ライフサイエンスコーパス: pathway

1 we show that Wdp modulates the Hedgehog (Hh) pathway.

2 age and platelet activation through the TLR4 pathway.

3 from patients during their AAA surveillance pathway.

4 bolite generated in the isoleucine catabolic pathway.

5 for nuclear import of Gag through the TNPO3 pathway.

6 associated with the hedgehog (hh) signaling pathway.

7 functions within the cilium to regulate the pathway.

8 ll cancers exhibit malfunction along the p53 pathway.

9 cellular compartment to initiate a transport pathway.

10 tion by cis-regulating MAP3K4 via a p38 MAPK pathway.

11 t selective step in the antigen presentation pathway.

12 ctivation of TFL1 and repression of the LAP1 pathway.

13 ), the first enzyme in the sulfide oxidation pathway.

14 bute to complement activation via the lectin pathway.

15 ate immune signalling through the cGAS-STING pathway.

16 ty of a reductive and an oxidative quenching pathway.

17 both telomere cohesion and a DAXX-dependent pathway.

18 e domains in cellular feedback via the Hippo pathway.

19 atalyse the final step of the methanogenesis pathway.

20 tion (FDA) Emergency Use Authorization (EUA) pathway.

21 100%) received prior ICIs targeting the PD-1 pathway.

22 onfirm this potential role in the management pathway.

23 gramming of specific structural genes of the pathway.

24 rd comprehensive modeling of the MHC class I pathway.

25 that are predominantly activated by the Imd pathway.

26 may interact with an azithromycin-sensitive pathway.

27 e via both ERalpha dependent and independent pathways.

28 g mechanism that involves two ion-conducting pathways.

29 ularly distinct but functionally overlapping pathways.

30 lain the operation of other immune signaling pathways.

31 ulfur assimilation and cysteine biosynthetic pathways.

32 ers through regulation of diverse downstream pathways.

33 e for cross-regulation between different CDN pathways.

34 scales, from individual synapses to circuit pathways.

35 ated by inhibition of the CXCR4 and hedgehog pathways.

36 g resistance to therapies targeting anabolic pathways.

37 transfer and chain propagation are competing pathways.

38 alth has implicated air pollution and stress pathways.

39 pressed higher levels of adaptive resistance pathways.

40 primary hemostasis though several different pathways.

41 ry effects downstream from their main target pathways.

42 ssible interplay between the 2 Trp metabolic pathways.

43 s, transcriptional regulators, and metabolic pathways.

44 eletal organic matrix, and biomineralization pathways.

45 t-like effects and upregulated AKT/GSK3/EIF4 pathways.

46 g free energy landscapes, intermediates, and pathways.

47 d ubiquitylation and activated innate immune pathways.

48 ngaged in the control of divergent molecular pathways.

49 al because it carries all the genes for both pathways.

50 ng from 32 to 64% according to two synthetic pathways: (1) using a titanium-reductive amination react

51 ilatory nitrate reduction to ammonium (DNRA) pathway, a process that competes with denitrification, c

52 ies on an energy-intensive thermal treatment pathway (Acheson process) at about 3000 degrees C.

53 and is present in a wide range of signaling pathways across different evolutionary taxa.

54 TrkA is an important player in the signaling pathway activated by eotaxin-1 during eosinophil migrati

55 nsable for both ligand-independent signaling pathway activation and ligand-responsive signaling hyper

56 nscriptome profiling displayed that TGF-beta pathway activation and ossification-related processes we

57 ld partially be attributed to increased MAPK pathway activation and thromboxane generation.

58 lizing antibody partially downregulated mTOR pathway activation but showed no effect on viability.

59 c analysis of monocyte subsets and signaling pathway activation patterns in conventional monocytes an

60 ly it to learn network similarity and shared pathway activity for groups of cancers with related orig

61 domain-mediated interactions influence Hippo pathway activity.

62 icant differences in taxonomic or functional pathway alpha-diversity between CTX-T and CTX-N infants.

63 These findings suggest a transmission pathway analogous to that described for Toxoplasma gondi

64 ion is controlled via the same physiological pathway and if dioecy evolved independently.

65 asis displayed reduced activation of the AHR pathway and increased CYP1A1 enzymatic activity compared

66 ce resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress.

67 dings indicate a previously unknown assembly pathway and inspire a suggestion as to why this aggregat

68 3 (PI3), a gene in the antimicrobial peptide pathway and known to be involved in antimicrobial and an

69 n pathology affecting the ascending auditory pathway and multimodal cortex, depletion of cognitive re

70 s a potent inhibitor of both the alternative pathway and the terminal pathway, with possible applicat

71 as endocytosed in an AP2- and Tf-independent pathway and trafficked to the lysosome for degradation.

72 ith cell adhesion molecules and IFN response pathways and a strong negative correlation with Myc tran

73 ions that can disrupt intermediary metabolic pathways and cause defective absorption and metabolism o

74 Interestingly, enhanced innate-like pathways and characteristics develop progressively in MA

75 EF transcriptomic subgroups with distinctive pathways and clinical correlates, including a group clos

76 potential to circumvent steroid sensitivity pathways and decrease mucus plugging.

77 AS provide a powerful opportunity to explore pathways and mechanisms contributing to pathophysiology.

78 fically inhibits NF-kappaB and Akt signaling pathways and promotes accelerated cell death in HSV-infe

79 We assess the tractability of mitophagy pathways and prospects for drug discovery and consider i

80 central oncogenic driver activate divergent pathways and subvert transformation.

81 that constitute these microtubule nucleation pathways and their mode of action still need to be ident

82 pression, play important roles in epigenetic pathways, and are hypothesized to contribute to hybrid v

83 transcriptional networks, hormone signaling pathways, and plant developmental processes.

84 As a result, glutamine pathways are an emerging pharmacologic target.

85 This ignores the data dependencies and that pathways are incomplete or condition-specific.

86 ition receptors, internal cellular signaling pathways are induced to ultimately fend off the attack.

87 s studies have shown that Heck or alkylation pathways are preferred when stronger-coordinating direct

88 heless, mechanistic details of these sensory pathways are still sparse and represent a challenging fr

89 mmalian target of rapamycin (mTOR) signaling pathway as a candidate mechanism.

90 n activity-dependent manner, opening up this pathway as a means to pharmacologically modulate the rec

91 entified the aryl hydrocarbon receptor (AHR) pathway as a potent tumour suppressor in a SHH medullobl

92 entially expressed metabolites and metabolic pathways associated with neuropathology and cognitive pe

93 d early activation of pro-fibrotic signaling pathways before adverse ventricular remodeling and progr

94 s indicate that BBR antagonizes beta-catenin pathway by inhibiting beta-catenin translation and mTOR

95 e for Xinbeta in signaling via the Hippo-YAP pathway by recruiting NF2 to the ICD to modulate cardiac

96 system represents a previously unappreciated pathway by which type 3 immunity is modulated and immune

97 /DNA complexes, and provide insight into the pathways by which those complexes assemble.

98 Investigation of whether a certain signaling pathway can confer bistability involves a substantial am

99 eral components of the nuclear factor-kappaB pathway cause immunodeficiency.

100 e highly interconnected network, we identify pathway communities and hundreds of previously unknown p

101 alogous gene history for the mammalian Hippo pathway components and characterized their cancer-derive

102 requires the primary cilium (PC) where major pathway components are dynamically enriched.

103 mmunities and hundreds of previously unknown pathway contacts that represent potential points of cros

104 TBK2) is a key player in the cilium assembly pathway, controlling the final step of cilia initiation.

105 the mechanisms of HPgammaCD-induced cellular pathways could contribute to effective NPC therapies.

106 Eicosanoids were grouped by biosynthetic pathway, defined by (1) the fatty acid precursor, includ

107 This pathway-dependent targeting of kidney cancer arises from

108 l, which highlights their different toxicity pathways despite their similar structures.

109 e production reveals an additional bacterial pathway distinct from archaeal methanogenesis.

110 itical for chordoma survival and upregulated pathways dominated by ATF4-driven stress and proapoptoti

111 elease, we sought to elucidate the signaling pathway downstream of PAR4 activation that leads to such

112 tanding of the mechanisms controlled by MAPK pathway driving melanogenesis will help develop new trea

113 activity and prime protective immunity, the pathways driving this phenotype remain unclear.

114 t PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkne

115 may be attributed to different fragmentation pathways enabled by allylic versus vinylic carbons.

116 ncer arises from the fact that the secretion pathway enables ICG-PEG45 to be effectively effluxed out

117 , which proceed via two distinct mechanistic pathways: enantioselective acyl transfer promoted by ami

118 We examine regions and pathways expressing the stress-sensitive peptide cortico

119 However, the kinetic pathways, following which such development occurs, have

120 usefulness in providing a hugely beneficial pathway for accurate antibiotic prescribing and thus a n

121 Hydroxyl polymer doping thus offers a pathway for efficient H doping in green solvent-processe

122 o Ni(2+)-based compounds and offers a future pathway for optical readout of these molecules.

123 Wastewater is a common pathway for the spread of antibiotic resistance (AR) gen

124 coming virions into the retrograde transport pathway for trafficking to the nucleus.

125 In the kynurenine pathway for tryptophan degradation, an unstable metaboli

126 However, many NF-kappaB-mediated pathways for cell survival and apoptosis signaling in ca

127 have yet been identified, and the signaling pathways for cGAMP have been inferred to display a narro

128 Current evidence regarding the common pathways for genetic pathogenesis and the anatomical dis

129 th existing models on the ventral and dorsal pathways for language processing.

130 he IRBITs are at the nexus of the regulatory pathways for multiple renal transport processes.

131 insights in understanding intrinsic reaction pathways, for affording structure-activity relationships

132 ry activity, define mechanisms of signalling pathways from the gut microbiota to the brain and discus

133 had frequent mutations in IRF4 and NF-kappaB pathway genes (CARD11, CD79B, and MYD88), losses of 17p1

134 ic events, the role of PKI proteins in these pathways has remained elusive.

135 Several H-H bond forming pathways have been proposed for the hydrogen evolution r

136 ll proliferation via regulation of the Hippo pathway, highlighting the potential of protein tertiary

137 Despite their intact cGAS sensing pathway, human CD4(+) T cells failed to mount a reverse

138 findings implicate that the HSP90A-TCL1A-AKT pathway ignited by NANOG is a central molecular axis and

139 regulate diverse cellular and developmental pathways, implicating them in many diseases besides canc

140 ulence was still dependent on the mevalonate pathway in 10403S strains expressing the more active Gcp

141 AA1), a key enzyme in the auxin biosynthesis pathway in Arabidopsis thaliana is phosphorylated at Thr

142 ighlight a novel function of the Delta/Notch pathway in beta-cell insulin secretion.

143 reased activation of the NF-kappaB signaling pathway in bone marrow and BM-MSC of DeltaNC16A mice.

144 ncover a role for the beta-catenin signaling pathway in fine tuning the granulocytic production, open

145 nstrate that the Ras->Raf->rho kinase (ROCK) pathway in MBn suppresses ARM consolidation, allowing th

146 activated via a pharmacological interactions pathway in patients with liver injury is indicative of a

147 cal for its function in activating the Hippo pathway in response to osmotic stress.

148 cted, indicating a certain plasticity of the pathway in the amoeba.

149 dergo degradation through the 26S proteasome pathway in the dark.

150 ogically activating the mitotic surveillance pathway in the developing brain.

151 We introduce a complete mevalonate pathway in the peroxisome to convert acetyl-CoA to sever

152 In conclusion, this study identified the pathway in which ubiquitinated OAT1 degrades and unveile

153 Signaling pathways in cells were analyzed by immunoblots.

154 d that dynamic GNs generate new biosynthetic pathways in different Brassicaceae lineages by shuffling

155 repress the activity of proteostasis-related pathways in early adulthood.

156 ghlight DNA double-strand break (DSB) repair pathways in human cells, how DNA repair failures can lea

157 further understand the roles of these decay pathways in KSHV gene expression.

158 ical leukocyte subsets as well as associated pathways in nACD, providing insights into pathophysiolog

159 nclusions: We found enrichment of Rho-GTPase pathways in obese asthmatic Th cells, identifying them a

160 integrating light and temperature signaling pathways in plants remain poorly understood.

161 t the involvement of several decarboxylating pathways in the Kok effect, including the malic enzyme.

162 connection between the reward and circadian pathways in the regulation of pathological calorie consu

163 Differences in cell-signaling pathways in the uterine tissues of G12D and G12V mice we

164 emand, thus possibly representing one of the pathways in which familial risk is translated into the S

165 g primarily occurred through induced-folding pathways (in which intermolecular contacts form before o

166 regulates a number of endosomal trafficking pathways including retrograde transport to the trans-Gol

167 sis of the Banert cascade proceeding by both pathways including substituent effects and KIE.

168 ll death using components of the necroptotic pathway, including receptor-interacting protein kinase-3

169 ureus mutants deficient in central metabolic pathways, including glycolysis, gluconeogenesis, the tri

170 It currently hosts 298 reference pathways, including metabolic and transport pathways, tr

171 sion of genes (DEGs) involved in nociceptive pathways, including sensory neurons.

172 ce (such as information on biotransformation pathways) increases the likelihood of detecting plausibl

173 bit loss of function in modulating the Hippo pathway, inducing CIP, as well as attenuated suppression

174 clinical studies have shown that JAK or PI3K pathway inhibition is insufficient to eradicate the most

175 of N-acylethanolamides-lipoprotein-borne Hh pathway inhibitors required for Smo destabilization.

176 It remains unclear how these pathways interact to contribute to contextual modulation

177 acterial communities and microplastic uptake pathways into bivalves, and discuss whether they represe

178 enabling a detailed analysis of the various pathways involved in glyoxylate metabolism.

179 While the pathways involved in maintenance of the repressive heter

180 refore, we have identified a gene regulatory pathway involving CsCLV3, CsWUS, CsFUL1(A) and CsARF14 i

181 le differentially expressed gene clusters in pathways involving metabolism and circadian rhythm were

182 Hippo pathway is activated in major cellular components of the

183 As this pathway is critical for fungal cell wall integrity, the

184 yte growth factor receptor (c-MET) signaling pathway is dysregulated in several malignancies, includi

185 Moreover, the caspase-autophagy pathway is engaged by fear conditioning to facilitate as

186 Thus, the disruption of CD133 signal to PI3K pathway is essential to overcome Melanoma resistance to

187 the mechanism suggests that a cobalt-hydride pathway is involved in the reaction.

188 the clinical efficacy of inhibitors to this pathway is limited by resistance.

189 iates upstream signals to regulate the Hippo pathway is not clear.

190 The MAPK pathway is often found to be highly activated in TNBC, h

191 isoning may be cancer cell selective if this pathway is overactive in a cancer cell relative to a non

192 However, the HR pathway is primarily restricted to actively dividing cel

193 uggests that the MHC-II antigen presentation pathway is required for PIV-mediated protection against

194 Our results indicate that the endosomal pathway is required for the signaling cascade initiated

195 A unique feature of the vertebrate Hh pathway is that signal transduction requires the primary

196 ty and ubiquity of interbacterial antagonism pathways is becoming increasingly apparent, and the insi

197 ucleus communication by retrograde signaling pathways is essential for fine-tuning of responses to th

198 ding of how effectors manipulate nonimmunity pathways is only beginning to emerge.

199 rmalities in sleep and anxiety-related brain pathways is presented.

200 epair and ATR-Chk1 DNA damage response (DDR) pathways, it remains unknown how the APE2 gene is altere

201 3K9me2) silenced the expression of the Hippo pathway kinase LATS2, and this effect led to subsequent

202 ga-oxidation, a minor fatty acid degradation pathway known to be stimulated by C(12) accumulation, wa

203 crosslinks (TOP2-DPCs) in a direct-reversal pathway licensed by ZATTZNF451 SUMO2 E3 ligase and SUMOy

204 Components of these pathways localize to, or form distinct aggregates in the

205 upregulation of the cholesterol biosynthesis pathway may negatively impact fish growth due to its lar

206 tes with drugs that use endogenous transport pathways may lead to more effective treatments for disea

207 Inhibition of multiple growth factor pathways may postpone resistance and extend progression-

208 ition of the impairment of NR2B/PSD-95/MAP1A pathway, may be a novel and preferential option to ameli

209 shown to enhance the expression of the Toll pathway-mediated antimicrobial peptides when the flies w

210 expression changes that significantly impact pathways mediating the metabolism and transport of gluco

211 When expressed virally in "indirect pathway" medium spiny neurons (iMSNs) in the ventral str

212 responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary ma

213 Analysing mechanisms and pathways modulated by these genes, we find that they are

214 we report that the IKK2/NF-kappaB signaling pathway modulates metastasis-associated protein 2 (MTA2)

215 Alternative tumour suppressor pathways need to be explored to treat p53- deficient tum

216 Ni(I)-CO intermediate in the Wood-Ljungdahl pathway of anaerobic CO and CO(2) fixation.

217 Rationale: The IMPACT (Informing the Pathway of Chronic Obstructive Pulmonary Disease Treatme

218 an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-n

219 by targeting specific domain or proteostatic pathway of mHTT, providing novel insights into such path

220 Although the pathway of PIC assembly is well established, the mechani

221 el processing stage along the ventral visual pathway of the macaque monkey.

222 including further elucidating of the genetic pathway of which it is a part, determining its role in t

223 rst time, suppression of non-radiative decay pathways of a chromophore was tested by anchoring the ch

224 These results define the repair pathways of DNA interstrand crosslinks caused by an endo

225 es are intimately connected to intracellular pathways of fatty acid metabolism and therefore uniquely

226 e that either the canonical or non-canonical pathways of inflammasome activation have a limited role

227 DV) leader proteinase (Lpro) affects several pathways of the host innate immune response.

228 spurs interest in simulations of (un)binding pathways of TSPO ligands, which could reveal the molecul

229 anonical histone H2A.Z, thereby focusing the pathway on select sites such as transcriptionally active

230 Most bacteria have one pathway or the other, but the Gram-positive, facultative

231 rd integrating these data to identify active pathways or modules under certain experimental condition

232 The Akt/mTOR pathway played a critical role in the AML-EV-induced phe

233 The pathways promoting excessive activation are incompletely

234 ions across all Representative Concentration Pathway (RCP) scenarios to smaller spatial scales, in th

235 th process is mediated by several signalling pathways (referred to as intrinsic and extrinsic) trigge

236 The Hippo pathway regulates cell proliferation and organ size thro

237 3K lipid kinases signal through the PI3K/Akt pathway, regulating cell growth and proliferation.

238 onclusion, although targeting the PD-1/PD-L1 pathway reinvigorates exhausted CD8(+) T cells, it fails

239 Although the canonical pathway remained unchanged, autocrine SHH interference i

240 We identified 11 cellular pathways required for HIV-1 reactivation as druggable ta

241 e origin of low-oxidation-state iron and the pathways responsible for its formation and evolution rem

242 depend on type I IFN or on IL-22 signaling, pathways responsible for protection against acute stress

243 and chemogenetic inhibition of the PFC-BNST pathway restored abnormal responses to predator odor in

244 s in factors governing the hypoxia signaling pathway, resulting in metabolic dysregulation, heightene

245 ecades, the commonly accepted transformation pathway-sequential hydroxylation of the ring followed by

246 ion of downstream effectors of the PI3K/GSK3 pathway, SGK1 and GSK3, induced alterations in levels of

247 ts that target RNA processing and DNA repair pathways simultaneously as effective cancer therapies.

248 ddition of UBA I seed crystals modified this pathway such that only UBA I was observed throughout, wh

249 al regulators of these responses and related pathways such as autophagy and apoptosis.

250 questions concerning understudied migration pathways, such as the Sicilian route.

251 in addition to other protein quality control pathways, such as the ubiquitin-proteasome system, mitoc

252 tress, along with AMPK activation and mTORC1 pathway suppression, which subsequently triggered AMPK-d

253 red and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the rol

254 ated transcription factor (nMRTF) resistance pathway that amplifies noncanonical Gli1 activity, but c

255 nnected by a novel synapto-nuclear signaling pathway that surprisingly invoked mechanisms akin to Heb

256 idinium reactivates a latent septin assembly pathway that was suppressed during fungal evolution in o

257 with a focus on themes identified in the TLR pathways that also explain the operation of other immune

258 Inputs to molecular pathways that are the backbone of cellular activity driv

259 onal analyses in mice, we detected four main pathways that contribute to SVAS risk.

260 to adjacent epidermal keratinocytes through pathways that involve microtubule networks and the actin

261 As such, discovering signaling pathways that modulate albuminuria is desirable.

262 dissect the molecular pathways that respond to the state of glucose metabolism

263 Impairments to the pathways that transform all-trans-retinal back to 11-cis

264 key role in the regulation of cell metabolic pathways that underly normal human T cell responses have

265 t the S-OFF response is mediated by the S-ON pathway through inhibitory input from an undiscovered S-

266 HE4 overexpression activated the NF-kappaB pathway through the NF-kappaB transcription-activating g

267 ly unrecognized connection between these two pathways through our discovery that human aminolevulinic

268 ant p53 were driven by disruption of the WNT pathway, through preventing the binding of TCF4 to chrom

269 hierarchical structure of the visual motion pathway to demonstrate dissociation in the fMRI response

270 oring exotic physics and promises a scalable pathway to high-performance devices.

271 tions that provide insights into the diverse pathways to access triplet excited states in organic chr

272 ls science has been informed by nonclassical pathways to crystallization, based on biological process

273 Possible pathways to integrate organic and inorganic structures b

274 urvival, these bacteria rely on chemosensory pathways to sense and respond to changing environmental

275 ral component of all electrosensory feedback pathways to the electrosensory lateral line lobe (ELL).

276 pathways, including metabolic and transport pathways, transcriptional networks, hormone signaling pa

277 the immune system, autophagy, and apoptosis pathway transcripts, indicating that the DAP1 risk allel

278 The Wnt signaling pathway triggers human BTSC proliferation in vitro and i

279 gly, deletion or depletion of the N-end rule pathway ubiquitin E3 ligases in NatB mutants did not res

280 LAMTOR4 and LAMTOR5 in regulating the mTORC1 pathway under fed and starved conditions.

281 Here, we connect these two reaction pathways using bases and a simple Pd-based catalyst syst

282 typically associated with studies of patient pathways using patient interviews.

283 have enabled the development of AF screening pathways using the ubiquitous 12-lead ECG to detect asym

284 Vs to activate each zymogen of the intrinsic pathway was assessed in a buffer system.

285 Implementation of an ERAS pathway was associated with effective post-operative ana

286 Conservation of this regulatory pathway was confirmed in human psoriasis using vorapaxar

287 known components of the interferon signaling pathway, we found that replication termination factor 2

288 at suramin disrupts glycolytic or glycosomal pathways, we noted increased mitochondrial ATP productio

289 Significantly dysregulated genes and pathways were determined, and those in common with type

290 In brain, neuroprotective pathways were identified as potential targets regulated

291 global change drivers operate via different pathways when decreasing soil animal biomass.

292 nel mRNAs that are primed to activate rescue pathways when m6A levels drop.

293 ilize glycolytic and nucleotide biosynthesis pathways, whereas OXPHOS(low) BAP1 mutant UM cells emplo

294 vates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltration and ac

295 e evolutionary roots of this major signaling pathway, will shed light on the origins of regulated inn

296 ne bacteria transform DMSP via two competing pathways with considerably different biogeochemical impl

297 system that shares many conserved genes and pathways with humans.

298 or glucocorticoid-regulated genes and immune pathways with some of these genes mediating the effects

299 oth the alternative pathway and the terminal pathway, with possible applications in complement resear

300 channel combining the ON and OFF feedforward pathways within the output layer of the retina.