for the

56 developments concerning the potential viral pathomechanisms and involvement of viruses in Sjogren's

57 These findings provide insight into pathomechanisms and may have therapeutic relevance for t

58 Further research addressing differences in pathomechanisms and outcomes of SVD between female and m

59 een widely used to understand kidney disease pathomechanisms and play an important role in drug disco

60 Localising these pathomechanisms and processes within and across differen

61 However, their underlying pathomechanisms and regulation of RAN translation remain

62 The presented concept elucidates diverse pathomechanisms and risks of malignancies in patients wi

63 ed in cancer and understanding the molecular pathomechanisms and therapeutic consequences of mutation

64 de a framework to identify genotype-specific pathomechanisms and therapeutic targets to accelerate th

65 , further supporting their importance as ALS pathomechanisms and therapeutics targets.

66 nges in autism spectrum disorder may clarify pathomechanisms and thereby help identify targets for dr

67 Rodent models are useful to dissect pathomechanisms and to develop treatment strategies.

68 ar and structural insights, has revealed new pathomechanisms and unmet clinical needs that have thrus

69 natural history, (2) exploring its metabolic pathomechanisms, and (3) characterizing its histopatholo

70 , it is possible that pore leak represents a pathomechanism applicable to many channel diseases.

71 Its cause and pathomechanism are not fully known.

72 n individuals develop MDH and the underlying pathomechanism are unclear.

73 lasia, although their cellular and molecular pathomechanisms are not precisely known.

74 The key underlying pathomechanisms are unclear.

75 fore, a pressing need to identify innovative pathomechanism-based effective therapies for this condit

76 artners and to get a holistic picture of the pathomechanism behind BIN1 SH3 domain variants, we used

77 es, EVs and their cargo may predict specific pathomechanisms behind disease phenotypes.

78 This suggested parallels in the pathomechanisms between the development of POPFs and pan

79 Neuroinflammation is implicated as a pathomechanism, but the upstream mechanisms driving glio

80 s are the key initial events of the cellular pathomechanisms by carrying out a detailed developmental

81 s are the key initial events of the cellular pathomechanisms by carrying out a detailed developmental

82 ase in humans, and elucidates the underlying pathomechanisms by deciphering the sequence of events fr

83 ular dynamics simulations suggested that the pathomechanisms by which the variants cause muscle disea

84 The understanding of the pathomechanisms by which these mutations produce phenoty

85 The underlying pathomechanisms can affect numerous pathways involved in

86 hy in humans and suggest that multiple KIF3B pathomechanisms can impair kinesin-driven ciliary transp

87 ue cytokine production suggests that several pathomechanisms can modulate the expression of the immun

88 hat they group into three distinct molecular pathomechanisms: class 1 ATF6 mutants show impaired ER-t

89 ed questions on the epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment ou

90 -contraction coupling, providing a potential pathomechanism contributing to myopathies.

91 d loci with disease and to shed light on the pathomechanisms contributing to FTD.

92 ency lead to macrocephaly, while an opposing pathomechanism due to variants in the PH-domain of WDFY3

93 e regulation has made it possible to unravel pathomechanisms, enabling the design of new therapeutic

94 ere, we investigated how misglycosylation, a pathomechanism encompassing several genetic disorders, m

95 cal thinning constitutes a relevant cortical pathomechanism for altered cognitive activation in schiz

96 ansion, and malapposition comprises the main pathomechanism for both early and late BVS thrombosis, s

97 viral infection of the kidneys as the major pathomechanism for COVID-19-related kidney injury and im

98 ns, and when impaired, may represent a novel pathomechanism for epilepsy.

99 ting pore current have been established as a pathomechanism for hypokalaemic periodic paralysis.

100 eta-induced apoptosis in podocytes and a new pathomechanism for podocyte depletion in progressive glo

101 The pathomechanism for pycnodysostosis has been largely unkn

102 The pathomechanism for the myotonic dystrophies is not well

103 Moreover, we delineate a molecular pathomechanism for the neuropsychiatric symptoms of pati

104 ssion, here we suggest a critical role in AD pathomechanism for this phylogenetic layer-specific adap

105 Although the underlying pathomechanisms for differential GA progression remain u

106 By understanding distinct pathomechanisms, for example, the role of IL-1, novel en

107 t of segmental aortic stiffening as an early pathomechanism generating aortic wall stress and trigger

108 A new pathomechanism has recently been identified in a group o

109 Elucidating pathomechanisms has been hampered by disease heterogenei

110 The underlying pathomechanisms have not been fully understood and we re

111 3-sulfate (CSO(4)) in the epidermis but the pathomechanism how elevated epidermal CSO(4) causes icht

112 The pathomechanisms, however, are poorly understood.

113 ted podocyte phenotype and suggests a common pathomechanism in collapsing FSGS, whether idiopathic or

114 Endothelial dysfunction is a central pathomechanism in diabetes-associated complications.

115 rotein interactions, and represents a common pathomechanism in HCM.

116 The key pathomechanism in humans with persistent speech comprehe

117 lar ion and fluid secretion may constitute a pathomechanism in lung edema and aimed to identify under

118 of microRNA target sites might be a relevant pathomechanism in Mendelian disorders.

119 -beta-induced podocyte apoptosis is an early pathomechanism in mice developing focal-segmental glomer

120 together, our results provide a novel common pathomechanism in multiple polyglutamine diseases that i

121 dies in the inflamed lung represents a novel pathomechanism in sarcoidosis and should be considered f

122 the clinical relevance of WMH and underlying pathomechanism in the brain.

123 tosis of lung epithelial cells is a relevant pathomechanism in the development of hemorrhage-induced

124 lasts, further supporting a loss-of-function pathomechanism in this disease.

125 ans, and suggest a possible gene-environment pathomechanism in this disease.

126 d approach furthers the understanding of the pathomechanisms in ADHD and may advance treatment strate

127 ildren with AD and to investigate underlying pathomechanisms in atopic skin.

128 e metabolisms have recently emerged as novel pathomechanisms in diseases with mitochondrial dysfuncti

129 VB) and to characterize the mutation-related pathomechanisms in familial SND+AVB.

130 the potential of ECV to differentiate among pathomechanisms in HFpEF.

131 te our understanding of atopic dermatitis/AD pathomechanisms in infants/toddlers with early-onset AD,

132 ality and balance, suggesting convergence of pathomechanisms in microsatellite expansion disorders an

133 ification has furthered the understanding of pathomechanisms in steroid-resistant nephrotic syndrome

134 rations, which had correlations to known ALS pathomechanisms in the basic and clinical literature, an

135 ror brain size phenotypes caused by distinct pathomechanisms in Wnt/beta-catenin signaling through pr

136 r substrates of this OA-related inflammatory pathomechanism, in porcine articular chondrocytes expose

137 l as in intronic regions, and the mutational pathomechanisms included transcriptional repression, exo

138 Its etiology and pathomechanism is largely unknown, but misrouting of the

139 with a pronounced seasonal pattern, but the pathomechanism is not understood.

140 ocular surface disease (DAOSD), of which the pathomechanism is poorly understood.

141 The pathomechanism is still not fully understood, but there

142 The underlying pathomechanism is unclear.

143 Among the proposed pathomechanisms is coronary vasospasm.

144 A more complete understanding of underlying pathomechanisms is leading to new treatments, which will

145 It is unclear whether similar or different pathomechanisms lead to these distinct clinical presenta

146 Our data reveal that the immunometabolic pathomechanism leading to COPD progression is characteri

147 conductance regulator (CFTR) as an important pathomechanism leading to lung barrier failure in pneumo

148 To elucidate the pathomechanism leading to obstructive vascular disease i

149 ly and provide a basis for understanding the pathomechanisms leading from mutations in the COL7A1 gen

150 Nevertheless, we are focused on the pathomechanisms leading to CSSs, including impairment of

151 A deeper understanding of the pathomechanisms leading to stress-related psychiatric di

152 sease risk and indicated that common genetic pathomechanisms may mediate specific symptoms that are s

153 A synopsis of pathomechanisms, novel differential diagnoses, and advan

154 t, not impaired CSF dynamics, as the primary pathomechanism of a significant number of patients with

155 Herein, we discuss the pathomechanism of adverse reactions to biological agents

156 lammatory signaling pathways involved in the pathomechanism of ALD.

157 involve biological processes relevant to the pathomechanism of ALS.

158 great interest in further understanding the pathomechanism of ASPD.

159 Insight into the pathomechanism of atopic diseases demonstrated a pivotal

160 interaction is an essential component of the pathomechanism of bipolar disorder.

161 The pathomechanism of bronchiolitis obliterans remains uncle

162 The role of the venous environment in the pathomechanism of CCMs remains unclear.

163 phrotic syndrome, and ROS formation may be a pathomechanism of COQ2-nephropathy.

164 ctional analysis revealed that the molecular pathomechanism of D126G was the failure of protein secre

165 ggest involvement of Th17 lymphocytes in the pathomechanism of disc degeneration.

166 rming gain-of-glycosylation in P0 as a novel pathomechanism of disease.

167 The pathomechanism of DM1 is driven by accumulation of toxic

168 apse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in hum

169 US in cultured cells, and their roles in the pathomechanism of fALS remain obscure.

170 lying genetic lesion, offer insight into the pathomechanism of FCD.

171 yperexcitability of GABAergic neurons as the pathomechanism of FHM type 3.

172 et of pathogenic mutations is an alternative pathomechanism of FUS-related fALS diseases.

173 mannose-binding lectin-lectin pathway in the pathomechanism of HAE-C1-INH.

174 nt stimulatory effects on fibroblasts as the pathomechanism of hedgehog signaling in cGVHD.

175 Cx43 expression; this process is a possible pathomechanism of keratinocyte hyperproliferation in pso

176 suggests a role for activated T cells in the pathomechanism of liver damage.

177 f FLUX-reacting cytotoxic lymphocytes in the pathomechanism of liver injury and to dissect the involv

178 d a role for cytotoxic CD8(+) T cells in the pathomechanism of liver injury caused by FLUX.

179 plasmic transport is emerging as a prominent pathomechanism of multiple neurodegenerative diseases, i

180 Although the pathomechanism of NTG is still unknown, previous studies

181 structural abnormalities are related to the pathomechanism of PDM.

182 ch is potentially valuable for understanding pathomechanism of PDM.

183 Damage to podocytes is a central pathomechanism of proteinuric kidney disease.

184 A question has arisen regarding the pathomechanism of PXE, particularly the "metabolic" vers

185 thepsin K function provides insight into the pathomechanism of pycnodysostosis and may provide new dr

186 Moreover, to investigate the pathomechanism of RA by identifying correlations between

187 ely, our data indicate a potential causative pathomechanism of SCZ.

188 entifies cellular and matrix elements of the pathomechanism of SED.

189 fected by T. cruzi and provide a clue to the pathomechanism of sustained inflammation in Chagas disea

190 r acidic conditions might be relevant to the pathomechanism of the Asn-21 --> Ile mutation in heredit

191 is a valuable resource in understanding the pathomechanism of the disease.

192 P mutations failed to adequately explain the pathomechanism of the disease.

193 o C1-INH deficiency to better understand the pathomechanism of the evolution, course, and complete re

194 This study aimed to characterize the pathomechanism of the extracorporeal membrane oxygenatio

195 The pathomechanism of the mineralization is still obscure.

196 opathy in A/J(dys-/-) and BLAJ mice, but the pathomechanism of the myopathy is not understood.

197 gic children will outgrow their allergy, the pathomechanism of the natural development of tolerance r

198 Whereas the pathomechanism of the secondary mitochondrial dysfunctio

199 ect in mitochondrial translation defines the pathomechanism of their clinical disease.

200 epilepsy with centrotemporal spikes, and the pathomechanism of these epilepsies may be based on haplo

201 ation assays demonstrate that the underlying pathomechanism of these mutations is most likely a loss

202 However, the pathomechanism of this condition remains unclear.

203 To investigate the pathomechanism of this disease, we generated and phenoty

204 fects are at least partially involved in the pathomechanism of this disorder.

205 nce to a systemic involvement of H2O2 in the pathomechanism of vitiligo.

206 similarities and differences of two distinct pathomechanisms of arterial calcifications: intimal asso

207 rgetic coupling is required to delineate the pathomechanisms of BTHS cardiomyopathy.

208 h CD, monitoring treatment, and studying the pathomechanisms of CD and development of preventive and

209 that may lead to better understanding of the pathomechanisms of chronic GvHD.

210 provide a new model with which to study the pathomechanisms of CKD.

211 g these processes is crucial for elucidating pathomechanisms of connective tissue disorders character

212 functions, providing detailed insights into pathomechanisms of COVID-19 and informing therapeutic st

213 e believed to play a significant role in the pathomechanisms of CRS.

214 insight into specific uremia- and PD-induced pathomechanisms of CVD.

215 c pathways are thought to be involved in the pathomechanisms of different inflammatory phenotypes of

216 f the signalling pathways at the NMJ and the pathomechanisms of DOK7 CMSs.

217 ious neuroimaging research mainly focused on pathomechanisms of dyslexia at the cerebral cortex level

218 The pathomechanisms of ectopic mineralization are poorly und

219 Molecular pathomechanisms of enhanced reactive oxygen species (ROS

220 In a complementary approach to study pathomechanisms of FOXD2-dysfunction-mediated developmen

221 eveloped to advance our understanding of the pathomechanisms of genodermatoses.

222 d to greater understanding of the underlying pathomechanisms of giant cell arteritis.

223 We sought to investigate pathomechanisms of HI that could lead to the identificat

224 the mechanisms of tissue homeostasis and the pathomechanisms of human disease.

225 TCC-induced effects may play a role in the pathomechanisms of inflammatory disorders of the bone, i

226 erplay between these proteins is part of the pathomechanisms of MLC.

227 However, relevant pathomechanisms of nephrotic syndrome have not been stud

228 s functions in mammals and help to elucidate pathomechanisms of neurological abnormalities in muscula

229 A better understanding of pathomechanisms of neurological deterioration may lead t

230 Although the pathomechanisms of pathologic calcification are poorly u

231 framework to consolidate seemingly distinct pathomechanisms of progression of glomerular and tubuloi

232 The roles of IL-22 in the pathomechanisms of psoriasis have been well demonstrated

233 t a powerful model for both establishing the pathomechanisms of recessive RYR1 RM and pre-clinical te

234 derived free radicals play a central role in pathomechanisms of reperfusion injury after organ transp

235 recise roles of CEP290 in photoreceptors and pathomechanisms of retinal degeneration in CEP290-associ

236 Our study provides insights into the pathomechanisms of retinal degenerations associated with

237 The excretion pathomechanisms of SARS-CoV-2 are actually unknown.

238 Here, we investigate pathomechanisms of sensory hair cell death and suggest a

239 nding mouse models, provide insight into the pathomechanisms of soft tissue mineralization and point

240 erstanding neural mechanisms involved in the pathomechanisms of specific affective disorders.

241 ncer and address the clinical phenotypes and pathomechanisms of specific neurotoxic chemotherapeutic

242 ported and have been implicated as potential pathomechanisms of Sudden Unexpected Death in Epilepsy (

243 aggerated CD4(+)Tem response fits within the pathomechanisms of T1D and how the effector memory can b

244 Currently, the cellular and molecular pathomechanisms of the DES mutations leading to this dis

245 factors that make uncovering of the precise pathomechanisms of these acquired disorders exceedingly

246 ers it a potential common denominator in the pathomechanisms of these hereditary disorders.

247 )), respectively, to determine the differing pathomechanisms of these mutants.

248 This model will help further discover the pathomechanisms of this devastating disease.

249 ency of these models for studying AD-related pathomechanisms over time.

250 is caused by mutated TIA1 through a dominant pathomechanism probably involving altered stress granule

251 osphate, and the findings suggest a unifying pathomechanism relating to reduced inorganic pyrophospha

252 nt is not available, and many details of the pathomechanism remain unclear.

253 nt and progression, yet pinpointing specific pathomechanisms remain challenging.

254 ompletely understood as potential underlying pathomechanisms remain elusive, and no relationship to t

255 levance for outcome and survival, underlying pathomechanisms remain inadequately understood.

256 dividual and societal burden, the underlying pathomechanisms remain largely unknown.

257 une-mediated fibroinflammatory disease whose pathomechanisms remain poorly understood.

258 The precise pathomechanisms remain to be elucidated.

259 ogy of mood and anxiety disorders, but exact pathomechanisms remain to be understood.

260 related to complement dysregulation, but the pathomechanisms remain unknown in at least 30% of patien

261 Still, the evolutionary dimension of AD pathomechanism remains difficult to prove and has not be

262 ion, but effective targeting of this central pathomechanism remains elusive.

263 Here, we analyzed the pathomechanisms responsible for growth alterations in tr

264 The pathomechanism(s) by which mutant Cx26 hemichannels pert

265 Aiming to revitalize interest in pathomechanism-tailored RIA management, we describe the

266 sosomal homeostasis, illuminates a potential pathomechanism that is relevant to the role of AP-5 in n

267 H reveals novel insights into the integrated pathomechanisms that distinguish pathological versus phy

268 e growing knowledge in this field, the exact pathomechanisms that drive fibrosis remain elusive.

269 The molecular pathomechanisms that drive keloid formation are only par

270 diseases has increased our understanding of pathomechanisms that is relevant to common neurological

271 ation have been proposed as putative primary pathomechanisms that may underlie progression of renal d

272 characterized by complex genetic traits and pathomechanisms that translate into clinical heterogenei

273 oimmunity may lead to the discovery of novel pathomechanisms, therapeutic targets, and optimal biomar

274 olled investigation exploring the underlying pathomechanisms through the assessment of disease onset

275 cascade that is essential for the underlying pathomechanism, thus expanding the list of potential fut

276 uence of our incomplete understanding of the pathomechanisms triggered by HCM-causing variants.

277 ntial for hemostasis, but it is also a major pathomechanism underlying ischemic injury.

278 ole of KBTBD13 in muscle is unknown, and the pathomechanism underlying NEM6 is undetermined.

279 ylation has become a focus of attention as a pathomechanism underlying severe congenital muscular dys

280 Clarifying the pathomechanism underlying this gene-disease relationship

281 es could be fundamental in understanding the pathomechanisms underlying autism spectrum disorder.

282 odels in this study can be used to elucidate pathomechanisms underlying chemotherapy-induced polyneur

283 However, pathomechanisms underlying EFE formation are still scarc

284 ibuted to our understanding of the molecular pathomechanisms underlying muscle degeneration.

285 sis has transformed our understanding of the pathomechanisms underlying neurodegeneration.

286 al, genetic, and pathologic backgrounds, the pathomechanisms underlying neuromuscular disorders might

287 The pathomechanisms underlying restenosis of the bioabsorbab

288 of genetic modifiers to unravel the cellular pathomechanisms underlying SMA and the power of combinat

289 The pathomechanisms underlying the development of cutaneous

290 , we elucidate the intricate immunometabolic pathomechanisms underlying the obesity and autoimmunity

291 The pathomechanisms underlying very late stent thrombosis (V

292 r TBI will be needed to fully understand the pathomechanisms underpinning blood biomarkers' trajector

293 permitted identification of many novel FSHD pathomechanisms undetectable by previous approaches.

294 To study pathomechanisms using mouse models that recapitulate the

295 To further elucidate pathomechanisms, we examined whether heart-specific Dsg2

296 Expression of markers relevant for these pathomechanisms were analysed in biopsies of sIBM, polym

297 its severe cardiotoxic potential by a novel pathomechanism, where the concurrent dual functional sta

298 n in chondrocytes resulted in a feed-forward pathomechanism whereby increased function of Piezo1 indu

299 al occlusion by aggregated NETs emerges as a pathomechanism with relevance in a plethora of inflammat

300 r allogeneic antigens; however, they share a pathomechanism with the activation of cytotoxic T lympho