ライフサイエンスコーパス: pathophysiological

1 Cardiac muscle hypercontractility is a key pathophysiological abnormality in hypertrophic cardiomyo

2 ve started inventing strategies to block its pathophysiological activity in 1986.

3 However, our understanding of the pathophysiological alterations and mechanisms, especiall

4 t could advance current understanding of CNS pathophysiological alterations associated with SARS-CoV-

5 riven clustering, we identified three robust pathophysiological Alzheimer's disease subtypes within e

6 tic mechanisms may contribute to overlapping pathophysiological and clinical features between the dis

7 make inferences on the basis of the parallel pathophysiological and immunological features of the oth

8 We provide pathophysiological and microbiologic evidence to support

9 f AD and PD patient subgroups on a clinical, pathophysiological and molecular level.

10 B genes in B. fragilis seems to be linked to pathophysiological and nutritional competitive fitness f

11 s with a similar biochemical composition and pathophysiological aspects of degeneration.

12 w studies on animal experiments dealing with pathophysiological aspects of the parkinsonian state.

13 Aim of the present article is to review pathophysiological aspects which are relevant for the un

14 Mimicking the physiological or pathophysiological barrier function of endothelial and e

15 In this Review, we explore the pathophysiological basis of the link between parasitic i

16 Krebs von den Lungen (KL)-6 is pathophysiological biomarker of alveolar epithelial dama

17 Microvascular dysfunction (MVD) is a common pathophysiological change that occurs in various disease

18 d left ventricular (LV) and left atrial (LA) pathophysiological changes and their prognostic implicat

19 ed multiple organ dysfunction as well as the pathophysiological changes found in the lungs.

20 Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer's disease (AD) s

21 usceptible to ageing, the progression of the pathophysiological changes in these cells is still poorl

22 These pathophysiological changes might lead to gynaecological

23 ntractile function and may contribute to the pathophysiological changes observed in desmin-related my

24 te key left ventricular cardiac deficits and pathophysiological changes reported in humans with progr

25 marker of early pathogenesis by linking lung pathophysiological changes with an endotype of immune hy

26 increasingly implicates shared etiologic and pathophysiological characteristics among major psychiatr

27 This study aimed to describe specific pathophysiological characteristics of acute respiratory

28 reliable model with close resemblance to the pathophysiological characteristics of SU model, and this

29 This is the pathophysiological concentration range after brain injur

30 Here, we show that pathophysiological concentrations of asthma-associated p

31 mented by preclinical studies to outline the pathophysiological concepts that can be translated into

32 PTEN is implicated in a wide variety of pathophysiological conditions and traditionally studied

33 er, diverse forms of synaptic plasticity and pathophysiological conditions are associated with shifts

34 understanding of this vasculature's role in pathophysiological conditions has greatly improved in re

35 and are a characteristic feature in numerous pathophysiological conditions including the foreign body

36 aments in both physiological and potentially pathophysiological conditions of the heart.

37 e potent and non-toxic therapeutic leads for pathophysiological conditions regulated by PXR and AhR.

38 n of lncRNAs is associated with a variety of pathophysiological conditions such as cancer, diabetes,

39 clarify the importance of these channels in pathophysiological conditions such as pain and depressio

40 rs of renal function under physiological and pathophysiological conditions, gaps remain in our unders

41 response has been implicated in a variety of pathophysiological conditions, including infectious and

42 tional control of gene expression in several pathophysiological conditions.

43 he importance of DAMP-mediated activities in pathophysiological conditions.

44 es in pregnancy under both physiological and pathophysiological conditions.

45 esses impacts its function and is related to pathophysiological conditions.

46 uals, cell types, subcellular locations, and pathophysiological conditions.

47 regulation of epithelial plasticity and its pathophysiological consequences in development, fibrosis

48 inflammatory mRNAs should be beneficial, the pathophysiological consequences of other interactions re

49 However, the pathophysiological consequences stemming from these hete

50 nd homeostatic resolution, and highlight the pathophysiological consequences that can arise when this

51 fect of myostatin depends on the genetic and pathophysiological context and may not be efficacious in

52 rotease activities on NETs is available in a pathophysiological context to date.

53 of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease.

54 p fragmentation, that reflect differences in pathophysiological contributions of airway collapsibilit

55 perpetuation of inflammation is an important pathophysiological contributor to the global medical bur

56 aortoenteric fistulas and their clinical and pathophysiological correlation, as well as the diagnosti

57 glaucomatous deformation and reflect ongoing pathophysiological damage.

58 n give an insight into the establishment and pathophysiological degeneration of neural circuitry in P

59 These findings are reminiscent of the pathophysiological description of an injured human heart

60 tative approach that may protect against the pathophysiological development of SCZ.

61 ve been few studies performed to examine the pathophysiological differences between different types o

62 s and raise the consideration of significant pathophysiological diversity of human alcoholic liver in

63 Various novel circulating biomarkers in key pathophysiological domains are predictive of outcomes in

64 The exact pathophysiological effects and the underlying mechanisms

65 ovide a unique opportunity to understand the pathophysiological effects of genetic cardiomyopathy mut

66 lysine-binding site of KIV-10 can combat the pathophysiological effects of Lp(a).

67 sms whereby elevated ACs might contribute to pathophysiological effects remain largely unexplored.

68 nments in radial layers, thus, mimicking the pathophysiological environment of a tumor.

69 mensional (3D) cell culture models mimic the pathophysiological environment of in vivo tumors and are

70 how that platelet activation is an important pathophysiological event and a potential therapeutic tar

71 to NASH are commonly accompanied by several pathophysiological events including metabolic dysregulat

72 croglia, and their interplay are the primary pathophysiological events leading to disruption of the m

73 The circulating metabolome might reflect pathophysiological events related to acute IS.

74 ve decline, and once confirmed would provide pathophysiological evidence for neuroaxonal injury follo

75 We now provide pathophysiological evidence that the conversion of the r

76 a major unmet problem in epilepsy that lacks pathophysiological explanation and treatment.

77 ised care strategies and fostering follow-up pathophysiological explorations.

78 altered prefrontal-limbic connectivity is a pathophysiological feature of anxiety disorders.

79 Atrial-tissue fibrosis is a central pathophysiological feature of atrial fibrillation that a

80 dynamic causal modelling can disclose a core pathophysiological feature of proteinopathic network arc

81 However, the pathophysiological features and mechanism of the CSD sti

82 an Chips have enabled re-creation of complex pathophysiological features of human viral infections in

83 es NASH and ameliorates key histological and pathophysiological features of NASH along with improveme

84 Despite cachexia sharing pathophysiological features with a number of neuromuscul

85 Sepsis and cancer share a number of pathophysiological features, and both result from the in

86 Defining the incidence of this disorder, its pathophysiological features, and its contribution to imp

87 The need to understand the pathophysiological fingerprint and pathways of this dise

88 e how this channel contributes to normal and pathophysiological function in the central nervous syste

89 binding EGF (HB-EGF), with no defined immuno-pathophysiological function.

90 tinguished based on cell surface markers and pathophysiological function.

91 ation of such a circuit in physiological and pathophysiological functions and will provide valuable c

92 ignalling molecules that elicit a variety of pathophysiological functions in the kidney through the a

93 for further studying PRMT6 physiological and pathophysiological functions.

94 tial consequences on Tau's physiological and pathophysiological functions.

95 manifest by their distinct physiological and pathophysiological functions.

96 amework for patient subsegmentation based on pathophysiological, genetic, and molecular subsets will

97 hat sodium channels dysfunction may be a key pathophysiological hallmark in these disorders.

98 te the development of myocardial fibrosis, a pathophysiological hallmark of HFpEF.

99 Pathophysiological heterogeneity in the presentation of

100 n human gene transcription networks, and the pathophysiological impact of having increased viral prot

101 oss-sectional study quantified the long-term pathophysiological impact of these treatments on biomech

102 t in increased broadband gamma power and the pathophysiological implications for cognition and behavi

103 ypersensitive to CGRP, which underscores its pathophysiological importance.

104 Together, the findings point to a pathophysiological inflammatory consequence to the emerg

105 Its dysregulation leads to pathophysiological inflammatory processes in the skin.

106 frequent as stroke in the elderly, but many pathophysiological injury aspects are distinct in neonat

107 h on these questions should lead to improved pathophysiological insight and enhanced therapeutic stra

108 zed to reduce health disparities and enhance pathophysiological insight.

109 TMS studies have provided important pathophysiological insights across a range of neurodegen

110 slation of psychiatric genomic findings into pathophysiological insights and novel psychopharmacologi

111 Using these STFs, we show several pathophysiological insults in hypertrophic cardiomyopath

112 crocircuit-level detail is missing from this pathophysiological intuition.

113 A pathophysiological link between these two alterations is

114 etic pseudoceramide (pCer) and analyzed that pathophysiological linkage by microanalyzing ceramides u

115 Little is known about the pathophysiological linkages between altered ceramide pro

116 lasma insulin and did not protect from other pathophysiological manifestations of the db/db research

117 anisms and molecular bases of cardiovascular pathophysiological manifestations.

118 on functional microbiome alterations and/or pathophysiological measurements may allow for more accur

119 eceptor localization to synapses is a common pathophysiological mechanism for GABRB3 mutations, altho

120 These findings provide a potential pathophysiological mechanism for previously observed sex

121 ation-inhibition imbalances are considered a pathophysiological mechanism in many brain disorders inc

122 CRL1) was identified in the early 1990s, its pathophysiological mechanism is not fully understood and

123 and infertility are clearly associated, the pathophysiological mechanism remains unclear.

124 Whereas the underlying pathophysiological mechanism warrants further analysis,

125 nscriptional coregulation defects as a novel pathophysiological mechanism.

126 iated itch because little is known about its pathophysiological mechanism.

127 These proteins reveal different pathophysiological mechanisms and may be useful in the f

128 ghlighting the urgent need to identify novel pathophysiological mechanisms and therapies, as well.

129 induced, to allow better investigation into pathophysiological mechanisms and treatment strategies.

130 lar, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are complex, and there is

131 To investigate potential pathophysiological mechanisms associated with ALDH7A1 de

132 osensitivity to oxygen, but well-established pathophysiological mechanisms can account for most, if n

133 to differing characteristics and underlying pathophysiological mechanisms in NSTEMI and STEMI.

134 earch of WAT-related biology, in studying of pathophysiological mechanisms in obesity and diabetes, a

135 y of familial autoimmune diseases can reveal pathophysiological mechanisms involved in more common au

136 uerperium, classifying them according to the pathophysiological mechanisms involved: the prothromboti

137 Pathophysiological mechanisms leading to hypertension re

138 Our study provides novel insight into the pathophysiological mechanisms of ASD and SCZ.

139 underlying neuropathological correlates and pathophysiological mechanisms of cortical superficial si

140 information may inform future studies of the pathophysiological mechanisms of dry eye disease.

141 a) from apo(a) and LDL, as well as potential pathophysiological mechanisms of Lp(a), including (i) bi

142 n a possible link between infections and the pathophysiological mechanisms of suicidal behavior.

143 l for human disease and suggest that similar pathophysiological mechanisms related to iron sequestrat

144 l development during adolescence, triggering pathophysiological mechanisms related to schizophrenia t

145 estruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear.

146 atrial fibrillation (AF), but the underlying pathophysiological mechanisms remain unclear.

147 l review, we detail the plausible underlying pathophysiological mechanisms through which AF may promo

148 for RNA-related metabolism, determining the pathophysiological mechanisms through which TDP-43 media

149 ical aspects related to bradykinesia and the pathophysiological mechanisms underlying bradykinesia ar

150 circuit function may help to understand the pathophysiological mechanisms underlying movement disord

151 A better understanding of the pathophysiological mechanisms underlying spontaneous bra

152 Understanding the pathophysiological mechanisms underlying these complicat

153 Multiple pathophysiological mechanisms with the potential to be t

154 understand the potential toxins, underlying pathophysiological mechanisms, and identification of sus

155 organ systems, focusing on self-perpetuating pathophysiological mechanisms, aspects of increased susc

156 Through multiple pathophysiological mechanisms, CVD and NAFLD are associa

157 omeostatic imbalance is caused by a range of pathophysiological mechanisms, including disrupted reduc

158 unknown about the influence of risk factors, pathophysiological mechanisms, vulnerability factors for

159 Biomarkers, if indicative of the underlying pathophysiological mechanisms, would suggest strategies

160 ocusing on their epidemiology, aetiology and pathophysiological mechanisms.

161 nd represents a powerful tool to study their pathophysiological mechanisms.

162 ia, yet little is known about the underlying pathophysiological mechanisms.

163 s through better understanding of underlying pathophysiological mechanisms.

164 ymptom-specific effects in future studies on pathophysiological mechanisms.

165 ingle-trial analyses for assessing potential pathophysiological mechanisms.

166 nosing MMN and in further elucidation of its pathophysiological mechanisms.

167 slation of results, and the understanding of pathophysiological mechanisms.

168 ns, yet little is known about the underlying pathophysiological mechanisms.

169 ne responses raise the possibility of shared pathophysiological mechanisms.

170 atory properties is essential to outline PKU pathophysiological mechanisms.

171 rum of psychopathology arising from distinct pathophysiological mechanisms.

172 gG and albumin levels, suggesting suPAR as a pathophysiological mediator in podocyte dysfunction.

173 nd diabetes suggest that there may be common pathophysiological mediators associated with insulin res

174 logical data suggest the existence of common pathophysiological mediators in both diabetes and major

175 plications after stroke, and a comprehensive pathophysiological model of stroke-induced cardiac injur

176 abrication and use of a 3D physiological and pathophysiological motor unit model consisting of motor

177 The pathophysiological nature of the common ABCG2 gout and h

178 iology labs to gain insights into normal and pathophysiological neuroanatomy.

179 ay also act as a unifying phenomenon for the pathophysiological observations reported in Parkinson's

180 ify network synchrony as a driver of various pathophysiological observations reported in the literatu

181 Nearly all these studies in beta-cells used pathophysiological or supraphysiological levels of Myc a

182 uspected of driving a given physiological or pathophysiological outcome.

183 orities were proposed for characterizing the pathophysiological overlap and deleterious interactions

184 hnical improvements to the quantification of pathophysiological parameters of myocardial ischaemia ca

185 f features that combines both biological and pathophysiological parameters that personalise the digit

186 status with little regard to the underlying pathophysiological particularities.

187 ed neural responses, has been suggested as a pathophysiological pathway to autism, but direct evidenc

188 uman diseases, providing insight into shared pathophysiological pathways and opportunities for therap

189 atients with tuberculosis.Objectives: To map pathophysiological pathways at anatomically distinct pos

190 In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and

191 However, there may be common pathophysiological pathways for subtypes of the disease.

192 but also with neurological diseases sharing pathophysiological pathways like epilepsy.

193 These pathophysiological pathways might be amenable to pharmac

194 and rennin, both known to have roles in the pathophysiological pathways of cardiovascular disease, a

195 rgets owing to their involvement in specific pathophysiological pathways.

196 Importantly, we also found that pathophysiological perturbations such as elevated ADP co

197 h, which exposes donor hearts to substantial pathophysiological perturbations that can influence hear

198 communications are critical determinants of pathophysiological phenotypes, but methodologies for the

199 rm of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediate

200 ating a potential role of acetylation in the pathophysiological process leading to FUS-mediated ALS/F

201 a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitula

202 s signal from endosomes to control important pathophysiological processes and are therapeutic targets

203 The underlying pathophysiological processes and causal relationships of

204 t the individual patient level the important pathophysiological processes and needed therapeutic addi

205 ogen sulfide (H(2)S) is involved in numerous pathophysiological processes and shares overlapping func

206 cytosis sheds light on key physiological and pathophysiological processes and suggests novel therapeu

207 es developed in the effort to understand the pathophysiological processes associated with neurodegene

208 as been implicated in many physiological and pathophysiological processes associated with purinergic

209 In this review, the authors discuss several pathophysiological processes common to both CVD and canc

210 ons that can be targeted to address specific pathophysiological processes in FGIDs.

211 izable approach for linking deep learning to pathophysiological processes in human disease.

212 Steroid hormones are pivotal modulators of pathophysiological processes in many organs, where they

213 cRNAs have been shown to function in diverse pathophysiological processes in mice, it remains largely

214 logy and medicinal chemistry, summarizes the pathophysiological processes in which PARP plays a role

215 ng RNAs (lncRNAs) are emerging regulators of pathophysiological processes including atherosclerosis.

216 ibitory effect on feeding and anabolism, and pathophysiological processes increase melanocortin signa

217 little information regarding the underlying pathophysiological processes involved.

218 were studied to investigate shared or unique pathophysiological processes of asthma across tissues.

219 key inflammatory components involved in the pathophysiological processes of immune-related adverse e

220 study aims to depict the underlying cardiac pathophysiological processes of nonresponse to CRT in pa

221 How such mechanisms evolve during pathophysiological processes remain to be determined, bu

222 isease (VGD) and failure result from complex pathophysiological processes that can lead to complete o

223 des mediate many important physiological and pathophysiological processes through interactions with g

224 y organs and is further crucially engaged in pathophysiological processes underlying cancer, inflamma

225 us on sleep in research aiming to define the pathophysiological processes which result in PTSD, as we

226 ell-surface receptors that regulate numerous pathophysiological processes, and their large extracellu

227 critical roles in diverse physiological and pathophysiological processes, have important industrial

228 It has been associated with several pathophysiological processes, including blood pressure r

229 TPCs are involved in various pathophysiological processes, including cell growth and

230 n will also be important, and studies of key pathophysiological processes, including neuroinflammatio

231 enescent cells affect many physiological and pathophysiological processes.

232 n of adenosine (m(6)A) in RNA regulates many pathophysiological processes.

233 trigger EMTs and integrate them with broader pathophysiological processes.

234 e implicated in a wide variety of normal and pathophysiological processes.

235 railment of integrin function contributes to pathophysiological processes.

236 ological actions and participate in numerous pathophysiological processes.

237 ns play important roles in physiological and pathophysiological processes.

238 ise from a complex network of interdependent pathophysiological processes.

239 f HAT/DESC proteases in physiological and in pathophysiological processes.

240 -induced oxidative stress and redox-mediated pathophysiological processes.

241 nts are a powerful avenue to investigate the pathophysiological processes.

242 receptor (APLNR) is a GPCR involved in many pathophysiological processes; however, the correlation b

243 ns, thus representing a general trait in the pathophysiological progression of age-related hearing lo

244 During the pathophysiological progression of HF, the failing heart

245 downstream biological consequences depend on pathophysiological range extracellular matrix stiffness.

246 This Review summarizes the pathophysiological rationale and the latest clinical evi

247 ates, for the first time in our knowledge, a pathophysiological relationship between a clinically pai

248 onceptional period and future studies on the pathophysiological relationship between changes in 1C me

249 e mechanisms causing bile infarcts and their pathophysiological relevance are unclear.

250 The pathophysiological relevance is further demonstrated in

251 The panel agreed on the pathophysiological relevance of rapid passage of nutrien

252 These findings underscore the pathophysiological relevance of the LAPTM4B-24 isoform a

253 ould further expand our understanding of the pathophysiological relevance of this form of autophagy.

254 ion panels are defined on the basis of their pathophysiological relevance, but also need to be tested

255 ion with validated clinical scores supported pathophysiological relevance.

256 In addition to systemic RAS, the pathophysiological response of the local RAS within the

257 s environments to regulate physiological and pathophysiological responses remain incompletely underst

258 xposures to UFP and PM(2.5) can induce acute pathophysiological responses.

259 ting its function and potentially leading to pathophysiological responses.

260 mouse models of Rett Syndrome, suggesting a pathophysiological role for inhibitory interneurons.

261 While this observation suggests a key pathophysiological role for insufficient energy delivery

262 H. pylori infection may have a pathophysiological role in colorectal adenoma developmen

263 the way for future investigation into HO2's pathophysiological role in heme deficiency response.

264 liver-heart inflammatory axis has a pivotal pathophysiological role in the development of hepatic ca

265 iginally found as liver-resident ILCs, their pathophysiological role in the liver remains poorly inve

266 se findings further our understanding of the pathophysiological role of dorsal raphe serotonergic neu

267 This Review discusses the pathophysiological role of HIFs, angiogenesis, and metab

268 rovide a strong rationale for rethinking the pathophysiological role of IFN-lambda and its possible u

269 Here, we set out to determine the pathophysiological role of PC1 in cardiomyocytes.

270 cilitate future studies that investigate the pathophysiological role of PPARgamma in alcohol use diso

271 ssue mechanisms underlying CPVT, such as the pathophysiological role of sinus node dysfunction in CPV

272 regulation of the NLRP3 inflammasome and the pathophysiological role of triglyceride-rich lipoprotein

273 Due to their important physiological and pathophysiological roles and keen interest on the part o

274 tin have a common ancestral origin and their pathophysiological roles are increasingly the subject of

275 cells and highlight novel physiological and pathophysiological roles for TRPA1 and TRPV3 in these ce

276 transmitter with important physiological and pathophysiological roles in pregnancy.

277 Pathophysiological roles of cardiac dopamine system rema

278 both exhibit OASIS/Creb3l1 upregulation, the pathophysiological roles of OASIS in CKD remains unknown

279 Together, our results highlight the pathophysiological roles of P2X7Rs in a mouse model of R

280 ge inside the cell membrane triggers various pathophysiological signaling pathways, but the mechanism

281 ach of cardiac metabolism, physiological and pathophysiological signaling, and the mitochondrial comp

282 brief review discusses the physiological and pathophysiological significance of oxygen availability,

283 this review, we summarize the mechanisms and pathophysiological significance of the unconventional se

284 These results demonstrate a pathophysiological similarity between disease in muscles

285 participate in a range of physiological and pathophysiological situations such as learning and memor

286 of an underlying trans-synaptic mechanism of pathophysiological spread.

287 daptive significance, representing instead a pathophysiological state.

288 e of abnormal glycinergic inhibition in many pathophysiological states, such as hyperekplexia, epilep

289 ein composition of human urine in normal and pathophysiological states.

290 evelopment process is crucial to help define pathophysiological subsets of pain, evaluate target enga

291 evated dead space fraction may be a specific pathophysiological trait.

292 male mice, NMDAR ablation results in several pathophysiological traits, including increased cortical

293 logical activity, impact on the patient, and pathophysiological traits.

294 This work provides insight into the pathophysiological underpinnings of impulsivity and espe

295 However, it is unknown what the pathophysiological underpinnings of this high-risk state

296 Advancements in pathophysiological understanding have increased the arra

297 cortical atrophy, with implications for our pathophysiological understanding of Alzheimer syndromes

298 Our work contributes to the overall pathophysiological understanding of memory disorders and

299 l, morphological and genetic data as well as pathophysiological understanding.

300 estions from this review that challenge this pathophysiological view.