ライフサイエンスコーパス: pathophysiologic

1 ive prognostic significance of each of these pathophysiologic abnormalities in HFpEF is unknown.

2 a tool for evaluating one of the fundamental pathophysiologic abnormalities seen in heart failure (HF

3 erogeneous syndrome associated with multiple pathophysiologic abnormalities, including left ventricul

4 With increasing number of pathophysiologic abnormalities, there was a gradual incr

5 in HFpEF, reduced (worse) LA strain is a key pathophysiologic abnormality and is a stronger correlate

6 Specifically, pathophysiologic acidification inhibits CaR activity, th

7 Syt10 underlying the response of neurons to pathophysiologic activity and provide new therapeutic pe

8 Intriguingly, pathophysiologic activity can also trigger signaling cas

9 the Syt10 gene, which is strongly induced by pathophysiologic activity.

10 We investigated whether pathophysiologic alterations associated with IBS have cu

11 In this review, we summarize the salient pathophysiologic and clinical aspects of left bundle bra

12 obstruction with thick, adherent mucus is a pathophysiologic and clinical feature of muco-obstructiv

13 Here, we review the pathophysiologic and electrocardiographic correlations t

14 Uncontrolled inflammation is now considered pathophysiologic and is associated with many widely occu

15 tion content derived from imaging to include pathophysiologic and molecular processes.

16 The conflict between pathophysiologic and pragmatic feeding strategies remain

17 highlights and discusses clinical, genetic, pathophysiologic, and therapeutic aspects of this common

18 l mouse models of NASH, some exhibit the key pathophysiologic as well as histopathologic criteria for

19 these neuroimaging markers reflect distinct pathophysiologic aspects in CAA, no studies to date have

20 izures by (18)F-FET PET and to elucidate the pathophysiologic background.

21 Thus, these novel observations provide the pathophysiologic basis for the deregulation of glucose a

22 dosteronism, in HF and RHT, has provided the pathophysiologic basis for the inclusion of MRA in the o

23 first step towards better understanding the pathophysiologic basis of chronic antibody-mediated allo

24 presents mechanistic evidence related to the pathophysiologic basis of neonatal dysphagia as well as

25 We aimed to determine the pathophysiologic basis of the ST-segment in the BrS-ECG

26 ey have provided important insights into the pathophysiologic basis of these disorders and potential

27 The pathophysiologic basis of V2R-dependent cyst proliferati

28 te a key component of the chronic bronchitis pathophysiologic cascade that produces sputum and mediat

29 In this review, we define different pathophysiologic categories of AP dysfunction.

30 The pathophysiologic cause of delirium is not well understoo

31 en described, but the understanding of their pathophysiologic causes and neuroanatomical correlates r

32 gents to blunt LV dysfunction and associated pathophysiologic causes reported in PLWH.

33 stage in the Clinical, Etiologic, Anatomic, Pathophysiologic (CEAP) classification and across differ

34 istinctly altered local environment, several pathophysiologic changes are found that may promote brea

35 ysfunction grading system and understand the pathophysiologic changes associated with various grades

36 r extremity ischemia is also associated with pathophysiologic changes in calf skeletal muscle, includ

37 variations in interpretations resulted from pathophysiologic changes in corneal hydration and other

38 ne alterations with implications for chronic pathophysiologic changes in gastrointestinal tract.

39 The degree of ischemia-related pathophysiologic changes in lower extremity muscles and

40 d PTH secretion in vivo, we examined whether pathophysiologic changes in pHo can significantly alter

41 sturbed purinergic signaling might result in pathophysiologic changes like edema formation and atelec

42 Understanding the circulatory and pathophysiologic changes that occur within the uteroplac

43 o date there is almost no information on the pathophysiologic changes within the cerebral spinal flui

44 nterpretation of imaging cues as measures of pathophysiologic changes, characterization of the vascul

45 a discrete illness subtype, but to date its pathophysiologic characteristics are undetermined.

46 ion during hemodialysis, a first step toward pathophysiologic characterization of hemodialysis-mediat

47 scular smooth muscle cells (PAVSMCs) are key pathophysiologic components of pulmonary vascular remode

48 PARs and their cofactors in physiologic and pathophysiologic conditions have the potential to influe

49 es of the role of PXR in the physiologic and pathophysiologic conditions of other cellular processes

50 Under pathophysiologic conditions, however, immunity arises in

51 etachment from the GBM under physiologic and pathophysiologic conditions, including glomerular hypert

52 In other pathophysiologic conditions, such as volume overload, di

53 ream of growth factors in a diverse array of pathophysiologic conditions.

54 lating a number of physiologic processes and pathophysiologic conditions.

55 nt suggests that it is a relevant and direct pathophysiologic consequence of mHTT expression.

56 ven macrophage-mediated inflammation and its pathophysiologic consequences in sickle cell disease.

57 ing persistent overproduction of ROS and its pathophysiologic consequences.

58 specificity of S1P1 activation in normal and pathophysiologic contexts in vivo and can be applied to

59 tional cell biological systems in normal and pathophysiologic contexts remain poorly understood.

60 (BMI) and the risk of stillbirth defined by pathophysiologic contributors or causes.

61 lucose tolerance, in order to identify early pathophysiologic defects.

62 lasses designed to target one or more of the pathophysiologic derangements in acute decompensated hea

63 sed to test the impact of CFTR modulators on pathophysiologic development and correction.Methods: In

64 in biochemical pathways and how they promote pathophysiologic developments involving proinflammatory

65 from a diagnosis of exclusion into a direct pathophysiologic diagnosis.

66 ar vesicles will provide insights into their pathophysiologic, diagnostic, and therapeutic roles.

67 g body of literature demonstrating important pathophysiologic differences between ALI caused by diffe

68 ocusing especially on possible etiologic and pathophysiologic differences.

69 cardiac and noncardiac comorbidities, valve pathophysiologic disorders, and echocardiographic measur

70 This work strongly supports the notion of pathophysiologic divergence between individuals with sch

71 ured a panel of biomarkers representing four pathophysiologic domains: "inflammation" (tumor necrosis

72 s open the possibility that a physiologic or pathophysiologic downregulation of PDE4 activity/express

73 he importance of vascular alterations as key pathophysiologic drivers in lethal COVID-19.Supplemental

74 rexinoids would more effectively reverse the pathophysiologic effects of angiotensin II than an indiv

75 n linked to cancer, neurotoxicity, and other pathophysiologic effects.

76 No distinct pathophysiologic elements or specific biomarkers have be

77 HD and may have value in further elucidating pathophysiologic events and therapeutic strategies.

78 We demonstrate that central pathophysiologic events in ALI (inflammation, IL-1beta l

79 munologic responses governing biological and pathophysiologic events including the development of ski

80 ations in pH elicited by neural activity and pathophysiologic events such as hypoxia-ischemia and sei

81 m of miRNA-mediated integration of the early pathophysiologic events that facilitate tissue remodelli

82 Three major pathophysiologic events were considered to constitute CI

83 2 or HIF-1alpha can prevent or reverse these pathophysiologic events, restoring a state of insulin se

84 ng mechanistic insights into a wide range of pathophysiologic events.

85 nfluence a wide range of seemingly unrelated pathophysiologic events.

86 omerular hyperfiltration as a prognostic and pathophysiologic factor in diabetes may lead to improved

87 Little is known about the link between pathophysiologic factors and symptoms of irritable bowel

88 ferences may be the basis for the underlying pathophysiologic factors contributing to the development

89 of risk factors for MH may help clarify the pathophysiologic factors of MH and identify potential ne

90 At least 3 pathophysiologic factors were present in 20% of patients

91 (Hospital Anxiety and Depression scale), as pathophysiologic factors.

92 cell arteritis, and 1 of 193 (0.5%) for the pathophysiologic features of central retinal artery occl

93 Pathophysiologic features of CUNV were observed to be si

94 volume (ECV) accumulation is one of the key pathophysiologic features of heart failure with preserve

95 This mouse model mimics the pathology and pathophysiologic features of human adult-onset branching

96 a being a predictor of surgical success, the pathophysiologic features of open-angle glaucoma in youn

97 geable ranged from 29 of 199 (14.6%) for the pathophysiologic features of retinal detachment, 1 of 20

98 model of HCDD efficiently recapitulates the pathophysiologic features of the disease and demonstrate

99 ic, filter, and haptic materials; as well as pathophysiologic features of uveal biocompatibility, cap

100 ch disease, including 1 question about basic pathophysiologic features, 1 question about basic sympto

101 troparesis, therefore the diseases may share pathophysiologic features.

102 underlying dimensional vs disorder-specific pathophysiologic features.

103 hy and may represent an important underlying pathophysiologic foundation for cystoid macular edema in

104 ated methylation signatures discriminate HIV pathophysiologic frailty.

105 However, little is known about the pathophysiologic functions of kidney DN T cells.

106 significantly influence both physiologic and pathophysiologic glutamatergic neurotransmission.

107 photoacoustic measurements; upon addition of pathophysiologic H(2)O(2) concentrations, a clear increa

108 Aside from pathophysiologic imaging studies, an mGluR2 PET tracer w

109 onary disease (COPD), but their clinical and pathophysiologic implications have not been defined.

110 and should stimulate further studies on the pathophysiologic implications of RAGE axis in the mechan

111 rapeutics, have now clearly demonstrated the pathophysiologic importance of the complement system in

112 ls known for immunosuppressive properties in pathophysiologic inflammatory conditions.

113 Such pathophysiologic insights have led to the identification

114 These findings provide pathophysiologic insights into underlying causes of mort

115 On the basis of recently obtained pathophysiologic insights, we postulated that measuring

116 ory systems in isolation, ignoring the major pathophysiologic interactions between the systems in man

117 ted by the inability to accurately replicate pathophysiologic interactions of GBM cells with unique a

118 Here, we demonstrate that pathophysiologic levels of bilirubin excite peripheral i

119 ll-restricted IR/IGF-1R signaling provides a pathophysiologic link between systemic insulin resistanc

120 nal CNM-associated gene provide a definitive pathophysiologic link with these disorders, confirm that

121 fusogenicity, replicative fitness, and other pathophysiologic manifestations.

122 e used to determine the associations between pathophysiologic markers and outcomes.

123 improve care and should be guided by direct pathophysiologic markers of arrhythmic substrate, such a

124 ASD) (PTEN-ASD), with the aim of identifying pathophysiologic markers that specifically associate wit

125 Future studies may examine the pathophysiologic meaning of the finding.

126 Disruption of such connectivity is a key pathophysiologic mechanism for ADHD, and identifying her

127 scular inflammation is posited as a unifying pathophysiologic mechanism for heart failure with preser

128 idity-driven microvascular inflammation as a pathophysiologic mechanism for many but not all HFpEF pa

129 Together, these findings provide a plausible pathophysiologic mechanism for Scn1a gene mutation to im

130 aling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia.

131 However, the underlying pathophysiologic mechanism is still poorly understood.

132 the effects of dopamine dysregulation on the pathophysiologic mechanism of psychotic symptoms.

133 f PRDM13 in macular development, whereas the pathophysiologic mechanism of the fifth remains unknown

134 penetrant CID phenotype through a different pathophysiologic mechanism than previously described for

135 made in our understanding of the genetic and pathophysiologic mechanism underlying the development an

136 ate AD development, and explore the possible pathophysiologic mechanism.

137 rologic consequences might reveal underlying pathophysiologic mechanisms and clinical implications of

138 riants will provide insights into underlying pathophysiologic mechanisms and facilitate the developme

139 vo, in vitro, and in silico to better define pathophysiologic mechanisms and identify novel therapeut

140 fying subtypes of patients who share similar pathophysiologic mechanisms and may respond more uniform

141 risk factor for disease progression, but the pathophysiologic mechanisms are only incompletely unders

142 ure of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood.

143 Although the pathophysiologic mechanisms behind cardiac toxicity have

144 ively, our results provide insights into the pathophysiologic mechanisms behind chronic neurodegenera

145 We suspect that the pathophysiologic mechanisms by which HS virus infects ne

146 ity observed in HX and indicate that various pathophysiologic mechanisms contribute to the HX phenoty

147 rcise impairment, indicating that additional pathophysiologic mechanisms contribute to the limb manif

148 complement cascade, led us to consider other pathophysiologic mechanisms for this disease.

149 obesity-related traits may arise from shared pathophysiologic mechanisms in patients with MDD.

150 Because dietary intake may influence pathophysiologic mechanisms in sporadic amyotrophic late

151 Common pathophysiologic mechanisms include systemic and endomyo

152 , there is still very little known about the pathophysiologic mechanisms involved.

153 minophen-induced hypotension, and assess the pathophysiologic mechanisms involved.

154 Various pathophysiologic mechanisms leading to sickness behavior

155 However, elucidation of the multiple pathophysiologic mechanisms leading to vaso-occlusion an

156 date our findings and to delineate the exact pathophysiologic mechanisms linking migraine and OMCNP.

157 Although the pathophysiologic mechanisms linking these phenomena have

158 Biomarkers of diverse pathophysiologic mechanisms may improve risk stratificat

159 Pathophysiologic mechanisms may include loss of toleranc

160 y of research has begun to shed light on the pathophysiologic mechanisms of CSA.

161 flammatory response to surgery are potential pathophysiologic mechanisms of delirium.

162 Among the various pathophysiologic mechanisms of electrical instability, l

163 Recent advances in the understanding of the pathophysiologic mechanisms of strokelike episodes in ME

164 evidence suggests that age affects the main pathophysiologic mechanisms of the acute respiratory dis

165 d risk of ischemic heart disease, though the pathophysiologic mechanisms remain unclear.

166 ial) function is important to understand the pathophysiologic mechanisms that contribute to MVD and t

167 Details of the pathophysiologic mechanisms that underlie complex disord

168 These findings elucidate the pathophysiologic mechanisms underlying acute postinfecti

169 Recent progress in the understanding of pathophysiologic mechanisms underlying IgE-associated al

170 Background The pathophysiologic mechanisms underlying painful symptoms

171 Furthermore, better delineation of the pathophysiologic mechanisms underlying the development o

172 This review will evaluate the multiple pathophysiologic mechanisms underlying the exercise impa

173 Endotypes further describe the functional or pathophysiologic mechanisms underlying the patient's dis

174 ave important implications for understanding pathophysiologic mechanisms underlying the synucleinopat

175 us HFrEF, emphasizing prevalence, underlying pathophysiologic mechanisms, and outcomes.

176 ification and ontology slow the discovery of pathophysiologic mechanisms, biobehavioral markers, risk

177 g with PET may offer important insights into pathophysiologic mechanisms, diagnosis, and disease prog

178 Insulin resistance results from several pathophysiologic mechanisms, including chronic tissue in

179 , clinical trials have focused on high-yield pathophysiologic mechanisms, including protein aggregati

180 To evaluate pathophysiologic mechanisms, we explored the relationshi

181 t disease entities characterized by specific pathophysiologic mechanisms.

182 TR should contribute to the understanding of pathophysiologic mechanisms.

183 s and prostate cancer appear to share common pathophysiologic mechanisms.

184 ancer and supports the possibility of common pathophysiologic mechanisms.

185 of RPD with other diseases that have defined pathophysiologic mechanisms.

186 share common histopathological features and pathophysiologic mechanisms.

187 es are subtypes of disease based on distinct pathophysiologic mechanisms.

188 d cellular phenotypes suggesting overlapping pathophysiologic mechanisms.

189 tolic dysfunction is widely considered a key pathophysiologic mediator of HFpEF, the prevalence of co

190 A better understanding of the pathophysiologic nature of HIV reservoirs and the impact

191 and the gene expression landscape underlying pathophysiologic network behavior in brain structures su

192 ont field mapping of persistent AF reveals a pathophysiologic network of a small number of spatially

193 study provides insight into the mechanism of pathophysiologic occurrence of diarrhea in UC and sugges

194 c state of the diaphragm, which might be one pathophysiologic origin of ventilator-induced diaphragma

195 s in ARMS2 and CFH, indicating a genetic and pathophysiologic overlap between cCSC and AMD.

196 ng similar stimulation paradigms, suggesting pathophysiologic overlap.

197 This finding reveals a potential pathophysiologic pathway involved in the intergeneration

198 One pathophysiologic pathway that may drive changes in DAerg

199 lygenic autoimmune disorders, as well as the pathophysiologic pathways and clinical features of monog

200 dinal investigations are needed to elucidate pathophysiologic pathways and target modifiable mechanis

201 eby hampering the identification of specific pathophysiologic pathways and therapeutic targets.

202 gic agents that target specific and critical pathophysiologic pathways have been developed to better

203 enotypic difference strongly suggests unique pathophysiologic pathways involved in the pathogenesis o

204 cation models but may also reflect important pathophysiologic pathways undergoing during cerebral isc

205 or endotypes, which arise through different pathophysiologic pathways.

206 (i.e., quantifiably infer the magnitude of a pathophysiologic perturbation), and helps explain comple

207 It is a recognized pathophysiologic phenomenon in ambulant poorly controlle

208 Therefore, pathophysiologic pHo changes can modulate CaR responsive

209 Finally, pathophysiologic pHo elevation reversibly suppressed PTH

210 Further, pathophysiologic phosphate concentrations elicit rapid a

211 mpliance and RV remodeling are the strongest pathophysiologic predictors of adverse outcomes.

212 ally could be related to the same underlying pathophysiologic process as their renal disease, and nei

213 t likely were related to the same underlying pathophysiologic process as their renal disease.

214 travascular haemolysis and consequently from pathophysiologic process of haemoglobin metabolism and i

215 reinforced behaviors and not the result of a pathophysiologic process.

216 probable AD dementia with evidence of the AD pathophysiologic process: 24 patients with age at onset

217 d biomarkers of early Alzheimer disease (AD) pathophysiologic processes (accumulation of neocortical

218 superior inner retinal biomarker for macular pathophysiologic processes and especially for glaucoma.

219 ce: Cardiac biomarkers provide insights into pathophysiologic processes and offer an attractive strat

220 It is unclear which pathophysiologic processes are responsible for this diff

221 networks may reveal the impact of underlying pathophysiologic processes as assessed with cerebrospina

222 wn to have a long preclinical phase in which pathophysiologic processes develop many years, even deca

223 peptides allows insight into various ongoing pathophysiologic processes in CKD.

224 iques can identify biomarkers reflecting key pathophysiologic processes in depression and whether suc

225 c value of biomarkers that reflect different pathophysiologic processes in patients with type 2 diabe

226 een shown to play a crucial role in multiple pathophysiologic processes like sepsis, inflammation, va

227 We further consider pathophysiologic processes recently implicated in the me

228 ward a diagnostic system based on underlying pathophysiologic processes that may cut across conventio

229 y a significant role in many physiologic and pathophysiologic processes, including synaptic transmiss

230 simultaneous presence of multiple coexisting pathophysiologic processes.

231 lcium waves (ICWs) in various physiologic or pathophysiologic processes.

232 heir central role in a wide variety of human pathophysiologic processes.

233 sion is critical for diverse physiologic and pathophysiologic processes.

234 r disorder (BD), that may reflect underlying pathophysiologic processes.

235 a membrane that play important roles in many pathophysiologic processes.

236 70s as an in vivo method to measure regional pathophysiologic processes.

237 of patient-derived GBM cells, with improved pathophysiologic properties as an experimental model.

238 The pathophysiologic ramifications of this prediction are pr

239 t raising phosphate concentration within the pathophysiologic range for CKD significantly inhibits Ca

240 reatment with trypsin; this finding may have pathophysiologic relevance by suggesting that, like beta

241 Although acute hypoxia is of utmost pathophysiologic relevance in health and disease, studie

242 ng that this mast cell/nerve crosstalk is of pathophysiologic relevance in patients with allergic dis

243 ese data provide preliminary support for the pathophysiologic relevance of neurosteroids in this cond

244 lso provide insight into how physiologic and pathophysiologic remodeling differs in adipose tissue an

245 The fundamental pathophysiologic response for the survival of all organi

246 Our goal was to characterize the pathophysiologic response to damage-associated molecular

247 mice display a significant reduction in the pathophysiologic responses seen in asthmatic wild-type l

248 These rapid molecular changes potentiate pathophysiologic responses throughout the body, resultin

249 y nucleotides released during physiologic or pathophysiologic responses.

250 The former is pathophysiologic resulting in intimal hyperplasia, where

251 n of historical articles and those regarding pathophysiologic risk factors, retinopathy of prematurit

252 2-part review, we discuss the epidemiologic, pathophysiologic, risk factors, and imaging aspects of c

253 2-part review, we discuss the epidemiologic, pathophysiologic, risk factors, and imaging aspects of c

254 Taken together, our findings established a pathophysiologic role and new function for LOXL2 in brea

255 ed ejection fraction, suggesting a different pathophysiologic role for both entities.

256 atic cancer, revealing a dual and contextual pathophysiologic role for REG3beta during pancreatitis a

257 These observations underscore an important pathophysiologic role for severely defective metabolism

258 he nitric oxide pathway playing an important pathophysiologic role in its development.

259 th a worse prognosis, and plays an important pathophysiologic role in PCa, which suggesting its poten

260 Platelets have a pathophysiologic role in the ischemic microvascular envi

261 Further studies to delineate the underlying pathophysiologic role of elevated WBC across a spectrum

262 m of GN with monoclonal IgG deposits and the pathophysiologic role of granulocyte colony-stimulating

263 6a levels and clinical parameters suggests a pathophysiologic role of miR-146a in CP.

264 A pathophysiologic role of the enterohormones peptide YY a

265 T receptor, and its physiologic and possible pathophysiologic roles are not fully elucidated.

266 ed to determine whether these processes have pathophysiologic roles in delirium and whether therapies

267 culating PUFAs to investigate their distinct pathophysiologic roles in glucose homeostasis in pregnan

268 in meta-inflammation, with a focus on their pathophysiologic roles in obesity, type 2 diabetes, dysl

269 h has been learned about the physiologic and pathophysiologic roles of the ECS.

270 y, and discuss the potential physiologic and pathophysiologic roles thereof in kidney.

271 part fundamentally different physiologic and pathophysiologic roles to these two endocannabinoids.

272 ating a variety of important physiologic and pathophysiologic roles.

273 elial cell fusion, an effect that may reduce pathophysiologic sequelae of NiV infection.

274 These data point to a pathophysiologic sequence by which monogenic mutations i

275 In the pathophysiologic setting of cerebral ischemia, excitotox

276 and/or function of these cells in different pathophysiologic settings.

277 Whether the clinical or pathophysiologic significance of the "treatable trait" h

278 ture longitudinal studies should examine the pathophysiologic significance of the shift from MTL hype

279 ary atrial fibrillation), and intensity of a pathophysiologic state (i.e., quantifiably infer the mag

280 to modulate the emergence of MDSCs in those pathophysiologic states in which these cells play an imm

281 of the tissue microenvironment in a range of pathophysiologic states, including acute and chronic res

282 emand across a wide range of physiologic and pathophysiologic states, yet, when compared with other o

283 ene expression in a range of physiologic and pathophysiologic states.

284 pe across a network of human physiologic and pathophysiologic states.

285 by GIV during diverse cellular processes and pathophysiologic states.

286 (BAT), where substrate preference changes in pathophysiologic states.

287 rnate scaffold protein, SHPS-1, resulting in pathophysiologic stimulation of vascular smooth muscle c

288 uences cellular responses to physiologic and pathophysiologic stresses.

289 tion of results from these correlational and pathophysiologic studies supports the hypothesis that ga

290 ence and focusing on human epidemiologic and pathophysiologic studies.

291 ion, abnormalities of which form the direct, pathophysiologic substrate for SCD.

292 pression of Syt10 is strongly upregulated by pathophysiologic synaptic activity after kainic acid (KA

293 Excessive release of glutamate triggered by pathophysiologic synaptic activity has been put forward

294 In response to pathophysiologic synaptic activity, multiple signaling c

295 Although both pathophysiologic tissue classes were present within inju

296 tion may play a role in both physiologic and pathophysiologic tissue repair.

297 ises to transform clinical care by advancing pathophysiologic understanding and fostering novel thera

298 nologic characterization, as well as current pathophysiologic understanding and specific therapies fo

299 A better pathophysiologic understanding of the neurodevelopmental

300 m)Tc-NTP 15-5) targeting proteoglycans has a pathophysiologic validity for in vivo imaging of rheumat