ライフサイエンスコーパス: penile

1 aniofacial, 1 scalp, 1 abdominal wall, and 1 penile).

2 reduction in SHIV infection probability via penile (10-1074) or vaginal (10-1074 or 3BNC117) challen

3 Penile acquisition of HIV accounts for most infections a

4 cancer, including cervical, vulvar, vaginal, penile, anal, and head-and-neck cancers.

5 ent malignancies (cervical, vaginal, vulvar, penile, anal, tongue, tonsillar, and oropharyngeal).

6 rom years 1958 through 2015 to identify 3641 penile and 8856 vulvar/vaginal cancers and to calculate

7 tly explain the observed association between penile and oral HPV infections.

8 This study examined the concordance of penile and oral human papillomavirus (HPV) infections in

9 hat Fkbp51 is an AR target gene essential to penile and prostate development.

10 onstrate that comparably large reductions in penile and vaginal SHIV infection risk among macaques we

11 Data on familial risks in penile and vulvar/vaginal cancers and in second primary

12 Congenital penile anomalies (CPAs) are among the most common human

13 e was successfully treated by embolizing the penile artery using an autologous clot.

14 successfully treated by embolization of the penile artery with an autologous clot in two sessions wi

15 widely used to treat impotence by improving penile blood flow via elevation of cGMP.

16 ined target volume, with higher doses to the penile bulb but no significant differences in rectal or

17 ined target volume, with higher doses to the penile bulb but no significant differences in rectal or

18 Analysis of the rectum, bladder, and penile bulb volumes receiving 40 Gy and 60 Gy demonstrat

19 g 40 Gy and 60 Gy demonstrated that only the penile bulb volumes were significantly higher after regi

20 For organs at risk (rectum, bladder, and penile bulb), the volumes receiving 40 Gy and 65 Gy befo

21 , anal (OR, 15.5; 95% CI, 11.0 to 21.9), and penile cancer (OR, 1.8; 95% CI, 0.9 to 3.7).

22 RR for second penile cancer after penile cancers was 11.68 (7.95-17.18

23 ionally, male circumcision appears to reduce penile cancer and cervical cancer and is likely due to e

24 WES was performed on penile cancer and matched germline DNA from 27 patients

25 ated in, respectively, 5 and 6 patients with penile cancer during an SN biopsy procedure using indocy

26 Modern conservative organ-sparing surgery in penile cancer has shown that good oncological control ca

27 Penile cancer is a rare malignancy affecting more than 4

28 Although penile cancer is rare in the developed world, it present

29 Penile cancer localized to the prepuce can be excised us

30 SPCs were diagnosed in 16.8% of penile cancer patients and in them 45.9% of deaths were

31 ney, upper tract urothelial, testicular, and penile cancer published in the past 18 months.

32 ly invasive ilioinguinal lymphadenectomy for penile cancer remains exploratory at this time.

33 cedures, phimosis or hypospadias repair, and penile cancer resection.

34 identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1

35 The familial RR for concordant (same) penile cancer was 3.22 (1.34-7.74), and it was 2.72 (1.6

36 .9% of deaths were caused by SPC (other than penile cancer).

37 alignancies of renal, bladder, prostate, and penile cancer, a group of anatomically localised disease

38 rehensive analysis of somatic alterations in penile cancer, highlighting the complex landscape of alt

39 c alterations determining the development of penile cancer.

40 etermine the somatic mutational landscape of penile cancer.

41 th bulky regional lymph node metastases from penile cancer.

42 the independent genetic events that occur in penile cancer.

43 lence in association with different types of penile cancer.

44 nts to reduce the morbidity and mortality of penile cancer.

45 RR for second penile cancer after penile cancers was 11.68 (7.95-17.18), while that for co

46 ical, 24 anal, 67 vulvar, 12 vaginal, and 24 penile cancers) with prediagnostic blood samples (collec

47 n = 10), a melanoma on the trunk (n = 6), or penile carcinoma (n = 9) who were scheduled for sentinel

48 Metastatic penile carcinoma derived from cholangiocarcinoma (CCA) h

49 ial of male circumcision provided exfoliated penile cells from 2 anatomical sites (glans/coronal sulc

50 were examined in primary human explants from penile, cervical, and rectal tissues.

51 l syphilis chancres are less noticeable than penile chancres.

52 l syphilis chancres are less noticeable than penile chancres.

53 welling that led to the onset of the ventral penile cleft.

54 ases) was detected in 17/59 (29%) PSCCs; all penile condylomata (8/8) were positive for low-risk HPV6

55 osis are localized fibrotic disorders of the penile connective tissues that can substantially impair

56 Peyronie's disease, urethral stricture and penile (corpora cavernosa) fibrosis are localized fibrot

57 asibility of engineering the entire pendular penile corporal bodies in a rabbit model.

58 sly demonstrated that a short segment of the penile corporal body can be replaced using naturally der

59 corpora can be engineered for total pendular penile corporal body replacement.

60 us to compare cortical magnification of the penile cortex and the whisker-barrel-cortex systems.

61 chniques such as near-infrared spectroscopy, penile cuff compression and computational flow modelling

62 Ventral penile curvature occurs in both hypospadias and so-calle

63 ied for prolonged periods of time, improving penile curvature, indentation, and even restoring length

64 commonly used methods to straighten ventral penile curvature.

65 Reconstruction for total penile defects presents unique challenges due to its ana

66 of procedures have been developed to correct penile deformity secondary to Peyronie's disease.

67 lymphedema develops after a prepuce-sparing penile degloving procedure.

68 repuce can be preserved in selected cases of penile degloving procedures, phimosis or hypospadias rep

69 The neonatal phase of penile development is controlled by the balance of AR to

70 ction as reflected by anogenital distance or penile dimensions at birth.

71 Measurements of anogenital distance and penile dimensions were taken, and a sample of the mother

72 associated protein kinase (ROCK) increase in penile endothelial and smooth muscle cells.

73 that EETs, produced by CYP epoxygenases, in penile endothelial cells serve as vasodilators.

74 d risk factors are a potential threat to the penile endothelium and the smooth muscle tissue leading

75 f non-sexually transmitted infection GUD and penile epithelial trauma is needed, as both are commonly

76 limited correlation between HSV-2, GUD, and penile epithelial trauma suggests that these are distinc

77 HIV) infection, genital ulcer disease (GUD), penile epithelial trauma, multiple recent sex partners,

78 ora scaffolds repair the defects and recover penile erectile and ejaculation function successfully.

79 ieved blockbuster status in the treatment of penile erectile dysfunction (PED).

80 of high-flow priapism and for restoration of penile erectile function.

81 that adenosine was induced during sustained penile erection and contributes to PI3K/AKT activation a

82 apism is featured with prolonged and painful penile erection and is prevalent among males with sickle

83 spliced forms of nNOS are major mediators of penile erection and so may be targets for therapeutic in

84 Sustained penile erection elicited by either intracavernous forsko

85 NOS phosphorylation, and subsequent impaired penile erection featured with the reduction of ratio of

86 Priapism, abnormally prolonged penile erection in the absence of sexual excitation, is

87 Priapism is a condition of persistent penile erection in the absence of sexual excitation.

88 Normal penile erection is under the control of multiple factors

89 A key role for nitric oxide (NO) in penile erection is well established, but the relative ro

90 Subsequent evaluation of 59a in the rat penile erection model revealed in vivo activity, compara

91 C6' treatment reversed abnormalities in key penile erection signaling molecules, including phosphodi

92 Priapism is a disorder of persistent penile erection unrelated to sexual interest or desire.

93 aling via A(2B)R activation, contributing to penile erection via PI3K/AKT-dependent eNOS activation.

94 ted by neuronal NO synthase (nNOS) initiates penile erection, but has not been thought to participate

95 mediates both initiation and maintenance of penile erection, implying unique approaches for treating

96 gnaling is implicated in normal and abnormal penile erection, the exact role and the underlying mecha

97 established model of electrically stimulated penile erection.

98 red for elevated adenosine-induced prolonged penile erection.

99 Penile exposure to more concentrated virus inocula produ

100 onferred durable protection against repeated penile exposures to simian-human immunodeficiency virus

101 challenged with a series of escalating dose penile exposures to SIVmac 251.

102 an essential role of increased adenosine in penile fibrosis and a novel therapeutic possibility for

103 urgent condition, given its association with penile fibrosis and eventual erectile dysfunction.

104 y ADA enzyme therapy successfully attenuated penile fibrosis in both mouse models, indicating an esse

105 nderstanding of the molecular mechanisms for penile fibrosis in priapism.

106 is a novel causative factor contributing to penile fibrosis in two independent animal models of pria

107 f increased adenosine in the pathogenesis of penile fibrosis via A(2B)R signaling and offer a potenti

108 ntial target for prevention and treatment of penile fibrosis, a dangerous complication seen in priapi

109 mechanism responsible for adenosine-mediated penile fibrosis, we purified corpus cavernosal fibroblas

110 imilar signaling pathways for progression to penile fibrosis.

111 R is essential for excess adenosine-mediated penile fibrosis.

112 suggest the benefit of stem cells for use in penile fibrosis.

113 nodeficiency virus (SIV) strain SIVmac251 by penile foreskin exposure.

114 secondary to penetrating gunshot wounds and penile fracture requires immediate surgical exploration

115 We found that penile (glans, foreskin, coronal sulcus) T cells and, to

116 nile stump of the recipient and attached the penile graft.

117 ly to a paucity of relevant animal models of penile HIV infection.

118 a prospective observational study to assess penile HIV shedding after MC.

119 kines had a greater likelihood of detectable penile HIV shedding at the subsequent visit, compared to

120 Penile HIV shedding is significantly reduced after heali

121 Among men with a detectable plasma VL, penile HIV shedding was detected at 136 visits (16.8%).

122 dose-dependent and temporal association with penile HIV shedding, suggesting that genital immune acti

123 Among men with detectable penile HIV shedding, the median log10 HIV copies/millili

124 amination Survey and had results of oral and penile HPV DNA testing were examined.

125 The proportion of men with penile HPV increased from 3.7% in men reporting no prior

126 er among those with than among those without penile HPV infection (19.3% vs 4.4%; prevalence ratio, 4

127 objective was to determine the prevalence of penile HPV infection in the United States.

128 Prevalence of penile HPV infection increases with increasing age.

129 umcision might also protect MSM from HSV and penile HPV infection.

130 hts to estimate the population prevalence of penile HPV infection.

131 Our findings indicate that penile HPV is common among men in the United States.

132 Detectable penile HSV-2 shedding was present in 9.7% of men (17 of

133 weekly penile lavage samples were tested for penile HSV-2 shedding.

134 overall (0.84, 0.75-0.95; k=5; I(2)=0%) and penile human papillomavirus (HPV) infection among HIV-in

135 The epidemiology of penile human papillomavirus (HPV) infection is not well

136 defects in select reproductive organs (e.g. penile hypospadias and prostate dysgenesis but normal te

137 r and vigorous sexual activity might lead to penile implant extrusion.

138 es using free vascularised tissue flaps with penile implants are undesirable in this often socioecono

139 innovations have continually improved these penile implants since that time.

140 Electrical stimulation of the penile innervation increases S1412 phosphorylation that

141 is study, we determined that, by day 7 after penile inoculation, SIV has moved first to the inguinal

142 ocation of all the spinal pathways conveying penile input to the rostral medulla is not known.

143 esions of the T8 spinal cord and loss of all penile inputs after lesioning the dorsal three-fifths of

144 rated the loss of low but not high threshold penile inputs to medullary reticular formation (MRF) neu

145 ion in men exposed to the virus by insertive penile intercourse is likely to help with the rational d

146 sions (EGLs) in men, including condyloma and penile intraepithelial neoplasia (PeIN).

147 Penile involvement is a rare, self-limiting, benign geni

148 Penile lavage samples collected from the coronal sulcus

149 Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedd

150 Preoperative and weekly penile lavages collected for 6 wk and then at 12 wk were

151 e hypospadias and cryptorchidism and altered penile length in male rats, all of which correlated with

152 Mean penile length SDS decreased as the severity of hypospadi

153 ys with hypospadias had shorter mean AGD and penile length SDS than healthy boys (both p < 0.0001).

154 Mean AGD and penile length SDS values in boys with cryptorchidism wer

155 In the study population, AGD and penile length were reduced in boys with hypospadias or c

156 Transgenic mice also exhibited reduced penile length, focal spermatogenic anomalies, diminished

157 ery of erectile function and prevent loss of penile length, penile rehabilitation should be initiated

158 a tertiary center for measurement of AGD and penile length; they were compared with 487 healthy full-

159 cytokines was also associated with a higher penile log10 HIV VL at the subsequent visit among HIV sh

160 The psychosociological effects of penile loss in a young man are devastating and replacing

161 omplicated by gangrene is a leading cause of penile loss in young men in South Africa.

162 , urinary and sexual function after complete penile loss.

163 )] were tested in neuronal cell cultures and penile lysates for NO release (Griess assay) and biologi

164 antiandrogenic and estrogenic signals induce penile malformations and demonstrate that the timing of

165 ll carcinoma (PSCC) accounts for over 95% of penile malignancies and causes significant mortality and

166 ow that conditional deletion of Ihh inhibits penile masculinization.

167 e characterized in cervicovaginal lavage and penile meatal swab through high-throughput 16s ribosomal

168 al swabs, 88.4% and 97.8% for self-collected penile meatal swabs, and 90.9% and 99.4% for male urine

169 article represents the first case report of penile metastasis from CCA.

170 We determined how the vaginal and penile microbiomes contribute to HSV-2 serostatus within

171 ly, identification of the composition of the penile microbiota and its biological role might lead to

172 this case report, we want to present a rare Penile Mondor's disease with literature review.

173 The step-by-step movement of SIV from penile mucosal surfaces to the draining lymph nodes may

174 ng by Luxol-Fast-Blue suggested about 57% of penile nerve fibers were myelinated.

175 Fiber counts in the dorsal penile nerve were not different in prepubertal (1,620 +/

176 ice and performed fiber counts of the dorsal penile nerve.

177 o 4 times less cortical area is devoted to a penile-nerve-fiber than to a whisker-nerve-fiber.

178 No partners reported penile numbness.

179 he past year, no history of genital warts or penile or anal cancer, and no current diagnosis of a sex

180 To date, there is no case of penile or urogenital system metastasis from CCA describe

181 Pearly penile papules (PPPs) are benign, dome-shaped lesions fo

182 mediated ADORA2B signaling underlies reduced penile PDE activity by decreasing PDE5 gene expression i

183 m in both ADA(-/-) and SCD mice by restoring penile PDE5 gene expression to normal levels.

184 which may curtail the depth or direction of penile penetration and/or semen movement.

185 erlying mechanism for adenosine signaling in penile physiology remain elusive.

186 ninvasive surrogates for cystometry, such as penile plethysmography, lack sufficient evidence to allo

187 Inflatable penile prostheses are associated with decreasing risks o

188 Because inflatable penile prostheses are vastly preferred by patients over

189 Because of this, inflatable penile prostheses remain a viable tertiary treatment opt

190 (53% [95% CI, 50%-56%]) of patients without penile prostheses reported use of medications or other d

191 However, early placement of a penile prosthesis following radical prostatectomy is now

192 niques allow safe placement of a three-piece penile prosthesis in patients with a history of pelvic s

193 Concurrent implantation of a penile prosthesis is an option for certain patients who

194 s not successful, surgical implantation of a penile prosthesis may be considered.

195 Penile prosthesis placement results in early return to s

196 ecent advancements in three-piece inflatable penile prosthesis technology of interest to surgeons who

197 Although the first inflatable penile prosthesis was introduced over 30 years ago for t

198 or all physicians, who implant life-changing penile prosthetics, to understand the most recent advanc

199 ng coitus may contribute to both vaginal and penile protection by trapping HIV before it can reach ta

200 was conducted to assess the current state of penile reconstruction and transplantation options, as we

201 with angiogenic cells hold great promise for penile reconstruction to restore reproductive capability

202 , and urinary function in patients requiring penile reconstruction.

203 onsiderable potential for patients requiring penile reconstruction.

204 cess to a new host predominantly through the penile, rectal, or vaginal/cervical mucosal tissue after

205 omponent of the neural circuits that control penile reflexes in rats, circuits that are commonly refe

206 leus in the lumbar spinal cord that controls penile reflexes involved with copulation.

207 w of the current state of science supporting penile rehabilitation after radical prostatectomy.

208 g once per day was commenced after 1 week as penile rehabilitation and was continued for 3 months.

209 Penile rehabilitation is defined as the use of any drug

210 The purpose of penile rehabilitation is to prevent corpus cavernosal sm

211 function and prevent loss of penile length, penile rehabilitation should be initiated expeditiously

212 Penile rehabilitation strategies have been developed wit

213 as the components that are often included in penile rehabilitation strategies.

214 Although penile rehabilitation with medical modalities show good

215 collection, semen quality is higher with the penile robe electrical stimulus method compared with the

216 towards developing a tissue engineered human penile scaffold with potential for more successfully res

217 We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human

218 HPV detection was highest at the penile shaft (49.9% for the full cohort and 47.9% for th

219 cted specimens; detection was highest in the penile shaft (51.2% and 51.5%, respectively, P = 0.96),

220 At a minimum, the penile shaft and the glans penis/coronal sulcus should b

221 les ranged from 67.2% (kappa = 0.34) for the penile shaft to 95.0% (kappa = 0.89) for the foreskin.

222 did not differ by genital site (i.e., glans, penile shaft, or scrotum) of initial detection (P=.86).

223 lence in the glans penis and coronal sulcus, penile shaft, scrotum, semen, and urine was compared by

224 infection of the urethra, glans/corona, and penile shaft.

225 alence ranged from 6% in semen to 52% in the penile shaft.

226 corona, and 0.53 (95% CI, 0.28-0.99) for the penile shaft.

227 Urethral, glans penis/coronal sulcus, penile shaft/prepuce, scrotal, perianal, anal canal, sem

228 r long-acting cabotegravir (CAB LA) prevents penile SHIV acquisition in macaques.

229 pism requiring a surgically performed distal penile shunt.

230 We used a novel penile simian-human immunodeficiency virus (SHIV) transm

231 8), vaginal (SIR, 5.9), cervical (SIR, 1.5), penile (SIR, 8.2), and head and neck cancer (SIR, 2.8),

232 mph nodes could help prevent infection after penile SIV challenge.

233 cine did not protect vaccinated animals from penile SIV challenge.

234 hesus macaques at 1, 3, 7, and 14 days after penile SIV inoculation and quantified the levels of unsp

235 bertal stage was Tanner 4 for pubic hair and penile size, which contrasted with small testes (4.5 mL)

236 ated ED and the mechanism involves increased penile smooth muscle contractility through inhibition of

237 otocol for decellularizing whole-organ human penile specimens for total penile tissue engineering.

238 One deletion removes a sensory vibrissae and penile spine enhancer from the human androgen receptor (

239 of androgen-dependent sensory vibrissae and penile spines in the human lineage.

240 Equine penile squamous cell carcinoma (EpSCC) is a relatively c

241 Penile squamous cell carcinoma (PeSCCA) is a rare malign

242 Penile squamous cell carcinoma (PSCC) accounts for over

243 The incidence of penile squamous cell carcinoma (PSCC) has increased in d

244 Penile squamous cell carcinoma (PSCC) is a rare tumor as

245 Men with penile squamous cell carcinoma and regional lymph node i

246 onded to colon distension, 100% responded to penile stimulation (and DNP), and 85% responded to vagal

247 For penile strictures, a ventral onlay procedure using skin

248 and psychological characteristics, including penile stump length, and emotional suitability for the p

249 We surgically prepared the penile stump of the recipient and attached the penile gr

250 und in and under the epithelium covering all penile surfaces, the presence of antiviral effector B an

251 Participants provided a self-collected penile swab sample for HPV genotyping (Roche Linear Arra

252 Penile swab samples were collected from men aged 18-59 y

253 DNA was extracted from self-collected penile swab specimens, and HPV genotyping was performed

254 Oral rinse, penile swab, and vaginal swab specimens were evaluated b

255 Using penile swabs from males aged 14-59 years, we estimated t

256 Penile taxa (including Ureaplasma and Aerococcus) were a

257 We modeled vaginal and penile taxa and covariates contributing to HSV-2 status

258 We demonstrate that penile taxa are associated with HSV-2 in female partners

259 'Watering can penis' as a result of penile TB is a very rare clinical entity.

260 'watering can penis' was noted secondary to penile TB.

261 VLs were higher in penile than vaginal samples.

262 similar fibrotic gene expression profile in penile tissue (including procollagen I, TGF-beta(1), and

263 Current research in penile tissue engineering is largely restricted to roden

264 However, advances in penile tissue engineering show great promise and, in com

265 whole-organ human penile specimens for total penile tissue engineering.

266 Tissue engineering of penile tissue should focus on two main strategies: first

267 ocedures are limited by a shortage of native penile tissue.

268 us in rectal tissue compared to cervical and penile tissues and enhanced replication in tonsillar tis

269 Here, we show, using penile tissues from HIV-1-infected individuals under sup

270 and PDE activity is significantly reduced in penile tissues of two independent priapic models: SCD mi

271 ciently by migratory cells from cervical and penile tissues to CD4(+) T cells than individual acute E

272 TRIM5 to establish a novel nonhuman primate penile transmission model for AIDS mucosal pathogenesis

273 The high efficacy of CAB LA in the penile transmission model supports extending the clinica

274 valuated the effect of TRIM5 genotype on the penile transmission of SIVsmE660.

275 ssue transplants using a new rat heterotopic penile transplant model that includes preputial skin.

276 a scalp transplant, and 1 patient received a penile transplant.

277 Guidelines should be developed to address penile transplantation and must cover the donation of ti

278 We first performed a cadaver-to-cadaver penile transplantation as preparation.

279 r men with significant genitourinary injury, penile transplantation is being considered as an option

280 The state of penile transplantation is elementary.

281 INTERPRETATION: Penile transplantation restored normal physiological fun

282 esearch addressing the ethical dimensions of penile transplantation.

283 scholarly literature assessing the ethics of penile transplantation.

284 Syngeneic and allogeneic heterotopic penile transplantations were performed on Lewis and Brow

285 guidelines are established and disseminated, penile transplants should not be undertaken.

286 about the specific immunological features of penile transplants, limiting their application in comple

287 A 'watering can penis' secondary to penile tuberculosis is an extremely rare clinical entity

288 sian man consulted us after having undergone penile ultrasonography for pain and increased thickness

289 i.e. linear incomplete filling defect in the penile urethra and associated mild dilatation of the ant

290 The penile urethra has been reported to develop from two cel

291 tal malformation in which the opening of the penile urethra occurs on the ventral side of the penis)

292 ized, oversized, or multiple openings of the penile urethra.

293 affect mucosal tissues in the mouth and the penile urethra.

294 smoking, whereas clade 2 was associated with penile-vaginal sex and sharing of sex toys with female p

295 ility, proceeding ethically with research on penile vascularized composite allotransplantation will r

296 CT-1 was injected through the penile vein 30 min before clamping release and its effec

297 riapism when mating due to thrombosis of the penile vein, but neither Mrc1(-/-) nor Asgr2(-/-) mice d

298 ion of galaninergic neurons, the ability for penile vibratory stimulation (PVS) to elicit ejaculation

299 the development of various cancers including penile, vulva, oropharyngeal and cervical cancers.

300 Penile wounds after traumatic and surgical amputation re