ライフサイエンスコーパス: pathophysiology

1 biology and advanced understanding of cancer pathophysiology.

2 spect to differences in underlying causes or pathophysiology.

3 isoform-specific AMPKalpha repression on AD pathophysiology.

4 ute and chronic GVHD, in the context of GVHD pathophysiology.

5 ing in splicing changes that promote disease pathophysiology.

6 echanisms connecting gut microbiota and host pathophysiology.

7 mune activation as central to stress-related pathophysiology.

8 cognitive function and psychiatric disorder pathophysiology.

9 del depicting numerous genes contributing to pathophysiology.

10 dressed by understanding the complex disease pathophysiology.

11 hly prevalent disease with poorly understood pathophysiology.

12 s (ICS) affect this important aspect of COPD pathophysiology.

13 lation (AF) share an underlying inflammatory pathophysiology.

14 ntification of patient subgroups with shared pathophysiology.

15 contribution of vascular dysfunction in CRS pathophysiology.

16 roviding insights into intracranial aneurysm pathophysiology.

17 lated adjunctive therapies to ameliorate HCC pathophysiology.

18 e essential for understanding kidney disease pathophysiology.

19 n could advance hormone-based physiology and pathophysiology.

20 tween in vitro experimental models and human pathophysiology.

21 endocrine development and associated disease pathophysiology.

22 derived microvesicles may influence arterial pathophysiology.

23 nd experimentally leveraged, to elucidate AD pathophysiology.

24 rs have deepened our appreciation of disease pathophysiology.

25 nsula, limbic structures key to the disorder pathophysiology.

26 result from both inflammation and non-immune pathophysiology.

27 I IFN mechanisms to address its role in TBI pathophysiology.

28 an important role in cellular physiology and pathophysiology.

29 +) myeloid cells, in RSV infection-triggered pathophysiology.

30 as new targets of potential relevance to ALS pathophysiology.

31 ast, AMPKalpha2 suppression did not alter AD pathophysiology.

32 for future work to elucidate the underlying pathophysiology.

33 ute and chronic phases of multiple sclerosis pathophysiology.

34 -processing network heavily implicated in AD pathophysiology.

35 erventricular differences in their molecular pathophysiology.

36 regulatory processes and implicated in some pathophysiology.

37 this toxin-receptor pair plays in S. aureus pathophysiology.

38 rare IBD variants on disease prediction and pathophysiology.

39 e contribution of cytokine storm to COVID-19 pathophysiology.

40 edge gap between in vitro models and in vivo pathophysiology.

41 tasis and the key pathways implicated in ALS pathophysiology.

42 limited treatment options and poorly defined pathophysiology.

43 tions in brain connectivity may underlie its pathophysiology.

44 disorders is important for understanding the pathophysiology.

45 e among the key markers for determining RA's pathophysiology.

46 native to animal testing for the study of BM pathophysiology.

47 lore pathways and mechanisms contributing to pathophysiology.

48 ny of which have plausible links to COVID-19 pathophysiology.

49 major determinant of cardiac physiology and pathophysiology.

50 as9 to study TNNT2 variant pathogenicity and pathophysiology.

51 cutive control of motor commands in dystonia pathophysiology.

52 a central role in both metabolic health and pathophysiology.

53 ation of nearby genes implicated in progeria pathophysiology.

54 ular mechanisms, which underlie preeclampsia pathophysiology.

55 lamus seem to be implicated in schizophrenia pathophysiology.

56 ns in the context of vascular physiology and pathophysiology.

57 nterneurons has been linked to schizophrenia pathophysiology.

58 rcuits and targeted to the root cause of the pathophysiology.

59 leles of a single locus and their associated pathophysiologies.

60 role of these Orai1 channels in the cardiac pathophysiology, a transgenic mouse was generated with c

61 urnal, circadian) rhythms, suggesting common pathophysiologies across species.

62 here were no strong correlations between the pathophysiologies and no remarkable clusters among them.

63 d mortality requires knowing the responsible pathophysiologies and the therapeutic advances that are

64 Here, we review the pathophysiology and available diagnostic tests for IDA i

65 na that may facilitate research into disease pathophysiology and biomarker development for diagnostic

66 y relevant insight into the underlying acute pathophysiology and biomarker release kinetics following

67 tic approaches calls for reassessment of PML pathophysiology and clinical course.

68 eeclampsia and indicate distinct subtypes of pathophysiology and clinical morbidity.

69 current knowledge on this disease, including pathophysiology and clinical presentation, moving on to

70 temporal and spatial development of ischemic pathophysiology and determining neuronal activity signat

71 ules with potentially deleterious outcome in pathophysiology and disease, "oxidative distress." Refle

72 paradigm shifts in our understanding of the pathophysiology and downstream end-organ complications o

73 er organoids (RCOs) closely recapitulate the pathophysiology and genetic changes of corresponding tum

74 the population, although key facets of their pathophysiology and host interaction remain unclear.

75 t further characterize PBDE-induced diabetic pathophysiology and identify critical developmental time

76 f the role of this channel in physiology and pathophysiology and inform new therapeutic design.

77 re short and underscore its relevance to the pathophysiology and interventions of human telomere-driv

78 osed framework unites many ideas of tinnitus pathophysiology and may catalyze cooperative efforts to

79 acological thresholds correspond to exercise pathophysiology and myocardial ischemia in patients with

80 These technologies can mimic human pathophysiology and predict drug response, having profou

81 al imaging has offered novel insights on its pathophysiology and prognosis, but its use in AF-related

82 mportantly, many promising findings focus on pathophysiology and reflect group-level comparisons, but

83 Basophils and IgE contribute to MCTD pathophysiology and represent new candidate therapeutic

84 cussed as a potential factor influencing the pathophysiology and severity of inflammatory skin diseas

85 se that a better understanding of aetiology, pathophysiology and symptomatic treatments can arise fro

86 f these diseases could illuminate both their pathophysiology and the computational architecture of th

87 he complexity of immune dysregulation in MDS pathophysiology and the fine balance between smoldering

88 prove useful for longitudinal assessments of pathophysiology and therapeutics.

89 dditional work is needed to characterize the pathophysiology and to identify the definitive causes.

90 ults could have relevant implications on the pathophysiology and treatment of cholangiopathies.

91 Due to the complex nature of the pathophysiology and treatment of these diseases, it can

92 essential for the elucidation of the ME/CFS pathophysiology, and lead to accurate diagnoses, prevent

93 ronchiectasis, likely contributes to disease pathophysiology, and may be a target for pharmacotherapy

94 othelial cells that regulates cardiovascular pathophysiology, and provide a mechanism by which a sing

95 of these co-morbidities and their role in AD pathophysiology are currently unknown.

96 ative genes from germline and the underlying pathophysiology are unclear.

97 oups based on features reflecting underlying pathophysiology, are likely to have less clinical utilit

98 into normal human organ function and disease pathophysiology, as well as more accurately predict the

99 and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegen

100 ides an opportunity to dissect human disease pathophysiology at unprecedented resolutions(6), particu

101 mation, allowing visualization of infectious pathophysiology beyond morphologic imaging.

102 romotes thrombotic events and drives obesity pathophysiology, but a lack of essential analytical tool

103 ial dysfunctions appear also involved in ASD pathophysiology, but the mechanisms by which such altera

104 des evidence that MPs play a key role in SCD pathophysiology by triggering a proinflammatory phenotyp

105 n our Review Article, we discuss the disease pathophysiology, clinical manifestation, evidence based

106 These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progre

107 Human disease pathophysiology commonly involves metabolic disruption a

108 ients attending the HIV outpatient clinic of Pathophysiology Department at <<Laiko>> General Hospital

109 chronic GVHD preclinical models that have a pathophysiology distinct from acute GVHD, Itpkb-/- donor

110 metabolism can differentially influence GAS pathophysiology during soft tissue infection.

111 logy (eg, heart rate and blood pressure) and pathophysiology (eg, onset of adverse cardiovascular eve

112 We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes

113 d that metabolite changes signify underlying pathophysiology for future disease development.

114 ss has been made in the understanding of CRS pathophysiology: from the epithelium and epithelial-mese

115 esult of our incomplete understanding of its pathophysiology, functional dyspepsia is difficult to tr

116 A central mechanism for COVID-19 pathophysiology has been proposed: imbalance of angioten

117 hese results elucidating somatotroph adenoma pathophysiology identify pathways for targeted treatment

118 our understanding of disease mechanisms and pathophysiology in a disorder with diverse clinical phen

119 sociations between neuroimmune responses and pathophysiology in brain disorders such as Alzheimer's d

120 eletal geochemistry to shed light on disease pathophysiology in corals.

121 will provide insights into the BDNF mediated pathophysiology in coronary artery disease (CAD) that ma

122 d treatment for hypertension, the underlying pathophysiology in each patient has to be taken into con

123 y kidney disease according to its underlying pathophysiology in order to develop more precise and eff

124 COVID-19 pathophysiology includes respiratory failure but involve

125 y has potential downstream effects on asthma pathophysiology, including on airway epithelial cells, m

126 The pathophysiology is complex and involves a strong genetic

127 These findings indicate that atrial pathophysiology is critically dependent on local EpAT ac

128 demonstrates the diversity of sensory neuron pathophysiology is due in part to subtype-dependent sens

129 eater understanding of aetiopathogenesis and pathophysiology is emerging and includes intestinal comp

130 ding of atopic dermatitis (AD) and psoriasis pathophysiology is largely derived from skin biopsy stud

131 ially recapitulate key disease features, and pathophysiology is poorly understood.

132 Although schizophrenia's pathophysiology is still unclear, postmortem studies poi

133 Today, its pathophysiology is thought to involve the cold-induced f

134 ynuclein, which is critically involved in PD pathophysiology, is upregulated in inflamed segments of

135 ailures, and CNS trauma were the most common pathophysiologies leading to morbidity and mortality in

136 y may be increased because of the underlying pathophysiology leading to Fontan palliation, remodellin

137 The pathophysiologies of different IBMFSs are variable and c

138 However, the precise role of GR in the pathophysiology of AD remains unclear.

139 GR seems to occupy a central position in the pathophysiology of AD.

140 es, which has important implications for the pathophysiology of addiction.

141 factors may vary greatly and, therefore, the pathophysiology of AHF is highly heterogeneous.

142 oxygen species are centrally involved in the pathophysiology of airway diseases such as asthma and ch

143 e epithelial barrier to the forefront of the pathophysiology of airway inflammation, different approa

144 heterozygous mouse model sheds light on the pathophysiology of altered memory and cognitive function

145 acetylcholine receptor (alpha7-nAChR) in the pathophysiology of Alzheimer's disease.

146 that vHipp-NAcSh activity is relevant to the pathophysiology of anhedonia and depression as well as t

147 r responses have been well documented in the pathophysiology of anxiety and may play an important rol

148 in AT(1) receptor pathway contributes to the pathophysiology of ARDS, whereas activation of the ACE-2

149 concept that RA plays a critical role in the pathophysiology of arrhythmogenesis.

150 Yet how SMCs contribute to the pathophysiology of atherosclerosis remains elusive.

151 A prominent hypothesis regarding the pathophysiology of autism is that an increase in the bal

152 bition are hypothesized to contribute to the pathophysiology of autism.

153 Understanding the pathophysiology of autoimmunity and hyperinflammation in

154 sly unappreciated clues in understanding the pathophysiology of behavioural, psychiatric and neurodeg

155 nisms of binocular rivalry, the other on the pathophysiology of bipolar disorder.

156 es have evolved in recent years, deciphering pathophysiology of cardiac rejection.

157 local B cell response may contribute to the pathophysiology of CAV through a mechanism that needs to

158 isease, which would provide insight into the pathophysiology of chronic cachexia and a tool to test t

159 nflammasome substantially contributes to the pathophysiology of chronic cerebral hypoperfusion-induce

160 Our understanding of the pathophysiology of chronic rhinosinusitis (CRS) is conti

161 ANKA) has been extensively used to study the pathophysiology of CM.

162 cortex maturation has been implicated in the pathophysiology of cognitive deficits in psychiatric dis

163 s, provide insight into the potential immune pathophysiology of COPD exacerbations, and indicate that

164 lters platelet function to contribute to the pathophysiology of COVID-19 remains unknown.

165 st x-ray tomography as a tool to unravel the pathophysiology of Covid-19, extending conventional hist

166 linked to the cardiovascular-renal-pulmonary pathophysiology of COVID-19.

167 l a possible detrimental role of NETs in the pathophysiology of COVID-19.

168 In this review, the latest research on the pathophysiology of CRS with a focus on potential novel b

169 rtension, whereas the role of TGFbeta in the pathophysiology of CTEPH is unknown.

170 ting TRD provided a new understanding of the pathophysiology of depression, a paradigm shift from mon

171 contribute to a better understanding of the pathophysiology of diabetes.

172 in nutrient metabolism and insight into the pathophysiology of diabetes.

173 on has emerged as a central component of the pathophysiology of diffuse parenchymal diseases includin

174 he context of both normal physiology and the pathophysiology of disease and then extended to discuss

175 The pathophysiology of disease is not fully understood, and

176 f UPR signalling and its implications in the pathophysiology of disease might open new therapeutic av

177 itical to advancing our understanding of the pathophysiology of diseases involving the cerebellum.

178 ium dynamics and their potential role in the pathophysiology of disorders characterized by dysfunctio

179 As a result, D2R is involved in the pathophysiology of disorders such as schizophrenia and d

180 early 2000s, a greater understanding of the pathophysiology of diverticulosis and diverticular disea

181 ealed the implication of LXR and Nox4 in the pathophysiology of DPN.

182 R) for psychosis to further characterize the pathophysiology of early psychosis.

183 ling may provide additional insight into the pathophysiology of emphysema and inflammatory lung disea

184 h opens up new horizons in understanding the pathophysiology of endometriosis.

185 Findings may provide novel insights into the pathophysiology of epileptic seizures with respect to AN

186 h balance, which may offer new clues for the pathophysiology of epithelial structures.

187 Advances in understanding the pathophysiology of facioscapulohumeral dystrophy (FSHD)

188 buse burden advance our understanding of the pathophysiology of FND.

189 g recognition of duodenal alterations in the pathophysiology of functional dyspepsia (FD), the effect

190 As our understanding of the pathophysiology of functional dyspepsia increases, it is

191 The pathophysiology of functional gastrointestinal disorders

192 ent stem cells as a model to investigate the pathophysiology of FXS in human neurons, we reveal key n

193 the mechanisms of lithium action and on the pathophysiology of galactosemia.

194 f GDM and is usefulness in investigating the pathophysiology of GDM.

195 gist investigate the angle structure and the pathophysiology of glaucoma caused by MPS.

196 Additionally, the pathophysiology of GO (and likely pretibial myxoedema) i

197 The pathophysiology of Graves orbitopathy has also been revi

198 The importance of tissue damage in the pathophysiology of GVHD rationalizes the development of

199 tile output for energy conservation and that pathophysiology of HCM results from destabilization of t

200 Myocardial fibrosis may contribute to the pathophysiology of heart failure with preserved ejection

201 is recognized as playing a major role in the pathophysiology of heart failure; however, clinical tool

202 Thus, our model provides explanations of the pathophysiology of hemoglobinopathies and other disease

203 overed X4 viruses as potential agents in the pathophysiology of HIV-PAH.

204 we examine our current understanding of the pathophysiology of HRS-1 and existing challenges in its

205 The underlying pathophysiology of idiopathic OAB is not clearly known a

206 16 mice can be a useful model to examine the pathophysiology of increased upper airway collapsibility

207 sion and provide insight into the underlying pathophysiology of inherited skin blistering.

208 These findings suggest a race-specific pathophysiology of insulin resistance, which has implica

209 The pathophysiology of irritable bowel syndrome is incomplet

210 nd experimental interrogations to understand pathophysiology of K(v)7-associated EE.

211 Here, we outline the pathophysiology of Kawasaki disease and summarize and di

212 Despite its public health importance, the pathophysiology of Lassa fever in humans is poorly under

213 rotrophic factor (BDNF), a key player in the pathophysiology of major depression and the action of an

214 ) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD).

215 ce and is an ideal target for addressing the pathophysiology of many brain-related diseases.

216 ssion, miRNAs are strongly implicated in the pathophysiology of many complex diseases.

217 However, a possible role for ILC2s in the pathophysiology of mastocytosis remains unexplored.

218 stigate the role of basophils and IgE in the pathophysiology of MCTD.

219 ggests that cytokines play a key role in the pathophysiology of MDD and alterations in peripheral cyt

220 rest has been consistently implicated in the pathophysiology of MDD, potentially driven in part by ex

221 ostasis, thus providing new insight into the pathophysiology of metabolic disease.

222 Gut microbiota plays a role in the pathophysiology of metabolic diseases, which include non

223 between basal ganglia and cerebellum in the pathophysiology of movement disorders.

224 cellular studies of the normal function and pathophysiology of mural cells in a variety of disease m

225 This Review revisits the pathophysiology of myocardial ischaemia-reperfusion inju

226 studies implicating selected variants in the pathophysiology of NAFLD and highlight opportunities for

227 s of this motor cortex microcircuit with the pathophysiology of neurodegenerative diseases affecting

228 e reveal potential neural substrates for the pathophysiology of neuropsychiatric disease-associated c

229 circadian misalignment, contributing to the pathophysiology of OSA and potentially other diseases th

230 our findings expand our understanding of the pathophysiology of OSB and support the need for an early

231 ensory perception and sheds new light on the pathophysiology of pain and itch as well as the physiolo

232 The genetics and pathophysiology of Parkinson's disease (PD) strongly imp

233 The pathophysiology of pediatric anxiety appears to involve

234 ons in these processes may contribute to the pathophysiology of psychiatric disorders.

235 further investigations of shared and unique pathophysiology of psychiatric disorders.

236 dysregulation may be transdiagnostic of the pathophysiology of psychotic disorders such as DD and SZ

237 the prefrontal cortex that contribute to the pathophysiology of PTSD in humans.

238 analysis may facilitate comprehension of the pathophysiology of respiratory drive in critically ill p

239 nsequences of AHT are controversial, and the pathophysiology of retinal research findings is still no

240 ecognized to play a role in the etiology and pathophysiology of schizophrenia and other psychiatric d

241 n Glx in the left STG may be critical to the pathophysiology of schizophrenia.

242 urobiological factors that contribute to the pathophysiology of seasonal mood variations.

243 Little is known about the pathophysiology of seizure-induced headaches.

244 Alterations in gut microbiota impact the pathophysiology of several diseases, including cancer.

245 The pathophysiology of some of these novel variants has been

246 ty of limbic circuits is associated with the pathophysiology of stress-related disorders.

247 ances understanding of the genetic basis and pathophysiology of Takayasu arteritis and provides clues

248 t that gamma oscillations have a role in the pathophysiology of the abnormal LTP-like plasticity in P

249 d antioxidants are a critical contributor of pathophysiology of the CSD, and that is first explored t

250 The pathophysiology of the disease remains unclear, but the

251 Despite widespread interest in the pathophysiology of the disease, relatively little is kno

252 ter accord with the current knowledge of the pathophysiology of the disease.

253 s, mainly because it helps to understand the pathophysiology of the infection.

254 The pathophysiology of the leading cause of pediatric acute

255 the need for further investigation about the pathophysiology of this disease to provide clues for dev

256 s may open new avenues for understanding the pathophysiology of this disease, especially via longitud

257 th adult-onset HLH and can contribute to the pathophysiology of this disease.

258 The pathophysiology of this shock is unclear, and effective

259 Particularly, the pathophysiology of tumors without MYCN amplification rem

260 owledge on the role of beta-cell mass in the pathophysiology of type 1 and type 2 diabetes by enablin

261 VEGFs and Ang1 participate in the pathophysiology of U-HAE increasing the basal vascular p

262 The pathophysiology of visual symptoms might involve dysfunc

263 Is it merely a marker of underlying pathophysiology, or does it play a causal role in the pr

264 We review the pathophysiology, percutaneous therapeutic treatment opti

265 ay to study human intestinal development and pathophysiology, perhaps for therapeutic discovery.

266 nderstand its clinical relevance, underlying pathophysiology, possible means of early diagnosis and p

267 ntestinal disease of incompletely understood pathophysiology predominantly affecting premature infant

268 rse cTnI proteoforms to establish proteoform-pathophysiology relationships.

269 utions of transporter dysfunction to disease pathophysiology remain ambiguous as the fundamental rela

270 ognosis than normal-flow (NF) AS, though its pathophysiology remained unclear.

271 delirium, but our understanding of delirium pathophysiology remains limited.

272 tion of defined neuronal subtypes to seizure pathophysiology, remains poorly understood.

273 rther studies are required to understand the pathophysiology, response to treatment, and outcomes of

274 stigate the critical uncertainties regarding pathophysiology, risk factors and management.

275 on (AF) may improve the understanding of the pathophysiology, risk prediction, and development of new

276 a translational mouse model of the dopamine pathophysiology seen in schizophrenia and test approache

277 d age and cardiovascular risk factors, their pathophysiology, systemic implications, and management d

278 Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer p

279 at the hormone ghrelin may contribute to the pathophysiology that follows chronic stress.

280 es will provide insights into physiology and pathophysiology that more closely resemble intact intest

281 eizure activity in the brain is a widespread pathophysiology that, in principle, should yield to inte

282 ing sphingolipid biology with cardiovascular pathophysiology, these results suggest the potential uti

283 rent understanding of major depression, from pathophysiology to treatment.

284 diagnosis of MS induced cardiac and vascular pathophysiology, to assess prognosis, and understand the

285 widely used for research in the physiology, pathophysiology, toxicology, and pharmacology of the ren

286 iew discusses current evidence regarding the pathophysiology, transmission, diagnosis, and management

287 We describe the pathophysiology, treatment, and outcome of Crigler-Najja

288 ity, we gained a better understanding of the pathophysiology underlying human atherosclerosis.

289 which there are many) and instead target the pathophysiology underlying MECP2 disorders.

290 providing evidence of new insights into the pathophysiology underlying USH2A-retinal disease.

291 recognition surrounding the diversity of AD pathophysiology underscores the need for holistic system

292 (VBM) studies and resting-state voxel-based pathophysiology (VBP) studies of blood flow, glucose met

293 cognitive function and psychiatric disorder pathophysiology, via its hypothesised effects on adult h

294 onin gene-related peptide (CGRP) in migraine pathophysiology was identified over 30 years ago, but th

295 Other frequent pathophysiologies were inflammation (n = 104, 35.6%) rel

296 the group with both elevated amyloid and tau pathophysiology were declining approximately three times

297 is a neurological disorder of heterogeneous pathophysiology, which causes involuntary muscle contrac

298 A better understanding of bradykinesia pathophysiology will serve as the new starting point for

299 ed pathways in nACD, providing insights into pathophysiology with the potential to unravel novel ther

300 Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary