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1 amino acid [aa] residues of delta) reveals a pentameric, 145- angstrom long fiber with an N-terminal
2 of the monomers contributes unequally to the pentameric (2:1:1:1) complex of Rho dimer and Gt heterot
3 r dynamics simulations of both monomeric and pentameric Abeta, which demonstrate decreased formation
4 ate anesthetics are allosteric coagonists at pentameric alpha1beta3gamma2 GABA(A) receptors, modulati
5 xpression in Xenopus oocytes of concatenated pentameric (alpha7)5-, (alpha7)4(beta2)1-, and (alpha7)3
8 nge its own structure in response but remain pentameric, and then bind to pathogenic proteins deposit
10 or capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers results in the fo
12 e-II PKA-AKAP18gamma complexes reveal hetero-pentameric assemblies that adopt a range of flexible tri
14 nally identified subunit LvgA, and that this pentameric assembly binds Legionella effector proteins.
15 e external scaffolding protein D organize 12 pentameric assembly intermediates into procapsids, a rea
16 ffolding protein B mediates the formation of pentameric assembly intermediates, whereas the external
17 However, monomers are incorporated into 12 pentameric assembly intermediates, which become the caps
20 verage resolution of 4.4 angstrom, reveals a pentameric assembly that in contrast to other characteri
24 fined and more stable chimera comprised of a pentameric B subunit of ETEC heat-labile toxin (LTB) in
25 en linked to the simultaneous binding of the pentameric B subunit to multiple copies of glycosphingol
26 sferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of Plt
30 relevance of the dissociation of circulating pentameric C-reactive protein (pCRP) to its monomeric su
31 n, concanavalin A, and pyruvate kinase), and pentameric (C-reactive protein) complexes, ranging in si
35 scL when the majority of the subunits of the pentameric channel contain the fluorescent mEos3.2 prote
36 Although the precise biological role of this pentameric channel is still unknown, this report is neve
39 n brain, mediating its actions chiefly via a pentameric chloride ion channel, the GABAA receptor.
40 iled-coil domain appended to one face of the pentameric cholera toxin B-subunit (CTB) enabled the ord
41 of imine-based pentafoil molecular knots and pentameric circular helicates despite, in practice, the
42 of an imine-based pentafoil knot and related pentameric circular helicates, each derived from a commo
43 onformation is ideal for encapsulating small pentameric clusters, either a water molecule or a fluori
46 69 and genetically engineered to express CMV pentameric complex (gH/gL/pUL128/pUL130/pUL131) was deve
47 nse against HCMV glycoprotein B (gB) and the pentameric complex (PC) and the ADCC response in HCMV-se
48 GP129, which encodes a subunit of the GPCMV pentameric complex (PC) believed to govern viral entry i
49 ion of the genome encoding components of the pentameric complex (PC), in particular homologs of human
50 r neutralizing antibodies (nAbs) against CMV pentameric complex (PC)-mediated epithelial cell entry d
51 ressed and purified soluble gH/gL/pUL128-131 pentameric complex and gH/gL from Chinese hamster ovary
52 lasmic reticulum, is a membrane-bound hetero-pentameric complex consisting of Gpi8, Gpi16, Gaa1, Gpi1
53 -strain-like strains of CMV, which display a pentameric complex consisting of the viral glycoproteins
54 he necessity to monitor the integrity of the pentameric complex during the vaccine manufacturing proc
55 photocycle, the question arises whether the pentameric complex formed in the membrane via specific c
56 efective human cytomegalovirus with restored pentameric complex glycoprotein H (gH)/gL/pUL128-131 for
58 light the importance of the gH/gL/pUL128-131 pentameric complex in HCMV vaccine design and emphasize
59 accine candidate but the glycoprotein H (gH) pentameric complex is now recognized as the major target
61 Thus, inclusion of epitopes derived from the pentameric complex may provide enhanced efficacy by indu
63 the dominant virus-neutralizing antigen-the pentameric complex of glycoprotein H (gH), gL, and pUL12
64 and together with the gH/gL/UL128/130/131 a pentameric complex permits infection of epithelial, endo
65 ct with the epitopes of the gH/gL/pUL128-131 pentameric complex resulting in viral neutralization, we
68 eplication-defective virus with the restored pentameric complex, rhesus macaques can develop broadly
69 domain of Arno can also associate to form a pentameric complex, which suggests that the uncompetitiv
78 in a sequential manner, with tetrameric and pentameric complexes forming as intermediate states lead
80 ated ion channel family, neuronal nAChRs are pentameric, composed of various permutations of alpha (a
82 s of alpha4 and beta2 subunits and establish pentameric concatemers as a means to delineate interacti
83 p16 of varphi29 was previously reported as a pentameric configuration by cryo-electron microscopy (cr
84 eta2 subunits expressed with free alpha5 and pentameric constructs incorporating a single copy of alp
87 solution structure reveals a DotLMNYZ hetero-pentameric core from which the flexible IcmSW module pro
89 tro exposure of normal neutrophils to native pentameric CRP led to a dose- and time-dependent loss of
94 the activation, blockade, and regulation of pentameric Cys-loop ion channels at the atomic level.
95 xamine the role of the NCKAP1 subunit of the pentameric cytoskeletal SCAR/WAVE complex, a major downs
97 using a trimeric protein (TriEst) to a small pentameric de novo-designed coiled coil domain, separate
100 ral pH, bm-Calpha-PNA 1 forms a higher order pentameric double duplex of a triplex composed of two bm
101 could select Mg(2+) over Ca(2+), a bilayered pentameric filter lined with a ring of amides and a ring
103 f intact FMDV particles (146 S; 8200 kDa) or pentameric FMDV coat protein aggregates (12 S; 282 kDa)
104 hotoinduced conformational transition of the pentameric foldamer 105 is reflected in distinct spectra
105 Crystal structures of delta revealed novel pentameric folding repeats, which we term beta-bracelets
106 e show that monomeric CRP (mCRP) but not the pentameric form (pCRP) upregulates IL-8 and CCL2 levels
116 upport a unique vaccine concept based on the pentameric gH complex, we established a panel of 45 mono
117 as dependent on high-level expression of the pentameric gH/gL/gpUL128-131A complex, a feature of WT b
119 addition, we eliminated subunits of a viral pentameric glycoprotein complex thus limiting cell tropi
121 ELISA-based ligand binding assays, purified pentameric H2O2-treated CRP bound to a number of immobil
126 ution structures of dimeric, tetrameric, and pentameric IgA-Fc linked by the joining chain (JC) and i
129 suggest that OLPVRII might be a light-gated pentameric ion channel analogous to pentameric ligand-ga
130 y of, the wild-type alpha7nAChR ligand-gated pentameric ion channel, the findings point to the existe
132 ranslocated across cellular membranes by the pentameric ion channel/transporter FocA that, together w
135 c acetylcholine (ACh) receptors (nAChRs) are pentameric ligand-gated cation channels that include at
140 omopentameric cation-selective member of the pentameric ligand-gated ion channel (pLGIC) superfamily.
143 -electron microscopy Torpedo model; the only pentameric ligand-gated ion channel imaged in a native l
146 agree with the structure of the prototypical pentameric ligand-gated ion channel the Torpedo nicotini
147 The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free e
149 domain of the serotonin type 3A receptor, a pentameric ligand-gated ion channel, is crucial for regu
156 -derived structure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still l
157 itter-gated ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique
172 w insights into the signalling mechanisms of pentameric ligand-gated ion channels and enhance current
173 ne receptor (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in
174 e receptors (nAChRs) belong to the family of pentameric ligand-gated ion channels and mediate fast ex
175 ma-aminobutyric acid (GABA(A)) receptors are pentameric ligand-gated ion channels and the main driver
176 r this loop, which is vestigial in bacterial pentameric ligand-gated ion channels and was largely rem
179 igand binding at the extracellular domain of pentameric ligand-gated ion channels initiates a relay o
181 receptor (nAChR) belongs to a superfamily of pentameric ligand-gated ion channels involved in many ph
183 he M3-M4 linker but also the M1-M2 linker of pentameric ligand-gated ion channels modulates function
186 ways for activation, as illustrated here for pentameric ligand-gated ion channels that are principal
187 obutyric acid type A (GABA(A)) receptors are pentameric ligand-gated ion channels that mediate fast i
190 ns with M1/M3 to reduce the sensitivities of pentameric ligand-gated ion channels to their surroundin
192 with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamin
193 e maturation and function of the prokaryotic pentameric ligand-gated ion channels, GLIC and ELIC, was
194 ht-gated pentameric ion channel analogous to pentameric ligand-gated ion channels, however, future pa
195 teroids potently and allosterically modulate pentameric ligand-gated ion channels, including GABA(A)
197 Although numerous studies have focused on pentameric ligand-gated ion channels, the details of ane
205 lore the unusual host-guest chemistry of the pentameric macrocycle [{P(mu-N(t) Bu}(2) NH](5) with a r
207 -nitrite transporters) form a superfamily of pentameric membrane channels that translocate monovalent
208 ome the founding father of a broad family of pentameric membrane receptors, paving the way for their
211 be bound, recognition of the canonical AUUUA pentameric motif is possible by binding to two registers
214 in is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-termi
216 receptor subunit, an "accessory" subunit of pentameric nicotinic receptors, that has been shown to p
218 pose a new family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found i
219 he acetylcholine binding protein (AChBP) are pentameric oligomers in which binding sites for nicotini
220 hesis of an azide functionalized fluorescent pentameric oligothiophene that can be utilized as a liga
221 molecules are SH3(5) (S) and PRM(5) (P), two pentameric, oppositely charged protein constructs; hepar
223 tcomes correlate with the requirement of the pentameric penton base to simultaneously bind several in
224 denine recognition and ATP hydrolysis in the pentameric phage T4 large "terminase" (gp17) motor.
226 attached, regardless of their position, the pentameric phenylenevinylenes are well water-soluble.
227 aluation of three novel aldehyde-substituted pentameric phenylenevinylenes carrying branched oligo(et
230 ng this model into a cryo-EM map generated a pentameric pRNA structure; five helices projecting from
233 ructures of tetrameric (cinnamtannin A2) and pentameric procyanidins (cinnamtannin A3) were elucidate
234 he isolation and semisynthesis of dimeric to pentameric procyanidins from T. cacao by countercurrent
235 meric B2 and B5, trimeric C1, tetrameric and pentameric procyanidins, were isolated from unroasted co
236 the spatial arrangement of the hexameric and pentameric protein capsomers in the growing shell during
242 housands of subunits including hexameric and pentameric proteins that form a shell to encapsulate the
243 ype I restriction enzymes (REases) are large pentameric proteins with separate restriction (R), methy
244 of the amino acid sequence of AgSF1 reveals pentameric QPGSG iterations that are similar to conserve
246 esolution structures of other members of the pentameric receptor superfamily provide touchstones for
254 -referential contigs predominantly contained pentameric repeats, especially two motifs: AATGG and GTG
255 e with the receptor by forming an asymmetric pentameric ring around a region of the receptor carboxy-
256 catemer recognized by TerS, assembles into a pentameric ring motor on the prohead's portal vertex and
260 in of the capsid protein forms hexameric and pentameric rings, while C-terminal domain homodimers con
262 LFC) consists of the inactive Rag dimer, the pentameric scaffold Ragulator, and the FLCN:FNIP2 (FLCN-
263 engrafting the V1V2 domain into trimeric and pentameric scaffolds in structurally constrained conform
265 quence consisting of inverted repeats of the pentameric sequence nGAAn, known as heat shock elements
268 uracy of this approach by characterising the pentameric state of phospholamban, a key player in the r
269 iation' state into a catalytically competent pentameric state, is accompanied by substantial domain r
271 d beta2 subunits assemble in two predominant pentameric stoichiometries, which differ in their sensit
275 these receptors do not form their functional pentameric structure in cell lines, and mechanisms that
276 ma by determining which residues support the pentameric structure in the presence or absence of Mg(2+
279 -fold homodecamer of two head-to-head facing pentameric subunits, harboring 10 active sites at the in
280 ay dead end or at best served for storage of pentameric subunits, which was later shown to be unlikel
283 the procapsid conclusively demonstrates the pentameric symmetry of the pRNA and illuminates the rela
284 by mass spectrometry revealed that a hetero-pentameric tau3-delta-delta' Bacillus subtilis clamp-loa
286 f different proteins that form hexameric and pentameric tiles, which interact to allow the formation
289 ture that has 42 turret-like projections: 12 pentameric turrets positioned on the icosahedral 5-fold
290 shape consistent with an arrangement of two pentameric units connected by an interstitial dimer.
291 and functional assays suggest that it forms pentameric units resembling viral capsomeres that assemb
294 jacent capsomers affect the positions of the pentameric vertices, resulting in different triangulatio
295 minant SIMs in a SIM cluster often contain a pentameric VIDLT ((V/I/L/F/Y)(V/I)DLT) core sequence tha
300 juni cap complex, which reveals that FliD is pentameric, with the N-terminal region of the protomer f