ライフサイエンスコーパス: pentakisphosphate

1 ling molecule 5-InsP(7) (5-diphosphoinositol pentakisphosphate).

2 uding Ins(1,3,4,5,6)P(5) (inositol-1,3,4,5,6-pentakisphosphate).

3 PhyA in complex with myo-inositol hexa- and pentakisphosphate.

4 d levels of its precursor, diphosphoinositol pentakisphosphate.

5 ed dephosphorylation of inositol (1,3,4,5,6) pentakisphosphate.

6 some 9 that encodes human inositol 1,3,4,5,6-pentakisphosphate 2-kinase (InsP(5) 2-kinase).

7 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) catalyzes the syn

8 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) converts inositol 1,3,

9 rt a ciliary role for the inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1) that generates inosito

10 We report here that inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1), which generates inosi

11 polyphosphate multikinase (TbIPMK), inositol pentakisphosphate 2-kinase (TbIP5K) and inositol hexakis

12 IPK1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) phosphorylates inositol 1,3,

13 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, an enzyme encoded by the gen

14 sphate (IP6) by Ipk1, the inositol-1,3,4,5,6-pentakisphosphate 2-kinase, is required for Gle1-mediate

15 ficity 6-/3-kinase and an inositol 1,3,4,5,6-pentakisphosphate 2-kinase, respectively.

16 we observed increased expression of inositol pentakisphosphate 2-kinase, which was present in granule

17 ptides that increased (fragments of inositol pentakisphosphate 2-kinase, zona occludens 3, and FAT tu

18 Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP5 2-Ks) are part of a fam

19 inhibitor, 2-O-benzyl-myo-inositol 1,3,4,5,6-pentakisphosphate (2-O-Bn-InsP5), could affect PDK1/PLCg

20 -Cas9 knockout of PPIP5Ks (diphosphoinositol pentakisphosphate 5-kinases type 1 and 2, i.e., PPIP5K K

21 pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7) as follows: during a period

22 P(6) kinase-2 (IP6K2), a 5-diphosphoinositol pentakisphosphate (5-IP(7)) synthase upregulated in pati

23 (IP6K1), which generates 5-diphosphoinositol pentakisphosphate (5-IP7), physiologically mediates nume

24 pyrophosphate, 5-diphosphoinositol-1,2,3,4,6-pentakisphosphate (5-IP7).

25 nositol pyrophosphate IP7 [diphosphoinositol pentakisphosphate (5-PP-IP5)], mediates apoptosis.

26 the beta phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5), suggesting that increased l

27 the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5or IP7)in vitro.

28 akisphosphate (InsP(6)) to diphosphoinositol pentakisphosphate, a "high energy" candidate regulator o

29 nonical pathway, acting to generate inositol pentakisphosphate, a key second messenger of Wnt3a.

30 ol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphos

31 trakisphosphate and subsequently to inositol pentakisphosphate and has also been described to functio

32 hydrolyze the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate.

33 icient routes to 2-O-acyl inositol 1,3,4,5,6-pentakisphosphates and myo-inositol 1,3,4,5,6-pentakisph

34 ol pyrophosphates 5-InsP7 (diphosphoinositol pentakisphosphate) and 1,5-InsP8 (bis-diphosphoinositol

35 K(m) for ZmIPK1 using myo-inositol 1,3,4,5,6-pentakisphosphate as a substrate is 119 microm with a V(

36 on, our results implicate inositol 1,3,4,5,6-pentakisphosphate as an inhibitor of nonstop mRNA decay.

37 ion of inositol pyrophosphates from inositol pentakisphosphate but not inositol hexakisphosphate is i

38 s that synthesis of the majority of inositol pentakisphosphate, hexakisphosphate and pyrophosphate sp

39 in Rat-1 cells increased inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) levels about 2-3-fold

40 and 6-phosphate groups of inositol 1,3,4,5,6-pentakisphosphate in IP binding and IPK1 activation.

41 rease the cellular levels of either inositol pentakisphosphate, inositol hexakisphosphate or other di

42 Specifically, cellular inositol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphat

43 tase (Minpp1) metabolizes inositol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphat

44 etrakisphosphate (InsP(4)) isomers, inositol pentakisphosphate (InsP(5)) and InsP(6), whereas its dep

45 st InsP(6) kinases were identified; inositol pentakisphosphate (InsP(5)) was phosphorylated to diphos

46 (6) by phosphorylation of inositol 1,3,4,5,6-pentakisphosphate (InsP(5)).

47 Diphosphoinositol pentakisphosphate (InsP(7)) and bis-diphosphoinositol te

48 NA encoding the mammalian inositol 1,3,4,5,6-pentakisphosphate (InsP5) 2-kinase (2-kinase), the enzym

49 ase in the levels of both inositol 1,3,4,5,6-pentakisphosphate (InsP5) and inositol 1,2,3,4,5,6-hexak

50 Diphosphoinositol pentakisphosphate (InsP7) and bis-diphosphoinositol tetr

51 Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetr

52 Diphosphoinositol pentakisphosphate (InsP7) contains an energetic pyrophos

53 ol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol

54 rophosphates, such as diphospho-myo-inositol pentakisphosphates (InsP7), are an important family of s

55 inositol polyphosphates, especially inositol pentakisphosphate (IP(5)) accumulation.

56 ylated inositols, such as inositol 1,3,4,5,6-pentakisphosphate (IP(5)) and inositol hexakisphosphate

57 hrough phosphorylation of inositol 1,3,4,5,6-pentakisphosphate (IP(5)) by a 2-kinase.

58 phate (IP(4)), generating inositol-1,3,4,5,6-pentakisphosphate (IP(5)), which can be further phosphor

59 the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP(7)) physiologically phosphorylates

60 ol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP(7)), are water-soluble inositol ph

61 or inositol tetrakisphosphate (IP4)/inositol pentakisphosphate (IP5) 2-kinase activity in phosphate s

62 kinase (IPMK) and its major product inositol pentakisphosphate (IP5) regulate a variety of cellular f

63 such as inositol tetrakisphosphate, inositol pentakisphosphate (IP5), and inositol hexakisphosphate (

64 sed substantially by IP4, inositol 1,3,4,5,6-pentakisphosphate (IP5), and IP6.

65 nositol tetrakisphosphate (IP4) and inositol pentakisphosphate (IP5).

66 2-kinase (IPK1) converts inositol 1,3,4,5,6-pentakisphosphate(IP5) to inositol hexakisphosphate (IP6

67 to pyrophosphates such as diphosphoinositol pentakisphosphate (IP7) and bis-diphosphoinositol tetrak

68 pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (IP7), are generated by a family of in

69 pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (IP7), are generated by a family of in

70 he inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death

71 Diphosphoinositol pentakisphosphate (IP7), the most abundant inositol pyro

72 the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7), which physiologically inhibits

73 phosphates, most notably 5-diphosphoinositol pentakisphosphate (IP7).

74 ncipal product of which is diphosphoinositol pentakisphosphate (IP7).

75 -terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenge

76 cation from rat brain of a diphosphoinositol pentakisphosphate kinase (PPIP5K) that synthesizes (PP)2

77 domain of the dual-domain diphosphoinositol pentakisphosphate kinase 2 (VIP2KD) in Arabidopsis thali

78 rtance of signaling by the diphosphoinositol pentakisphosphate kinases (PPIP5Ks) to the metabolism an

79 sphate kinases (IP6Ks) and diphosphoinositol pentakisphosphate kinases (PPIP5Ks), regulate phosphate

80 nals interconverted by the diphosphoinositol pentakisphosphate kinases (PPIP5Ks).

81 activities of full-length diphosphoinositol pentakisphosphate kinases (PPIP5Ks).

82 etically (knockout [KO] of diphosphoinositol pentakisphosphate kinases [PPIP5Ks] that synthesize InsP

83 mutant phenotypes, placing diphosphoinositol pentakisphosphate kinases in plant Pi signal transductio

84 phosphatase activities of diphosphoinositol pentakisphosphate kinases in vitro.

85 eport that deletion of two diphosphoinositol pentakisphosphate kinases VIH1/2 impairs plant growth an

86 he inositol pyrophosphate disphosphoinositol pentakisphosphate (PP-InsP(3)/InsP(7)) is formed in mamm

87 d two non-Nudix compounds: diphosphoinositol pentakisphosphate (PP-InsP(5)) and bis-diphosphoinositol

88 We recently discovered a diphosphoinositol pentakisphosphate (PP-InsP(5)) phosphatase in Saccharomy

89 These homologues are diphosphoinositol pentakisphosphate (PP-InsP(5)/InsP(7)) and bis(diphospho

90 Diphosphoinositol pentakisphosphate (PP-InsP5 or 'InsP7') and bisdiphospho

91 t inositol pyrophosphates (diphosphoinositol pentakisphosphate (PP-InsP5) and bisdiphosphoinositol te

92 slightly lowered levels of diphosphoinositol pentakisphosphate (PP-InsP5) in DDT1 MF-2 cells.

93 was found to phosphorylate diphosphoinositol pentakisphosphate (PP-InsP5) to (PP)2-InsP4 (Vmax = 8.3

94 hexakisphosphate (IP6) and diphosphoinositol pentakisphosphate (PP-IP5 or IP7) kinase with similarity

95 Diphosphoinositol pentakisphosphate (PP-IP5) and bis(diphospho)inositol te

96 Diphosphoinositol pentakisphosphate (PP-IP5) and bis(diphospho)inositol te

97 n of another novel kinase, diphosphoinositol pentakisphosphate (PP-IP5) kinase, which uses PP-IP5 as

98 t the kinase required for inositol 1,3,4,5,6-pentakisphosphate production (Ipk2) is localized in the

99 he inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase Akt

100 5-diphosphoinositol pentakisphosphate, the most abundant inositol pyrophosph

101 2-kinase) phosphorylates inositol 1,3,4,5,6-pentakisphosphate to inositol 1,2,3,4,5,6-hexakisphospha

102 zes the conversion of myo-inositol 1,3,4,5,6-pentakisphosphate to phytic acid.

103 addition, SopB hydrolyzes inositol 1,3,4,5,6 pentakisphosphate to yield inositol 1,4,5, 6-tetrakispho

104 the jasmonate co-receptor complex, inositol pentakisphosphate, which interacts with both COI1 and JA

105 entakisphosphates and myo-inositol 1,3,4,5,6-pentakisphosphate with biologically interesting and anti