ライフサイエンスコーパス: pedunculopontine

1 The role of the pedunculopontine and cuneiform nuclei, and related brain

2 c reticular formation (MRF) is formed by the pedunculopontine and cuneiform nuclei, two neuronal stru

3 phalic reticular formation (MRF), namely the pedunculopontine and cuneiform nuclei.

4 ressors on brainstem (upper pons, containing pedunculopontine and lateraldorsal tegmental nuclei; BS)

5 The mesopontine tegmentum, including the pedunculopontine and laterodorsal tegmental nuclei (PPN

6 Neurons of the pedunculopontine and laterodorsal tegmental nuclei synap

7 in the gigantocellular region, in the caudal pedunculopontine and laterodorsal tegmental nuclei, dors

8 NC, as noted above, and to medial tegmentum, pedunculopontine and laterodorsal tegmental nuclei, dors

9 lateral geniculate, deep mesencephalic, red, pedunculopontine and laterodorsal tegmental, cuneiform,

10 raphe, parabrachial complex, pontine oralis, pedunculopontine and ventral tegmental area.

11 gray, the cuneiform, and the lateral dorsal, pedunculopontine, and subpeduncular pontine tegmental nu

12 ion of inputs originating from dorsal raphe, pedunculopontine, and subthalamic nuclei were tested for

13 Parkinson's disease, the additional loss of pedunculopontine cholinergic neurones, which control REM

14 timulation of the dopaminergic region evoked pedunculopontine dopamine release in vivo.

15 d, visual looming, and air puffs, except for pedunculopontine GABAergic cells, which did not respond

16 ocomotion during which activity increased in pedunculopontine glutamatergic cells.

17 oked by visual looming or sound, activity in pedunculopontine glutamatergic neurons was higher than w

18 y of dopamine neurons, whereas activation of pedunculopontine inputs increased burst firing.

19 The pedunculopontine-laterodorsal tegmental nuclear complex

20 Available sleep-relevant areas (pedunculopontine/laterodorsal tegmentum, nucleus basalis

21 l type-specific activity in the cuneiform or pedunculopontine nuclei during locomotion, non-locomotor

22 mitter-based cell types in the cuneiform and pedunculopontine nuclei during locomotion, non-locomotor

23 tergic neurons in the midbrain reticular and pedunculopontine nuclei show short latency and phasic ch

24 neurons in the basal forebrain, striatum and pedunculopontine nuclei, i.e. the neurons that innervate

25 c zone of the laterodorsal tegmentum and the pedunculopontine nuclei, referred to as rapid eye moveme

26 c zone of the laterodorsal tegmentum and the pedunculopontine nuclei, referred to as Wake/REM-on neur

27 ions with dramatic enrichment of both in the pedunculopontine nuclei, the accessory olfactory bulb, a

28 striatal projection neurons by the raphe and pedunculopontine nuclei.

29 Collaterals from the pedunculopontine nucleus (Ch5 area) to rostral [vasopres

30 to GABA expression in neurons in the caudal pedunculopontine nucleus (cPPN).

31 c locomotor region (MLR), which includes the pedunculopontine nucleus (PPN) and the cuneiform nucleus

32 Cholinergic neuronal loss in the pedunculopontine nucleus (PPN) associates with abnormal

33 Whereas cholinergic neurons of the pedunculopontine nucleus (PPN) carry an associative/moto

34 The pedunculopontine nucleus (PPN) has long been considered

35 f glutamatergic Chx10-derived neurons in the pedunculopontine nucleus (PPN) in mice arrests all ongoi

36 dies, mainly in animals, have shown that the pedunculopontine nucleus (PPN) in the upper brainstem ha

37 The pedunculopontine nucleus (PPN) is a promising new target

38 The pedunculopontine nucleus (PPN) located in the mesopontin

39 Because the pedunculopontine nucleus (PPN) plays an important role i

40 Optogenetic stimulation of the cholinergic pedunculopontine nucleus (PPN) promotes glioma growth in

41 Because the pedunculopontine nucleus (PPN) regulates sleep and arous

42 es that preserved subcortical axons from the pedunculopontine nucleus (PPN) to the VTA, we compared t

43 Recent animal studies suggest that the pedunculopontine nucleus (PPN), a small brainstem struct

44 tum, substantia nigra, basal forebrain (BF), pedunculopontine nucleus (PPN), and habenula (HB) encode

45 tamate afferents: dorsal raphe nucleus (DR), pedunculopontine nucleus (PPN), and subthalamic nucleus

46 rons in the rostral brainstem, including the pedunculopontine nucleus (PPN), are critical for switchi

47 rs of the superior colliculus (DLSC) and the pedunculopontine nucleus (PPN), but the contributions of

48 The pedunculopontine nucleus (PPN), the cholinergic arm of t

49 While the cuneiform nucleus (CnF) and pedunculopontine nucleus (PPN), the main components of t

50 In terms of topography in the tegmental pedunculopontine nucleus (PPN), Type I neurons were disp

51 These brainstem structures include the pedunculopontine nucleus (PPN), which is traditionally c

52 gross motor impact through inhibition of the pedunculopontine nucleus (PPN).

53 rticularly within a brainstem structure, the pedunculopontine nucleus (PPN).

54 nce of modulatory input from the cholinergic pedunculopontine nucleus (PPN).

55 arise in various brain nuclei, including the pedunculopontine nucleus (PPN).

56 nd parabrachial nuclei, periaqueductal gray, pedunculopontine nucleus (PPT) and laterodorsal tegmentu

57 in both the thalamus (rho=-0.88, P<.001) and pedunculopontine nucleus (rho=-0.80, P<.010) were invers

58 were positively correlated with those in the pedunculopontine nucleus (rho=0.81, P<.004) and binding

59 ral tegmental area, reticular formation, and pedunculopontine nucleus and a dense nonreciprocal proje

60 Parkinson's disease, which involves both the pedunculopontine nucleus and cholinergic basal forebrain

61 Inclusions were detected in neurons of the pedunculopontine nucleus and in other brain stem regions

62 s from other cholinergic nuclei, such as the pedunculopontine nucleus and nucleus basalis of Meynert.

63 tor and intralaminar thalamus as well as the pedunculopontine nucleus and the midbrain reticular form

64 Impaired integrity of pedunculopontine nucleus cholinergic neurons and their t

65 tion of cholinergic neurons in the brainstem pedunculopontine nucleus complex and their thalamic effe

66 during gait, and suggest that differences in pedunculopontine nucleus connectivity contribute to poor

67 Local field potentials recorded from pedunculopontine nucleus electrodes in such patients hav

68 within the MLR, clinicians have targeted the pedunculopontine nucleus exclusively, while leaving the

69 Furthermore, unilateral stimulation of pedunculopontine nucleus glutamatergic axons in the stri

70 Structural connectivity of the pedunculopontine nucleus has been related to freezing an

71 In addition, degeneration of the pedunculopontine nucleus impairs behavioural flexibility

72 ics from the cholinergic basal forebrain and pedunculopontine nucleus in 99 people with Parkinson's d

73 lation of the hypothalamus, basal ganglia or pedunculopontine nucleus in decorticate animals results

74 we recorded local field potentials from the pedunculopontine nucleus in parkinsonian patients during

75 g to quantify structural connectivity of the pedunculopontine nucleus in patients with Parkinson's di

76 c activation of glutamatergic axons from the pedunculopontine nucleus induced monosynaptic excitation

77 Excitatory inputs from the pedunculopontine nucleus interact with timed inhibitory

78 The pedunculopontine nucleus is one of the major nuclei of t

79 l deep brain stimulation targets such as the pedunculopontine nucleus may help treat the balance and

80 fic to one subregion, while the amygdala and pedunculopontine nucleus preferentially affiliated with

81 We also chose the pedunculopontine nucleus region (PPN) due to mounting ev

82 Alpha power was maximal in the caudal pedunculopontine nucleus region and beta power was maxim

83 hic distribution of neuronal activity in the pedunculopontine nucleus region and concur with animal d

84 rkinsonian patients, stimulation of a caudal pedunculopontine nucleus region selectively improves gai

85 ility that stimulation of caudal and rostral pedunculopontine nucleus regions may differ in their cli

86 Chronic pedunculopontine nucleus stimulation improved Freezing o

87 Pedunculopontine nucleus stimulation improved objective

88 Pedunculopontine nucleus stimulation is an emerging ther

89 In Parkinson's disease, pedunculopontine nucleus stimulation is an emerging trea

90 However, the efficacy and precise effects of pedunculopontine nucleus stimulation on Parkinsonian gai

91 essed the impact of unilateral and bilateral pedunculopontine nucleus stimulation on triggered episod

92 Pedunculopontine nucleus stimulation restored StartReact

93 g; however, these deficits were unchanged by pedunculopontine nucleus stimulation.

94 eezing and postural instability, relieved by pedunculopontine nucleus stimulation.

95 es of Parkinsonian disorders, treatable with pedunculopontine nucleus stimulation.

96 nts with severe gait freezing implanted with pedunculopontine nucleus stimulators below the pontomese

97 We also assessed asymmetry of pedunculopontine nucleus structural connectivity via dif

98 nterference was correlated with asymmetry of pedunculopontine nucleus structural connectivity, Go-NoG

99 ces in executive dysfunction were related to pedunculopontine nucleus structural network connectivity

100 ra-striatal cholinergic projections from the pedunculopontine nucleus to the substantia nigra pars re

101 hat the more left hemisphere-lateralized the pedunculopontine nucleus tract volume, the poorer the pe

102 that free-water-corrected DTI metrics in the pedunculopontine nucleus were associated with performanc

103 We report reduced connectivity of the pedunculopontine nucleus with the cerebellum, thalamus a

104 tegmentum, superior and inferior colliculi, pedunculopontine nucleus), and in the lumbosacral spinal

105 The pedunculopontine nucleus, a component of the reticular f

106 ojecting to the striatum also innervated the pedunculopontine nucleus, a known locomotor center, and

107 ger-Westphal nucleus, parabigeminal nucleus, pedunculopontine nucleus, and laterodorsal tegmental nuc

108 c and glutamatergic neurons in the tegmental pedunculopontine nucleus, and/or inhibitory GABAergic pr

109 a, various thalamic and hypothalamic nuclei, pedunculopontine nucleus, Barrington's nucleus, retrofac

110 However, a dopaminergic innervation of the pedunculopontine nucleus, considered part of the MLR, wa

111 within cholinergic and other neurons in the pedunculopontine nucleus, cuneiform nucleus, and griseum

112 of the substantia nigra and extended to the pedunculopontine nucleus, red nucleus and subthalamic nu

113 ections between the spinal cord, cerebellum, pedunculopontine nucleus, subcortical and frontal/prefro

114 basis pontis, numerous thalamic nuclei, the pedunculopontine nucleus, the oculomotor nucleus, the hi

115 a thalamocortical system, in particular, the pedunculopontine nucleus, to address gait disorders that

116 Using seed regions from the pedunculopontine nucleus, we were able to delineate whit

117 also restored on cholinergic neurons of the pedunculopontine nucleus, where their loss correlates wi

118 cts with Parkinson's disease is modulated by pedunculopontine nucleus-thalamic but not cortical choli

119 ervation to the striatum, originating in the pedunculopontine nucleus.

120 beled WGA-HRP/ChAT neurons were found in the pedunculopontine nucleus.

121 y, we found dopaminergic fibers in the human pedunculopontine nucleus.

122 nuclei of the basal ganglia, as well as the pedunculopontine (PPN) and cuneiform (Cnf) nuclei.

123 Cholinergic neurons of the pedunculopontine (PPN) and laterodorsal tegmental (LDT)

124 Cholinergic neurons of the pedunculopontine (PPN) and laterodorsal tegmental nucleu

125 holinergic output neurons located within the pedunculopontine (PPT) and laterodorsal tegmental (LTD)

126 rons in the laterodorsal tegmental (LDT) and pedunculopontine (PPT) nuclei has been implicated in man

127 Morphological features of rat pedunculopontine projection neurons were investigated in

128 he mesopontine tegmental area, including the pedunculopontine tegmental (PPT) and lateral dorsal tegm

129 ntracellular signaling mechanisms within the pedunculopontine tegmental (PPT) nucleus for the regulat

130 The pedunculopontine tegmental (PPT) nucleus has long been c

131 The pedunculopontine tegmental (PPT) nucleus has long been i

132 e brain with the highest levels found in the pedunculopontine tegmental area, the lateral dorsal tegm

133 ibuted within the laterodorsal tegmental and pedunculopontine tegmental nuclei (LDT and PPT), choline

134 distributed throughout the laterodorsal and pedunculopontine tegmental nuclei (LDT and PPT).

135 The laterodorsal and pedunculopontine tegmental nuclei (LDT-PPT) are involved

136 hese include the locus coeruleus, dorsal and pedunculopontine tegmental nuclei, dorsal raphe, and lat

137 sure, parabrachial nucleus, laterodorsal and pedunculopontine tegmental nuclei, nucleus incertus, and

138 9%), oral pontine reticular nucleus (64.5%), pedunculopontine tegmental nucleus (55.7%), and dorsal r

139 131%); laterodorsal tegmental nucleus (56%); pedunculopontine tegmental nucleus (86%); dorsal raphe n

140 The SNr is reciprocally connected with the pedunculopontine tegmental nucleus (PPN) in the brainste

141 glia are more highly interconnected with the pedunculopontine tegmental nucleus (PPN) than with any o

142 n as an important source of afferents to the pedunculopontine tegmental nucleus (PPN).

143 of the laterodorsal tegmentum (LDT) and the pedunculopontine tegmental nucleus (PPN).

144 responsible for this behaviour, placing the pedunculopontine tegmental nucleus (PPT) at its centre.

145 active avoidance by inhibiting cells in the pedunculopontine tegmental nucleus (PPT), not by inhibit

146 he periventricular gray corresponding to the pedunculopontine tegmental nucleus (PPT), the laterodors

147 ia projections to cholinergic neurons of the pedunculopontine tegmental nucleus (PPT).

148 olateral mesopontine tegmentum comprises the pedunculopontine tegmental nucleus (PPT).

149 d by either medial forebrain bundle (MFB) or pedunculopontine tegmental nucleus (PPTg) activation of

150 The pedunculopontine tegmental nucleus (PPTg) has been propo

151 The pedunculopontine tegmental nucleus (PPTg) in the mesopon

152 The pedunculopontine tegmental nucleus (PPTg) is a brainstem

153 The pedunculopontine tegmental nucleus (PPTg) is defined by

154 Pedunculopontine tegmental nucleus (PPTg) lesions in rod

155 carbachol (5 micrograms in 250 nl) into the pedunculopontine tegmental nucleus (PPTg) or the nucleus

156 Cholinergic projections from the pedunculopontine tegmental nucleus (PPTg) to the retrotr

157 Cholinergic projections from the pedunculopontine tegmental nucleus (PPTg) to the rostral

158 We focused on activity in the pedunculopontine tegmental nucleus (PPTg), a mesencephal

159 GABA into the ventral tegmental area (VTA), pedunculopontine tegmental nucleus (PPTg), and oral pont

160 5-HT(1A)) receptor-responsive neurons in the pedunculopontine tegmental nucleus (PPTn) become maximal

161 omical and neurophysiological data about the pedunculopontine tegmental nucleus (PPTN), lateral hypot

162 ntified cholinergic neurons in the brainstem pedunculopontine tegmental nucleus and basal forebrain.

163 e in the cholinergic cell body region of the pedunculopontine tegmental nucleus and in the cholinocep

164 The findings support a critical role for pedunculopontine tegmental nucleus glutamate neurotransm

165 ntion and arousal.SIGNIFICANCE STATEMENT The pedunculopontine tegmental nucleus is the source of chol

166 We used optogenetics to demonstrate that the pedunculopontine tegmental nucleus sends glutamatergic p

167 aqueductal gray matter, reticular formation, pedunculopontine tegmental nucleus, and dorsal raphe nuc

168 inger-Westphal nucleus, periaqueductal gray, pedunculopontine tegmental nucleus, caudal ventrolateral

169 ze prodynorphin-derived peptides, except the pedunculopontine tegmental nucleus, the accessory trigem

170 gmental area, the retrorubral field, and the pedunculopontine tegmental nucleus.

171 ction from the deep mesencephalic reticular, pedunculopontine tegmental, dorsal raphe, median raphe,

172 y ipsilateral labeling in the paralemniscal, pedunculopontine tegmental, Kolliker-Fuse, and parabrach

173 arify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmen

174 Cells in the pedunculopontine tegmentum (PPT) play a key role in the

175 Aergic fibers that project to an area in the pedunculopontine tegmentum (PPT) within the midbrain loc

176 study examines the effects of lesioning the pedunculopontine tegmentum (PPTg) and laterodorsal tegme

177 s that projected to the visual thalamus: the pedunculopontine tegmentum and, to a lesser extent, the

178 CaMKII-expressing neurons in the pedunculopontine tegmentum area (PPT) of the midbrain lo

179 ivity, and at 6 and 12 months the numbers of pedunculopontine tegmentum choline acetyltransferase-pos

180 The pedunculopontine tegmentum nucleus (PPT) is critically i

181 ne acetyltransferase-positive neurons in the pedunculopontine tegmentum of Tg2576 mice at 2 months ev

182 dbrain circuit, including the input from the pedunculopontine tegmentum to the VTA.

183 tivation of cholinergic projections from the pedunculopontine tegmentum to vlPAG relieved pain, even

184 nt cholinergic/nitrergic projection from the pedunculopontine tegmentum, gamma-aminobutyric acid (GAB

185 n of sleep, including the lateral dorsal and pedunculopontine tegmentum.