ライフサイエンスコーパス: pellucida

1 h the oocyte prior to assembly into the zona pellucida.

2 42.3% and 27.2% of activity variation in P. pellucida.

3 event that occurs upon contact with the zona pellucida.

4 ing sperm are not able to penetrate the zona pellucida.

5 ding, penetration, and signaling by the zona pellucida.

6 d, sperm-binding ligand on the ovulated zona pellucida.

7 or secretion and incorporation into the zona pellucida.

8 sequently to definitive endoderm of the area pellucida.

9 ired for mouse sperm binding to the egg zona pellucida.

10 inner, thick extracellular matrix, the zona pellucida.

11 ecreted prior to incorporation into the zona pellucida.

12 ng sulfated carbohydrates of the oocyte zona pellucida.

13 ytosis, enabling sperm to penetrate the zona pellucida.

14 sites were distributed over the entire zona pellucida.

15 dhesin with differing avidities for the zona pellucida.

16 nant form capable of binding to the pig zona pellucida.

17 ed acrosome reaction, and penetrate the zona pellucida.

18 in ovaries isolated from mice lacking a zona pellucida.

19 olved in the sperm's passage across the zona pellucida.

20 tinct native B cell determinants of the zona pellucida.

21 to secretion and incorporation into the zona pellucida.

22 nd human sperm do not bind to the mouse zona pellucida.

23 nto the oviduct, and binding to the egg zona pellucida.

24 ed hatching of the blastocysts from the zona pellucida.

25 existence of a P-selectin ligand in the zona pellucida.

26 ctin ligand is expressed in the porcine zona pellucida.

27 ered by adhesion to the mammalian egg's zona pellucida.

28 ated, adult mZP3-/- females also lack a zona pellucida.

29 oocytes, the oocytes completely lack a zona pellucida.

30 ts sperm binding and penetration of the zona pellucida.

31 ucent shell of the blue-rayed limpet Patella pellucida.

32 recognition and penetration through the zona pellucida.

33 long the oviduct and penetration of the zona pellucida.

34 tact between the sperm and the oocyte's zona pellucida.

35 incapable of fusing with eggs that lack zona pellucida.

36 in in the egg's extracellular coat, the zona pellucida.

37 n mediating the binding of sperm to the zona pellucida.

38 binding and/or penetration through the zona pellucida.

39 he interaction of this protein with the zona pellucida.

40 with ADAM3 in sperm binding to the egg zona pellucida.

41 and named for its binding to the oocyte zona pellucida.

42 hese mutant mice cannot bind to the egg zona pellucida.

43 sperm with reduced ability to penetrate zona pellucida.

44 ore thrust to penetrate the cumulus and zona pellucida.

45 ular matrix of mouse eggs, known as the zona pellucida.

46 ically deficient in adhesion to the egg zona pellucida (0.3% of wild type) and to the egg plasma memb

47 thyroid hormone (Pth)-calcitonin (Calc)-zona pellucida 2 (2p2) was established.

48 Autoantibody to a zona pellucida 3 (ZP3) epitope was found to induce autoimmune

49 by regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed excl

50 on of CPEB after pachytene, we used the zona pellucida 3 (Zp3) promoter to generate transgenic mice e

51 analysis of the pattern of evolution of Zona Pellucida 3 (ZP3), a protein present on the avian egg co

52 pe mice, we have generated human ORMDL3 zona pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that overexpress

53 h the ZP3330-342 peptide of the ovarian zona pellucida 3 glycoprotein, ZP3.

54 epitope-specific autoantibody to murine zona pellucida 3 induces severe ovarian disease in neonatal,

55 macaques immunized with monkey or human zona pellucida 3 peptide (pZP3) in adjuvant, developed T-cell

56 nd in an interaction domain of the ZP3 (zona pellucida 3) protein.

57 immune complex with endogenous ovarian zona pellucida 3, and a pathogenic CD4(+) T cell response is

58 l knockout in growing oocytes using the Zona pellucida 3-Cre (Zp3-Cre) transgenic mice.

59 and, given the conserved nature of the zona pellucida, a similar phenotype is expected in other mamm

60 To prevent polyspermy, the zona pellucida, a structure that surrounds mammalian eggs, be

61 template the structure of CUB domain in zona pellucida adhesion protein PSP-I/PSP-II from porcine spe

62 perm to produce a secretory response to zona pellucida agonists.

63 ulted in human sperm penetration of the zona pellucida and accumulation in the perivitelline space, w

64 lacking ZP3 (Zp3(tm/tm)) do not form a zona pellucida and are infertile.

65 3-null mice, which never form a visible zona pellucida and are sterile.

66 d increases at the boundary between the area pellucida and area opaca during elongation.

67 ormal motility, and could penetrate the zona pellucida and bind to the oolemma.

68 avonoids and antioxidant activity in both P. pellucida and C. sinensis teas, the anti-inflammatory po

69 cts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos transf

70 for the prospective penetration of the zona pellucida and fusion with the egg.

71 Acrosome reaction, binding to zona pellucida and fusion with the oolemma were lower in Prdx

72 they demonstrate maximal binding to the zona pellucida and greatly increased sensitivity to ionophore

73 specifically reacted with ZP3 of oocyte zona pellucida and its affinity-purified antibodies completel

74 d significant reductions in a subset of zona pellucida and lectin-type proteins between wild-type and

75 oocytes exhibited irregularities of the zona pellucida and meiotic spindle.

76 bryo transduction protocols (removal of zona pellucida and subzonal microinjection).

77 f ZP2 in mediating sperm binding to the zona pellucida and support a model in which human sperm-egg r

78 Sperm also bind transiently to the egg zona pellucida and the egg plasma membrane and then fuse.

79 s between the cumulus cells outside the zona pellucida and the oocyte within.

80 ncorporated throughout the width of the zona pellucida and the transgenic mice are fertile.

81 dergo capacitation in order to bind the zona pellucida and undergo a Ca(2+) ionophore-induced acrosom

82 uman sperm did not bind to the chimeric zona pellucida, and notwithstanding the absence of mouse ZP3,

83 sperm motility, metabolism, binding to zona pellucida, and proteasome-mediated catabolism.

84 erm is induced by sperm adhesion to the zona pellucida, and signaling in the egg by gamete fusion.

85 cts with the female reproductive tract, zona pellucida, and the oolemma.

86 known to have binding activity for the zona pellucida, and this action may serve to anchor sperm dur

87 ), separating the former from the inner area pellucida (AP) epiblast.

88 The multimeric forms did not bind the zona pellucida as avidly as did the p105/45 monomer.

89 that the changes that take place in the zona pellucida at fertilization affected the interaction of t

90 In addition, heterologous zona pellucida binding assays revealed that sperm from subfer

91 These include a zona pellucida binding domain, which is present in a number o

92 Zona pellucida binding protein 1 (ZPBP1), a spermatid and spe

93 ulatory inhibitor subunit 1B (PPP1R1B), zona pellucida binding protein 2 (ZPBP2), and gasdermin B (GS

94 ly of zinc finger 3 (AIOLOS; IKZF3) and zona pellucida binding protein 2 (ZPBP2).

95 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA])

96 t rabbit proacrosin contains a specific zona pellucida binding site and that the loop containing argi

97 he latter, does not inhibit human sperm-zona pellucida binding under hemizona assay conditions.

98 here was no significant effect on sperm-zona pellucida binding; however, fertilization was reduced fr

99 motility, capacitation, binding to the zona pellucida, binding to the oocyte membrane, and penetrati

100 Many candidates have been proposed as zona pellucida-binding proteins.

101 n mouse eggs is required to produce the zona pellucida block to polyspermy.

102 t with the egg extracellular matrix, or zona pellucida, by the matrix glycoprotein ZP3.

103 Ability to penetrate the zona pellucida, cleavage rate, cleavage kinetics, and blastoc

104 Although a zona pellucida composed of ZP2 and ZP3 was formed around grow

105 The mouse zona pellucida consists of three glycoproteins that are synth

106 The mouse egg extracellular coat, or zona pellucida, consists of three glycoproteins, called mZP1-

107 rtly after blastocyst hatching from the zona pellucida constitute a major cause of pregnancy losses i

108 Results show that the ovulated zona pellucida contains at least two distinct ligands for spe

109 The mouse zona pellucida contains three glycoproteins, ZP1, ZP2, and ZP

110 Rgs2(-/-) eggs also underwent premature zona pellucida conversion in vivo.

111 that were sufficient to cause premature zona pellucida conversion.

112 us, cytoplasm, perivitelline space, and zona pellucida-could be visually differentiated in both oocyt

113 nels during gamete interaction inhibits zona pellucida-dependent Ca2+ elevations, as demonstrated by

114 ZP3, the glycoprotein agonist of the zona pellucida, depolarizes sperm membranes by activating a p

115 DPY, and terminating in a crosslinking zona pellucida domain and membrane anchor sequence.

116 light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent T

117 o controls the arrangement of two other zona pellucida domain proteins, Dumpy and Piopio, external to

118 possess an N-terminal signal peptide, a zona pellucida domain, a consensus furin-like cleavage site (

119 ructure and contained peptides from the zona pellucida domain, which is involved in cell differentiat

120 We show here that the zona pellucida domain-containing protein Dusky-like is essent

121 7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-associates into multim

122 In the absence of the zona pellucida, embryos lacking CTNNB1 undergo fission and th

123 Second, misexpression of Wnt1 in the area pellucida enables this region to form a primitive streak

124 the in vitro binding of murine sperm to zona pellucida-enclosed eggs.

125 capacitation, the ability to undergo a zona pellucida-evoked acrosome reaction, develops more slowly

126 tgun cell adhesion protein gene and the zona pellucida family transmembrane protein gene, CG13196.

127 parisons to be made with the process of zona pellucida formation in mammals.

128 Oocyte growth and zona pellucida formation proceed normally, but other aspects

129 Treatment of zona pellucida-free eggs with chymotrypsin reduces the abilit

130 mal when null spermatozoa were added to zona pellucida-free eggs, but in the presence of the extracel

131 oocyte membrane, and penetration of the zona pellucida-free oocyte.

132 ility of Tenr mutant sperm to fertilize zona pellucida-free oocytes and to bind to, but not fertilize

133 demonstrate that a genetic defect in a zona pellucida gene causes infertility and, given the conserv

134 isexpression of chordin in the anterior area pellucida generates an ectopic primitive streak that exp

135 oordinating the expression of the three zona pellucida genes during oogenesis.

136 teins in this regard because only human zona pellucida glycoprotein 3 (ZP3) and bovine proopiomelanoc

137 3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida glycoprotein 3 Cre (ZP3Cre)] and Control (C1ga

138 o specific O-linked oligosaccharides on zona pellucida glycoprotein 3.

139 c RNA and proteomic data, we identified zona pellucida glycoprotein 4 (ZP4) as a novel target for TNB

140 Each zona pellucida glycoprotein is synthesized in growing oocytes

141 located at the sperm combining site of zona pellucida glycoprotein mZP3.

142 a cell-surface receptor for the murine zona pellucida glycoprotein ZP3, standard immunoelectron micr

143 ZP3, an egg zona pellucida glycoprotein, produces a sustained increase of

144 in that functions as a receptor for the zona pellucida glycoprotein, ZP3, and as an inducer of the ac

145 ific oligosaccharide ligands within the zona pellucida glycoprotein, ZP3, via beta1,4-galactosyltrans

146 Zona pellucida glycoproteins are responsible for species-rest

147 glycoprotein ligand-1 (PSGL-1) and from zona pellucida glycoproteins of porcine oocytes indicate the

148 hese female fertilization proteins, the zona pellucida glycoproteins ZP2 and ZP3, are part of the mam

149 (approximately 83 000 Mr), one of three zona pellucida glycoproteins, and once bound undergo the acro

150 , such as the physiological stimulus of zona pellucida glycoproteins, results in a loss of chirality.

151 s and reveal novel functions for murine zona pellucida glycoproteins.

152 alTase bound ZP3 but did not bind other zona pellucida glycoproteins.

153 is extracellular matrix is known as the zona pellucida in eutherian mammals and consists of three gly

154 This matrix is known as the zona pellucida in mammals and is critically important for the

155 y induced Ab to ZP3335-342 bound to the zona pellucida in the functional and degenerative ovarian fol

156 These embryos do not hatch from the zona pellucida in vitro, fail to grow in culture, and exhibit

157 produced antibody that bound to native zona pellucida in vivo.

158 o the extracellular coat of the egg, or zona pellucida, in a species-specific manner.

159 tyrosine phosphorylation as well as the zona pellucida-induced acrosome reaction.

160 ion of the area opaca directly onto the area pellucida induces a new marginal zone from the latter; t

161 media and in their ability to fertilize zona pellucida-intact eggs.

162 ytes and to bind to, but not fertilize, zona pellucida-intact oocytes suggests that the normal-appear

163 ied antibodies completely blocked sperm-zona pellucida interaction in mice.

164 t sp56 may function in acrosomal matrix-zona pellucida interactions during and immediately following

165 esion event between mouse sperm and the zona pellucida is a high affinity event which is sufficient t

166 SignificanceHatching from the zona pellucida is a prerequisite for embryo implantation and

167 The mammalian zona pellucida is an egg extracellular matrix to which sperm

168 The zona pellucida is an extracellular matrix consisting of three

169 The zona pellucida is an extracellular matrix that mediates taxon

170 The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2 a

171 The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2,

172 The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2,

173 In mice, the zona pellucida is composed of three glycoproteins, but the pr

174 The mouse zona pellucida is composed of three glycoproteins, ZP1, ZP2 a

175 The mouse egg zona pellucida is constructed of three glycoproteins, called

176 itive streak formation in the posterior area pellucida is influenced by the adjacent posterior margin

177 After fertilization, the zona pellucida is modified ad minimus by cleavage of ZP2, and

178 mes indicates that sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosi

179 species-specific adhesion to the egg's zona pellucida, is a speciation gene in placental mammals.

180 nd anti-inflammatory activities of Peperomia pellucida (L.) Kunth tea with commercial Camellia sinens

181 Overall, unfermented and fermented P. pellucida leaves were best dried with microwaving and fr

182 Recently the zona pellucida like domain containing 1 protein (ZPLD1, also

183 yos, these data are consistent with the zona pellucida maintaining interactions between granulosa cel

184 esicle-intact oocytes but that lacked a zona pellucida matrix and had a disorganized corona radiata.

185 ent in MVA and is incorporated into the zona pellucida matrix of transgenic mice.

186 tated to prevent incorporation into the zona pellucida matrix, complementing earlier studies indicati

187 domain and assembled into the insoluble zona pellucida matrix.

188 Via its bipartite zona pellucida module (ZP-N/ZP-C), UMOD forms extracellular f

189 nitiate fertilization by binding to the zona pellucida (mZP), the specialized extracellular matrix of

190 covering of the egg known as the murine zona pellucida (mZP).

191 ein with a signal peptide followed by 3 zona pellucida N domains, consistent with extracellular local

192 ich the supramolecular structure of the zona pellucida necessary for sperm binding is modulated by th

193 the physical interaction of EVs and the zona pellucida of 4- to 8-cell stage embryos using transmissi

194 The antiserum also failed to label the zona pellucida of oocytes examined by laser scanning confocal

195 mediate recognition and binding to the zona pellucida of the egg are still not understood.

196 s: sperm bind and penetrate through the zona pellucida of the egg, adhere to the egg plasma membrane

197 ty interferes with sperm binding to the zona pellucida of the ovum.

198 Recombinant ZP3R/sp56 bound to the zona pellucida of unfertilized eggs but not to 2-cell embryos

199 SED1 binds specifically to the zona pellucida of unfertilized oocytes, but not to the zona o

200 ely surrounding the embryonic epiblast (area pellucida) of the chick embryo, is important in setting

201 fic manner to the extracellular matrix (zona pellucida) of the oocyte.

202 The extracellular coat, or zona pellucida, of the mouse egg consists of three glycoprote

203 t constitute the extracellular coat, or zona pellucida, of the oocyte.

204 steps, including the acrosome reaction, zona pellucida penetration, sperm-egg attachment, and membran

205 BMP-4 is misexpressed in the posterior area pellucida, primitive streak formation is inhibited.

206 Adhesion to the egg's zona pellucida promotes Ca2+ influx through voltage-sensitive

207 the recombinant N-terminal part of the zona pellucida protein 2 randomizes chirality in capacitated

208 The cuticle collagen ROL-6 and zona pellucida protein NOAH-1 display aberrant annular locali

209 is closely related to that of the mouse zona pellucida protein ZP2.

210 o not acrosome-react in response to egg zona pellucida proteins and have reduced fertilizing ability,

211 phore conjugated to solubilized porcine zona pellucida proteins to observe zona receptors on live boa

212 es encoding antifreeze glycoprotein and zona pellucida proteins, are highly expanded in the icefish g

213 pectrometric analysis of the native rat zona pellucida proteome (defined as the fraction of the total

214 e transient immunocontraceptive porcine zona pellucida (PZP), and found that repeated vaccinations ex

215 ever, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstand

216 Sperm at the surface of the zona pellucida remained acrosome-intact for more than 2 hours

217 liculogenesis and those that encode the zona pellucida required for fertilization and early embryonic

218 ent in a number of proteins such as the zona pellucida sperm binding proteins, and uromodulin, In add

219 ur until the morula stage, and that the zona pellucida suffices to maintain blastomere proximity.

220 The extracellular zona pellucida surrounding mammalian eggs is formed by intera

221 loendopeptidase that cleaves ZP2 in the zona pellucida surrounding mouse eggs to prevent additional s

222 ired for formation of the extracellular zona pellucida surrounding mouse eggs.

223 The mammalian zona pellucida surrounding ovulated eggs mediates sperm bindi

224 in mammals is mediated primarily by the zona pellucida surrounding ovulated eggs.

225 The zona pellucida surrounding ovulated mouse eggs contains three

226 ilization occurs when sperm contact the zona pellucida surrounding the egg.

227 barriers and penetrate the cumulus and zona pellucida surrounding the egg.

228 The zona pellucida surrounding the pig oocyte contains two Mr 55,

229 The extracellular zona pellucida surrounds mammalian eggs and mediates taxon-sp

230 The extracellular zona pellucida surrounds ovulated eggs and mediates gamete re

231 high K(+) or by addition of solubilized zona pellucida (sZP).

232 s and secreted to form an extracellular zona pellucida that mediates sperm binding and fertilization.

233 Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in

234 malian oocytes synthesize and secrete a zona pellucida that surrounds the growing oocytes, ovulated e

235 is a protein in the mammalian egg coat (zona pellucida) that binds sperm and stimulates acrosomal exo

236 nded by a thick extracellular coat, the zona pellucida, that plays important roles during early devel

237 elatively thick extracellular coat, the zona pellucida, that plays vital roles during oogenesis, fert

238 BSA, as measured by the ability of the zona pellucida to induce the acrosome reaction and by success

239 red for the structural integrity of the zona pellucida to minimize precocious hatching and reduced fe

240 the mammalian egg extracellular matrix (zona pellucida) to allow penetration of the egg coat.

241 Uromodulin is a zona pellucida-type protein essentially produced in the thick

242 out 75-80% of the murine sperm bound to zona pellucida under well defined in vitro conditions is carb

243 t sperm and shown to bind to homologous zona pellucida using an in vitro assay.

244 lthough porcine sperm first contact the zona pellucida via their plasma membrane, the regions of the

245 rm were able to fertilize eggs once the zona pellucida was removed but displayed persistent abnormal

246 teas, the anti-inflammatory potential of P. pellucida was significantly (p < 0.05) improved.

247 idant and anti-inflammatory activities in P. pellucida were significantly (p < 0.05) lower than C. si

248 fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2, and

249 associate with the inner aspect of the zona pellucida, which is distinct from the plasma membrane.

250 ablish a tenacious association with the zona pellucida, yet they are capable of fertilization.

251 mans, is dependent on the presence of a zona pellucida (ZP) around growing oocytes and unfertilized e

252 r extracellular segment that includes a zona pellucida (ZP) domain and several plasminogen N-terminal

253 Proteins harboring a zona pellucida (ZP) domain are prominent components of verteb

254 The zona pellucida (ZP) domain is a bipartite protein structural

255 s; the Tecta(L1820F,G1824D/+) mouse for zona pellucida (ZP) domain mutations causing stable mid-frequ

256 We show in Drosophila that the zona pellucida (ZP) domain protein Piopio interacts and coope

257 ich contains chondroitin proteoglycans, Zona Pellucida (ZP) domain proteins, and other glycoproteins

258 Additionally, we identify two zona pellucida (ZP) domain proteins, Piopio (Pio), and Dumpy

259 tein, bone morphogenetic protein-1) and zona pellucida (ZP) domain-containing protein we find promine

260 eins share a sequence designated as the zona pellucida (ZP) domain.

261 ludes a domain of eight cysteines and a zona pellucida (ZP) domain.

262 ents and extracellular matrices through zona pellucida (ZP) domains.

263 se proteins is related to mammalian egg zona pellucida (ZP) glycoproteins ZP1-3 and possesses an N-te

264 OMD), cortical granule (CG) status, and zona pellucida (ZP) hardening as well as the integrity of the

265 OMD), cortical granule (CG) exocytosis, zona pellucida (ZP) hardening, and spindle/chromatin integrit

266 egg by a single sperm, the egg coat or zona pellucida (ZP) hardens and polyspermy is irreversibly bl

267 olved directly in binding to the female zona pellucida (ZP) in a species-specific manner.

268 ation of fertilization, including sperm-zona pellucida (ZP) interactions as well as the early events

269 The zona pellucida (ZP) is a highly organized extracellular coat

270 The zona pellucida (ZP) is an extracellular matrix that surrounds

271 essential to fertilization, and the egg zona pellucida (ZP) is generally believed to be an in vivo in

272 The zona pellucida (ZP) is vital for species-specific fertilizati

273 resolution, comprised of the bipartite zona pellucida (ZP) module in a helical arrangement with a ri

274 ading to conformational activation of a Zona Pellucida (ZP) polymerisation domain.

275 All mutant oocytes had an altered zona pellucida (ZP) that was thinner than the control ZP, and

276 ation the spermatozoon binds to the egg zona pellucida (ZP) via sperm receptor(s) and undergoes an ac

277 mammalian sperm must first bind to the zona pellucida (ZP), a glycoprotein matrix surrounding the eg

278 ession of an antibody that binds to the zona pellucida (ZP), a glycoprotein matrix that surrounds the

279 The zona pellucida (ZP), an ovarian extracellular structure, cont

280 matozoa bound tightly or penetrated the zona pellucida (ZP), and fewer underwent acrosome reactions.

281 Zona pellucida (ZP), the extracellular matrix sheltering mamm

282 he morphological characteristics of the zona pellucida (ZP), trophectoderm (TE), blastocoel (BC), and

283 -EC) binds to the microvillar region of zona pellucida (ZP)-free eggs, the region of the membrane to

284 fects also show impaired binding to the zona pellucida (ZP).

285 major component of the oocyte-specific zona pellucida (ZP).

286 rix coating of the oocyte, known as the zona pellucida (ZP).

287 s-specific binding activity for the egg zona pellucida (ZP).

288 ing eggs in fish (chorion) and mammals (zona pellucida [ZP]) regulate gamete recognition before ferti

289 fertilization, spermatozoa bind to the zona pellucida (ZP1, ZP2, ZP3) surrounding ovulated mouse egg