ライフサイエンスコーパス: pentraxin

1 otein Narp (from neuronal activity-regulated pentraxin).

2 Limulus C-reactive protein, the other plasma pentraxin.

3 une-complex-mediated phagocytosis by soluble pentraxins.

4 1-27% identical to those of the large fusion pentraxins.

5 N terminus of all other known horseshoe crab pentraxins.

6 jor IgA receptor, FcalphaRI, as a ligand for pentraxins.

7 Neuronal pentraxin 1 (NP1) is a pro-apoptotic protein induced by

8 Neuronal pentraxin 1 (NP1) was identified as a rat protein that m

9 Here, we investigated the role of neuronal pentraxin 1 (NP1), a member of a newly recognized subfam

10 Neuronal pentraxin 1 (NP1), a protein with exclusive CNS expressi

11 Neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and neuro

12 ns of the taipoxin-binding proteins neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipo

13 el members of the pentraxin family (neuronal pentraxin 1 and 2) that are expressed in the nervous sys

14 the AMPA receptor clustering factor neuronal pentraxin 1 from presynaptic terminals by signaling thro

15 ions, we show that the Id3 and NP1 (neuronal pentraxin 1) genes become transcriptionally active follo

16 ural elements from cerebellin-1 and neuronal pentraxin-1.

17 Neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and neuronal pentraxin receptor (NPR)

18 roteins neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipoxin-associated calcium-bindi

19 We show here that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccR

20 a deep-layer-specific reduction in neuronal pentraxin 2 (NPTX2) within excitatory neurons, decreased

21 In these models, neuronal pentraxin 2 (NPTX2), an activity-dependent immediate ear

22 heavy chain), synapse dysfunction [neuronal pentraxin 2 (NPTX2)], astrogliosis (glial fibrillary aci

23 nd that a set of proteins including neuronal pentraxin 2 and fatty acid binding protein 3 changed acr

24 F) treated with PRM-151, a recombinant human pentraxin 2 protein, in a phase 2 double-blind, randomis

25 , visinin-like protein 1 (VILIP-1), neuronal pentraxin 2, and beta-synuclein, along with positron emi

26 xpression profiles, such as that of neuronal pentraxin 2, differed between full responders and nonres

27 erum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral ar

28 wth factor (2.1-fold, P = .005) and neuronal pentraxin-2 (3.0-fold, P = .029).

29 tabolites and synaptic markers like neuronal pentraxin-2 (NPTX2), suggesting that altered neurotransm

30 FX/SR-AI-complex comprises a third protein, pentraxin-2 (PTX2).

31 mation, including increased plasma levels of pentraxin-2 and activated antigen-presenting cells, CD4

32 he fibrocyte inhibitor serum amyloid P (SAP; pentraxin-2) significantly prolonged survival and slowed

33 x component, the heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) from human AM that has greater

34 Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purified from huma

35 Because heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) purified from human amniotic me

36 t correlated with reduction in persephin and pentraxin 3 (Pearson correlation coefficients = 0.682 an

37 gistic induction of several MMPs, activin A, pentraxin 3 (PTX-3), and IL-8.

38 Of 12 PRMs tested, the long pentraxin 3 (PTX3) and mannose-binding lectin (MBL) boun

39 in these beneficial responses, we identified pentraxin 3 (PTX3) as a leading antifibrotic candidate.

40 e pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal

41 The long pentraxin 3 (PTX3) has been shown to be important in mai

42 Pentraxin 3 (PTX3) is a fluid-phase pattern recognition

43 Pentraxin 3 (PTX3) is a fluid-phase pattern recognition

44 Pentraxin 3 (PTX3) is a fluid-phase pattern recognition

45 Pentraxin 3 (PTX3) is a multifunctional molecule that pl

46 Pentraxin 3 (PTX3) is a soluble pattern recognition mole

47 Pentraxin 3 (PTX3) is a soluble pattern recognition mole

48 Long pentraxin 3 (PTX3) is an essential component of humoral

49 show that the humoral innate immune molecule Pentraxin 3 (PTX3) is expressed in the developing rodent

50 5 (IL-5), IL-10, Forkhead box P3 (FOXP3) and pentraxin 3 (PTX3) levels besides biochemical study of t

51 n the different types of dietary protein and pentraxin 3 (PTX3) levels in HD patients.

52 The long pentraxin 3 (PTX3) modulates different effector pathways

53 Baseline levels of the long pentraxin 3 (PTX3) was an independent predictor of suppr

54 of this study was to investigate the role of pentraxin 3 (PTX3), a pivotal component of the innate im

55 Pentraxin 3 (PTX3), a prototypic long pentraxin that pla

56 he proteins inter-alpha-inhibitor (IalphaI), pentraxin 3 (PTX3), and TNF-stimulated gene-6 (TSG-6) ha

57 The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental r

58 Pentraxin 3 (PTX3), the prototype of long pentraxins, ha

59 Pentraxin 3 (PTX3), the prototypic long pentraxin, is a

60 of the innate immune system via miR-224 and pentraxin 3 (Ptx3).

61 ed plasma levels of markers of inflammation (pentraxin 3 and C-reactive protein) and endothelial cell

62 nes such as inducible nitric oxide synthase, pentraxin 3 and Id1; resulted in activation of mitogen-a

63 y, we show that soluble HC-HA also contained pentraxin 3 and induced the apoptosis of both formyl-Met

64 nity such as Mincle, dectin-1, dectin-2, and pentraxin 3 are strongly upregulated in DC treated simul

65 cle, and, modulation of cycle-specific serum pentraxin 3 levels over various cycles indicate stromal

66 y, Jaillon et al. (2014) describe a role for pentraxin 3 molecules in complementing the host's cellul

67 The long pentraxin PTX3 (pentraxin 3) has emerged as a component of humoral innat

68 ry factor, insulin-like growth factor 1, and pentraxin 3, 3 predicted targets of miR-29b.

69 tumor necrosis factor-stimulated gene 6, and pentraxin 3, all of which are necessary for normal cumul

70 for the APPs serum amyloid A, complement C3, pentraxin 3, and alpha2-antiplasmin in the liver, despit

71 ater increases in proinflammatory cytokines, pentraxin 3, and inducible nitric oxide synthase transcr

72 binds to the FH ligands C-reactive protein, pentraxin 3, and malondialdehyde epitopes.

73 ze physiological C1q ligands such as IgG and pentraxin 3, and to trigger C1r and C1s activation.

74 n via pattern recognition receptors, such as pentraxin 3, dectin-1, and Toll-like receptors, leads to

75 ive to WT transfectants, including genes for pentraxin 3, granulocyte-macrophage colony-stimulating f

76 on, such as inducible nitric oxide synthase, pentraxin 3, Id1, and scavenger receptor-A.

77 TGF-beta target genes (e.g., adrenomedullin, pentraxin 3, KN motif and ankyrin repeat domains 4, inte

78 CCL3, and CCL20, as well as the opsonin long pentraxin 3, were up-regulated during the first 2 to 6 h

79 We have recently shown that FHR-1 binds to pentraxin 3.

80 Pentraxin-3 (PTX3) analyses of sera from 87 leprosy pati

81 n this context, acute-phase proteins such as Pentraxin-3 (PTX3) are released; however, little is know

82 erleukin (IL)-1beta, IL-6, IL-21, IL-33, and pentraxin-3 (PTX3) concentrations in patients with and w

83 Pentraxin-3 (PTX3) is a member of the pentraxin family o

84 Pentraxin-3 (PTX3) is a multifactorial protein involved

85 Pentraxin-3 (PTX3) is a prototype of the long pentraxin

86 Elevated long pentraxin-3 (PTX3) levels are associated with the develo

87 us (HSV), as well as the inflammatory marker pentraxin-3 (PTX3), and to analyze their association wit

88 Mannose binding lectin 2 and pentraxin-3 (PTX3), two activators of the complement pat

89 marked increases in the acute phase proteins pentraxin-3 and chitinase-3-like-1.

90 s, including laminin and collagen, alongside pentraxin-3 and hepatocyte growth factor, as potential r

91 isoprostanes changed by -3.0% and -9.7%, and pentraxin-3 changed by +50.6% and -11.0% in the placebo

92 to improve upon clinically available tests: pentraxin-3 in giant cell arteritis and Takayasu's arter

93 mong biomarkers to assess clinical activity, pentraxin-3 is perhaps the most promising, but its valid

94 ent HC.HA complexes that are cross-linked by pentraxin-3) and that this occurs via the formation of c

95 ttern recognition receptors, including TLR9, pentraxin-3, and lectin-like oxidized LDL receptor-1, wa

96 e proteins, inter-alpha-inhibitor (IalphaI), pentraxin-3, and TNF-stimulated gene-6 (TSG-6), driving

97 chitinase-3-like protein 1, osteopontin, and pentraxin-3, in hOE cells; however, their expression lev

98 inal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confou

99 In HAE, FAP- a, tPA, uPAR, pentraxin-3, Tie-2, sE-selectin, and VE-cadherin were si

100 In HAE, FAP- alpha, tPA, uPAR, pentraxin-3, Tie-2, sE-selectin, and VE-cadherin were si

101 6), the enzyme that transfers HCs to HA, and pentraxin-3, which further stabilizes the matrix.

102 anes, and 3) inflammation assessed by plasma pentraxin-3.

103 Like immune complex, pentraxin aggregation and opsonization of pathogen resul

104 s of the protomer, and the C terminus of the pentraxin alpha-helix 169-176, particularly Tyr(175).

105 This long pentraxin also failed to bind to products of the interac

106 of GPR56/ADGRG1, an aGPCR with two domains [pentraxin and laminin/neurexin/sex hormonebinding globul

107 ntified the first putative integral membrane pentraxin and named it neuronal pentraxin receptor (NPR)

108 C-reactive protein (CRP) is a unique serum pentraxin and the prototype acute phase reactant.

109 Although conceptually separated, both pentraxins and antibodies are important factors in contr

110 ce suggests a direct link between the innate pentraxins and humoral Fc receptors.

111 nderstanding of the origins and evolution of pentraxins and innate immunity is discussed.

112 st demonstration of heteromultimerization of pentraxins and release of a pentraxin complex by proteol

113 orylethanolamine-agarose, which isolates the pentraxins and separates limulin from the other sialic a

114 l and functional work that bridge the innate pentraxins and the adaptive Fc receptor functions.

115 Pentraxins are a family of ancient innate immune mediato

116 Pentraxins are acute-phase proteins that belong to a fam

117 Mutational and binding studies show that pentraxins are diverse in their binding specificity for

118 Pentraxins are innate pattern recognition molecules whos

119 Pentraxins are major proteins of the innate immune syste

120 cture and the discovery that both prototypic pentraxins are present in Limulus raises the possibility

121 ynaptogenic activity of NP1 by forming mixed pentraxin assemblies.

122 phaRI both in solution and on cells, and the pentraxin binding site on the receptor appears distinct

123 1 complex, but it is unknown how CRP, or any pentraxin, binds to C1.

124 Plasma that was depleted in the pentraxins by passage over phosphorylethanolamine-agaros

125 The pentraxin C-reactive protein (CRP), an innate immune sys

126 o investigate whether FHR-1 binds to another pentraxin, C-reactive protein (CRP), analyze the functio

127 The related pentraxin, C-reactive protein (CRP), is a strong acute-p

128 xin signature" sequence and a characteristic pentraxin calcium-binding domain.

129 In many ways, pentraxins can be regarded as innate antibodies.

130 ltimerization of pentraxins and release of a pentraxin complex by proteolysis.

131 eport that native Narp in brain is part of a pentraxin complex that includes NP1.

132 erent quaternary structure compared to other pentraxins, comprising a glycosylated D4 symmetrical oct

133 mic NPCD isoforms are composed of a neuronal pentraxin domain (formerly thought exclusively extracell

134 ciation of Kv4.2 with a protein containing a pentraxin domain (PPTX).

135 ushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extrace

136 Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellula

137 factor type A, epidermal growth factor, and pentraxin domain containing 1) is a large extracellular

138 factor type-A, epidermal growth factor, and pentraxin domain containing 1; beta(TOPCAT)=0.539; P<0.0

139 mGluR1/5), TACE cleaves NPR and releases the pentraxin domain from its N-terminal transmembrane domai

140 this peptide and a conserved portion of the pentraxin domain that is involved in the homo- and heter

141 ushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1), an extrac

142 , Sushi von Willebrand factor type A EGF and pentraxin domain-containing protein 1(SVEP1), R-spondin

143 s, while their closely homologous C-terminal pentraxin domains mediate association with AMPA-type glu

144 ielded a 2.5- angstrom map of the C-terminal pentraxin domains that revealed a radically different qu

145 lpha-helices that extended N terminal of the pentraxin domains that were not fully resolved.

146 immune system (e.g., complement C1q and C3, pentraxins, Dscam), members of the major histocompatibil

147 early gene Narp (neuronal activity-regulated pentraxin) encodes a secreted synaptic protein that can

148 Because members of the collectin and pentraxin families of serum proteins bind to blebs on ap

149 e previously identified novel members of the pentraxin family (neuronal pentraxin 1 and 2) that are e

150 Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which incl

151 serum amyloid P component are members of the pentraxin family of oligomeric serum proteins which has

152 C-reactive protein (CRP) is a member of the pentraxin family of proteins and an acute phase reactant

153 lectins is limulin, which is a member of the pentraxin family of proteins and is found in the plasma

154 amyloid P component (SAP) is a member of the pentraxin family of proteins.

155 normal serum components which belong to the pentraxin family of proteins.

156 equence indicates homology to members of the pentraxin family of secreted lectins that include C-reac

157 The pentraxin family of soluble PRMs comprises long and shor

158 non-fibrillar glycoprotein belonging to the pentraxin family of the innate immune system.

159 More recently, members of the pentraxin family were found to interact with cell-surfac

160 SAP, a member of the pentraxin family, binds to Fcgamma receptors and modifie

161 ysis shows that PPTX is a member of the long pentraxin family, is 53% identical to mouse PTX3, and ha

162 P), a member of the evolutionarily conserved pentraxin family, is a normal component of a number of b

163 Serum amyloid P (SAP) is a member of the pentraxin family.

164 consistent with the lectin properties of the pentraxin family.

165 ctin structure to be determined, reveals the pentraxin fold and a novel doubly stacked octameric ring

166 The serum-amyloid-P-component-like pentraxin from Limulus polyphemus, a recently discovered

167 entraxin-3 (PTX3) is a prototype of the long pentraxin group.

168 An invertebrate SAP-like pentraxin has not previously been identified and it has

169 Pentraxin 3 (PTX3), the prototype of long pentraxins, has been described to be associated with end

170 ning 35 calcium exchanger beta repeats and a pentraxin homology domain.

171 Promoter hypermethylation of neuronal pentraxin II (NPTX2), a risky methylated gene, was confi

172 Nptx2 encodes neuronal pentraxin II (or neuronal activity-regulated pentraxin,

173 yloid P component (SAP), two major classical pentraxins in humans, are soluble pattern recognition mo

174 broader role than complement activation for pentraxins in immunity.

175 to activate FcalphaRI defines a function for pentraxins in inflammatory responses involving neutrophi

176 ct the localization and function of neuronal pentraxins in neuronal uptake or synapse formation and r

177 esults establish antibody-like functions for pentraxins in the FcgammaR pathway, suggest an evolution

178 ber of a newly recognized subfamily of "long pentraxins," in the HI injury cascade.

179 The classical pentraxins include serum amyloid P component (SAP) and C

180 ular, high-sensitivity C-reactive protein, a pentraxin innate immune recognition molecule and classic

181 Narp (neuronal activity-regulated pentraxin) is a secreted immediate-early gene (IEG) regu

182 Pentraxin 3 (PTX3), the prototypic long pentraxin, is a soluble pattern recognition receptor inv

183 dentify a patch of conserved residues on the pentraxin/laminin-neurexin-sex-hormone-binding-globulin-

184 previously unidentified domain that we term Pentraxin/Laminin/neurexin/sex-hormone-binding-globulin-

185 iencies of the classical pathway and certain pentraxins lead to impaired handling of apoptotic cells

186 The serum amyloid P component (SAP)-like pentraxin Limulus polyphemus SAP is a recently discovere

187 The use of FcgammaR by the pentraxins links innate and adaptive immunity and may ha

188 tory leukoprotease inhibitor (SLPI), elafin, pentraxin, LL-37, alpha-defensins and beta-defensin-2, a

189 a1 and alpha4beta1 integrins, the N-terminal pentraxin module of thrombospondin-1 is a ligand for alp

190 and is derived from a similar position in a pentraxin module.

191 ROS) and expression of a PC-specific mucosal pentraxin (Mptx2) in activated PCs.

192 secretion of the neuronal activity-regulated pentraxin (Narp) by hippocampal axons is restricted to c

193 Neuronal activity regulated pentraxin (Narp) has been implicated in the aggregation

194 Neuronal activity regulated pentraxin (Narp) is a secreted neuronal product which cl

195 diate early gene neuronal activity-regulated pentraxin (NARP) is an alpha-amino-3-hydroxy-5-methyl-4-

196 ic strength, the neuronal activity-regulated pentraxin (Narp), and glutamate decarboxylase (GAD65).

197 pentraxin II (or neuronal activity-regulated pentraxin, Narp), which is involved in the clustering of

198 distinguishes it as the first serum-related pentraxin not expressed in the liver.

199 ere, we report that a member of the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR)

200 over, we show that axonally derived neuronal pentraxins NP1 and NPR are required for GluR4 recruitmen

201 We hypothesized that neuronal pentraxin (NP1), a proapoptotic protein induced by low n

202 Neuronal pentraxins (NPs) are hypothesized to play important role

203 Neuronal pentraxins (NPs) define a family of proteins that are ho

204 Neuronal pentraxins (NPTX) and their corresponding receptors (NPT

205 on complex involving ADGRB3 and two neuronal pentraxins, NPTX1 and NPTXR.

206 We identified that the secreted neuronal pentraxin Nptx2 binds complement C1q and thereby regulat

207 value of cerebrospinal fluid (CSF) neuronal pentraxins (NPTXs), a family of proteins involved in hom

208 imulus C-reactive protein, the most abundant pentraxin of the plasma.

209 anisms that parallel the known role of short pentraxins outside the CNS.

210 The long pentraxin, pentraxin 3 (PTX3), can play beneficial or de

211 Human serum amyloid P component, a pentraxin protein that is very closely related to CRP, s

212 ng concentrations of the constitutive plasma pentraxin protein, serum amyloid P component (SAP), in s

213 Relative deficiency of pentraxin proteins is implicated in the pathogenesis of

214 strate the existence of a separate family of pentraxin proteins that are expressed in the human brain

215 ences in terms of interleukin (IL)-6, IL-10, pentraxin (PTX) 3, soluble fragment of tumor necrosis fa

216 The pentraxin (PTX) domain, which is predicted by sequence h

217 cavenger receptor cysteine rich (SRCR); (ii) pentraxin (PTX); (iii) polycystine-1, lipoxygenase, alph

218 The long pentraxin PTX3 (pentraxin 3) has emerged as a component

219 aeruginosa strain and treated with the long pentraxin PTX3.

220 esolution structure of the prototypical long pentraxin, PTX3.

221 1), neuronal pentraxin 2 (NP2), and neuronal pentraxin receptor (NPR) are members of a new family of

222 native usage of CUG and AUG TISs in neuronal pentraxin receptor (NPR) mRNA produced two proteoforms,

223 the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR), undergoes regulated cleavage b

224 ral membrane pentraxin and named it neuronal pentraxin receptor (NPR).

225 Specifically, both human and mouse pentraxins recognize major forms of Fc receptors in solu

226 Pentraxin-related protein 3 (PTX3), commonly produced by

227 We have proposed that these three neuronal pentraxins represent a novel neuronal uptake pathway tha

228 ere we describe the structural mechanism for pentraxin's binding to FcgammaR and its functional activ

229 id sequence, the first invertebrate SAP-like pentraxin sequence, have been determined.

230 presented here and the known horseshoe crab pentraxin sequences, suggest that adaptation and refinem

231 The systemic pentraxin serum amyloid P (SAP) inhibits inflammation.

232 studies demonstrated that PTX3 and the short pentraxin serum amyloid P express sialic acids that are

233 The pentraxins, serum amyloid P component (SAP) and C-reacti

234 Regions of homology include an 8 amino acid "pentraxin signature" sequence and a characteristic pentr

235 RNAi knockdown and knockout of the neuronal pentraxins significantly decreases GluR4 targeting to sy

236 om Limulus polyphemus, a recently discovered pentraxin species and important effector protein of the

237 nding to phosphocholine, is established as a pentraxin species distinct from all other known horsesho

238 hemus SAP is a recently discovered, distinct pentraxin species, of known structure, which does not bi

239 entified a calcium-dependent lectin from the pentraxin superfamily in the egg jelly coat from the Sou

240 Pentraxin 3 (PTX3), a prototypic long pentraxin that plays a non-redundant role in innate immu

241 distinct from all other known horseshoe crab pentraxins that exist in many variant forms sharing a hi

242 vities have been attributed to SAP and other pentraxins, their biological functions remain unclear.

243 Pentraxin then accumulates AMPA receptors on the postsyn

244 Pentraxin three, a regulator of innate immunity and neur

245 A possible role of pentraxins to maintain extracellular proteostasis is dis

246 ion structural information exists about long pentraxins, unlike the short pentraxins, where there is

247 e role of these receptors in phagocytosis by pentraxins using zymosan as a ligand.

248 In contrast, neuronal pentraxins were decreased in all neurodegenerative disea

249 Neuronal pentraxins were identified as general indicators of neur

250 ists about long pentraxins, unlike the short pentraxins, where there is an abundance of both X-ray an

251 el class of protein, which we named neuronal pentraxin with chromo domain (NPCD), as a PTPRO-interact

252 This novel protein, NPCD (Neuronal Pentraxin with Chromo Domain), has multiple cytoplasmic

253 Phylogenetic analysis clusters Limulus SAP pentraxin with the horseshoe crab C-reactive proteins (C

254 ily of soluble PRMs comprises long and short pentraxins, with the former containing unique N-terminal

255 ium-binding site is similar to that in human pentraxins, with two calcium ions bound in each subunit.