ライフサイエンスコーパス: penetration

1 ing the paper to heat treatment to allow wax penetration.

2 ised near the boiling point permitted enzyme penetration.

3 ng that DBO functionalization did not impair penetration.

4 t vascular extravasation and pervasive tumor penetration.

5 nsitizers with high sensitivity, safety, and penetration.

6 compositions and to investigate nanoparticle penetration.

7 infection structure (IFS) formation and host penetration.

8 id ionic liquid (CAGE) to enhance its dermal penetration.

9 sma exposure and partial blood-brain barrier penetration.

10 d, maintaining low Pgp efflux needed for CNS penetration.

11 tective barriers against oxygen and moisture penetration.

12 onal sub-cellular resolution and deep tissue penetration.

13 remaining six mGlu receptors), and high CNS penetration.

14 ngth of lux (peak 490 nm) has limited tissue penetration.

15 ization with high resolution and deep tissue penetration.

16 rgeting, efficient cell uptake, and membrane penetration.

17 e of their low phototoxicity and high tissue penetration.

18 pharmacokinetic properties, including brain penetration.

19 eactions that can inactivate viruses without penetration.

20 tion on the NLRP3 inflammasome and its brain penetration.

21 ize its pharmacokinetic properties and brain penetration.

22 g peptide-penetratin (Pen) for enhanced cell penetration.

23 ct time, tear dilution and poor corneal cell penetration.

24 e interfacial resistance and severe Li-metal penetration.

25 ent antibodies, which further reduces tissue penetration.

26 selection of these attributes for increased penetration.

27 strategies in enhancing epidermal and dermal penetration.

28 improve nuclease resistance and enhance cell penetration.

29 nature of most methods used to measure cell penetration.

30 cluding its high cost and non-uniform tissue penetration.

31 g a role for SR-As in SNA uptake and 3D raft penetration.

32 matically recording neurons within a grid of penetrations.

33 saccade-related CD neurons using the grid of penetrations.

34 Fluorescein penetration (0.09%) was less than rhodamine B (6.98%) at

35 ics (DMPK) properties with significant brain penetration (17-19%, mice).

36 nus Au-MnO nanoparticles (NPs) with promoted penetration ability.

37 tiforme (GBM) is constrained by insufficient penetration across the blood-brain barrier (BBB).

38 is retardation of drug diffusion due to poor penetration across the matrix.

39 topical administration because of poor drug penetration across the stratum corneum.

40 nstrated a 2.5-fold increase in maximum drug penetration and a 3-fold increase in drug retention at 5

41 arved sediments characterized by deep oxygen penetration and a prevalence of oxidized nitrogen.

42 l proteins in the cell wall for appressorial penetration and abundance of which for invasive growth.

43 ard PEG surface chemistries to achieve mucus penetration and address some of the challenges encounter

44 over the laryngeal inlet, protecting against penetration and aspiration of food into the airway.

45 Immunostaining revealed V565 tissue penetration and association with inflammatory cells, whi

46 th equal tumor uptake due to improved tissue penetration and cellular distribution.

47 corneal epithelial surface and trans-corneal penetration and corneal adsorbance measured at fixed tim

48 al barrier function allowed deeper bacterial penetration and denser neutrophil infiltration in the de

49 solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes,

50 otor adaptor that coordinates virus membrane penetration and disassembly.

51 Investigating the penetration and distribution of a topical drug's active

52 in efflux-compromised strains indicate that penetration and efflux properties of many redesigned BC

53 he drug-loaded SqNPs showed improved biofilm penetration and enhanced efficacy in relevant biological

54 econdary CBA targeting moiety for deep tumor penetration and enhanced uptake in tumor cells.

55 after topical application is ocular surface penetration and existing models are in vivo or use large

56 s in vivo, with the advantage of deep tissue penetration and fewer interactions with the surroundings

57 TMNPs showed enhanced penetration and growth inhibition on MCs.

58 al processes involved in spore biology, host penetration and haustorium formation and function.

59 d to blood vessels because it possesses deep penetration and high resolution in biological tissue.

60 tion of molecular processes with deep tissue penetration and high spatiotemporal resolution.

61 The luc signal had enhanced tissue penetration and improved anatomical co-registration with

62 ltagpi7 mutant showed significant defects in penetration and invasive growth.

63 lectrolyte of MoB can facilitate electrolyte penetration and LiPS redox, guaranteeing a high utilizat

64 -Vst7 module regulates VdSho1-mediated plant penetration and melanin production in V. dahliae, contri

65 proteins aiming to significantly enhance BBB penetration and modulate Abeta-induced neuronal damage b

66 to 13 days before surgery to evaluate brain penetration and modulation of the PI3K pathway in resect

67 r internalization rate enabled higher tissue penetration and more cell killing.

68 lated biological applications where the deep penetration and non-invasive nature of NIR light coupled

69 ce status, mouth opening, risk of aspiration/penetration and QOL in HNC patients.

70 profile across species with excellent brain penetration and residence time.

71 the nanotherapeutic to EphA2 improved tumour penetration and resulted in markedly enhanced antitumour

72 ith filleted bases to ensure successful skin penetration and retention during application.

73 todynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages incl

74 These improvements in drug penetration and retention translated into an enhanced th

75 rence at 16 days post injection for both Dox penetration and retention.

76 predicted by models that accounted for light penetration and scavenging of reactive oxygen species.

77 icular lesion creation with capacity for fat penetration and sparing of nearby coronary arteries beca

78 delivery and significantly improve the tumor penetration and therapeutic efficacy of chemotherapeutic

79 rs, but proper dosing can improve the tissue penetration and thus therapeutic efficacy of these biolo

80 equired for conidiation, IFS formation, host penetration and virulence of the pathogen.

81 8 displayed excellent brain penetration and was well-tolerated in mice.

82 For particular isotopes, collimator penetration and x-ray fluorescence contributed a signifi

83 may curtail the depth or direction of penile penetration and/or semen movement.

84 ing and fibronectin assembly, increases drug penetration, and downregulates ITGA5/FN1 expression, res

85 bility in human hepatocytes, excellent brain penetration, and efficacy in Tsc1(GFAP)CKO mice qualify

86 ions drive their recognition, nondestructive penetration, and elaborate reengineering of the host's c

87 resources, access to health care, insurance penetration, and healthcare regulation.

88 functions including cell recognition, tissue penetration, and imaging.

89 ding substantial oral bioavailability, brain penetration, and significant inhibition of exosome relea

90 w brightness, high cytotoxicity, poor tissue penetration, and unwanted side effects.

91 ted with patients exhibiting any aspiration (Penetration Aspiration Scale score >= 6) (p = 0.016; odd

92 One third of patients (n = 68) aspirated (Penetration Aspiration Scale score >= 6) on at least one

93 Aspiration (Penetration Aspiration Scale score >= 6) was further cat

94 rther categorized into nonsilent aspiration (Penetration Aspiration Scale score = 6 or 7) and silent

95 Scale score = 6 or 7) and silent aspiration (Penetration Aspiration Scale score = 8).

96 thology was evaluated, and for each bolus, a Penetration Aspiration Scale score was assigned.

97 ed with measures of radiological aspiration (penetration aspiration scale, Spearman rank rs = 0.49, p

98 cytosolic delivery, the recent chloroalkane penetration assay (CAPA) is coupled with automated high

99 lls near the epidermis, inhibiting M. oryzae penetration at the early stage of infection.

100 iquely difficult due to a highly restrictive penetration barrier and other mechanisms that allow bact

101 The penetration barrier makes screening conventional synthet

102 tions, is herein proposed for predicting BBB penetration based on five physicochemical descriptors: n

103 hesize in defined sizes, may have poor brain penetration because of its negative charge, and is a pow

104 amic imaging of the droplet meniscus and its penetration behavior into the surface texture, we expose

105 infrared open exciting opportunities in deep-penetration bioimaging, chemically specific sensing, and

106 xtensively from 100 kHz to 10 MHz, with high penetration but less localization.

107 ide capsule of Klebsiella pneumoniae resists penetration by antimicrobials and protects the bacteria

108 , we observed that PIP(2) can drive membrane penetration by both syt1 and Doc2beta in the absence of

109 ribe the results of our analysis of cellular penetration by different classes of conformationally sta

110 of VLCFAs prevents septin assembly and host penetration by M. oryzae.

111 how various in-vivo 'features' such as tumor penetration, cell interactions, and increased resistance

112 his treatment group had a 5-fold maximum Dox penetration compared to Dox alone ISFIs (0.53 +/- 0.22 c

113 rmulation demonstrated an improved BBB model penetration cross the in vitro BBB model and an enhanced

114 required for bsr-d1-mediated resistance and penetration-dependent immunity, and advanced our underst

115 were evaluated based on the treatment area, penetration depth and thermal distribution due to laser

116 Power penetration depth dropped with temperature at 915 MHz (f

117 wing to scattering and absorption limits the penetration depth for imaging.

118 A light to obtain a PDT effect, limiting the penetration depth inside tissues and, therefore, the pos

119 e, which is unlike standard PDT, where light penetration depth is limited in biological tissues.

120 m, respectively, for optical sectioning at a penetration depth of approximately 750 mum through live

121 overcomes the limitations imposed by shallow penetration depth of ultraviolet excitation, photostabil

122 PME studies, we suggest specifying the fiber penetration depth or the fiber-sample distance with the

123 s of low energy, less health risks, and high penetration depth through various media.

124 significant inverse relationship with target penetration depth, although TCSP's relationship is stron

125 y imaged with 980 nm excitation, having deep penetration depth, by a fluorescence microscope on a cov

126 ts high sensitivity and specificity at large penetration depth.

127 Extractions were performed varying fiber penetration depths (10-60 mm) at different times (10-60

128 -contrast, high-resolution medical images at penetration depths of up to 5 cm.

129 microvascular images at clinically relevant penetration depths, which can be potentially leveraged t

130 ifferent relative phase speeds and different penetration depths.

131 ar imaging resolution at clinically relevant penetration depths.

132 gical applications by offering higher tissue penetration, diminished phototoxicity, and compatibility

133 It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioact

134 ts demonstrate that PGA-FLUO within an HA-CP penetration enhancer represents an effective topical tre

135 he extract was incorporated in liposomes and penetration enhancer-containing vesicles (PEVs) modified

136 sdermal absorption of NOB, compared to other penetration enhancers.

137 bining STXM with SRS precisely dissected the penetration enhancing effects of ethanol.

138 we develop and apply methods to measure the penetration factor and indoor loss rates for ambient NO(

139 The penetration factor for NO was confirmed to be ~1 and the

140 firmed to be ~1 and the mean (+/-s.d.) NO(2) penetration factor was 0.72 +/- 0.06 with a mean relativ

141 e find that the temperature-dependent vortex penetration field H(p)(T), second magnetization peak H(s

142 included evaluation of cytotoxicity, tissue penetration, foam stability, temperature changes and tot

143 ight field and promises an increase in depth penetration for imaging.

144 l therapies, allowing rates of trans-corneal penetration for potential therapies such as siRNA to be

145 tem is particularly well developed with deep penetration for water withdrawal.

146 ant growth rate remain far below the maximum penetration force these pollen tubes are able to generat

147 ion is impeded primarily due to limited drug penetration from the tumor/boundary interface and poor i

148 Electro-penetration graphs showed that Myzus persicae aphids est

149 nt rate performance, sensitivity, collimator penetration, hardware versus object scatter, spectral cr

150 onists with improved water solubility, brain penetration, high EP2 potency, and selectivity.

151 attention because of their superior optical penetration, higher spatial resolution, and lower optica

152 auto-fluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emissio

153 on and actin-dependent protrusion of a rigid penetration hypha(3).

154 d toxicity in mice, it also demonstrated CNS penetration in a PK study and significant reduction of p

155 doses of antiangiogenic agents improve drug penetration in a poorly perfused tumor.

156 reater than threefold enhanced cell membrane penetration in breast, cervical, and multiple myeloma ca

157 t there is indeed a pH-dependent deep tissue penetration in ex vivo tumor multicellular spheroids.

158 The approach will open up enhanced depth penetration in light-sheet imaging to a wide range of en

159 the tumor vascular level, and their reduced penetration in normal tissue would be expected to lower

160 is orally bioavailable and showed good brain penetration in rats.

161 the short term with more New Energy Vehicle penetration in the long term.

162 llantoic Membrane assay, which assesses cell penetration into an organic membrane.

163 eral potential advantages including enhanced penetration into bulk materials, in particular biologica

164 anthocyanins, from absorption into blood to penetration into CSF, was tracked to facilitate the desi

165 tion to the impending stresses linked to the penetration into isotonic host tissues and a possible re

166 ies of the MN array were investigated and MN penetration into luminal vasculature was confirmed in vi

167 However, the effect of hindering lipid-chain penetration into nano-pockets on channel structure has n

168 Drug penetration into solid tumours remains a major challenge

169 d graft-host vessel anastomosis; host vessel penetration into the graft increased approximately eight

170 surface and meanwhile prevents its vertical penetration into the LiF-enriched SEI from forming Li de

171 ated closely with fine roots, showing hyphal penetration into the roots, which in some cases were int

172 the SEI/Li interface and prevent Li dendrite penetration into the SEI.

173 the nucleation energy and suppressing the Li penetration into the SSEs.

174 itors bosentan and ambrisentan improved drug penetration into tumors and restored blood flow in tumor

175 In this study, we made intracellular penetrations into 89 motoneurons in the cervical enlarge

176 reatment of solid tumors, for which antibody penetration is limited to a few cell diameters around th

177 revealed that inhibitor 19 had moderate CNS penetration (K(puu) = 0.17) and analog 26 had high CNS p

178 n (K(puu) = 0.17) and analog 26 had high CNS penetration (K(puu) = 1.0).

179 eutic modality with the advantages of deeper penetration, less energy dissipation and minimal normal-

180 1-2.4), while INH and KAN showed poor tissue penetration (median RPL 0.4, range 0.03-0.73).

181 nd LZD showed moderate yet suboptimal lesion penetration (median RPL 0.61, range 0.21-2.4), while INH

182 In this paper, a market-penetration model is combined with a vehicle fleet model

183 mic therapy (SDT) has the advantages of high penetration, non-invasiveness, and controllability, and

184 cornea and sclera (5 mm diameter) to assess penetration of a candidate neuroprotective siRNA.

185 sizes of molecule, thus potentially allowing penetration of a range of analytes within the porous mat

186 tration dosing strategy to improve the tumor penetration of ADCs.

187 ctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the re

188 on of the epithelial barrier that allows the penetration of allergens, irritants, and microbes into a

189 This implies that attempts to improve the penetration of antimicrobials into S. maltophilia by con

190 in barrier (BBB) is the major impediment for penetration of antiretroviral drugs, causing therapeutic

191 (CNS) are challenging to address due to low penetration of antiretroviral drugs, lack of resident T

192 e show here that in VEEV, the trajectory and penetration of antiviral resistance reflected the microe

193 , we provide discussion on the challenges of penetration of aptamers in the analytical field.

194 ing allows probing of a sample at a depth of penetration of around 0.5-5 mum, which makes it suitable

195 ting peptide (CPP) that allows for effective penetration of biological barriers.

196 The low penetration of blood-borne therapeutics into the brain c

197 y and cost-effectively assesses transcorneal penetration of candidate topical therapies, allowing rat

198 essels limit the intratumoral permeation and penetration of chemo or nanotherapeutic drugs.

199 The poor and nonselective penetration of current chemotherapeutics across the plas

200 dNTPs) to fuel DNA synthesis, thus requiring penetration of dNTPs into the viral capsid.

201 rst, the impact of ion stoichiometry on skin penetration of drugs is assessed using CAGE, which evide

202 ormulations has been hampered by inefficient penetration of drugs through the intestinal mucus and ep

203 The penetration of enveloped viruses into target cells requi

204 While high-power IR laser sources enable the penetration of ever thicker aqueous samples, thereby mit

205 The fluid penetration of exposed dentin areas was investigated by

206 unctionally linked conditions to prevent the penetration of female gametophytes by multiple pollen tu

207 The penetration of fluorescent ultrasmall gold nanoparticles

208 In the present study, the penetration of functionalized, fluorescent gold nanorods

209 nical-strength requirements for failure-free penetration of human and murine skin to simultaneously d

210 nucleophilicity due to the higher interface penetration of IPM.

211 applications but are limited by the depth of penetration of light.

212 the nano-shield can effectively inhibit the penetration of lithium dendrites owing to the reduced st

213 s indicate the GPI anchoring facilitates the penetration of M. oryzae into host cells by affecting th

214 hybridization revealed increased epithelial penetration of oral bacteria in Grhl2 KO mice compared w

215 The penetration of outer limiting membrane by photoreceptor

216 y) ADC constructs to demonstrate that tissue penetration of protein-drug conjugates plays a major rol

217 difficulties, but blood-brain barrier (BBB) penetration of related drugs is poor.

218 e, bringing new prospects for the widespread penetration of renewables and extensive power-sector dec

219 The tubular penetration of rhodamine B-combined CPNE7 was confirmed

220 bulk density, improved aeration, and better penetration of roots in the soil.

221 K(Ca)3.1 channel activators to enhance cell penetration of small cationic toxins into cancer cells e

222 Moreover, the penetration of SNPs was lower in SVGA.

223 eering advances may be used to enhance brain penetration of systemic delivery therapies.

224 py revealed strong fungal cell wall binding, penetration of the cell membrane at discrete foci, follo

225 ization of MS and IHC signals showed limited penetration of the clinically tested drug perifosine int

226 ules to polymers is effective at prohibiting penetration of the drug through the BBB and is a valid t

227 c tumor drug resistance or inefficient tumor penetration of the drugs.

228 elease of mu1 peptides, which facilitate the penetration of the endosomal membrane to release transcr

229 In either case, due to the high penetration of the energetic gamma rays emitted by (137)

230 case of the nonenveloped polyomavirus SV40, penetration of the ER membrane to reach the cytosol is a

231 tube attraction and prevent the approach and penetration of the female gametophyte by late-arriving p

232 to facilitate and increased drilling rate of penetration of the fluids and an enhanced equivalent cir

233 g had paradigm status, little is known about penetration of the genomic RNA (gRNA) into the cell.

234 The nanopillars induce deformation and penetration of the Gram-positive and Gram-negative bacte

235 sion, likely during the interaction with and penetration of the host cell.

236 tes biological imaging because there is deep penetration of the light and negligible background fluor

237 a differential biofilm distribution, greater penetration of the mucus layer and increased colonizatio

238 micro bubble formation, plasma negation and penetration of the plasma along the nanojunction.

239 the subducting slab, slab break-off and the penetration of the slab into the lower mantle; the role

240 the metallocenium ion, resulting in a faster penetration of the weakly associated TFAB(1-) anion thro

241 When evaluating the diffusion and penetration of theranostic nanoparticles, the extracellu

242 To quantify the penetration of these phototoxic effects, 1(4+) was photo

243 become a popular approach for improving drug penetration of transdermal devices and increasing cellul

244 This represents an improvement in depth penetration of up to two orders of magnitude compared to

245 For example, the penetration of visible light through most reaction media

246 However, the poor tissue penetration of visible wavelengths impedes the use of th

247 tal challenge that can be achieved with high penetrations of variable renewable energy.

248 xolitinib and 16 ILs, the dependence of skin penetration on the chemical properties of ILs is examine

249 d MUC2, it did not show improved mucus layer penetration or colonization of the colonic epithelium.

250 does not need to be cleared, while antibody penetration or light scattering issues are minimized.

251 Although dispensable for growth and initial penetration, OSP24 is important for infectious growth in

252 tes dependence on viral tropism and promoter penetration, particularly in non-rodent species.

253 internal turgor pressure is directed onto a penetration peg emerging from the unmelanized, thin-wall

254 an oxidative resistance and is important for penetration peg formation in V. dahliae.

255 tages of appressorial development, including penetration peg formation, but cuticle penetration was u

256 The second phase, host entry by the penetration peg originating from the appressoria formed

257 effects were observed on risk of aspiration/penetration, performance status and all domains of QOL.

258 rrier disruption and that increased allergen penetration predisposes to allergic sensitization.

259 electivity, and/or blood-brain barrier (BBB) penetration profile.

260 er ink was included due to its adherence and penetration properties.

261 FBIC showed penetration rates of about 275 +/- 87 um and higher cyto

262 showed significantly higher infectivity and penetration rates when compared to the other strains.

263 -end Rule (CendR) motif with cell-and tissue penetration receptor neuropilin-1 (NRP-1).

264 Poor tissue penetration remains a major challenge for antibody-based

265 radially enlarge cortical cells upon greater penetration resistance (i.e. phenotypic plasticity) and

266 of root growth, particularly under high soil penetration resistance.

267 um aestivum) genotypes under three levels of penetration resistance.

268 oth dry and compacted soil, due to high soil penetration resistance.

269 his study, we characterize the released drug penetration, retention, and overall therapeutic response

270 trate that positioning of the virus membrane penetration site couples two decisive infection events,

271 ng angle of incidence or increasing depth of penetration, suggesting an irregular distribution of agg

272 of donors from areas of increased community penetration supported a safe and effective LTx practice

273 human CF mucus ex vivo with ~600-fold better penetration than control, improve uptake into lung epith

274 -sized rhodamine exhibited faster and higher penetration than the antibody.

275 gy delivery in the pericardium is limited by penetration through epicardial fat and coronary anatomy.

276 neutral charged peptide coatings that enable penetration through human CF mucus ex vivo with ~600-fol

277 incidence, quasiparticles exhibit unimpeded penetration through potential barriers independent of th

278 dministration, due to the polymer preventing penetration through the blood-brain barrier (BBB).

279 ritical micelle concentration, enabling drug penetration through the mucus and efficient transporter-

280 itinib, was shown to have higher intraocular penetration through transscleral diffusion following sub

281 trates the distinct cellular uptakes and BBB penetrations through receptor-mediated transcytosis.

282 eters deep), with some samples having (57)Fe penetration throughout at a level that is similar to the

283 rption and scattering significantly prevents penetration to deep brain regions.

284 lling internalization, clearance, and tissue penetration to maximize cell killing.

285 rption, the time-dependent effects of Cd(II) penetration to MOF pores was taken by fluorescence and e

286 activated by the capsule as it impedes their penetration to the bacterial membrane.

287 eservoir in the brain because of inefficient penetration to the blood-brain barrier (BBB).

288 In order to precisely monitor the cadmium penetration to the framework pores, in addition to full

289 ssing the bioavailability, stability, tumour penetration, toxicity profile in non-malignant tissues,

290 siCASP2 penetration was 0.01% by 60 min.

291 Brain penetration was confirmed by biodistribution studies in

292 hat complete monochloramine or free chlorine penetration was not observed.

293 uding penetration peg formation, but cuticle penetration was unsuccessful due to reduced appressorial

294 tors for octadecane at 20 and 40 mm of fiber penetration were 21.8 and 44.5, respectively, after 10 m

295 ost examinations of host range, eclipse, and penetration were conducted before this "host-induced" un

296 ectrolytic lesions, recovered from electrode penetrations, were used to align the physiological map t

297 ke, and those that measure cytosolic/nuclear penetration, which represents only productive uptake.

298 ophilicity for favorable blood-brain barrier penetration, while the use of optimized-length spacers b

299 90% CO(2) reductions from the same renewable penetrations with as little as 9% renewable curtailment.

300 These altered CAPHs display superior cell penetration within macrophage cells, and in some cases,